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The map label for this gene is ribBA [H]

Identifier: 213691301

GI number: 213691301

Start: 448391

End: 449596

Strand: Direct

Name: ribBA [H]

Synonym: Blon_0388

Alternate gene names: 213691301

Gene position: 448391-449596 (Clockwise)

Preceding gene: 213691300

Following gene: 213691302

Centisome position: 15.83

GC content: 58.54

Gene sequence:

>1206_bases
ATGAACCATCAGTCGGTGCAAGCGGCGTTGCAGGCGCTGCGGGAAGGAAAACTCGTTCTGGTCATCGATGACGAGGACCG
GGAGAACGAGGGGGATCTCATCTGTGCCGCGCAGTCGGCCACCACATGGAACGTCAATTTCATGGCAACCCACGCCAAGG
GATTGATCTGCATGCCCATGAGCGAGCAACTGGCCCACAAGCTGATGCTTCCGCCCATGGTCGAGCACAACACCGATAAC
CATGAAACCGCTTTTACGGTGTCCATTGATTACCGTGGCACCACGACCGGCATCTCCGCCGAAGAACGGGGATTGACGGC
TCGCATGTGCGTCTCCGATGACGTGGAACCCCTCGATTTCCGCAGACCGGGGCATATGTTCCCCCTGGTGGCGAAGAAGG
GTGGCGTTCTGGAACGGAACGGGCACACGGAGGCGACCGTCGACCTCATGCGGTTGGCGGGATTGCGCGAATGCGGCCTG
TGCTGCGAGATCATGGACGACGATGGCCGGATGATGAGGACACCCGACCTGACCCGGTTCGCCCAGGAGCATCAGATCCC
GCTCCTGACCATCAAGGAACTGCAGGAATACAGGAAAGCGCACGATACGCTCGTCGAATGCGTCTCGACCGTGGCGATGC
CCACGCGATACGGGGAATTCACGGCGCACTGCTATGTGAACAGGTTGAACGGCGAGCATCATGTCGCGCTGGTCATGGGG
GATCTGGGCGACGGGACCGATGTGTTGTGCCGGGTGCACTCGGAATGCCTGACCGGTGACGTCTTCGGCTCGTTGCGTTG
CGATTGCGGTCAGCAGTTGGACGCGGCGATGCGAACGATCGCGGAGCATGGCTCTGGCGTGCTGCTGTACATGCGTCAGG
AAGGGCGGGGCATCGGTCTGGTCAACAAGCTGAAGGCCTACCGTCTGCAGGACGAGGGCATGGACACGCTCGACGCCAAT
CTCGCGTTGGGGTTCCCCGGTGACGCGAGGGAGTACTACATCGGAGCGCAGATTCTCAGGGATCTGGGGATACGGTCTAT
GCTCCTGCTGACCAACAATCCCGACAAAGTGTATCAATTGGAAGACTATGGAATGGAGATCCGCGACAGAATACCAATCG
AAATCGAAGCCAATGCTTACGACAGTTTCTATCTCAAAACCAAGAAAAACCGCATGGGACATATCCTGAACATGGAGGAG
GAATAA

Upstream 100 bases:

>100_bases
ACGTATTGGGAAAATACGTGCGGAACATGATGACGACCCGGACGGGACTGACGCAGGATCTGCTGTCCCGGTGCGGGTTC
TGAGAAAGGATGTATGAATC

Downstream 100 bases:

>100_bases
ATGCACACGTTCGAAGGCGATCTGGTAGCCGAAAACATCACGATAGGCATCGTTGTGGCGAGGTTCAACGAGTTCATCAC
CTCAAAACTGCTGGCAGGGG

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MNHQSVQAALQALREGKLVLVIDDEDRENEGDLICAAQSATTWNVNFMATHAKGLICMPMSEQLAHKLMLPPMVEHNTDN
HETAFTVSIDYRGTTTGISAEERGLTARMCVSDDVEPLDFRRPGHMFPLVAKKGGVLERNGHTEATVDLMRLAGLRECGL
CCEIMDDDGRMMRTPDLTRFAQEHQIPLLTIKELQEYRKAHDTLVECVSTVAMPTRYGEFTAHCYVNRLNGEHHVALVMG
DLGDGTDVLCRVHSECLTGDVFGSLRCDCGQQLDAAMRTIAEHGSGVLLYMRQEGRGIGLVNKLKAYRLQDEGMDTLDAN
LALGFPGDAREYYIGAQILRDLGIRSMLLLTNNPDKVYQLEDYGMEIRDRIPIEIEANAYDSFYLKTKKNRMGHILNMEE
E

Sequences:

>Translated_401_residues
MNHQSVQAALQALREGKLVLVIDDEDRENEGDLICAAQSATTWNVNFMATHAKGLICMPMSEQLAHKLMLPPMVEHNTDN
HETAFTVSIDYRGTTTGISAEERGLTARMCVSDDVEPLDFRRPGHMFPLVAKKGGVLERNGHTEATVDLMRLAGLRECGL
CCEIMDDDGRMMRTPDLTRFAQEHQIPLLTIKELQEYRKAHDTLVECVSTVAMPTRYGEFTAHCYVNRLNGEHHVALVMG
DLGDGTDVLCRVHSECLTGDVFGSLRCDCGQQLDAAMRTIAEHGSGVLLYMRQEGRGIGLVNKLKAYRLQDEGMDTLDAN
LALGFPGDAREYYIGAQILRDLGIRSMLLLTNNPDKVYQLEDYGMEIRDRIPIEIEANAYDSFYLKTKKNRMGHILNMEE
E
>Mature_401_residues
MNHQSVQAALQALREGKLVLVIDDEDRENEGDLICAAQSATTWNVNFMATHAKGLICMPMSEQLAHKLMLPPMVEHNTDN
HETAFTVSIDYRGTTTGISAEERGLTARMCVSDDVEPLDFRRPGHMFPLVAKKGGVLERNGHTEATVDLMRLAGLRECGL
CCEIMDDDGRMMRTPDLTRFAQEHQIPLLTIKELQEYRKAHDTLVECVSTVAMPTRYGEFTAHCYVNRLNGEHHVALVMG
DLGDGTDVLCRVHSECLTGDVFGSLRCDCGQQLDAAMRTIAEHGSGVLLYMRQEGRGIGLVNKLKAYRLQDEGMDTLDAN
LALGFPGDAREYYIGAQILRDLGIRSMLLLTNNPDKVYQLEDYGMEIRDRIPIEIEANAYDSFYLKTKKNRMGHILNMEE
E

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=200, Percent_Identity=48.5, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1787533, Length=190, Percent_Identity=50.5263157894737, Blast_Score=194, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6320695, Length=203, Percent_Identity=44.3349753694581, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319438, Length=172, Percent_Identity=47.093023255814, Blast_Score=139, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44943; Mature: 44943

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHQSVQAALQALREGKLVLVIDDEDRENEGDLICAAQSATTWNVNFMATHAKGLICMPM
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCEEEEEEEEEECCCCEEEECC
SEQLAHKLMLPPMVEHNTDNHETAFTVSIDYRGTTTGISAEERGLTARMCVSDDVEPLDF
HHHHHHHHCCCCHHCCCCCCCCEEEEEEEEECCCCCCCCHHHCCCEEEEEECCCCCCCCC
RRPGHMFPLVAKKGGVLERNGHTEATVDLMRLAGLRECGLCCEIMDDDGRMMRTPDLTRF
CCCCCEEEEEECCCCEEECCCCCHHHHHHHHHCCCHHCCCEEEEECCCCCEEECCCHHHH
AQEHQIPLLTIKELQEYRKAHDTLVECVSTVAMPTRYGEFTAHCYVNRLNGEHHVALVMG
HHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEEEEE
DLGDGTDVLCRVHSECLTGDVFGSLRCDCGQQLDAAMRTIAEHGSGVLLYMRQEGRGIGL
CCCCCHHHHHHHHHHHHCCHHCCCEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCH
VNKLKAYRLQDEGMDTLDANLALGFPGDAREYYIGAQILRDLGIRSMLLLTNNPDKVYQL
HHHHHHHEECCCCCCEECCCEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEE
EDYGMEIRDRIPIEIEANAYDSFYLKTKKNRMGHILNMEEE
CCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCEECCCCC
>Mature Secondary Structure
MNHQSVQAALQALREGKLVLVIDDEDRENEGDLICAAQSATTWNVNFMATHAKGLICMPM
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCEEEEEEEEEECCCCEEEECC
SEQLAHKLMLPPMVEHNTDNHETAFTVSIDYRGTTTGISAEERGLTARMCVSDDVEPLDF
HHHHHHHHCCCCHHCCCCCCCCEEEEEEEEECCCCCCCCHHHCCCEEEEEECCCCCCCCC
RRPGHMFPLVAKKGGVLERNGHTEATVDLMRLAGLRECGLCCEIMDDDGRMMRTPDLTRF
CCCCCEEEEEECCCCEEECCCCCHHHHHHHHHCCCHHCCCEEEEECCCCCEEECCCHHHH
AQEHQIPLLTIKELQEYRKAHDTLVECVSTVAMPTRYGEFTAHCYVNRLNGEHHVALVMG
HHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEEEEE
DLGDGTDVLCRVHSECLTGDVFGSLRCDCGQQLDAAMRTIAEHGSGVLLYMRQEGRGIGL
CCCCCHHHHHHHHHHHHCCHHCCCEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCH
VNKLKAYRLQDEGMDTLDANLALGFPGDAREYYIGAQILRDLGIRSMLLLTNNPDKVYQL
HHHHHHHEECCCCCCEECCCEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEE
EDYGMEIRDRIPIEIEANAYDSFYLKTKKNRMGHILNMEEE
CCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA