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The map label for this gene is qacA [H]

Identifier: 213691538

GI number: 213691538

Start: 735173

End: 736588

Strand: Direct

Name: qacA [H]

Synonym: Blon_0639

Alternate gene names: 213691538

Gene position: 735173-736588 (Clockwise)

Preceding gene: 213691537

Following gene: 213691539

Centisome position: 25.95

GC content: 60.31

Gene sequence:

>1416_bases
ATGTCGACAGTCAGATCCGAAAAAATGCTTGATGAGGGCGGCAAGTCCATTGTCGCTTTGATGGCTGCGCTGATGGCGTC
GGTCTTCGCTTTTCAGCTCAACGCTTCCATGCTTTCGCCGGCGCTTACCACTATGGAGCGCGGGCTGAACACCAGCAGTT
CACAGATCAGTCTCACCCAGACGGTCTTCTTCACCGCATGTGCGCTGTTCTCACTGTTCCTGCCTCGACTGGGCGATCTC
GCAGGCCGCAAGAAAGTATTGCTGGGCATGCTGAGCATCACCGCCATCGGCTGTGTGGTCTCGGCGTTGGCCGTGAATGT
GCCCATGCTGATGGTCGGTCGCGTGATGCAGGGCGTATGCGGACCGGTGGTGCCGATGACGCTCATCATGCTGCACGCCA
AGGTGACTGAGGACGCCAAATATGCGCGACTGATGTCGATTCTTACCTCGGTGAACGGCGGTATTGGCGGTGTTGACGCC
ATCCTCGGCGGCTGGCTTGCCGGCACGTTCGGCTTCCGTTCCGTGTTCTGGGTGATGGTCGGTGTCGCCGTGGTCGCAAT
CGTGCTGGTGTCGATGTTCGCCGATGAAAGCACGGCCAAAGAGACCCCGAAGATGGATTGGGCCGGTGCAATCGTTCTTG
GCATCGCCTTCCTGGCAGCCTATCTGGCCATCAATGAAATACAGAAACTCGGCGACGCGAATTGGGTGCTCGTCGCTATC
GAGGTGGTAGCGGCTGCGGTCGCCTTCGTGATCTTCTGGAAGGTCGAGAACCGCAATCCCGCACCGATGGTCACCACCCA
CTATCTCAAGCAGCCGCGCACCTGGGGCCTGCTGCTCACCACATTGCTCACCATGACCGGCGTGTTCGCCATCATGAACG
GCGTTGTGCCGGCCTTGGCTCAGGACGGTAAGTTCGGCACCGGATTGGGAGCCGACGTGGTGTCGTTCGCCACGCTGACC
CCATATGCTTTGGTTGGTCTGGTCTTCGGCGTGGTCGCCGGTGTGCTTGCCTCCCAGTTCGGTTACCATCGCATGCTCCG
CGTGGGCATTCTGGTCAGCTTGGTCGGCGTGCTGTTCGGCGTATACGTTGCACACTTCCCGAGCGTATGGGCCTTGCTGG
TTATCTCGGTGGTGCTCGGTGTGGCATACGCGGGCACGGCGAACATCATGCTCAACGGTTTGGGTATTGTGCTGTCGCCG
GACGACAACCCAGGATACTTGCCCGGCCTCAATGCGGGCGCGTTCAACCTCGGCGCAGGCCTGAGCTACGCAGTGCTATA
TGCCGTGATGAACGCATTCGCGGGCTCCTCGGGCGGCACTGCCGGTTACTCGGCGGCAATGATCGCGTCGGCCGTGCTTC
TGGGCCTTGCTCTGCTGGCTTCGTTCGCCATCCCCAAGCTTGAACGAGCTGCTTGA

Upstream 100 bases:

>100_bases
GAAACTCGACTTCGATAAGTTCTGGGATCTCATTGTCGATGCCATCGTTGCTATCGGCTGACGGGCGAAGAGGAATGCGT
AAAAGGACAAGGGAATAGTC

Downstream 100 bases:

