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The map label for this gene is hipA [C]

Identifier: 213692233

GI number: 213692233

Start: 1524248

End: 1525588

Strand: Reverse

Name: hipA [C]

Synonym: Blon_1353

Alternate gene names: 213692233

Gene position: 1525588-1524248 (Counterclockwise)

Preceding gene: 213692234

Following gene: 213692232

Centisome position: 53.86

GC content: 58.39

Gene sequence:

>1341_bases
ATGCGAGGAGAACGACTGCATGTCTGGACCGACGGGGACCATGTGGGGGAATTCATGCGAACCTCCGGCGGACATGTTTC
ATTCCACTATGATTCCAAGGAAGGCGCGCCGATAAGCCTCAGTCTGCCCCGAACCGGGAAATCCTCCGGAAAAGCGGCGT
CGGCCTTTCTCGAAAACCTGCTTCCCGACGATGAGAACGCCCGTCGTAGGATGGCGTCGCGACTCCATCTGGATTCGACG
GACACGTTCAAACTTCTTGCGGATGCGGATACGGTAGGCGGACTCGTATTCTCGGACAAGCCCGAACTCCCGCACCATCC
CATCGAGGCGAAACCCCTCGACGAGGAGGAAATCGGCAATCAGATAGGATACGTGCGTGCGAACGGATACAACTGGTTCG
CACGGGATGATGAGGATGAGTTCTATGAGCGGGATACGCCGAAATGCCGTTTCTCCATCGCCGGAGGCCAGCCCAAGTTC
ACGCTCGCCCGACGTGCTGGTGTCTGGCTCTGGCCCAACGCATCCATCCCCTCCACCCATATCATCAAACCTGAAATGAG
GGATTGTCCCGGCAGCCACAGGGTGGAGGATGCCGCCCTGACGCTCGGGACTCTTTGCGGATTGCCGGTATCCGAGCATG
GCATTCTCACCGCGAATGGGGCGGAGGCTTTCATCACCCGACGTTTCGATCGCATCGTGGATGGAAACAACGTGAGACGA
ATCCATTGCGAGGATCTAGCGCAGGCCATGGGCATGGACCCCGAATCCAAGTATGAAATCGGCGCCGCAAGCTGCGTCCG
TTTCCTGCACCATTTCGACCCAAGCGATGAAACCGGATATGAATGGGTTCGCCGGCTCGCCTTCAACGTCTCGTCGGGTG
ATTCGGACTCCCACGGCAAGAACTATTCGATTGTTCTTGCCGAAAACGGGTTCCGTTTCGCGCCAATGTACGACATGACA
GTCACCAGAATATGGCCTCATGTGGATCAGGAGATGGCGATGCCGATCAACGGAGTCGAATTCGCGGAACTGCTCACCCC
ATTCGACTGGGAGGCCTTCGCGGAGGAGGCCGGTTTGGACGGGGAACGTGTGGCGCATATCGCCCGGACCATGGCGGGAG
CCGTTCTCGACCATCTGGATGAGGCATCGGCCGGTTTGCCCGATTCGCTGAGGGAATCCATGCGTAAGGCGGTTTCGAAG
GCAAACGAGAACATCCAGCCACTGCACAGAAGGATGTCGAAGCCAAAGGCGAATACGGCATCCTTCAGCGGGGGCGGCGT
CTGGGTGAGCCCTCATATCCGAAGCGGATATGAGGTCAGTGGATACTGGCGCAGCCGCTGA

Upstream 100 bases:

>100_bases
TGGCGGAATGCGGGATCGTACCGCTGGAAGCGGCCCTGCGCGTGTTCGCCACACTCGGCGTCAAACCCGATAGGGTTCCG
CCCGAATATCTGGAGGCATG

Downstream 100 bases:

>100_bases
CCCCGTTTCCCTGATTAGGGGGACGCATACCCGGGGCATGGAACGATTCGACGATTCCATAGCCACCCTGGACGGCCCCC
AGCTGCTCGCCCTGTTCGAG

Product: HipA domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MRGERLHVWTDGDHVGEFMRTSGGHVSFHYDSKEGAPISLSLPRTGKSSGKAASAFLENLLPDDENARRRMASRLHLDST
DTFKLLADADTVGGLVFSDKPELPHHPIEAKPLDEEEIGNQIGYVRANGYNWFARDDEDEFYERDTPKCRFSIAGGQPKF
TLARRAGVWLWPNASIPSTHIIKPEMRDCPGSHRVEDAALTLGTLCGLPVSEHGILTANGAEAFITRRFDRIVDGNNVRR
IHCEDLAQAMGMDPESKYEIGAASCVRFLHHFDPSDETGYEWVRRLAFNVSSGDSDSHGKNYSIVLAENGFRFAPMYDMT
VTRIWPHVDQEMAMPINGVEFAELLTPFDWEAFAEEAGLDGERVAHIARTMAGAVLDHLDEASAGLPDSLRESMRKAVSK
ANENIQPLHRRMSKPKANTASFSGGGVWVSPHIRSGYEVSGYWRSR

Sequences:

>Translated_446_residues
MRGERLHVWTDGDHVGEFMRTSGGHVSFHYDSKEGAPISLSLPRTGKSSGKAASAFLENLLPDDENARRRMASRLHLDST
DTFKLLADADTVGGLVFSDKPELPHHPIEAKPLDEEEIGNQIGYVRANGYNWFARDDEDEFYERDTPKCRFSIAGGQPKF
TLARRAGVWLWPNASIPSTHIIKPEMRDCPGSHRVEDAALTLGTLCGLPVSEHGILTANGAEAFITRRFDRIVDGNNVRR
IHCEDLAQAMGMDPESKYEIGAASCVRFLHHFDPSDETGYEWVRRLAFNVSSGDSDSHGKNYSIVLAENGFRFAPMYDMT
VTRIWPHVDQEMAMPINGVEFAELLTPFDWEAFAEEAGLDGERVAHIARTMAGAVLDHLDEASAGLPDSLRESMRKAVSK
ANENIQPLHRRMSKPKANTASFSGGGVWVSPHIRSGYEVSGYWRSR
>Mature_446_residues
MRGERLHVWTDGDHVGEFMRTSGGHVSFHYDSKEGAPISLSLPRTGKSSGKAASAFLENLLPDDENARRRMASRLHLDST
DTFKLLADADTVGGLVFSDKPELPHHPIEAKPLDEEEIGNQIGYVRANGYNWFARDDEDEFYERDTPKCRFSIAGGQPKF
TLARRAGVWLWPNASIPSTHIIKPEMRDCPGSHRVEDAALTLGTLCGLPVSEHGILTANGAEAFITRRFDRIVDGNNVRR
IHCEDLAQAMGMDPESKYEIGAASCVRFLHHFDPSDETGYEWVRRLAFNVSSGDSDSHGKNYSIVLAENGFRFAPMYDMT
VTRIWPHVDQEMAMPINGVEFAELLTPFDWEAFAEEAGLDGERVAHIARTMAGAVLDHLDEASAGLPDSLRESMRKAVSK
ANENIQPLHRRMSKPKANTASFSGGGVWVSPHIRSGYEVSGYWRSR

Specific function: Unbalanced Or Excessive Expression Of Hipa Is Toxic To The Cell. [C]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli hipA, H.influenzae HI_0665 and y4dM [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=447, Percent_Identity=27.9642058165548, Blast_Score=131, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 49628; Mature: 49628

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGERLHVWTDGDHVGEFMRTSGGHVSFHYDSKEGAPISLSLPRTGKSSGKAASAFLENL
CCCCEEEEEECCHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHH
LPDDENARRRMASRLHLDSTDTFKLLADADTVGGLVFSDKPELPHHPIEAKPLDEEEIGN
CCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHCCEEECCCCCCCCCCCCCCCCCHHHHCC
QIGYVRANGYNWFARDDEDEFYERDTPKCRFSIAGGQPKFTLARRAGVWLWPNASIPSTH
CCCEEEECCEEECCCCCCHHHHHCCCCCEEEEECCCCCCEEEHHHCCEEECCCCCCCCCE
IIKPEMRDCPGSHRVEDAALTLGTLCGLPVSEHGILTANGAEAFITRRFDRIVDGNNVRR
EECCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEE
IHCEDLAQAMGMDPESKYEIGAASCVRFLHHFDPSDETGYEWVRRLAFNVSSGDSDSHGK
EEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
NYSIVLAENGFRFAPMYDMTVTRIWPHVDQEMAMPINGVEFAELLTPFDWEAFAEEAGLD
CEEEEEECCCEEEEEECCCHHHHHCCCCCHHHCCCCCCCHHHHHHCCCCHHHHHHHHCCC
GERVAHIARTMAGAVLDHLDEASAGLPDSLRESMRKAVSKANENIQPLHRRMSKPKANTA
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCC
SFSGGGVWVSPHIRSGYEVSGYWRSR
CCCCCCEEECCCCCCCCEECCEECCC
>Mature Secondary Structure
MRGERLHVWTDGDHVGEFMRTSGGHVSFHYDSKEGAPISLSLPRTGKSSGKAASAFLENL
CCCCEEEEEECCHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHH
LPDDENARRRMASRLHLDSTDTFKLLADADTVGGLVFSDKPELPHHPIEAKPLDEEEIGN
CCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHCCEEECCCCCCCCCCCCCCCCCHHHHCC
QIGYVRANGYNWFARDDEDEFYERDTPKCRFSIAGGQPKFTLARRAGVWLWPNASIPSTH
CCCEEEECCEEECCCCCCHHHHHCCCCCEEEEECCCCCCEEEHHHCCEEECCCCCCCCCE
IIKPEMRDCPGSHRVEDAALTLGTLCGLPVSEHGILTANGAEAFITRRFDRIVDGNNVRR
EECCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEE
IHCEDLAQAMGMDPESKYEIGAASCVRFLHHFDPSDETGYEWVRRLAFNVSSGDSDSHGK
EEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
NYSIVLAENGFRFAPMYDMTVTRIWPHVDQEMAMPINGVEFAELLTPFDWEAFAEEAGLD
CEEEEEECCCEEEEEECCCHHHHHCCCCCHHHCCCCCCCHHHHHHCCCCHHHHHHHHCCC
GERVAHIARTMAGAVLDHLDEASAGLPDSLRESMRKAVSKANENIQPLHRRMSKPKANTA
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCC
SFSGGGVWVSPHIRSGYEVSGYWRSR
CCCCCCEEECCCCCCCCEECCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]