BacMap

Definition	Bifidobacterium longum subsp. infantis ATCC 15697, complete genome.
Accession	NC_011593
Length	2,832,748

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The map label for this gene is cypB [H]

Identifier: 213691863

GI number: 213691863

Start: 1155203

End: 1155742

Strand: Reverse

Name: cypB [H]

Synonym: Blon_0972

Alternate gene names: 213691863

Gene position: 1155742-1155203 (Counterclockwise)

Preceding gene: 213691864

Following gene: 213691859

Centisome position: 40.8

GC content: 61.67

Gene sequence:

>540_bases
ATGACTACCATTATCATGCGCACCTCCGAGGGCGACATCACCATCAACCTGTTCGACGACAAGGCACCGAACACCGTGGC
CAACTTCCTGGGCCTCGCCACCGGCGAGAAGGAATGGGCCGACCCGTACACCGGCCAGCCTTCCCATGAACCCTTCTACA
ACGGTCTGACCTTCCACCGCATCATCAAGGATTTCATGATCCAGGGCGGCTGCCCGCTGGGCACCGGCACCGGCGGACCC
GGCTACGAATTCGACGATGAGATCGACCCCGGCCTGCAATTCGACAAGCCGTACCTGTTGGCCATGGCCAATGCCGGGCT
CCGCCGTGGCATGGACGGCAAAATCCACGGGACCAACGGCTCGCAGTTCTTCATCACCACCGTACCGACCCCTTGGCTCA
ACGGCCATCACACCATCTTCGGCGAAGTCGCCGACGACGCCTCCAAGAAGGTCGTCGACAAGCTCGAAGCACTGGGCACC
GATTCGTCCGACCGTCCGACCGAGCCCGCAGGAATCCTCTCCATCGAAGTGAAGCGGTAA

Upstream 100 bases:

>100_bases
TGTCTCTCCCGAGAGTAGTCCTCACAACAGGGCAGGTCCCACAAGGAGCATAGCTCATGCACCCACTGTCCGGTCTCAAG
CCCATGAGACACTTGGAGCC

Downstream 100 bases:

>100_bases
AAACCGCCCATACCTTCATGCCATAAGTGCCACAAGGCGGGGCCCCGATCCGACGATTCGGACCGGGGCCCCGCCGTATG
CCACCCACATCCCTACTTCA

Product: Peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase B; Cyclophilin ScCypB; Rotamase B; S-cyclophilin [H]

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MTTIIMRTSEGDITINLFDDKAPNTVANFLGLATGEKEWADPYTGQPSHEPFYNGLTFHRIIKDFMIQGGCPLGTGTGGP
GYEFDDEIDPGLQFDKPYLLAMANAGLRRGMDGKIHGTNGSQFFITTVPTPWLNGHHTIFGEVADDASKKVVDKLEALGT
DSSDRPTEPAGILSIEVKR

Sequences:

>Translated_179_residues
MTTIIMRTSEGDITINLFDDKAPNTVANFLGLATGEKEWADPYTGQPSHEPFYNGLTFHRIIKDFMIQGGCPLGTGTGGP
GYEFDDEIDPGLQFDKPYLLAMANAGLRRGMDGKIHGTNGSQFFITTVPTPWLNGHHTIFGEVADDASKKVVDKLEALGT
DSSDRPTEPAGILSIEVKR
>Mature_178_residues
TTIIMRTSEGDITINLFDDKAPNTVANFLGLATGEKEWADPYTGQPSHEPFYNGLTFHRIIKDFMIQGGCPLGTGTGGPG
YEFDDEIDPGLQFDKPYLLAMANAGLRRGMDGKIHGTNGSQFFITTVPTPWLNGHHTIFGEVADDASKKVVDKLEALGTD
SSDRPTEPAGILSIEVKR

