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The map label for this gene is sdhA [H]

Identifier: 213692569

GI number: 213692569

Start: 1861059

End: 1862900

Strand: Direct

Name: sdhA [H]

Synonym: Blon_1701

Alternate gene names: 213692569

Gene position: 1861059-1862900 (Clockwise)

Preceding gene: 213692568

Following gene: 213692570

Centisome position: 65.7

GC content: 63.36

Gene sequence:

>1842_bases
ATGTATGATGCGGTGATCGTCGGCGCCGGAGCGGCCGGCCTGTCGGCGGCGTTGGGACTGCTGCGCTCCCCCAAAATCAC
CGAGCTCAAGGAACAAGGCGTGGACCCGAAGATCCTCGTGGTCTCCAAACTGCAGCCGCTGCGTTCGCACACCGGTTCGG
CCGAGGGCGGCATCGCCGCGAGCCTGGGCAATGTGGAGTCCGATGACTGGCACTGGCATTACTACGACACCATCAAGGGC
GGCGACTGGCTCGTCGACCAGGACGCGGCCAAACTGCTCGCCGAATACGCGCCGCAGACCGTGATCAACCTGGAGCGTCA
GGGCGTGGCCTTCTCCCGTACCGATGACGGGCATATCGCCCAGCGCCGGTTCGGCGGCCACACGCGCGAGTTCGGCGGTG
CCCCGGTCAAGCGCGCCGCCTATGCGGCCGACCGCATCGGCCACCAGATTCTGCACGCCTTGTGGCAGCAGTGCGTGGCG
GCAGGCGTCGAGTTCGCCGAGGAATGGTATGTGACCGATCTGGTGCTCGCCGACGACGGCAAGCAGGCGGCCGGCATCGT
GGCATTTGACACGCATTCGGGCAAGATTCAGGCCATCCACGCGCGCAACGTGCTGCTTGCCACCGGTGGCGCGGGCCGAC
TGTTCCATACCACATCGAATTCCTGGGACCTGACCGGCGACGGCATGGCATTGGCCTTGGCCGCCGGCCTGCAGCTGGAG
GACATCGAATTTGTGCAATTCCACCCCACCGGACTCGCGCACACCGGCATCCTGCTGTCCGAGGCGGCCCGCGCCGAAGG
CGGCATCCTGAGGAACGCCGACGGTGAGCCGTTTATGGAACGCTACGCCCCAGAGCATAGGGATCTGGCCGCGCGAGACG
TGGTCTCCCGCTCCATCATGGCGGAGATCGACGCCGGCCGCGGCGTCGCCGACCCGAAGGACCCGGATGGTCCGAAGGAC
TGCGTCTGGCTGGACATGACCGGCATCGACCCCGAACGTATGAAGGAAGTGCTACCGCAGGTGGTCGAAACCATCGAGCA
GTACGCGAACCTCGATCCGGCCAAGGACCTGGTGCCTATCAAGCCCACTGCGCATTACACGATGGGCGGCATCCCCATCA
CCACCAATGGCGAGGTGTACCGTTGGGCCGACGGTGCCGTGCAGGTAGTCGATGGACTGTTCTCCGCTGGCGAATGCTCT
TGTGTCTCCGTACATGGTGCGAATCGTCTGGGCGGCAATTCTCTGCTCGACGCCTGCCTGTTCGGTACACGTGCTGGTCA
GACGATGGCCGCACGCATCGTCGAGAACCCGGTTGACTCCCCTATGGCCGAAGATTCGGCCGATGACATGCTGACCGATG
CCGCCGATCAGGCTGCCGATTCCCGCAAGGCAGAGCTTGACGAACTGCTCGCCGGACCGATGGACGATTCAGACGATGGC
GGGCCCACCGCCAATCCTTATCAGCTCATAGCCCAACTCGGATCAGTGATGGAGCAGGCTCTGGCCGTACGTTGCACCGC
TCAGACCATCGATACGGCGTTGACTCAGATCAACAACGACATCACACCGGTTGCCGATACCTTGCGGGCCCATGACAAGA
CCGCCGCTTTCAATCAGGAGGTCACCGCCATCTGGGAAGTCCGTCATCTAATCGAACTGGCCGAGGCCATGCTGCACGCT
TCCGAATCCCGTCAGGAATCCCGCGGATCCATGCAACGCCTTGATTTCCCCGAACGCGACGATGAGCATTTCCTTGCTCA
CTCGATGGTCGCCGATGATGGTCCGGCAAGTTTCAAGCCGGTGCACATCACCGACTATCCACCCAAGAAGCGCGAGTACT
GA

Upstream 100 bases:

>100_bases
TGAGCAGCCGTGTCGGCTAATCGGCTTCCATGACACGGCTCGAAGACTGTTCGGCGGGTGTGCGAGAATCGAACCCATGA
GTCCGAAACGTTTGGAAGAT

Downstream 100 bases:

>100_bases
TCCGCTGGTGGTAATACCAAGCCGCCTAGGGCTTGTGGCACAATAGGTTGGCTGATTATTGGACTTGACATCCCACTGTT
TCATGGAGGCAGAACATGGC

Product: Succinate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 613; Mature: 613

Protein sequence:

>613_residues
MYDAVIVGAGAAGLSAALGLLRSPKITELKEQGVDPKILVVSKLQPLRSHTGSAEGGIAASLGNVESDDWHWHYYDTIKG
GDWLVDQDAAKLLAEYAPQTVINLERQGVAFSRTDDGHIAQRRFGGHTREFGGAPVKRAAYAADRIGHQILHALWQQCVA
AGVEFAEEWYVTDLVLADDGKQAAGIVAFDTHSGKIQAIHARNVLLATGGAGRLFHTTSNSWDLTGDGMALALAAGLQLE
DIEFVQFHPTGLAHTGILLSEAARAEGGILRNADGEPFMERYAPEHRDLAARDVVSRSIMAEIDAGRGVADPKDPDGPKD
CVWLDMTGIDPERMKEVLPQVVETIEQYANLDPAKDLVPIKPTAHYTMGGIPITTNGEVYRWADGAVQVVDGLFSAGECS
CVSVHGANRLGGNSLLDACLFGTRAGQTMAARIVENPVDSPMAEDSADDMLTDAADQAADSRKAELDELLAGPMDDSDDG
GPTANPYQLIAQLGSVMEQALAVRCTAQTIDTALTQINNDITPVADTLRAHDKTAAFNQEVTAIWEVRHLIELAEAMLHA
SESRQESRGSMQRLDFPERDDEHFLAHSMVADDGPASFKPVHITDYPPKKREY

Sequences:

>Translated_613_residues
MYDAVIVGAGAAGLSAALGLLRSPKITELKEQGVDPKILVVSKLQPLRSHTGSAEGGIAASLGNVESDDWHWHYYDTIKG
GDWLVDQDAAKLLAEYAPQTVINLERQGVAFSRTDDGHIAQRRFGGHTREFGGAPVKRAAYAADRIGHQILHALWQQCVA
AGVEFAEEWYVTDLVLADDGKQAAGIVAFDTHSGKIQAIHARNVLLATGGAGRLFHTTSNSWDLTGDGMALALAAGLQLE
DIEFVQFHPTGLAHTGILLSEAARAEGGILRNADGEPFMERYAPEHRDLAARDVVSRSIMAEIDAGRGVADPKDPDGPKD
CVWLDMTGIDPERMKEVLPQVVETIEQYANLDPAKDLVPIKPTAHYTMGGIPITTNGEVYRWADGAVQVVDGLFSAGECS
CVSVHGANRLGGNSLLDACLFGTRAGQTMAARIVENPVDSPMAEDSADDMLTDAADQAADSRKAELDELLAGPMDDSDDG
GPTANPYQLIAQLGSVMEQALAVRCTAQTIDTALTQINNDITPVADTLRAHDKTAAFNQEVTAIWEVRHLIELAEAMLHA
SESRQESRGSMQRLDFPERDDEHFLAHSMVADDGPASFKPVHITDYPPKKREY
>Mature_613_residues
MYDAVIVGAGAAGLSAALGLLRSPKITELKEQGVDPKILVVSKLQPLRSHTGSAEGGIAASLGNVESDDWHWHYYDTIKG
GDWLVDQDAAKLLAEYAPQTVINLERQGVAFSRTDDGHIAQRRFGGHTREFGGAPVKRAAYAADRIGHQILHALWQQCVA
AGVEFAEEWYVTDLVLADDGKQAAGIVAFDTHSGKIQAIHARNVLLATGGAGRLFHTTSNSWDLTGDGMALALAAGLQLE
DIEFVQFHPTGLAHTGILLSEAARAEGGILRNADGEPFMERYAPEHRDLAARDVVSRSIMAEIDAGRGVADPKDPDGPKD
CVWLDMTGIDPERMKEVLPQVVETIEQYANLDPAKDLVPIKPTAHYTMGGIPITTNGEVYRWADGAVQVVDGLFSAGECS
CVSVHGANRLGGNSLLDACLFGTRAGQTMAARIVENPVDSPMAEDSADDMLTDAADQAADSRKAELDELLAGPMDDSDDG
GPTANPYQLIAQLGSVMEQALAVRCTAQTIDTALTQINNDITPVADTLRAHDKTAAFNQEVTAIWEVRHLIELAEAMLHA
SESRQESRGSMQRLDFPERDDEHFLAHSMVADDGPASFKPVHITDYPPKKREY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=549, Percent_Identity=38.9799635701275, Blast_Score=389, Evalue=1e-108,
Organism=Escherichia coli, GI1786942, Length=581, Percent_Identity=40.447504302926, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1790597, Length=595, Percent_Identity=34.9579831932773, Blast_Score=338, Evalue=6e-94,
Organism=Escherichia coli, GI1788928, Length=615, Percent_Identity=29.1056910569106, Blast_Score=197, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17505833, Length=618, Percent_Identity=37.2168284789644, Blast_Score=390, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17550100, Length=609, Percent_Identity=38.2594417077176, Blast_Score=379, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6322701, Length=593, Percent_Identity=38.4485666104553, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6322416, Length=570, Percent_Identity=38.7719298245614, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI17137288, Length=547, Percent_Identity=39.3053016453382, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24655642, Length=547, Percent_Identity=39.3053016453382, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24655647, Length=547, Percent_Identity=39.3053016453382, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24663005, Length=620, Percent_Identity=36.7741935483871, Blast_Score=356, Evalue=3e-98,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66007; Mature: 66007