>100_bases
CCAAAGGTGTGCGTAACGCGCTCGCCATCACCGAACTGTTCGGTCATCCGGAAGTCGAGGTTTACAAGGGTCTACCACAT
TCCAGCACCACCGATTCCTT

Product: major facilitator superfamily MFS_1

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MSTVRSEKMLDEGGKSIVALMAALMASVFAFQLNASMLSPALTTMERGLNTSSSQISLTQTVFFTACALFSLFLPRLGDL
AGRKKVLLGMLSITAIGCVVSALAVNVPMLMVGRVMQGVCGPVVPMTLIMLHAKVTEDAKYARLMSILTSVNGGIGGVDA
ILGGWLAGTFGFRSVFWVMVGVAVVAIVLVSMFADESTAKETPKMDWAGAIVLGIAFLAAYLAINEIQKLGDANWVLVAI
EVVAAAVAFVIFWKVENRNPAPMVTTHYLKQPRTWGLLLTTLLTMTGVFAIMNGVVPALAQDGKFGTGLGADVVSFATLT
PYALVGLVFGVVAGVLASQFGYHRMLRVGILVSLVGVLFGVYVAHFPSVWALLVISVVLGVAYAGTANIMLNGLGIVLSP
DDNPGYLPGLNAGAFNLGAGLSYAVLYAVMNAFAGSSGGTAGYSAAMIASAVLLGLALLASFAIPKLERAA

Sequences:

>Translated_471_residues
MSTVRSEKMLDEGGKSIVALMAALMASVFAFQLNASMLSPALTTMERGLNTSSSQISLTQTVFFTACALFSLFLPRLGDL
AGRKKVLLGMLSITAIGCVVSALAVNVPMLMVGRVMQGVCGPVVPMTLIMLHAKVTEDAKYARLMSILTSVNGGIGGVDA
ILGGWLAGTFGFRSVFWVMVGVAVVAIVLVSMFADESTAKETPKMDWAGAIVLGIAFLAAYLAINEIQKLGDANWVLVAI
EVVAAAVAFVIFWKVENRNPAPMVTTHYLKQPRTWGLLLTTLLTMTGVFAIMNGVVPALAQDGKFGTGLGADVVSFATLT
PYALVGLVFGVVAGVLASQFGYHRMLRVGILVSLVGVLFGVYVAHFPSVWALLVISVVLGVAYAGTANIMLNGLGIVLSP
DDNPGYLPGLNAGAFNLGAGLSYAVLYAVMNAFAGSSGGTAGYSAAMIASAVLLGLALLASFAIPKLERAA
>Mature_470_residues
STVRSEKMLDEGGKSIVALMAALMASVFAFQLNASMLSPALTTMERGLNTSSSQISLTQTVFFTACALFSLFLPRLGDLA
GRKKVLLGMLSITAIGCVVSALAVNVPMLMVGRVMQGVCGPVVPMTLIMLHAKVTEDAKYARLMSILTSVNGGIGGVDAI
LGGWLAGTFGFRSVFWVMVGVAVVAIVLVSMFADESTAKETPKMDWAGAIVLGIAFLAAYLAINEIQKLGDANWVLVAIE
VVAAAVAFVIFWKVENRNPAPMVTTHYLKQPRTWGLLLTTLLTMTGVFAIMNGVVPALAQDGKFGTGLGADVVSFATLTP
YALVGLVFGVVAGVLASQFGYHRMLRVGILVSLVGVLFGVYVAHFPSVWALLVISVVLGVAYAGTANIMLNGLGIVLSPD
DNPGYLPGLNAGAFNLGAGLSYAVLYAVMNAFAGSSGGTAGYSAAMIASAVLLGLALLASFAIPKLERAA

Specific function: Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48947; Mature: 48816

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVRSEKMLDEGGKSIVALMAALMASVFAFQLNASMLSPALTTMERGLNTSSSQISLTQ
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
TVFFTACALFSLFLPRLGDLAGRKKVLLGMLSITAIGCVVSALAVNVPMLMVGRVMQGVC
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
GPVVPMTLIMLHAKVTEDAKYARLMSILTSVNGGIGGVDAILGGWLAGTFGFRSVFWVMV
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GVAVVAIVLVSMFADESTAKETPKMDWAGAIVLGIAFLAAYLAINEIQKLGDANWVLVAI
HHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
EVVAAAVAFVIFWKVENRNPAPMVTTHYLKQPRTWGLLLTTLLTMTGVFAIMNGVVPALA
HHHHHHHHHHHHEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDGKFGTGLGADVVSFATLTPYALVGLVFGVVAGVLASQFGYHRMLRVGILVSLVGVLFG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VYVAHFPSVWALLVISVVLGVAYAGTANIMLNGLGIVLSPDDNPGYLPGLNAGAFNLGAG
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEECCEEEECCCCCCCCCCCCCCCCCHHCCC
LSYAVLYAVMNAFAGSSGGTAGYSAAMIASAVLLGLALLASFAIPKLERAA
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
STVRSEKMLDEGGKSIVALMAALMASVFAFQLNASMLSPALTTMERGLNTSSSQISLTQ
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH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HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]