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The map label for this gene is hpt [H]

Identifier: 213691453

GI number: 213691453

Start: 619174

End: 619737

Strand: Direct

Name: hpt [H]

Synonym: Blon_0548

Alternate gene names: 213691453

Gene position: 619174-619737 (Clockwise)

Preceding gene: 213691452

Following gene: 213691454

Centisome position: 21.86

GC content: 57.09

Gene sequence:

>564_bases
ATGCGAATCGCTGACGTTGAGGAAGATATTGACCACGAGCTGGTCAGCAAAGAACAGATCGATGCCAAGATCCACGAGAT
GGCCGCTCTCGCGAGCGAGGATTACCGCGATAAGAATCCGCTGCTCGTTGCGGTGCTGAAAGGGGCCGTGAATACGCTGG
TCGCATTCACCCAGGCCATGAGCATTCCTGTACAGATCGACTTCATGAGCCTGTCGAGCTATGGCTCGGGCACAGTGTCG
AGCGGTGAGGTCACAGTCAGGCAGGATTTGTCCGCCGATGTTCGCGGACGGCACATCTTGATTGTGGAGGATATTGTTGA
TTCAGGACACACGCTCGCGTGGCTGGTCACAGAACTGAAACGTCGTGGTGCCGCTTCCGTGGAGGTCTTCGCTTTGCTGA
GCAAGCCCTCCCGCCGAGAGGTGGACGTTGATGTGAAGTACGCCGGCTATGAGATTCCGGACGAGTTCGTCGTCGGCTTC
GGCCTCGACTTTGACGAACGCTACCGCAACCTCGATTCGATCGCGGTCCTCAAGCCGTCCGTCTACCAAGGAGTGCAAGC
ATGA

Upstream 100 bases:

>100_bases
CTGGTCGTCGATTGGCATGGCCAAGGCGGCGTCTCACTTCCCAGAGGTTATTCAGCCAATCGCAAGAAACACGTCATTCG
CGTGTGCCAAGATGGTGCGC

Downstream 100 bases:

>100_bases
GCTTCCCGCAAGGGCCGGGTAACGGCAATAATCCGAACCCGAACAACAACCGTAACAACGGCAACCCGTTCACTAACCCG
TTCAACCGTGGCAATAACGG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MRIADVEEDIDHELVSKEQIDAKIHEMAALASEDYRDKNPLLVAVLKGAVNTLVAFTQAMSIPVQIDFMSLSSYGSGTVS
SGEVTVRQDLSADVRGRHILIVEDIVDSGHTLAWLVTELKRRGAASVEVFALLSKPSRREVDVDVKYAGYEIPDEFVVGF
GLDFDERYRNLDSIAVLKPSVYQGVQA

Sequences:

>Translated_187_residues
MRIADVEEDIDHELVSKEQIDAKIHEMAALASEDYRDKNPLLVAVLKGAVNTLVAFTQAMSIPVQIDFMSLSSYGSGTVS
SGEVTVRQDLSADVRGRHILIVEDIVDSGHTLAWLVTELKRRGAASVEVFALLSKPSRREVDVDVKYAGYEIPDEFVVGF
GLDFDERYRNLDSIAVLKPSVYQGVQA
>Mature_187_residues
MRIADVEEDIDHELVSKEQIDAKIHEMAALASEDYRDKNPLLVAVLKGAVNTLVAFTQAMSIPVQIDFMSLSSYGSGTVS
SGEVTVRQDLSADVRGRHILIVEDIVDSGHTLAWLVTELKRRGAASVEVFALLSKPSRREVDVDVKYAGYEIPDEFVVGF
GLDFDERYRNLDSIAVLKPSVYQGVQA

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=146, Percent_Identity=36.3013698630137, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI9910262, Length=181, Percent_Identity=29.2817679558011, Blast_Score=81, Evalue=5e-16,
Organism=Escherichia coli, GI87081689, Length=164, Percent_Identity=40.8536585365854, Blast_Score=137, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17510817, Length=147, Percent_Identity=34.0136054421769, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20628; Mature: 20628

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIADVEEDIDHELVSKEQIDAKIHEMAALASEDYRDKNPLLVAVLKGAVNTLVAFTQAM
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHH
SIPVQIDFMSLSSYGSGTVSSGEVTVRQDLSADVRGRHILIVEDIVDSGHTLAWLVTELK
CCCEEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEHHCCCCCHHHHHHHHHH
RRGAASVEVFALLSKPSRREVDVDVKYAGYEIPDEFVVGFGLDFDERYRNLDSIAVLKPS
HCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHEEEECCCHHHHHCCCCCEEEECCH
VYQGVQA
HHCCCCC
>Mature Secondary Structure
MRIADVEEDIDHELVSKEQIDAKIHEMAALASEDYRDKNPLLVAVLKGAVNTLVAFTQAM
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHH
SIPVQIDFMSLSSYGSGTVSSGEVTVRQDLSADVRGRHILIVEDIVDSGHTLAWLVTELK
CCCEEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEHHCCCCCHHHHHHHHHH
RRGAASVEVFALLSKPSRREVDVDVKYAGYEIPDEFVVGFGLDFDERYRNLDSIAVLKPS
HCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHEEEECCCHHHHHCCCCCEEEECCH
VYQGVQA
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]