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The map label for this gene is pyrD [H]

Identifier: 213692321

GI number: 213692321

Start: 1604627

End: 1605598

Strand: Reverse

Name: pyrD [H]

Synonym: Blon_1446

Alternate gene names: 213692321

Gene position: 1605598-1604627 (Counterclockwise)

Preceding gene: 213692322

Following gene: 213692320

Centisome position: 56.68

GC content: 65.95

Gene sequence:

>972_bases
ATGACCGCAAACAACCAGTCCGCGCAGGGCAGCGACAACCACATCAACCTGTACGAGCCCCACGTGTGGAAGCACCACAC
CAAGGTGGCCGGTCTGGAATGGAAGAATCCGGTCGGCACCGCCTCCGGCACCTTCCAGTACGCCGCTGTCCGCTGGTTCT
ACGACGTCAGCCAGCTCGGCGCCGTATGCACCAAGGGCGCCTCGCCCGTGCCGTGGGAGGGCAATCCTTCGCCGCGCACC
GCCGAATCGCCGGCCGCGAACATCAACGCTGTGGGCCTGCAGAACCCCGGCATCGACCATTACTTGGCCGAAGACCTGCC
CAAGCTCAAGGCCGCGGGCGCGTTCGTCATCTCCAATGTCGCCGGACATTGCGATGACGATTACGCGGCGGTCGTGGAAA
AGCTCGCCGACTCCGACGCGGACATGCTGGAAATCAACGTCAGCTGCCCGAACGTTTCCGCCGGCGGCATGAGCGTGGGC
ACCGACCCGGTGGCCCTCGCCAATCTTATGGACCGGCTGCGCCCGATGACCGACAAGCCGATGATCGTCAAACTCACGCC
GAACGTCACCGACATCACCGTGCCGGCGCGCGCGGCCGTGGAACACGGCGCCGATGCGTTGAGCATGATCAACACGCTCA
AAGGTATGCGCATCAACATTCGCACAGGCCAGCCGATCATCGCCAACGTCACCGGCGGCATATCCGGCCCGGCCGTGCTG
CCGGTCGGCCTGGCAGCCGTCTACCGGGTGCGCACCGCACTGCCGGAGATTCCGATCATCGGCCTCGGCGGCATCGACAG
CGGCGAGAAGGCGCTCGAATACCTGTACGCCGGCGCGAACGCCGTCGAAGTGGGTGCGGCCGCGCTCTTCGACCCGGTGG
CCCCGCTGCGCGTCGCCCGCGAACTCGACTACCTGCTGGACAGCCGTCCCGAACTCGCTGCTAAACTGGCCGCAGGACAG
ACTTGGAGGTAA

Upstream 100 bases:

>100_bases
CCTGCGTGCTGTGCACCATCGACACCATGGACGGCCGCCTCAAGGTCTGCTCCGACGGACCCGTGTTCACCCGCGAACAG
CTCGGATGGGGGGAGTGACG

Downstream 100 bases:

>100_bases
GGAACATCATGGCAGAAACACTCGCACATCGCTTCACTGAATTCCTGTTGGAATCCAACGCGCTGAAGTTCGGCGACTTC
ACGCTGAAGTCCGGCCGCAA

Product: dihydroorotate dehydrogenase family protein

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTANNQSAQGSDNHINLYEPHVWKHHTKVAGLEWKNPVGTASGTFQYAAVRWFYDVSQLGAVCTKGASPVPWEGNPSPRT
AESPAANINAVGLQNPGIDHYLAEDLPKLKAAGAFVISNVAGHCDDDYAAVVEKLADSDADMLEINVSCPNVSAGGMSVG
TDPVALANLMDRLRPMTDKPMIVKLTPNVTDITVPARAAVEHGADALSMINTLKGMRINIRTGQPIIANVTGGISGPAVL
PVGLAAVYRVRTALPEIPIIGLGGIDSGEKALEYLYAGANAVEVGAAALFDPVAPLRVARELDYLLDSRPELAAKLAAGQ
TWR

Sequences:

