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The map label for this gene is cpx [H]

Identifier: 213691066

GI number: 213691066

Start: 173869

End: 175221

Strand: Direct

Name: cpx [H]

Synonym: Blon_0145

Alternate gene names: 213691066

Gene position: 173869-175221 (Clockwise)

Preceding gene: 213691065

Following gene: 213691067

Centisome position: 6.14

GC content: 60.09

Gene sequence:

>1353_bases
ATGTCAATACGCAAGGAGCTGACCGCCCAGAACGTACTGCTGGGTTTCCAGCATGTGTTCGTTTCCAATGTTTGGCTTGA
TCCGGTATTCGTGGCCGGAGCAATCGGCTTACCTATTGCCCTGTCGTCGAACATGATTAACGCCATCTTCATCGTCTCCG
GCCTGGTTACTCTGATCCAGGCCACTCGGCTGGTTCGCCTGCCGGTGGTGCAGGGGCCGTCAGCCGCGTTTGACGCGTTG
ATGATCGCGGCAGGTACGGCTGGCATGCTGGGGGCGGCGAGTTCGTCCATTCTCATCGCTTCGCTTGTGTTCCTGTTGCT
GTGCCTGACCGGTGTGATAGAGCGGATGAGGTTCCTGTTCTCTCCGATGATCTCGGGCGTGGTCATCTTTATGGTCGGTG
TTTCGCTGTCCGGATTCACGCTGAGCGAGTTTCTTGGTGGGGCTCCCGGCGACAAAACGTTTGCCGATCCGCACATCCTG
ACCGTGTCGATCCTGACCACGGCGATTGTGCTTGTCCTGTCGCTGCTCGGCAAGGGTCTGCTTAAGTCGTTCTCATTCCT
CATCGCGCTTGTCGTCGGCACCGTGGTCGCCGCGGCGTTTGGCATGGTGGACTTCTCTCCTGTGGCTTCCAAGGGATGGT
TGGGCCTGCCGACCTTCATGCCTTACGGGCCGTTTACGTTTGACTGGAAGATCTTCATTCCGTTCTTCATCGCCTATATG
GTTGCCGTCATGGAGGCTCTCGGCGTCTATCAGGCGGCTTCCGAGATTCAAGGCACGACCCTCGAACGCAAGCAGGTGCG
CTACGGCCTCGCCGGCGAGGCGGCAGGTTCGGCCATTTCCTCGTTGATTGGTGGATTCACCACCACCGCATACCCGCAAA
ATGTCGGCCTGCTCAACCTGACCGGCGAAGGCAAGCTGCGCACGCGCACGCCTGTGATCATCGCCGCCATCCTGTTGCTG
ATTCTGGGCTTCGTGCCAAAGGCAGGCGCGCTGCTGTCCGTCATTCCCTCGGCAGTCGTCGGAGGCATCTTCCTGCCGGC
TGCGGCCAGCCTGATCGTGACCGGTCTGCGAGCCTTGCGCAAGGTCGCTGATGACGAGCGCCGTCAAACGGTCATCGGCA
TGTCTCTGCTGCTCGGCATCGCCCTGCCCAAGGCGCTCTCCGGCCTGACCGGCGGCGCAAGCGTGTTCTTTGGCAACAAC
ATCATGGTCGGTGTATTCAGCGCCATCATTCTCAATGCGCTGTTCATCGCTCTTCCGGATTTGGTGGCGAAGCATCGTGC
GCCGGCGTCCATGGATGTTCCAGCAGCCGATTCGGCGGATGGGACTGGCGCCGCGGCGCACGATGAACGATAA

Upstream 100 bases:

>100_bases
CCCTTCGAACCTGTGAGCTAACACTCGCGTAGGGAATACGACGGTTGAACTCCTCTGTTCGGCTCGGCATCCCATATGCG
CGTTGAGAGAGAGGAAGCGT

Downstream 100 bases:

>100_bases
TGCTGGTTGATATTGGATATTGACAGGAGCGATGCAATGACTGATGTGATGGATGACGCGCGTCGTATCAAGCGCGGGAT
TCTGGATTTTATCCATACCT

Product: Xanthine/uracil/vitamin C permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MSIRKELTAQNVLLGFQHVFVSNVWLDPVFVAGAIGLPIALSSNMINAIFIVSGLVTLIQATRLVRLPVVQGPSAAFDAL
MIAAGTAGMLGAASSSILIASLVFLLLCLTGVIERMRFLFSPMISGVVIFMVGVSLSGFTLSEFLGGAPGDKTFADPHIL
TVSILTTAIVLVLSLLGKGLLKSFSFLIALVVGTVVAAAFGMVDFSPVASKGWLGLPTFMPYGPFTFDWKIFIPFFIAYM
VAVMEALGVYQAASEIQGTTLERKQVRYGLAGEAAGSAISSLIGGFTTTAYPQNVGLLNLTGEGKLRTRTPVIIAAILLL
ILGFVPKAGALLSVIPSAVVGGIFLPAAASLIVTGLRALRKVADDERRQTVIGMSLLLGIALPKALSGLTGGASVFFGNN
IMVGVFSAIILNALFIALPDLVAKHRAPASMDVPAADSADGTGAAAHDER