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=178, Percent_Identity=44.3820224719101, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI7706339, Length=174, Percent_Identity=42.5287356321839, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI42560244, Length=169, Percent_Identity=43.1952662721894, Blast_Score=113, Evalue=9e-26,
Organism=Homo sapiens, GI4758950, Length=176, Percent_Identity=42.6136363636364, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI64276486, Length=177, Percent_Identity=36.1581920903955, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI6631100, Length=166, Percent_Identity=43.3734939759036, Blast_Score=103, Evalue=6e-23,
Organism=Homo sapiens, GI4826932, Length=137, Percent_Identity=48.9051094890511, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI4505991, Length=175, Percent_Identity=42.2857142857143, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI10863927, Length=154, Percent_Identity=40.2597402597403, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI19557636, Length=179, Percent_Identity=35.195530726257, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI5454154, Length=169, Percent_Identity=39.6449704142012, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI5031987, Length=156, Percent_Identity=39.7435897435897, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI178057341, Length=157, Percent_Identity=40.1273885350318, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI256017253, Length=157, Percent_Identity=40.1273885350318, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI221139811, Length=157, Percent_Identity=40.1273885350318, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI256017251, Length=157, Percent_Identity=40.1273885350318, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI169164185, Length=154, Percent_Identity=38.961038961039, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI169163623, Length=154, Percent_Identity=38.961038961039, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI169163387, Length=154, Percent_Identity=38.961038961039, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI310129267, Length=154, Percent_Identity=38.3116883116883, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI310120620, Length=154, Percent_Identity=38.3116883116883, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI209417936, Length=157, Percent_Identity=38.8535031847134, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI30102944, Length=157, Percent_Identity=38.8535031847134, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI219842199, Length=157, Percent_Identity=38.8535031847134, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI310110104, Length=154, Percent_Identity=37.6623376623377, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI5174637, Length=154, Percent_Identity=39.6103896103896, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI310127646, Length=152, Percent_Identity=38.8157894736842, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI310114371, Length=152, Percent_Identity=38.8157894736842, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI310119221, Length=152, Percent_Identity=38.8157894736842, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI303305009, Length=139, Percent_Identity=41.0071942446043, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI45439316, Length=139, Percent_Identity=41.0071942446043, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI310132444, Length=154, Percent_Identity=36.3636363636364, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI310113152, Length=154, Percent_Identity=36.3636363636364, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI150418007, Length=154, Percent_Identity=37.012987012987, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI239751853, Length=153, Percent_Identity=36.6013071895425, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI113428306, Length=153, Percent_Identity=36.6013071895425, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI169214050, Length=153, Percent_Identity=36.6013071895425, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI22547212, Length=173, Percent_Identity=35.2601156069364, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI7657473, Length=173, Percent_Identity=35.2601156069364, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI22547215, Length=173, Percent_Identity=35.2601156069364, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI310114540, Length=151, Percent_Identity=36.4238410596026, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310127745, Length=151, Percent_Identity=36.4238410596026, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310119290, Length=151, Percent_Identity=36.4238410596026, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI20911035, Length=161, Percent_Identity=30.4347826086957, Blast_Score=68, Evalue=4e-12,
Organism=Escherichia coli, GI1786736, Length=187, Percent_Identity=32.620320855615, Blast_Score=67, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17506311, Length=178, Percent_Identity=46.0674157303371, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17539496, Length=173, Percent_Identity=43.9306358381503, Blast_Score=115, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17551284, Length=161, Percent_Identity=44.0993788819876, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17551282, Length=161, Percent_Identity=44.0993788819876, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17565860, Length=169, Percent_Identity=43.1952662721894, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17552784, Length=160, Percent_Identity=42.5, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17552780, Length=162, Percent_Identity=41.9753086419753, Blast_Score=97, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17566266, Length=162, Percent_Identity=41.358024691358, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17559074, Length=158, Percent_Identity=41.7721518987342, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17506307, Length=162, Percent_Identity=41.9753086419753, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71997782, Length=145, Percent_Identity=37.9310344827586, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71980594, Length=178, Percent_Identity=32.5842696629214, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=167, Percent_Identity=34.1317365269461, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539498, Length=156, Percent_Identity=40.3846153846154, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17532643, Length=170, Percent_Identity=39.4117647058824, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17532641, Length=178, Percent_Identity=34.2696629213483, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17552782, Length=166, Percent_Identity=37.9518072289157, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32563659, Length=167, Percent_Identity=31.1377245508982, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=156, Percent_Identity=45.5128205128205, Blast_Score=108, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6323562, Length=159, Percent_Identity=45.2830188679245, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323246, Length=168, Percent_Identity=39.8809523809524, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320510, Length=167, Percent_Identity=40.7185628742515, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321848, Length=167, Percent_Identity=38.3233532934132, Blast_Score=85, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6322492, Length=187, Percent_Identity=35.8288770053476, Blast_Score=79, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17986117, Length=179, Percent_Identity=41.8994413407821, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24650807, Length=166, Percent_Identity=42.7710843373494, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19922912, Length=177, Percent_Identity=39.5480225988701, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI20130249, Length=162, Percent_Identity=43.2098765432099, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19922376, Length=177, Percent_Identity=35.5932203389831, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357249, Length=177, Percent_Identity=34.4632768361582, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45549139, Length=156, Percent_Identity=40.3846153846154, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24586038, Length=170, Percent_Identity=38.8235294117647, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17647301, Length=156, Percent_Identity=37.8205128205128, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664125, Length=155, Percent_Identity=38.7096774193548, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357783, Length=155, Percent_Identity=38.7096774193548, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17136360, Length=167, Percent_Identity=35.3293413173653, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24652460, Length=159, Percent_Identity=32.7044025157233, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 19447; Mature: 19316

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIIMRTSEGDITINLFDDKAPNTVANFLGLATGEKEWADPYTGQPSHEPFYNGLTFHR
CEEEEEEECCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
IIKDFMIQGGCPLGTGTGGPGYEFDDEIDPGLQFDKPYLLAMANAGLRRGMDGKIHGTNG
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHCCCCCEEECCCC
SQFFITTVPTPWLNGHHTIFGEVADDASKKVVDKLEALGTDSSDRPTEPAGILSIEVKR
CEEEEEECCCCCCCCCEEEEEEHHCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure 
TTIIMRTSEGDITINLFDDKAPNTVANFLGLATGEKEWADPYTGQPSHEPFYNGLTFHR
EEEEEEECCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
IIKDFMIQGGCPLGTGTGGPGYEFDDEIDPGLQFDKPYLLAMANAGLRRGMDGKIHGTNG
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHCCCCCEEECCCC
SQFFITTVPTPWLNGHHTIFGEVADDASKKVVDKLEALGTDSSDRPTEPAGILSIEVKR
CEEEEEECCCCCCCCCEEEEEEHHCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9025285 [H]