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The map label for this gene is fabG [C]

Identifier: 213691954

GI number: 213691954

Start: 1253420

End: 1254127

Strand: Direct

Name: fabG [C]

Synonym: Blon_1070

Alternate gene names: 213691954

Gene position: 1253420-1254127 (Clockwise)

Preceding gene: 213691953

Following gene: 213691955

Centisome position: 44.25

GC content: 61.44

Gene sequence:

>708_bases
ATGCCAACCACAACAGGTAAGAAAATCGCCATCGTCACCGGCAGCGCGCTGGGTTTGGGCTACGAGCTCGCCAGCCAACT
CATCGCCAAGGGCTGGCTGGTGGCCGGCATCGACTTCAACGCCGAACGTCAGGCCGAGCTGAGCACGCAGTGGCCCGCCG
AATCCTACCGCGCCTTCGTAGGCGACATCACTGACGAAGCGTTCGTCAAGGAATCCGTGGCGAGCATCGCTGCGCTTGGT
CACATCGACCTGCTCATCAACAACGCCGGCCAGCCCTCGTTCAAGGTGCCCACCGCCTATGAGGCCGCCGATGTCGACAC
ATGCCTCAAAGGTCTCAAAGGCATGATCCTGTGGACGGTGGAAACCCTCAAGACCTGTGGCGAGCGTGACGTGAAAATCG
CCCAGATCATGAGCACCGCCGCCACGCGGGGCAACGCGAACGAAAGCGTGTACTGCGCCACCAAGTGGGGCGAGAAGGGC
TACACCAAGAGCCTGCAGGCCGCATACAAGGGCACCAGCGTCAAGGTGGTCGCCGTCTATCCGGGCGGCATCGACACCGC
CTTCTACCGTGATAGCCATGACTACGTCTCCGAAGCCAAGCAGCACACCTTCATGCAGCCCGGTCCGCTGGCCGAGGTCA
TCCTCTTCAACCTGATCAACGAGGCCAACCTCACCGTCACCGACATCGAGATCAACCGCAACAGCTGA

Upstream 100 bases:

>100_bases
TCAGCAAAGAGCGGGTTAACCCTAGGTTCCCCTCGCTGAGGGGAGCTGGCCGCCGTAGGCGGCCTGAGGGGAGTCTCGCA
AGCATGCAAAGGAAACAACC

Downstream 100 bases:

>100_bases
GCTGGCAGGTTATACACATATCCACCGATTCGGCCGAGCTGGTTGCGCGCAGAAGTTGGTTATGCCATCGTGAGTTGTAT
CCGTGAATAACGCGGTTCAC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MPTTTGKKIAIVTGSALGLGYELASQLIAKGWLVAGIDFNAERQAELSTQWPAESYRAFVGDITDEAFVKESVASIAALG
HIDLLINNAGQPSFKVPTAYEAADVDTCLKGLKGMILWTVETLKTCGERDVKIAQIMSTAATRGNANESVYCATKWGEKG
YTKSLQAAYKGTSVKVVAVYPGGIDTAFYRDSHDYVSEAKQHTFMQPGPLAEVILFNLINEANLTVTDIEINRNS

Sequences:

>Translated_235_residues
MPTTTGKKIAIVTGSALGLGYELASQLIAKGWLVAGIDFNAERQAELSTQWPAESYRAFVGDITDEAFVKESVASIAALG
HIDLLINNAGQPSFKVPTAYEAADVDTCLKGLKGMILWTVETLKTCGERDVKIAQIMSTAATRGNANESVYCATKWGEKG
YTKSLQAAYKGTSVKVVAVYPGGIDTAFYRDSHDYVSEAKQHTFMQPGPLAEVILFNLINEANLTVTDIEINRNS
>Mature_234_residues
PTTTGKKIAIVTGSALGLGYELASQLIAKGWLVAGIDFNAERQAELSTQWPAESYRAFVGDITDEAFVKESVASIAALGH
IDLLINNAGQPSFKVPTAYEAADVDTCLKGLKGMILWTVETLKTCGERDVKIAQIMSTAATRGNANESVYCATKWGEKGY
TKSLQAAYKGTSVKVVAVYPGGIDTAFYRDSHDYVSEAKQHTFMQPGPLAEVILFNLINEANLTVTDIEINRNS

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI31542939, Length=188, Percent_Identity=29.7872340425532, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=192, Percent_Identity=29.6875, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787820, Length=181, Percent_Identity=32.0441988950276, Blast_Score=62, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322067, Length=185, Percent_Identity=32.972972972973, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641232, Length=242, Percent_Identity=28.099173553719, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24641388, Length=195, Percent_Identity=29.7435897435897, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25335; Mature: 25204

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTTTGKKIAIVTGSALGLGYELASQLIAKGWLVAGIDFNAERQAELSTQWPAESYRAFV
CCCCCCCEEEEEECCCHHCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHH
GDITDEAFVKESVASIAALGHIDLLINNAGQPSFKVPTAYEAADVDTCLKGLKGMILWTV
CCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEH
ETLKTCGERDVKIAQIMSTAATRGNANESVYCATKWGEKGYTKSLQAAYKGTSVKVVAVY
HHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEE
PGGIDTAFYRDSHDYVSEAKQHTFMQPGPLAEVILFNLINEANLTVTDIEINRNS
CCCCCCEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCC
>Mature Secondary Structure 
PTTTGKKIAIVTGSALGLGYELASQLIAKGWLVAGIDFNAERQAELSTQWPAESYRAFV
CCCCCCEEEEEECCCHHCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHH
GDITDEAFVKESVASIAALGHIDLLINNAGQPSFKVPTAYEAADVDTCLKGLKGMILWTV
CCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEH
ETLKTCGERDVKIAQIMSTAATRGNANESVYCATKWGEKGYTKSLQAAYKGTSVKVVAVY
HHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEE
PGGIDTAFYRDSHDYVSEAKQHTFMQPGPLAEVILFNLINEANLTVTDIEINRNS
CCCCCCEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]