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The map label for this gene is exoA [H]

Identifier: 213691818

GI number: 213691818

Start: 1093868

End: 1094728

Strand: Reverse

Name: exoA [H]

Synonym: Blon_0926

Alternate gene names: 213691818

Gene position: 1094728-1093868 (Counterclockwise)

Preceding gene: 213691827

Following gene: 213691807

Centisome position: 38.65

GC content: 57.61

Gene sequence:

>861_bases
ATGACCATCACCATTACCACGTCTAACGTCAACGGCATTCGTGCGGCCAAACGCAAGGGCATCGAGGATTGGGCCGGCAA
GCATGCGCCGGATGTCTGGTGCATACAGGAGGTTCGCGCGCCTCAAGACGATGTCGATTCTATTTTCGATGAATTTGGTT
TCGAATACGCCACCGCCGGCAAGATCGAGGCACCGGCCAACCTCCATGCCATGAACGAGGTCTGCCGGGTGAAAGGCCGC
GCGGGAGTCGGACTGCTCACCGACTTGGAAGTGCTTGACAAGCGATATGGTCTGCCAGGTCTGAGCGAGGATGTGGATTC
AGGGCGTTGGATCGAAACCGATGTCAAAACGCCTGAAGGCTACGCGATCACCGTGGCATCCGTATATGTGCATGCCGGCA
ACACTGACGATCCGACCAAAATGGAACAGAAGTACCGTTTTCTGGACACGATGCTGAAGCGCATGGGAGCGTTGCGGGAC
GAGGCTGCGCATGGCGGCAAACAGGCCGTGCTCTGCGGCGATTTCAACATCGCGCACACGCCGCTTGATATCAAGAACGC
CAAGGCCAATGAGAAGCACGCCGGATTTCTGCCCGAAGAACGTGCCTACGTGGACAAATGGCTGGACGAATACGAGTTCG
TGGATGTGATGCGTTCGTTGGCCGGCGACATTCAGGGGCCATACACCTGGTGGAGCCAACGAGGGCGCGCTTTCGACAAC
AATGTCGGCTGGAGAATCGACTACCAGTTCGCCACGCCCGAGTTGGCGGAGACCGCACGCGGATTCGTCATCGACAAGGC
TCCCACGTATGACAAACGCTGGTCCGATCACGCCCCACTCACGATCACATACGAGGTATGA

Upstream 100 bases:

>100_bases
GCAACCTTGCTAACACTAGCACTCAGGCTTAGAGAAAGCTGAGCATCGCGGCCGCCGATGTCCGGTTCGATTCGTAGGGA
GGCCAAAATAGTATGGCCGC

Downstream 100 bases:

>100_bases
CGTATTCCGTGGGACAACATCCGAAAATCGACGATTTTCGCGGGCCGTCCCACACCCCGCATCATGAGTAATTATCGACC
ACACTAAGAATGGCGTAATT

Product: exodeoxyribonuclease III Xth

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MTITITTSNVNGIRAAKRKGIEDWAGKHAPDVWCIQEVRAPQDDVDSIFDEFGFEYATAGKIEAPANLHAMNEVCRVKGR
AGVGLLTDLEVLDKRYGLPGLSEDVDSGRWIETDVKTPEGYAITVASVYVHAGNTDDPTKMEQKYRFLDTMLKRMGALRD
EAAHGGKQAVLCGDFNIAHTPLDIKNAKANEKHAGFLPEERAYVDKWLDEYEFVDVMRSLAGDIQGPYTWWSQRGRAFDN
NVGWRIDYQFATPELAETARGFVIDKAPTYDKRWSDHAPLTITYEV

Sequences:

>Translated_286_residues
MTITITTSNVNGIRAAKRKGIEDWAGKHAPDVWCIQEVRAPQDDVDSIFDEFGFEYATAGKIEAPANLHAMNEVCRVKGR
AGVGLLTDLEVLDKRYGLPGLSEDVDSGRWIETDVKTPEGYAITVASVYVHAGNTDDPTKMEQKYRFLDTMLKRMGALRD
EAAHGGKQAVLCGDFNIAHTPLDIKNAKANEKHAGFLPEERAYVDKWLDEYEFVDVMRSLAGDIQGPYTWWSQRGRAFDN
NVGWRIDYQFATPELAETARGFVIDKAPTYDKRWSDHAPLTITYEV
>Mature_285_residues
TITITTSNVNGIRAAKRKGIEDWAGKHAPDVWCIQEVRAPQDDVDSIFDEFGFEYATAGKIEAPANLHAMNEVCRVKGRA
GVGLLTDLEVLDKRYGLPGLSEDVDSGRWIETDVKTPEGYAITVASVYVHAGNTDDPTKMEQKYRFLDTMLKRMGALRDE
AAHGGKQAVLCGDFNIAHTPLDIKNAKANEKHAGFLPEERAYVDKWLDEYEFVDVMRSLAGDIQGPYTWWSQRGRAFDNN
VGWRIDYQFATPELAETARGFVIDKAPTYDKRWSDHAPLTITYEV

Specific function: Major Apurinic-Apyrimidinic Endonuclease Of E.Coli. It Removes The Damaged DNA At Cytosines And Guanines By Cleaving On The 3' Side Of The Ap Site By A Beta-Elimination Reaction. It Exhibits 3'-5'-Exonuclease, 3'-Phosphomonoesterase, 3'-Repair Diesterase

COG id: COG0708

COG function: function code L; Exonuclease III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA repair enzymes AP/ExoA family [H]

Homologues:

Organism=Homo sapiens, GI18375505, Length=283, Percent_Identity=30.0353356890459, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI18375503, Length=283, Percent_Identity=30.0353356890459, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI18375501, Length=283, Percent_Identity=30.0353356890459, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1788046, Length=295, Percent_Identity=28.8135593220339, Blast_Score=96, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71989536, Length=205, Percent_Identity=27.3170731707317, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221330655, Length=293, Percent_Identity=29.3515358361775, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI17136678, Length=293, Percent_Identity=29.3515358361775, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000097
- InterPro:   IPR020847
- InterPro:   IPR020848
- InterPro:   IPR005135
- InterPro:   IPR004808 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.11.2 [H]

Molecular weight: Translated: 32109; Mature: 31978

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITITTSNVNGIRAAKRKGIEDWAGKHAPDVWCIQEVRAPQDDVDSIFDEFGFEYATAG
CEEEEEECCCCHHHHHHHCCCHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCEECCC
KIEAPANLHAMNEVCRVKGRAGVGLLTDLEVLDKRYGLPGLSEDVDSGRWIETDVKTPEG
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCC
YAITVASVYVHAGNTDDPTKMEQKYRFLDTMLKRMGALRDEAAHGGKQAVLCGDFNIAHT
CEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEC
PLDIKNAKANEKHAGFLPEERAYVDKWLDEYEFVDVMRSLAGDIQGPYTWWSQRGRAFDN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCC
NVGWRIDYQFATPELAETARGFVIDKAPTYDKRWSDHAPLTITYEV
CCCEEEEEEECCCHHHHHHCCEEEECCCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
TITITTSNVNGIRAAKRKGIEDWAGKHAPDVWCIQEVRAPQDDVDSIFDEFGFEYATAG
EEEEEECCCCHHHHHHHCCCHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCEECCC
KIEAPANLHAMNEVCRVKGRAGVGLLTDLEVLDKRYGLPGLSEDVDSGRWIETDVKTPEG
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCC
YAITVASVYVHAGNTDDPTKMEQKYRFLDTMLKRMGALRDEAAHGGKQAVLCGDFNIAHT
CEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEC
PLDIKNAKANEKHAGFLPEERAYVDKWLDEYEFVDVMRSLAGDIQGPYTWWSQRGRAFDN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCC
NVGWRIDYQFATPELAETARGFVIDKAPTYDKRWSDHAPLTITYEV
CCCEEEEEEECCCHHHHHHCCEEEECCCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]