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The map label for this gene is der [H]

Identifier: 213692049

GI number: 213692049

Start: 1349315

End: 1351444

Strand: Direct

Name: der [H]

Synonym: Blon_1167

Alternate gene names: 213692049

Gene position: 1349315-1351444 (Clockwise)

Preceding gene: 213692048

Following gene: 213692051

Centisome position: 47.63

GC content: 62.54

Gene sequence:

>2130_bases
GTGATTCGCGTTGCCATCGACGGCCCCGCCGGCGTGGGCAAGTCGTCCACGTCCAAGGCGCTGGCCAAGTATTTCGGATA
CGCCTACCTTGACACGGGCGCGATGTATCGTGCCTGCGCTTGGTGGTGCTTGAAGCAGGGCATCGATCTGGACGCCGAAA
CCGTGGATGAGCGTGTCATCACCGAAGCGGTGGGCGAGTTCTTCACCGGCGACCATTTCGATATCTCCGTGGACCCGGAC
AACCCCTGCGTATTCGCCGACGACGAGGACATCTCCGAGGCCATTCGTTCCTCCGAAGTCTCCAGCCATGTCTCCAAGGT
GTCGAACGTCATCCCGGTGCGCAACGTGCTCATCGCCGCCCAGCGCGCCTACATCGCCCGCGAGGCGTCGGCCGACTCCT
TCTCCGGGGGTTTGGGCATCGTGGCCGAGGGCCGCGATATCACCACTGTGGTGTCCCCGGACGCCGAGGTGCGCGTGCTG
CTGACCGCCCGTGAGGAGGTCCGTCAGGCCCGTCGCACCGGCCAAGCCGTCAAGGGCGTGGGTGCTGAGGATGTGGCCGC
GCGCGACAAGGCCGATTCCAAGGTCACCAGCTTCCTGACCGCCGCCGATGGCGTTACCACCATCGACAATTCCGATCTGG
ACTTCGCCCACACGCTCGATCTGCTCATCGGTCTGGTCGAGGACGCCATCGAGAACCAGGAATACGAGCAGTATGCCGCC
AATCTCGAAGGCTATGAGTTGGACGAGGGCGATGAGGATCTGATTTCCGGCCGTGGTTTCACGGAAGGTGCGCGCAAGGC
CGGCCCCAAGCCGGTGGGCGTGCTGGCTATTGTAGGCCGTCCGAACGTGGGCAAATCATCCTTGGTCAACCGTATCCTCG
GCCGCCGTGCCGCCGTTGTGGAAGACACGCCGGGCGTTACGCGAGACCGTGTGAGCTATGACGCGGAATGGGCTGGCACC
GACTTCAAGCTGGTGGACACGGGCGGCTGGGAAGCCGACGTGGAAGGCATTGAATCCGCCATCGCCTCACAGGCACAGGT
TGCCGTGACCTTGGCCGATGCTGTGGTATTCGTTGTCGATGGTCAAGTGGGCATGACCACCACCGATGAGCGCATCGTCA
AGATGCTGCGTGCCGCCGGCAAGCCGATCGTGCTGGCCGTCAACAAGATCGACGACCAGGCCAGCGAATACCTTGCCGCC
GAATTCTGGAAGCTCGGCCTCGGCGAACCATACTCGATTTCCGCCATGCACGGCAGGGGAGTGGGCGACCTGCTGGACGT
TGCGCTCGACAAGCTCAAGCAGGCCGAGAAGACTTCCGGCTACCTCACGCCTTCCGGCCTGCGCCGCGTGGCTCTGGTGG
GCCGTCCGAACGTGGGCAAGTCGTCTCTGCTCAATCAGCTGGCGCGCGAAGAACGTGCCGTTGTCAACGATTTGGCCGGC
ACTACGCGCGACCCCGTCGACGAAATCGTCAACATCGATGGCGAGGACTGGTTGTTCATCGACACCGCCGGCATCAAGCG
ACGCCAGCACAAGCTCACAGGCGCGGAATATTATTCCTCTCTGCGCACGCAGGCCGCCATCGAGCGCTGTGAATTGGCGC
TGATCCTGTTTGATGCATCGCAGCCGGTATCCGATCAGGATTTGAAGGTCATGTCCACCGCCGTGGATGCGGGCCGTGCA
ATCGTGCTCGTATTCAACAAGTGGGATGCGATGGACGAGTTCGACAAGCAGCGTCTCGAACGCCTGTGGAACACCGAATT
CGACCGTGTGATGTGGGCCGAGCGTGTGAACCTGTCCGCCAAGACCGGCTGGCACACCAACCGTCTGACGCGAGCCATGG
ATAAGGCCTTGGAATCCTGGGATCAGCGTATTCCTACAGGCAAGCTCAACGCCTTCCTCGGCAAAATTCAGGCCGCCCAC
CCGCACCCGTTGCGTGGTGGCAAGCAGCCGCGAATCCTCTTCGCCACGCAGGCATCCACGCGCCCGCCGCGTTTCGTGAT
CTTCGCCACCGGCTTCCTCGAGCACGGCTACCGCCGCTACATCGAGCGTTCGCTGCGCGAGGAATTCGGCTTCGAAGGCA
CGCCAATCCAGATCTCCGTGAACATCCGCGAAAAGAAGAAGCGGAAGTGA

