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The map label for this gene is pepPI [H]

Identifier: 213691780

GI number: 213691780

Start: 1047699

End: 1049288

Strand: Reverse

Name: pepPI [H]

Synonym: Blon_0888

Alternate gene names: 213691780

Gene position: 1049288-1047699 (Counterclockwise)

Preceding gene: 213691781

Following gene: 213691779

Centisome position: 37.04

GC content: 63.77

Gene sequence:

>1590_bases
ATGGGTGAAGTGATCACCGCCAAGGACAAGGAATATGAGGCCGAAGAGCGCGCTACGGCGCCGGGCGCGAACCAGTCGAT
GAGCGACCGCGTGAACAACCGCTCGCTGCGCCCGCAGTCGGCCGCATTCAAGGAGTTCATGAAGTCCGGCTGGGCCGATG
ACGATCCGGAGATCAAGCCTCTCGAATCCTCCAAGTTCACGCCAGCCCGTCTTGAGGCGCTGGGCAAGGCATTCCCCGGC
GAGCGTCTGGTCATTCCGGCCGGCCAGCCGAAGGTGCGCAACAATGATTGCGATTACATGTTCCGCCCGGACACCACGTT
CGCCTACTACACCGGCCTGGGTTCCGATTATGAAGCTGGTGCCGTGCTGGTCCTGAACCCGGTCGATCCCGACTCCCCCG
AAGCTGCCGCCGGCAAGACCCACACCCCGGAACTGTTTGTGGCACCGCGCGCCGACAACTCCACCGAGGACTTCTTCATG
TCCGCCCACTACGGCGAATACTGGGTTGGCCCGCGTGCTGGCCTCCAGGAGATGCAGGCGATGACCGGCATCGAAACCCA
CGACATCGCCCAGCTGGCTGACGCCCTGTCCAAGGACGTGGGTGCCGAGGCCGGTGCCGTGCGTGTGCGCGTGGTCAGCG
AGACCGACCCCGAAATCACTTCGATGGTCGAGTCCATCCGCGAGGCCAACGGTTTCGCCGATCCGGACAAGAACTCCGCA
TCCGACGACAAGCTGCACGAGTTCGCCGCCGAGGCACGCATGGTCAAAGACGGCTACGAAATCAACGAGATGCGCAAGGC
CGTGGACGCCACCAAGCATGGCTTCGACCGCCTGCTGTCCGCACTGCCGGACGCGCTGGACAAGCCGCGCTCCGAGCGTA
TCCTCGAAGGCGCGTTCAACGCTGTATCCCGCGAGATCGGCAACGCCGTCGGCTACGACTCCATCGTGGCCTCCGGCCCC
CACGCTCCGATTCTGCATTGGATGCGCAACACCGGTGTGGTGAAGAACGGCGACATGCTGTTGGTGGATGCCGGCGTTGA
GGTCGATTCCCTGTACACGGCCGACATCACCCGTACCTTCCCGACCAACGGCAAGTTCACCGACTTCCAGAAGCGTCTGT
ACCAGGCCGTGCTCGACTCGCAGCAGGCCGGTTTCGAAGCCGCCAAGCCGGGTGCCACCTACTCCGACATCCACCACGCC
TGCATGCGCGTGATTGCCGAATGTCTGCACGATTGGGGTCTGCTGCCGGTGAGCGTCGAGGAGTCGCTGTCTCCGCAAGG
CCAGCAGCACCGCCGTTGGCTCGCCTGCGGTGTGGCCCACCACTTGGGTCTTGATGTGCACGATTGCGCGCAGGCTCGTT
TCGAGTCCTATCAGGGCGCGCCGATTCGTCCGGGCATGATCTTCACGATCGAGCCCGGCCTGTACTTCCGCGAGGATGAT
CTGCTGATTCCGCCGGAATACCGCGGCATCGGCATCCGTATCGAGGACGACGTGCTCATGACCGAGAACGGCCCCGAATG
GATTTCCGCCGGCATCCCGAAGACCATCGAGGGAGTCGAGGCGTGGATGTCGGAACGGGCCAACGCATGA

Upstream 100 bases:

>100_bases
GGTTTTACCGTCAGCCGTCAATCGTGGCACATCGCATAAAGCCGACTAGTATGAAGTGGGAATCGATGATTCGACAACAA
CTACATACAGGAGAGTGGCA

Downstream 100 bases:

>100_bases
GCACGCCCCCGTTCATTCTGGAACTGCGTAAGAAGATCGGCCATGATTTGTTGTGGCTGCATGGCGTGACGGCATGCGTA
CTTGACGAACATGGACGCAT

Product: peptidase M24

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase I; Aminopeptidase P I; APP; PEPP I; X-Pro aminopeptidase I; Xaa-Pro aminopeptidase I [H]

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MGEVITAKDKEYEAEERATAPGANQSMSDRVNNRSLRPQSAAFKEFMKSGWADDDPEIKPLESSKFTPARLEALGKAFPG
ERLVIPAGQPKVRNNDCDYMFRPDTTFAYYTGLGSDYEAGAVLVLNPVDPDSPEAAAGKTHTPELFVAPRADNSTEDFFM
SAHYGEYWVGPRAGLQEMQAMTGIETHDIAQLADALSKDVGAEAGAVRVRVVSETDPEITSMVESIREANGFADPDKNSA
SDDKLHEFAAEARMVKDGYEINEMRKAVDATKHGFDRLLSALPDALDKPRSERILEGAFNAVSREIGNAVGYDSIVASGP
HAPILHWMRNTGVVKNGDMLLVDAGVEVDSLYTADITRTFPTNGKFTDFQKRLYQAVLDSQQAGFEAAKPGATYSDIHHA
CMRVIAECLHDWGLLPVSVEESLSPQGQQHRRWLACGVAHHLGLDVHDCAQARFESYQGAPIRPGMIFTIEPGLYFREDD
LLIPPEYRGIGIRIEDDVLMTENGPEWISAGIPKTIEGVEAWMSERANA

Sequences:

>Translated_529_residues
MGEVITAKDKEYEAEERATAPGANQSMSDRVNNRSLRPQSAAFKEFMKSGWADDDPEIKPLESSKFTPARLEALGKAFPG
ERLVIPAGQPKVRNNDCDYMFRPDTTFAYYTGLGSDYEAGAVLVLNPVDPDSPEAAAGKTHTPELFVAPRADNSTEDFFM
SAHYGEYWVGPRAGLQEMQAMTGIETHDIAQLADALSKDVGAEAGAVRVRVVSETDPEITSMVESIREANGFADPDKNSA
SDDKLHEFAAEARMVKDGYEINEMRKAVDATKHGFDRLLSALPDALDKPRSERILEGAFNAVSREIGNAVGYDSIVASGP
HAPILHWMRNTGVVKNGDMLLVDAGVEVDSLYTADITRTFPTNGKFTDFQKRLYQAVLDSQQAGFEAAKPGATYSDIHHA
CMRVIAECLHDWGLLPVSVEESLSPQGQQHRRWLACGVAHHLGLDVHDCAQARFESYQGAPIRPGMIFTIEPGLYFREDD
LLIPPEYRGIGIRIEDDVLMTENGPEWISAGIPKTIEGVEAWMSERANA
>Mature_528_residues
GEVITAKDKEYEAEERATAPGANQSMSDRVNNRSLRPQSAAFKEFMKSGWADDDPEIKPLESSKFTPARLEALGKAFPGE
RLVIPAGQPKVRNNDCDYMFRPDTTFAYYTGLGSDYEAGAVLVLNPVDPDSPEAAAGKTHTPELFVAPRADNSTEDFFMS
AHYGEYWVGPRAGLQEMQAMTGIETHDIAQLADALSKDVGAEAGAVRVRVVSETDPEITSMVESIREANGFADPDKNSAS
DDKLHEFAAEARMVKDGYEINEMRKAVDATKHGFDRLLSALPDALDKPRSERILEGAFNAVSREIGNAVGYDSIVASGPH
APILHWMRNTGVVKNGDMLLVDAGVEVDSLYTADITRTFPTNGKFTDFQKRLYQAVLDSQQAGFEAAKPGATYSDIHHAC
MRVIAECLHDWGLLPVSVEESLSPQGQQHRRWLACGVAHHLGLDVHDCAQARFESYQGAPIRPGMIFTIEPGLYFREDDL
LIPPEYRGIGIRIEDDVLMTENGPEWISAGIPKTIEGVEAWMSERANA

