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The map label for this gene is gmk [H]

Identifier: 213691636

GI number: 213691636

Start: 860465

End: 861055

Strand: Direct

Name: gmk [H]

Synonym: Blon_0740

Alternate gene names: 213691636

Gene position: 860465-861055 (Clockwise)

Preceding gene: 213691635

Following gene: 213691638

Centisome position: 30.38

GC content: 64.13

Gene sequence:

>591_bases
ATGACTGAAAACACCCATGCCGGCCGTCTAATCGTCCTGACTGGCCCCACCGCAGTAGGTAAAGGCACTGTGGAGGCCAA
GCTGCGCGCCGACCACCCCGAAGTGTGGGTGTCCGTTTCCGCCACCACGCGCGCTCCGCGCCCCGGCGAGGTTGATGGCG
TCAACTACTGGTTCCTCGCTGAAGACGAGTTCCTGGCCCGCGAAGCGGCGGGGGAGTTCCTGGAAACCGCCGTGGTGCAC
GGCATGGCCCACTACGGTACATTGCTGGCTCCGGTGGAGGAGCATCTGGCTGCCGGCGTGCCAACAATTCTGGAAATCGA
TTTGCAGGGCGCCCGCCGCGTCAAGCAGCGCGCCGCCGAACTCGACTTGGAAGTGGTGTACGTGTTCATCGCGCCGCCGA
GCTTTGAAGAGCTCGAGCGCCGTCTGATCGGCCGCGGCACCGAAACCGCCGAACAGCAGGCCCGTCGCCTGGAAACCGCC
AAAGTGGAGCTCGCCGCCGAAAACGAATTCGACGTCACCATCGTCAACGAAACCGTCGATCAGGCCGCCGCCGACCTCTG
GTCCGTCATCGCCAAGGAATACGGGCTGTAA

Upstream 100 bases:

>100_bases
TGTTCGTCGGGGCTGTAACAGTTACCGGTCATCTCGCCGGTGAGCCGTTACCACATTGGATTCATAATCGCTGCACACCA
CATCATCTCCGGAGGAACCC

Downstream 100 bases:

>100_bases
CGTGTGCGAATAGGTTCTGTTCGTACTGAGATGTCCATGCTTGGCATGGTGTGCTCATGTGATTATGCGTGTTCAGTCCC
TGCCAGTCGGCCCTCACAAT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MTENTHAGRLIVLTGPTAVGKGTVEAKLRADHPEVWVSVSATTRAPRPGEVDGVNYWFLAEDEFLAREAAGEFLETAVVH
GMAHYGTLLAPVEEHLAAGVPTILEIDLQGARRVKQRAAELDLEVVYVFIAPPSFEELERRLIGRGTETAEQQARRLETA
KVELAAENEFDVTIVNETVDQAAADLWSVIAKEYGL

Sequences:

>Translated_196_residues
MTENTHAGRLIVLTGPTAVGKGTVEAKLRADHPEVWVSVSATTRAPRPGEVDGVNYWFLAEDEFLAREAAGEFLETAVVH
GMAHYGTLLAPVEEHLAAGVPTILEIDLQGARRVKQRAAELDLEVVYVFIAPPSFEELERRLIGRGTETAEQQARRLETA
KVELAAENEFDVTIVNETVDQAAADLWSVIAKEYGL
>Mature_195_residues
TENTHAGRLIVLTGPTAVGKGTVEAKLRADHPEVWVSVSATTRAPRPGEVDGVNYWFLAEDEFLAREAAGEFLETAVVHG
MAHYGTLLAPVEEHLAAGVPTILEIDLQGARRVKQRAAELDLEVVYVFIAPPSFEELERRLIGRGTETAEQQARRLETAK
VELAAENEFDVTIVNETVDQAAADLWSVIAKEYGL

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=190, Percent_Identity=39.4736842105263, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI4504221, Length=190, Percent_Identity=39.4736842105263, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI226874831, Length=190, Percent_Identity=39.4736842105263, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI38570142, Length=190, Percent_Identity=31.0526315789474, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI262118259, Length=179, Percent_Identity=30.7262569832402, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI262118255, Length=179, Percent_Identity=30.7262569832402, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4505237, Length=179, Percent_Identity=30.7262569832402, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI262118263, Length=179, Percent_Identity=30.7262569832402, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1790080, Length=188, Percent_Identity=40.4255319148936, Blast_Score=128, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193203132, Length=187, Percent_Identity=35.8288770053476, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17508835, Length=183, Percent_Identity=36.6120218579235, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320662, Length=188, Percent_Identity=44.1489361702128, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21356141, Length=189, Percent_Identity=39.6825396825397, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45554489, Length=187, Percent_Identity=31.0160427807487, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24640542, Length=187, Percent_Identity=31.0160427807487, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI45554481, Length=191, Percent_Identity=30.3664921465969, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI116007136, Length=191, Percent_Identity=31.413612565445, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI85724806, Length=191, Percent_Identity=30.3664921465969, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161077626, Length=187, Percent_Identity=29.9465240641711, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281362232, Length=185, Percent_Identity=29.7297297297297, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161078485, Length=185, Percent_Identity=29.7297297297297, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24648810, Length=185, Percent_Identity=29.7297297297297, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24648808, Length=185, Percent_Identity=29.7297297297297, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161078487, Length=185, Percent_Identity=29.7297297297297, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281362230, Length=185, Percent_Identity=29.7297297297297, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 21432; Mature: 21301

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTENTHAGRLIVLTGPTAVGKGTVEAKLRADHPEVWVSVSATTRAPRPGEVDGVNYWFLA
CCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCEEEEEEE
EDEFLAREAAGEFLETAVVHGMAHYGTLLAPVEEHLAAGVPTILEIDLQGARRVKQRAAE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHH
LDLEVVYVFIAPPSFEELERRLIGRGTETAEQQARRLETAKVELAAENEFDVTIVNETVD
CCEEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEECCCCEEEEECHHHH
QAAADLWSVIAKEYGL
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TENTHAGRLIVLTGPTAVGKGTVEAKLRADHPEVWVSVSATTRAPRPGEVDGVNYWFLA
CCCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCEEEEEEE
EDEFLAREAAGEFLETAVVHGMAHYGTLLAPVEEHLAAGVPTILEIDLQGARRVKQRAAE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHH
LDLEVVYVFIAPPSFEELERRLIGRGTETAEQQARRLETAKVELAAENEFDVTIVNETVD
CCEEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEECCCCEEEEECHHHH
QAAADLWSVIAKEYGL
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12381787 [H]