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The map label for this gene is ftsI [H]

Identifier: 213691744

GI number: 213691744

Start: 1001387

End: 1003189

Strand: Direct

Name: ftsI [H]

Synonym: Blon_0850

Alternate gene names: 213691744

Gene position: 1001387-1003189 (Clockwise)

Preceding gene: 213691743

Following gene: 213691745

Centisome position: 35.35

GC content: 58.4

Gene sequence:

>1803_bases
GTGAACACCATTCGTCGCATCGTAGAGTTCGCCAAGGTCAAGACCTTCGCGTTCAAATGCATTGCCATCGGCGCCGCATT
GGCGTTGGTGGCGTCGGCATGCGTGATTCAGCTGGCCTCCATCCAGCTCATCGGTGGCCGTCAAACCGCACAAGCGGCCA
CGGCTAACCGCACCCTGACCGTGACGTTGAGCGCCAAGCGTGGGCGTATCCTCGACGCCAACGGCTCCGTGCTCGCTCAA
AGCGTGGAGCGTTATACTATCGTCGCCAATCCGGAGGCTGCACAGGAGTTCGAGCCGATTACCTGCAATGACAACACCCG
TGATTACTGCCACGAAATTGACGGCAAACCCGTGGGCGCTACCGGAGCGTCGGCCGTGGGCCGACTGCTGGCCAAAGTCT
TGGATATGAACGCCATGGAACTGGGAGCTGATCTGTCCGGTACCGGGCAGTATGTGATTCTGAAGAAAGACGTGACCCCA
CAGGTCAAGCGCAGCATCGAGGCGTTGCACCTGGGCGGTATTGTCTGGGGTGAGCTGAGCAGTGAACGACTGTATGCGGA
TGGCGATCTCATGGGCGCGCTGCTTGGCGGCGTGAACGACAACGGCGATGGCGTCGCCGGCATCGAGCAGGTCGAGAACA
AGACGCTTACCGGAACCGATGGCCATGAAACCTACCAGCGTGGTAATGGCGGCGAAGAGATTCCCGGCACCATGACCGAA
TCGGTGGCGGCCAAAAATGGCGACGATGTCACCCTGACCATTGACCGTGATGTGCAATGGTATGTCAAAAAGGCCTTGAA
GGAGGCCGAGTCCAAGTATGGTGCAGCGTGGGCGATCGCCGTGGTGCAGGATGTCCAGAGCGGGGAGATTCTCGCACTGG
CCGATAGCGATGAAGTACAGGCTGGTACCGATGCGGCGAAGATGAGCCCGTCTCGGGCCGTGTCCGAAACCTTCGAGCCT
GGTTCGGTGGGCAAGGTCATCTCCATGTCCGGCTATCTGCAGACGGGACTGCATAAGATGAGCGATCAATTGTCGGTCCC
GGACCACATCACACAGAAGGGCCAGACCTACAAGGACTCATTCGACCACGGCACTGAGCGCTGGACGCTCGCCGGCATTC
TGCAGAACTCATCGAACGTCGGCATGATTATGGCCGGGGAGAACTATCCGGATGAGCAACGCTACGAGTACCTGACCAAA
TTCGGTATCGGACAACCGACCGGACTGAACCTGCCCGGTGAATCGAGCGGTCTGCTCACCAGCCCTTCGGCATGGGATCT
GCGTACGCGCAACACCATCCTGTTTGGTCAGGGCTACACCGTCAACGCCCTGCAGCTCAACAACGTGGTGGCCACCATCG
CGAACAAGGGTGTCAAGCAGCAGCAGTCGATCATCAGATCAACCACCGATGCCAATGGCAAGACCACTGAGACCAAGAAG
GGCGAAGCCACCCGCGTGGTGGATGAAAAGGTCGCATCGGACATGATGAATGCGATGGAATCAGTGGCGGAGAGCTACAA
CAAGTTCGTCAAGGTCGATGGTTACCGCATGGCCGCCAAGTCCGGTACCGCAGAGGTGCAGGGTTCGGATGGCGCGCTCT
CGTCCATTATCTCCGATTATTCCGTGGTGATTCCCGCGGACAACCCGCGCTATGCGGTCACCGTGGTAATGAAGGATCCG
AATGGTGTGTTCGGCGGTCTGACGGCCGGCCCTGTTTCCGCACAGATTTGTGAGTTCCTTATGCAGAAATACGAGGTGCC
TGTCTCCAGTCCACGAAAAAATGCTATTCCAGTCACGTGGTAA

Upstream 100 bases:

>100_bases
CGAACCTGCCCGACAAGGCCAGCGACATGGGCATGGTCCCGCAGCAGGGATCAGTGTCCATCGACTTAAGCGGATACCAG
TCCAACAAAGGCGGAACCCA

Downstream 100 bases:

>100_bases
GGATCAGGGGAGAAAGGCGATAGCCCATGAGTGCAGTGAGCGAATCCATCGCCCAGCGGGTGACCTTGGGAATGCTGGTC
GAACGGTACGGTTTTGAAGT

Product: Peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MNTIRRIVEFAKVKTFAFKCIAIGAALALVASACVIQLASIQLIGGRQTAQAATANRTLTVTLSAKRGRILDANGSVLAQ
SVERYTIVANPEAAQEFEPITCNDNTRDYCHEIDGKPVGATGASAVGRLLAKVLDMNAMELGADLSGTGQYVILKKDVTP
QVKRSIEALHLGGIVWGELSSERLYADGDLMGALLGGVNDNGDGVAGIEQVENKTLTGTDGHETYQRGNGGEEIPGTMTE
SVAAKNGDDVTLTIDRDVQWYVKKALKEAESKYGAAWAIAVVQDVQSGEILALADSDEVQAGTDAAKMSPSRAVSETFEP
GSVGKVISMSGYLQTGLHKMSDQLSVPDHITQKGQTYKDSFDHGTERWTLAGILQNSSNVGMIMAGENYPDEQRYEYLTK
FGIGQPTGLNLPGESSGLLTSPSAWDLRTRNTILFGQGYTVNALQLNNVVATIANKGVKQQQSIIRSTTDANGKTTETKK
GEATRVVDEKVASDMMNAMESVAESYNKFVKVDGYRMAAKSGTAEVQGSDGALSSIISDYSVVIPADNPRYAVTVVMKDP
NGVFGGLTAGPVSAQICEFLMQKYEVPVSSPRKNAIPVTW

Sequences:

>Translated_600_residues
MNTIRRIVEFAKVKTFAFKCIAIGAALALVASACVIQLASIQLIGGRQTAQAATANRTLTVTLSAKRGRILDANGSVLAQ
SVERYTIVANPEAAQEFEPITCNDNTRDYCHEIDGKPVGATGASAVGRLLAKVLDMNAMELGADLSGTGQYVILKKDVTP
QVKRSIEALHLGGIVWGELSSERLYADGDLMGALLGGVNDNGDGVAGIEQVENKTLTGTDGHETYQRGNGGEEIPGTMTE
SVAAKNGDDVTLTIDRDVQWYVKKALKEAESKYGAAWAIAVVQDVQSGEILALADSDEVQAGTDAAKMSPSRAVSETFEP
GSVGKVISMSGYLQTGLHKMSDQLSVPDHITQKGQTYKDSFDHGTERWTLAGILQNSSNVGMIMAGENYPDEQRYEYLTK
FGIGQPTGLNLPGESSGLLTSPSAWDLRTRNTILFGQGYTVNALQLNNVVATIANKGVKQQQSIIRSTTDANGKTTETKK
GEATRVVDEKVASDMMNAMESVAESYNKFVKVDGYRMAAKSGTAEVQGSDGALSSIISDYSVVIPADNPRYAVTVVMKDP
NGVFGGLTAGPVSAQICEFLMQKYEVPVSSPRKNAIPVTW
>Mature_600_residues
MNTIRRIVEFAKVKTFAFKCIAIGAALALVASACVIQLASIQLIGGRQTAQAATANRTLTVTLSAKRGRILDANGSVLAQ
SVERYTIVANPEAAQEFEPITCNDNTRDYCHEIDGKPVGATGASAVGRLLAKVLDMNAMELGADLSGTGQYVILKKDVTP
QVKRSIEALHLGGIVWGELSSERLYADGDLMGALLGGVNDNGDGVAGIEQVENKTLTGTDGHETYQRGNGGEEIPGTMTE
SVAAKNGDDVTLTIDRDVQWYVKKALKEAESKYGAAWAIAVVQDVQSGEILALADSDEVQAGTDAAKMSPSRAVSETFEP
GSVGKVISMSGYLQTGLHKMSDQLSVPDHITQKGQTYKDSFDHGTERWTLAGILQNSSNVGMIMAGENYPDEQRYEYLTK
FGIGQPTGLNLPGESSGLLTSPSAWDLRTRNTILFGQGYTVNALQLNNVVATIANKGVKQQQSIIRSTTDANGKTTETKK
GEATRVVDEKVASDMMNAMESVAESYNKFVKVDGYRMAAKSGTAEVQGSDGALSSIISDYSVVIPADNPRYAVTVVMKDP
NGVFGGLTAGPVSAQICEFLMQKYEVPVSSPRKNAIPVTW

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=574, Percent_Identity=30.6620209059233, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1786854, Length=634, Percent_Identity=23.0283911671924, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 63919; Mature: 63919

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIRRIVEFAKVKTFAFKCIAIGAALALVASACVIQLASIQLIGGRQTAQAATANRTLT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHCCCCEEE
VTLSAKRGRILDANGSVLAQSVERYTIVANPEAAQEFEPITCNDNTRDYCHEIDGKPVGA
EEEECCCCEEEECCCHHHHHCCCEEEEEECCCHHHHCCCCCCCCCCHHHHHHCCCCCCCC
TGASAVGRLLAKVLDMNAMELGADLSGTGQYVILKKDVTPQVKRSIEALHLGGIVWGELS
CCHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEECCC
SERLYADGDLMGALLGGVNDNGDGVAGIEQVENKTLTGTDGHETYQRGNGGEEIPGTMTE
CCEEEECCHHHHHHHCCCCCCCCCCCHHHHHCCCEECCCCCHHHHHCCCCCCCCCCHHHH
SVAAKNGDDVTLTIDRDVQWYVKKALKEAESKYGAAWAIAVVQDVQSGEILALADSDEVQ
HHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCEEEEECCCCCC
AGTDAAKMSPSRAVSETFEPGSVGKVISMSGYLQTGLHKMSDQLSVPDHITQKGQTYKDS
CCCCHHHCCCHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCHHHHHCCCCHHHH
FDHGTERWTLAGILQNSSNVGMIMAGENYPDEQRYEYLTKFGIGQPTGLNLPGESSGLLT
HCCCCCCEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
SPSAWDLRTRNTILFGQGYTVNALQLNNVVATIANKGVKQQQSIIRSTTDANGKTTETKK
CCCCCCEECCCEEEEECCEEEEEEEHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCC
GEATRVVDEKVASDMMNAMESVAESYNKFVKVDGYRMAAKSGTAEVQGSDGALSSIISDY
CCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCEEEECCCCCCEEECCCHHHHHHHCCC
SVVIPADNPRYAVTVVMKDPNGVFGGLTAGPVSAQICEFLMQKYEVPVSSPRKNAIPVTW
EEEEECCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNTIRRIVEFAKVKTFAFKCIAIGAALALVASACVIQLASIQLIGGRQTAQAATANRTLT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHCCCCEEE
VTLSAKRGRILDANGSVLAQSVERYTIVANPEAAQEFEPITCNDNTRDYCHEIDGKPVGA
EEEECCCCEEEECCCHHHHHCCCEEEEEECCCHHHHCCCCCCCCCCHHHHHHCCCCCCCC
TGASAVGRLLAKVLDMNAMELGADLSGTGQYVILKKDVTPQVKRSIEALHLGGIVWGELS
CCHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEECCC
SERLYADGDLMGALLGGVNDNGDGVAGIEQVENKTLTGTDGHETYQRGNGGEEIPGTMTE
CCEEEECCHHHHHHHCCCCCCCCCCCHHHHHCCCEECCCCCHHHHHCCCCCCCCCCHHHH
SVAAKNGDDVTLTIDRDVQWYVKKALKEAESKYGAAWAIAVVQDVQSGEILALADSDEVQ
HHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCEEEEECCCCCC
AGTDAAKMSPSRAVSETFEPGSVGKVISMSGYLQTGLHKMSDQLSVPDHITQKGQTYKDS
CCCCHHHCCCHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCHHHHHCCCCHHHH
FDHGTERWTLAGILQNSSNVGMIMAGENYPDEQRYEYLTKFGIGQPTGLNLPGESSGLLT
HCCCCCCEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
SPSAWDLRTRNTILFGQGYTVNALQLNNVVATIANKGVKQQQSIIRSTTDANGKTTETKK
CCCCCCEECCCEEEEECCEEEEEEEHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCC
GEATRVVDEKVASDMMNAMESVAESYNKFVKVDGYRMAAKSGTAEVQGSDGALSSIISDY
CCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCEEEECCCCCCEEECCCHHHHHHHCCC
SVVIPADNPRYAVTVVMKDPNGVFGGLTAGPVSAQICEFLMQKYEVPVSSPRKNAIPVTW
EEEEECCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]