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDAVIVGAGAAGLSAALGLLRSPKITELKEQGVDPKILVVSKLQPLRSHTGSAEGGIAA
CCCEEEEECCHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEECCCHHHHCCCCCCCCEEE
SLGNVESDDWHWHYYDTIKGGDWLVDQDAAKLLAEYAPQTVINLERQGVAFSRTDDGHIA
ECCCCCCCCCEEEEEEEECCCCEEECHHHHHHHHHHCCHHEEEHHHCCCEEECCCCCHHH
QRRFGGHTREFGGAPVKRAAYAADRIGHQILHALWQQCVAAGVEFAEEWYVTDLVLADDG
HHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCC
KQAAGIVAFDTHSGKIQAIHARNVLLATGGAGRLFHTTSNSWDLTGDGMALALAAGLQLE
CCCCCEEEEECCCCEEEEEEECCEEEEECCCCEEEEECCCCCEECCCCHHHHHHCCCEEC
DIEFVQFHPTGLAHTGILLSEAARAEGGILRNADGEPFMERYAPEHRDLAARDVVSRSIM
CEEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHH
AEIDAGRGVADPKDPDGPKDCVWLDMTGIDPERMKEVLPQVVETIEQYANLDPAKDLVPI
HHHCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEC
KPTAHYTMGGIPITTNGEVYRWADGAVQVVDGLFSAGECSCVSVHGANRLGGNSLLDACL
CCCCCEEECCEEEECCCCEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHH
FGTRAGQTMAARIVENPVDSPMAEDSADDMLTDAADQAADSRKAELDELLAGPMDDSDDG
HCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GPTANPYQLIAQLGSVMEQALAVRCTAQTIDTALTQINNDITPVADTLRAHDKTAAFNQE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHCHH
VTAIWEVRHLIELAEAMLHASESRQESRGSMQRLDFPERDDEHFLAHSMVADDGPASFKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHCCCCCCCCCC
VHITDYPPKKREY
EEECCCCCCCCCC
>Mature Secondary Structure
MYDAVIVGAGAAGLSAALGLLRSPKITELKEQGVDPKILVVSKLQPLRSHTGSAEGGIAA
CCCEEEEECCHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEECCCHHHHCCCCCCCCEEE
SLGNVESDDWHWHYYDTIKGGDWLVDQDAAKLLAEYAPQTVINLERQGVAFSRTDDGHIA
ECCCCCCCCCEEEEEEEECCCCEEECHHHHHHHHHHCCHHEEEHHHCCCEEECCCCCHHH
QRRFGGHTREFGGAPVKRAAYAADRIGHQILHALWQQCVAAGVEFAEEWYVTDLVLADDG
HHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCC
KQAAGIVAFDTHSGKIQAIHARNVLLATGGAGRLFHTTSNSWDLTGDGMALALAAGLQLE
CCCCCEEEEECCCCEEEEEEECCEEEEECCCCEEEEECCCCCEECCCCHHHHHHCCCEEC
DIEFVQFHPTGLAHTGILLSEAARAEGGILRNADGEPFMERYAPEHRDLAARDVVSRSIM
CEEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHH
AEIDAGRGVADPKDPDGPKDCVWLDMTGIDPERMKEVLPQVVETIEQYANLDPAKDLVPI
HHHCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEC
KPTAHYTMGGIPITTNGEVYRWADGAVQVVDGLFSAGECSCVSVHGANRLGGNSLLDACL
CCCCCEEECCEEEECCCCEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHH
FGTRAGQTMAARIVENPVDSPMAEDSADDMLTDAADQAADSRKAELDELLAGPMDDSDDG
HCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GPTANPYQLIAQLGSVMEQALAVRCTAQTIDTALTQINNDITPVADTLRAHDKTAAFNQE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHCHH
VTAIWEVRHLIELAEAMLHASESRQESRGSMQRLDFPERDDEHFLAHSMVADDGPASFKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHCCCCCCCCCC
VHITDYPPKKREY
EEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7698664; 12704232 [H]