>Translated_323_residues
MTANNQSAQGSDNHINLYEPHVWKHHTKVAGLEWKNPVGTASGTFQYAAVRWFYDVSQLGAVCTKGASPVPWEGNPSPRT
AESPAANINAVGLQNPGIDHYLAEDLPKLKAAGAFVISNVAGHCDDDYAAVVEKLADSDADMLEINVSCPNVSAGGMSVG
TDPVALANLMDRLRPMTDKPMIVKLTPNVTDITVPARAAVEHGADALSMINTLKGMRINIRTGQPIIANVTGGISGPAVL
PVGLAAVYRVRTALPEIPIIGLGGIDSGEKALEYLYAGANAVEVGAAALFDPVAPLRVARELDYLLDSRPELAAKLAAGQ
TWR
>Mature_322_residues
TANNQSAQGSDNHINLYEPHVWKHHTKVAGLEWKNPVGTASGTFQYAAVRWFYDVSQLGAVCTKGASPVPWEGNPSPRTA
ESPAANINAVGLQNPGIDHYLAEDLPKLKAAGAFVISNVAGHCDDDYAAVVEKLADSDADMLEINVSCPNVSAGGMSVGT
DPVALANLMDRLRPMTDKPMIVKLTPNVTDITVPARAAVEHGADALSMINTLKGMRINIRTGQPIIANVTGGISGPAVLP
VGLAAVYRVRTALPEIPIIGLGGIDSGEKALEYLYAGANAVEVGAAALFDPVAPLRVARELDYLLDSRPELAAKLAAGQT
WR

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=284, Percent_Identity=32.7464788732394, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI45006951, Length=310, Percent_Identity=31.2903225806452, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI87082059, Length=224, Percent_Identity=30.8035714285714, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787177, Length=285, Percent_Identity=28.4210526315789, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71984108, Length=196, Percent_Identity=31.6326530612245, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322633, Length=296, Percent_Identity=32.4324324324324, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24640763, Length=173, Percent_Identity=36.4161849710983, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18858217, Length=173, Percent_Identity=36.4161849710983, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 33989; Mature: 33858

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANNQSAQGSDNHINLYEPHVWKHHTKVAGLEWKNPVGTASGTFQYAAVRWFYDVSQLG
CCCCCCCCCCCCCEEEECCCCHHHCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AVCTKGASPVPWEGNPSPRTAESPAANINAVGLQNPGIDHYLAEDLPKLKAAGAFVISNV
HHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHH
AGHCDDDYAAVVEKLADSDADMLEINVSCPNVSAGGMSVGTDPVALANLMDRLRPMTDKP
CCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
MIVKLTPNVTDITVPARAAVEHGADALSMINTLKGMRINIRTGQPIIANVTGGISGPAVL
EEEEECCCCEEEECCHHHHHHHCHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCHHH
PVGLAAVYRVRTALPEIPIIGLGGIDSGEKALEYLYAGANAVEVGAAALFDPVAPLRVAR
HHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHH
ELDYLLDSRPELAAKLAAGQTWR
HHHHHHCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
TANNQSAQGSDNHINLYEPHVWKHHTKVAGLEWKNPVGTASGTFQYAAVRWFYDVSQLG
CCCCCCCCCCCCEEEECCCCHHHCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AVCTKGASPVPWEGNPSPRTAESPAANINAVGLQNPGIDHYLAEDLPKLKAAGAFVISNV
HHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHH
AGHCDDDYAAVVEKLADSDADMLEINVSCPNVSAGGMSVGTDPVALANLMDRLRPMTDKP
CCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
MIVKLTPNVTDITVPARAAVEHGADALSMINTLKGMRINIRTGQPIIANVTGGISGPAVL
EEEEECCCCEEEECCHHHHHHHCHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCHHH
PVGLAAVYRVRTALPEIPIIGLGGIDSGEKALEYLYAGANAVEVGAAALFDPVAPLRVAR
HHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHH
ELDYLLDSRPELAAKLAAGQTWR
HHHHHHCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA