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The map label for this gene is hisD [H]

Identifier: 213691718

GI number: 213691718

Start: 969557

End: 970954

Strand: Direct

Name: hisD [H]

Synonym: Blon_0823

Alternate gene names: 213691718

Gene position: 969557-970954 (Clockwise)

Preceding gene: 213691717

Following gene: 213691719

Centisome position: 34.23

GC content: 66.24

Gene sequence:

>1398_bases
ATGAGTGAGAACATCATGCGAATCATTGACCTGCGTGGTCAGCACCTGTCCCGTGCCGAACTGCTCGCCGCGATGCCGCG
CGCCGCAATGGGCACTTCCGAAGCCACCGATCTGGTGCGTCCGATTCTGGACGATGTCAAGGAACGCGGTGCCGCGGCCC
TGCGCGACTTCGAGGAGAAGTTCGATCACGTGCGTCCCAAGAACCTGCGCGTGCCGGTCGAGGCGATCAAGGACGCCCTG
ACCACGCTCGACCCCGAAGTGCGCGCTGCCATCGAGGAATCGGTACGCCGCGCCCGCGCCGTGGCCGCCAACCAGGTGCC
GAAGGACTTCTACACCGACCTCGCCGAAGGTGCCCGCGTGGCCGAACGCTGGATTCCGATTCAGCGCGTCGGCCTGTATG
TGCCCGGCGGCAAGGCCGTCTACCCGAGCTCCGTCATCATGAACGCTGTGCCGGCCCAGGCCGCCGGCGTCGAATCGCTG
GCCATCGCCACCCCGCCCGCCCGCGACAATGAGGAAGGCCTGCCGAACAAGACCATCCTCGCCACCTGCGCCATCCTCGG
TGTTGACGAGGTATACGCGGTCGGCGGCGCTCAGGCCATCGCCATGTTCGCATACGGCGCCAAGGGCAGCGAGCCACAGG
ACGGCGACATCCTGTGCGATCCGGTTGACAAGATCACCGGCCCGGGCAACATCTTCGTGGCCACCGCCAAGTCGCTGGTC
TCCGCATTCGTGGGCATCGACGCGGTCGCCGGCCCCACCGAAATCGGCATCATCGCCGATGCAACCGCCAACCCGAGTCT
GCTGGCCGCCGACCTCATCGGCCAGGCCGAGCATGATGAGCTCGCCGGTTCCGTGCTGTTCACCGACTCCACCGAGATTG
CCGACAAGGTGCAGGAGAACCTCAAGTACCGCGTGCCGCGTACCGAGCACGCCGAGCGTGTCCACACGTCACTGTCCGGC
ACCCAGTCTGCCATCGTGCTGACCGACGGTCTCGACCAGTCCATCGACGCGGCCAACGCCTACGCCGCCGAACACCTTGA
GATTCAGACCAAGGATGCCGATGCTGTCGTCAAGCGCATCAAGAACGCCGGTGCCATCTTCCGCGGCCCGTACTCCCCGG
TGCCGCTGGGCGACTACATGTCCGGCTCCAACCACGTGCTGCCCACCGGCGGCACCGCCCGCTTCGCCGCCGGCCTCGGC
GTGCACACCTTCATGAAGCCGGTCGAAGTCATCGAATACGACGAGGAAGGCCTGAAGGCACTCGCCGCCCGCATCAACGC
CTTTGCGGTGTCCGAGGATCTGCCCGCCCACGGCGAGTGCGTGCTCTCCCGCTTCGTCAAGGATCCGTATGACAAGGCCA
CCCTGCGCGAGCAGGAGAAGGGAGCCGGTCTGCGATGA

Upstream 100 bases:

>100_bases
CTGCATCACGAATCCACATCACGCACGATAATCTCACGATACGGGTGAACATGGGCGTTCCTCGCCGCTTAGGCCCCTCA
CGTTGGTACGATGGGGCTTT

Downstream 100 bases:

>100_bases
GCTCGATTCCCGCAAACCTGCCGTTGCGCAACGACCTGATCGGTGAGGAGCCGTACGGCGCTCCCCAGCTGGACGTGCCG
GTGTGCCTGAACGTCAACGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSENIMRIIDLRGQHLSRAELLAAMPRAAMGTSEATDLVRPILDDVKERGAAALRDFEEKFDHVRPKNLRVPVEAIKDAL
TTLDPEVRAAIEESVRRARAVAANQVPKDFYTDLAEGARVAERWIPIQRVGLYVPGGKAVYPSSVIMNAVPAQAAGVESL
AIATPPARDNEEGLPNKTILATCAILGVDEVYAVGGAQAIAMFAYGAKGSEPQDGDILCDPVDKITGPGNIFVATAKSLV
SAFVGIDAVAGPTEIGIIADATANPSLLAADLIGQAEHDELAGSVLFTDSTEIADKVQENLKYRVPRTEHAERVHTSLSG
TQSAIVLTDGLDQSIDAANAYAAEHLEIQTKDADAVVKRIKNAGAIFRGPYSPVPLGDYMSGSNHVLPTGGTARFAAGLG
VHTFMKPVEVIEYDEEGLKALAARINAFAVSEDLPAHGECVLSRFVKDPYDKATLREQEKGAGLR

Sequences:

>Translated_465_residues
MSENIMRIIDLRGQHLSRAELLAAMPRAAMGTSEATDLVRPILDDVKERGAAALRDFEEKFDHVRPKNLRVPVEAIKDAL
TTLDPEVRAAIEESVRRARAVAANQVPKDFYTDLAEGARVAERWIPIQRVGLYVPGGKAVYPSSVIMNAVPAQAAGVESL
AIATPPARDNEEGLPNKTILATCAILGVDEVYAVGGAQAIAMFAYGAKGSEPQDGDILCDPVDKITGPGNIFVATAKSLV
SAFVGIDAVAGPTEIGIIADATANPSLLAADLIGQAEHDELAGSVLFTDSTEIADKVQENLKYRVPRTEHAERVHTSLSG
TQSAIVLTDGLDQSIDAANAYAAEHLEIQTKDADAVVKRIKNAGAIFRGPYSPVPLGDYMSGSNHVLPTGGTARFAAGLG
VHTFMKPVEVIEYDEEGLKALAARINAFAVSEDLPAHGECVLSRFVKDPYDKATLREQEKGAGLR
>Mature_464_residues
SENIMRIIDLRGQHLSRAELLAAMPRAAMGTSEATDLVRPILDDVKERGAAALRDFEEKFDHVRPKNLRVPVEAIKDALT
TLDPEVRAAIEESVRRARAVAANQVPKDFYTDLAEGARVAERWIPIQRVGLYVPGGKAVYPSSVIMNAVPAQAAGVESLA
IATPPARDNEEGLPNKTILATCAILGVDEVYAVGGAQAIAMFAYGAKGSEPQDGDILCDPVDKITGPGNIFVATAKSLVS
AFVGIDAVAGPTEIGIIADATANPSLLAADLIGQAEHDELAGSVLFTDSTEIADKVQENLKYRVPRTEHAERVHTSLSGT
QSAIVLTDGLDQSIDAANAYAAEHLEIQTKDADAVVKRIKNAGAIFRGPYSPVPLGDYMSGSNHVLPTGGTARFAAGLGV
HTFMKPVEVIEYDEEGLKALAARINAFAVSEDLPAHGECVLSRFVKDPYDKATLREQEKGAGLR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=422, Percent_Identity=37.6777251184834, Blast_Score=246, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6319819, Length=435, Percent_Identity=34.2528735632184, Blast_Score=232, Evalue=8e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 49434; Mature: 49303

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENIMRIIDLRGQHLSRAELLAAMPRAAMGTSEATDLVRPILDDVKERGAAALRDFEEK
CCCCHHHHHHCCCCCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDHVRPKNLRVPVEAIKDALTTLDPEVRAAIEESVRRARAVAANQVPKDFYTDLAEGARV
HHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AERWIPIQRVGLYVPGGKAVYPSSVIMNAVPAQAAGVESLAIATPPARDNEEGLPNKTIL
HHHCCCHHHEEEEECCCCCCCCHHHHHHCCCCHHCCCCCEEEECCCCCCCCCCCCCHHHH
ATCAILGVDEVYAVGGAQAIAMFAYGAKGSEPQDGDILCDPVDKITGPGNIFVATAKSLV
HHHHHHHHHHHHHCCCHHHHHHEEECCCCCCCCCCCEEECCHHHCCCCCCEEEEEHHHHH
SAFVGIDAVAGPTEIGIIADATANPSLLAADLIGQAEHDELAGSVLFTDSTEIADKVQEN
HHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCHHHHCCEEEEECCHHHHHHHHHH
LKYRVPRTEHAERVHTSLSGTQSAIVLTDGLDQSIDAANAYAAEHLEIQTKDADAVVKRI
HEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHEEEECCCHHHHHHHH
KNAGAIFRGPYSPVPLGDYMSGSNHVLPTGGTARFAAGLGVHTFMKPVEVIEYDEEGLKA
HHCCCEEECCCCCCCCCCCCCCCCEEECCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHH
LAARINAFAVSEDLPAHGECVLSRFVKDPYDKATLREQEKGAGLR
HHHHHHHHEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
SENIMRIIDLRGQHLSRAELLAAMPRAAMGTSEATDLVRPILDDVKERGAAALRDFEEK
CCCHHHHHHCCCCCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDHVRPKNLRVPVEAIKDALTTLDPEVRAAIEESVRRARAVAANQVPKDFYTDLAEGARV
HHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AERWIPIQRVGLYVPGGKAVYPSSVIMNAVPAQAAGVESLAIATPPARDNEEGLPNKTIL
HHHCCCHHHEEEEECCCCCCCCHHHHHHCCCCHHCCCCCEEEECCCCCCCCCCCCCHHHH
ATCAILGVDEVYAVGGAQAIAMFAYGAKGSEPQDGDILCDPVDKITGPGNIFVATAKSLV
HHHHHHHHHHHHHCCCHHHHHHEEECCCCCCCCCCCEEECCHHHCCCCCCEEEEEHHHHH
SAFVGIDAVAGPTEIGIIADATANPSLLAADLIGQAEHDELAGSVLFTDSTEIADKVQEN
HHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCHHHHCCEEEEECCHHHHHHHHHH
LKYRVPRTEHAERVHTSLSGTQSAIVLTDGLDQSIDAANAYAAEHLEIQTKDADAVVKRI
HEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHEEEECCCHHHHHHHH
KNAGAIFRGPYSPVPLGDYMSGSNHVLPTGGTARFAAGLGVHTFMKPVEVIEYDEEGLKA
HHCCCEEECCCCCCCCCCCCCCCCEEECCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHH
LAARINAFAVSEDLPAHGECVLSRFVKDPYDKATLREQEKGAGLR
HHHHHHHHEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12381787 [H]