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=461, Percent_Identity=30.3687635574837, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI260593665, Length=329, Percent_Identity=31.306990881459, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI149589008, Length=329, Percent_Identity=31.306990881459, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI260593663, Length=244, Percent_Identity=35.2459016393443, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI1789275, Length=463, Percent_Identity=29.5896328293737, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1788728, Length=269, Percent_Identity=27.1375464684015, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790282, Length=296, Percent_Identity=29.7297297297297, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17508215, Length=315, Percent_Identity=32.6984126984127, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71989583, Length=287, Percent_Identity=26.8292682926829, Blast_Score=101, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321118, Length=299, Percent_Identity=32.7759197324415, Blast_Score=143, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6320922, Length=370, Percent_Identity=28.9189189189189, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19920384, Length=452, Percent_Identity=30.5309734513274, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21357079, Length=496, Percent_Identity=29.8387096774194, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 58083; Mature: 57952

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEVITAKDKEYEAEERATAPGANQSMSDRVNNRSLRPQSAAFKEFMKSGWADDDPEIKP
CCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
LESSKFTPARLEALGKAFPGERLVIPAGQPKVRNNDCDYMFRPDTTFAYYTGLGSDYEAG
CCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCC
AVLVLNPVDPDSPEAAAGKTHTPELFVAPRADNSTEDFFMSAHYGEYWVGPRAGLQEMQA
EEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHEEECCCCCEECCCHHHHHHHHH
MTGIETHDIAQLADALSKDVGAEAGAVRVRVVSETDPEITSMVESIREANGFADPDKNSA
HHCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCC
SDDKLHEFAAEARMVKDGYEINEMRKAVDATKHGFDRLLSALPDALDKPRSERILEGAFN
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AVSREIGNAVGYDSIVASGPHAPILHWMRNTGVVKNGDMLLVDAGVEVDSLYTADITRTF
HHHHHHHHHCCCHHHHCCCCCHHHHHHHHCCCEEECCCEEEEECCCCCCCEEEECCEEEC
PTNGKFTDFQKRLYQAVLDSQQAGFEAAKPGATYSDIHHACMRVIAECLHDWGLLPVSVE
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHH
ESLSPQGQQHRRWLACGVAHHLGLDVHDCAQARFESYQGAPIRPGMIFTIEPGLYFREDD
HCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCEECCCC
LLIPPEYRGIGIRIEDDVLMTENGPEWISAGIPKTIEGVEAWMSERANA
EECCCCCCCEEEEEECCEEEECCCCHHHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GEVITAKDKEYEAEERATAPGANQSMSDRVNNRSLRPQSAAFKEFMKSGWADDDPEIKP
CCCCCCCCCCCCHHHHCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
LESSKFTPARLEALGKAFPGERLVIPAGQPKVRNNDCDYMFRPDTTFAYYTGLGSDYEAG
CCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCC
AVLVLNPVDPDSPEAAAGKTHTPELFVAPRADNSTEDFFMSAHYGEYWVGPRAGLQEMQA
EEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHEEECCCCCEECCCHHHHHHHHH
MTGIETHDIAQLADALSKDVGAEAGAVRVRVVSETDPEITSMVESIREANGFADPDKNSA
HHCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCC
SDDKLHEFAAEARMVKDGYEINEMRKAVDATKHGFDRLLSALPDALDKPRSERILEGAFN
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AVSREIGNAVGYDSIVASGPHAPILHWMRNTGVVKNGDMLLVDAGVEVDSLYTADITRTF
HHHHHHHHHCCCHHHHCCCCCHHHHHHHHCCCEEECCCEEEEECCCCCCCEEEECCEEEC
PTNGKFTDFQKRLYQAVLDSQQAGFEAAKPGATYSDIHHACMRVIAECLHDWGLLPVSVE
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHH
ESLSPQGQQHRRWLACGVAHHLGLDVHDCAQARFESYQGAPIRPGMIFTIEPGLYFREDD
HCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCEECCCC
LLIPPEYRGIGIRIEDDVLMTENGPEWISAGIPKTIEGVEAWMSERANA
EECCCCCCCEEEEEECCEEEECCCCHHHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]