Upstream 100 bases:

>100_bases
GCACTCAGATCGGCCCGATCAAACTCGGTGATCTGAAGCCCGGTTCCTACCGCGTGCTGTCCCAGACGGAAGTCCGTTCG
CTGTCCAAGGAGGTTGGCCT

Downstream 100 bases:

>100_bases
CACGCGCGTAATTTGCCAGATTTCATATATCTGGTAGATTATCTATTCGGTGCTTTTGCACCATCGGGCCGTAGCGCAGT
TTGGTAGCGCACTTGACTGG

Product: bifunctional cytidylate kinase/GTP-binding protein

Products: NA

Alternate protein names: GTP-binding protein EngA [H]

Number of amino acids: Translated: 709; Mature: 709

Protein sequence:

>709_residues
MIRVAIDGPAGVGKSSTSKALAKYFGYAYLDTGAMYRACAWWCLKQGIDLDAETVDERVITEAVGEFFTGDHFDISVDPD
NPCVFADDEDISEAIRSSEVSSHVSKVSNVIPVRNVLIAAQRAYIAREASADSFSGGLGIVAEGRDITTVVSPDAEVRVL
LTAREEVRQARRTGQAVKGVGAEDVAARDKADSKVTSFLTAADGVTTIDNSDLDFAHTLDLLIGLVEDAIENQEYEQYAA
NLEGYELDEGDEDLISGRGFTEGARKAGPKPVGVLAIVGRPNVGKSSLVNRILGRRAAVVEDTPGVTRDRVSYDAEWAGT
DFKLVDTGGWEADVEGIESAIASQAQVAVTLADAVVFVVDGQVGMTTTDERIVKMLRAAGKPIVLAVNKIDDQASEYLAA
EFWKLGLGEPYSISAMHGRGVGDLLDVALDKLKQAEKTSGYLTPSGLRRVALVGRPNVGKSSLLNQLAREERAVVNDLAG
TTRDPVDEIVNIDGEDWLFIDTAGIKRRQHKLTGAEYYSSLRTQAAIERCELALILFDASQPVSDQDLKVMSTAVDAGRA
IVLVFNKWDAMDEFDKQRLERLWNTEFDRVMWAERVNLSAKTGWHTNRLTRAMDKALESWDQRIPTGKLNAFLGKIQAAH
PHPLRGGKQPRILFATQASTRPPRFVIFATGFLEHGYRRYIERSLREEFGFEGTPIQISVNIREKKKRK

Sequences:

>Translated_709_residues
MIRVAIDGPAGVGKSSTSKALAKYFGYAYLDTGAMYRACAWWCLKQGIDLDAETVDERVITEAVGEFFTGDHFDISVDPD
NPCVFADDEDISEAIRSSEVSSHVSKVSNVIPVRNVLIAAQRAYIAREASADSFSGGLGIVAEGRDITTVVSPDAEVRVL
LTAREEVRQARRTGQAVKGVGAEDVAARDKADSKVTSFLTAADGVTTIDNSDLDFAHTLDLLIGLVEDAIENQEYEQYAA
NLEGYELDEGDEDLISGRGFTEGARKAGPKPVGVLAIVGRPNVGKSSLVNRILGRRAAVVEDTPGVTRDRVSYDAEWAGT
DFKLVDTGGWEADVEGIESAIASQAQVAVTLADAVVFVVDGQVGMTTTDERIVKMLRAAGKPIVLAVNKIDDQASEYLAA
EFWKLGLGEPYSISAMHGRGVGDLLDVALDKLKQAEKTSGYLTPSGLRRVALVGRPNVGKSSLLNQLAREERAVVNDLAG
TTRDPVDEIVNIDGEDWLFIDTAGIKRRQHKLTGAEYYSSLRTQAAIERCELALILFDASQPVSDQDLKVMSTAVDAGRA
IVLVFNKWDAMDEFDKQRLERLWNTEFDRVMWAERVNLSAKTGWHTNRLTRAMDKALESWDQRIPTGKLNAFLGKIQAAH
PHPLRGGKQPRILFATQASTRPPRFVIFATGFLEHGYRRYIERSLREEFGFEGTPIQISVNIREKKKRK
>Mature_709_residues
MIRVAIDGPAGVGKSSTSKALAKYFGYAYLDTGAMYRACAWWCLKQGIDLDAETVDERVITEAVGEFFTGDHFDISVDPD
NPCVFADDEDISEAIRSSEVSSHVSKVSNVIPVRNVLIAAQRAYIAREASADSFSGGLGIVAEGRDITTVVSPDAEVRVL
LTAREEVRQARRTGQAVKGVGAEDVAARDKADSKVTSFLTAADGVTTIDNSDLDFAHTLDLLIGLVEDAIENQEYEQYAA
NLEGYELDEGDEDLISGRGFTEGARKAGPKPVGVLAIVGRPNVGKSSLVNRILGRRAAVVEDTPGVTRDRVSYDAEWAGT
DFKLVDTGGWEADVEGIESAIASQAQVAVTLADAVVFVVDGQVGMTTTDERIVKMLRAAGKPIVLAVNKIDDQASEYLAA
EFWKLGLGEPYSISAMHGRGVGDLLDVALDKLKQAEKTSGYLTPSGLRRVALVGRPNVGKSSLLNQLAREERAVVNDLAG
TTRDPVDEIVNIDGEDWLFIDTAGIKRRQHKLTGAEYYSSLRTQAAIERCELALILFDASQPVSDQDLKVMSTAVDAGRA
IVLVFNKWDAMDEFDKQRLERLWNTEFDRVMWAERVNLSAKTGWHTNRLTRAMDKALESWDQRIPTGKLNAFLGKIQAAH
PHPLRGGKQPRILFATQASTRPPRFVIFATGFLEHGYRRYIERSLREEFGFEGTPIQISVNIREKKKRK

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis [H]

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain [H]

Homologues:

Organism=Escherichia coli, GI87082120, Length=460, Percent_Identity=35.8695652173913, Blast_Score=264, Evalue=2e-71,
Organism=Escherichia coli, GI1787139, Length=174, Percent_Identity=35.0574712643678, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI2367268, Length=107, Percent_Identity=41.1214953271028, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1788919, Length=121, Percent_Identity=34.7107438016529, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17507259, Length=131, Percent_Identity=33.587786259542, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323665, Length=198, Percent_Identity=28.2828282828283, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45550813, Length=163, Percent_Identity=33.1288343558282, Blast_Score=76, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 77630; Mature: 77630