Sequences:

>Translated_450_residues
MSIRKELTAQNVLLGFQHVFVSNVWLDPVFVAGAIGLPIALSSNMINAIFIVSGLVTLIQATRLVRLPVVQGPSAAFDAL
MIAAGTAGMLGAASSSILIASLVFLLLCLTGVIERMRFLFSPMISGVVIFMVGVSLSGFTLSEFLGGAPGDKTFADPHIL
TVSILTTAIVLVLSLLGKGLLKSFSFLIALVVGTVVAAAFGMVDFSPVASKGWLGLPTFMPYGPFTFDWKIFIPFFIAYM
VAVMEALGVYQAASEIQGTTLERKQVRYGLAGEAAGSAISSLIGGFTTTAYPQNVGLLNLTGEGKLRTRTPVIIAAILLL
ILGFVPKAGALLSVIPSAVVGGIFLPAAASLIVTGLRALRKVADDERRQTVIGMSLLLGIALPKALSGLTGGASVFFGNN
IMVGVFSAIILNALFIALPDLVAKHRAPASMDVPAADSADGTGAAAHDER
>Mature_449_residues
SIRKELTAQNVLLGFQHVFVSNVWLDPVFVAGAIGLPIALSSNMINAIFIVSGLVTLIQATRLVRLPVVQGPSAAFDALM
IAAGTAGMLGAASSSILIASLVFLLLCLTGVIERMRFLFSPMISGVVIFMVGVSLSGFTLSEFLGGAPGDKTFADPHILT
VSILTTAIVLVLSLLGKGLLKSFSFLIALVVGTVVAAAFGMVDFSPVASKGWLGLPTFMPYGPFTFDWKIFIPFFIAYMV
AVMEALGVYQAASEIQGTTLERKQVRYGLAGEAAGSAISSLIGGFTTTAYPQNVGLLNLTGEGKLRTRTPVIIAAILLLI
LGFVPKAGALLSVIPSAVVGGIFLPAAASLIVTGLRALRKVADDERRQTVIGMSLLLGIALPKALSGLTGGASVFFGNNI
MVGVFSAIILNALFIALPDLVAKHRAPASMDVPAADSADGTGAAAHDER

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082181, Length=424, Percent_Identity=27.5943396226415, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790087, Length=408, Percent_Identity=26.2254901960784, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87082178, Length=405, Percent_Identity=27.6543209876543, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788843, Length=287, Percent_Identity=27.8745644599303, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87081818, Length=397, Percent_Identity=26.448362720403, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17558856, Length=227, Percent_Identity=27.3127753303965, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71993493, Length=422, Percent_Identity=22.0379146919431, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17542262, Length=389, Percent_Identity=21.3367609254499, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356175, Length=471, Percent_Identity=23.1422505307856, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46724; Mature: 46593

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRKELTAQNVLLGFQHVFVSNVWLDPVFVAGAIGLPIALSSNMINAIFIVSGLVTLIQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHH
ATRLVRLPVVQGPSAAFDALMIAAGTAGMLGAASSSILIASLVFLLLCLTGVIERMRFLF
HHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SPMISGVVIFMVGVSLSGFTLSEFLGGAPGDKTFADPHILTVSILTTAIVLVLSLLGKGL
HHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LKSFSFLIALVVGTVVAAAFGMVDFSPVASKGWLGLPTFMPYGPFTFDWKIFIPFFIAYM
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHH
VAVMEALGVYQAASEIQGTTLERKQVRYGLAGEAAGSAISSLIGGFTTTAYPQNVGLLNL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
TGEGKLRTRTPVIIAAILLLILGFVPKAGALLSVIPSAVVGGIFLPAAASLIVTGLRALR
CCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVADDERRQTVIGMSLLLGIALPKALSGLTGGASVFFGNNIMVGVFSAIILNALFIALPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
LVAKHRAPASMDVPAADSADGTGAAAHDER
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SIRKELTAQNVLLGFQHVFVSNVWLDPVFVAGAIGLPIALSSNMINAIFIVSGLVTLIQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHH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HHHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11792842; 8162194 [H]