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVAIDGPAGVGKSSTSKALAKYFGYAYLDTGAMYRACAWWCLKQGIDLDAETVDERVI
CEEEEECCCCCCCCCHHHHHHHHHHCCCEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
TEAVGEFFTGDHFDISVDPDNPCVFADDEDISEAIRSSEVSSHVSKVSNVIPVRNVLIAA
HHHHHHHHCCCCEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRAYIAREASADSFSGGLGIVAEGRDITTVVSPDAEVRVLLTAREEVRQARRTGQAVKGV
HHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCCCEEEEEECHHHHHHHHHCCHHHHCC
GAEDVAARDKADSKVTSFLTAADGVTTIDNSDLDFAHTLDLLIGLVEDAIENQEYEQYAA
CCHHHHHCCCCHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHC
NLEGYELDEGDEDLISGRGFTEGARKAGPKPVGVLAIVGRPNVGKSSLVNRILGRRAAVV
CCCCCCCCCCCHHHHCCCCCCCHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEE
EDTPGVTRDRVSYDAEWAGTDFKLVDTGGWEADVEGIESAIASQAQVAVTLADAVVFVVD
ECCCCCCHHHCCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHEEEEEEEEEEEEEE
GQVGMTTTDERIVKMLRAAGKPIVLAVNKIDDQASEYLAAEFWKLGLGEPYSISAMHGRG
CCCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECCCC
VGDLLDVALDKLKQAEKTSGYLTPSGLRRVALVGRPNVGKSSLLNQLAREERAVVNDLAG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
TTRDPVDEIVNIDGEDWLFIDTAGIKRRQHKLTGAEYYSSLRTQAAIERCELALILFDAS
CCCCCHHHHHCCCCCCEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHEEEEEEEECC
QPVSDQDLKVMSTAVDAGRAIVLVFNKWDAMDEFDKQRLERLWNTEFDRVMWAERVNLSA
CCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
KTGWHTNRLTRAMDKALESWDQRIPTGKLNAFLGKIQAAHPHPLRGGKQPRILFATQAST
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCC
RPPRFVIFATGFLEHGYRRYIERSLREEFGFEGTPIQISVNIREKKKRK
CCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCC
>Mature Secondary Structure
MIRVAIDGPAGVGKSSTSKALAKYFGYAYLDTGAMYRACAWWCLKQGIDLDAETVDERVI
CEEEEECCCCCCCCCHHHHHHHHHHCCCEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
TEAVGEFFTGDHFDISVDPDNPCVFADDEDISEAIRSSEVSSHVSKVSNVIPVRNVLIAA
HHHHHHHHCCCCEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRAYIAREASADSFSGGLGIVAEGRDITTVVSPDAEVRVLLTAREEVRQARRTGQAVKGV
HHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCCCEEEEEECHHHHHHHHHCCHHHHCC
GAEDVAARDKADSKVTSFLTAADGVTTIDNSDLDFAHTLDLLIGLVEDAIENQEYEQYAA
CCHHHHHCCCCHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHC
NLEGYELDEGDEDLISGRGFTEGARKAGPKPVGVLAIVGRPNVGKSSLVNRILGRRAAVV
CCCCCCCCCCCHHHHCCCCCCCHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEE
EDTPGVTRDRVSYDAEWAGTDFKLVDTGGWEADVEGIESAIASQAQVAVTLADAVVFVVD
ECCCCCCHHHCCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHEEEEEEEEEEEEEE
GQVGMTTTDERIVKMLRAAGKPIVLAVNKIDDQASEYLAAEFWKLGLGEPYSISAMHGRG
CCCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECCCC
VGDLLDVALDKLKQAEKTSGYLTPSGLRRVALVGRPNVGKSSLLNQLAREERAVVNDLAG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
TTRDPVDEIVNIDGEDWLFIDTAGIKRRQHKLTGAEYYSSLRTQAAIERCELALILFDAS
CCCCCHHHHHCCCCCCEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHEEEEEEEECC
QPVSDQDLKVMSTAVDAGRAIVLVFNKWDAMDEFDKQRLERLWNTEFDRVMWAERVNLSA
CCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
KTGWHTNRLTRAMDKALESWDQRIPTGKLNAFLGKIQAAHPHPLRGGKQPRILFATQAST
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCC
RPPRFVIFATGFLEHGYRRYIERSLREEFGFEGTPIQISVNIREKKKRK
CCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12381787 [H]