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The map label for this gene is cadA [H]

Identifier: 213691024

GI number: 213691024

Start: 122187

End: 124349

Strand: Direct

Name: cadA [H]

Synonym: Blon_0103

Alternate gene names: 213691024

Gene position: 122187-124349 (Clockwise)

Preceding gene: 213691023

Following gene: 213691025

Centisome position: 4.31

GC content: 67.08

Gene sequence:

>2163_bases
ATGAGCGCACTCATCAGATTCTTCACCAAAATCCTCGATATTTGCCGGCTTGTACCGATGCTTCCGGTCGTCGTCATCGC
CGCGATTCCGTTGGCTTTACTAGGCGATTGGCATCCTTGGGGGCACGCGGCCGACATTGCGATGCTGGGCGATCCGGGCT
TCGGCCAATGGCTCATCATCGCGCTGGTGCTGATCATCGTGGCCGACACCGTGCGCGGCATGATCGACGATCTGCGGCAC
GGGCAGGTCGGCGTCGATCTGCTGGCCGTGGTCGCGATTCTCTCTACTGTGGCCGTCCACGAATACTGGGCGAGCTGGGC
GGTGATGCTGATGGTCACGTCCGGTGAAGCCATCGAGGAGTACGCCCAGGCCAAGGCCGAACACAGTCTGACCGCACTGA
TGGAAGCGGCGCCGCGGACCGCGCACGTCGTCAGCCTCCCCGGCGTGGGACGCGACTCGGCAGGCGATGCCGGCGATGCA
TCCGAGGGCTTCCGCCGCGTGGGCCAGTTTGCGACGGCGTCGGCCGCGCATCGATTCGATACGGTGCCGGTCGAACAGGT
GCGGCTCGGCGACGTGCTGATGGTGTTGCCGGGCGAAACCGTGCCGGTTGACGGCGAACTGTTGTCGGGCTCGGCCACGC
TTGACCTGAGCGACATCAACGGCGAGCCGGTGCCGCGTGAAGTGTTCGCCGGCGCCCGCGTGATGTCCGGCGCGGTGAAC
GGCTCGACTGCATTGACCATGCGTGCCACCCAAGTGGCCGCCGATTCGCAGTACCAGCGCATCCTCGAGCTCGTGGCCTC
CGCGCAGGAATCGCGGCCAGCCGTGGTGAAAACCGCTGACCGCTTGGCCGTGCCCTTCACCGTGCTTTCGTTGGTGATTG
CCGGCGTCGCATGGGCGGTGTCCGGGGTGCCGACGCGATTCGCCCAGGTGCTGGTGTTGGCCACGCCCTGCCCGCTGCTC
ATCGCCGCACCGGTGGCGTACATCGCCGGCACGGGTCGTCTCGCCGCGGCCGGCGTGCTGATCAAGGCGCAGGATGTGCT
GGAGAATCTCGGCCGCGTCACCCAGGTGTTCTTCGACAAGACCGGCACGCTCACCGTCAAACAACCGCAAGTGGTGCGCG
TCGAGATGCTGCCCGGCGCGGCGACCCAGTTCGACGGGGACCATGTGCTGATGATGGCCGGCGTGGTGGAAAGCTATTCG
GTGCATATCCTGTCCAAAGGCATCGCCAAGGCCGGAACGGAGGCGATGGCCAGACTGCGCCGGCAGTCCGAGAACGATGG
GCGGCCATGCCCCGAGTCGGACGCCGTCTGGTTCGGCGTCGGCCGCGAGCATCCGGTCGTCAAGGGCATCAACGAGGAGG
CCGGCAAGGGCGTTTCCGGCGAGGTGAACGGACACGTGGTGCGTGTGGGCCGGCTGTCGTTTGCCGCCGCCGGGAAGGAC
GGATTCCTGACGGCCGGCAACGCCGACCCCACTGGCCCGCGTCACGACCCGCGGCCCGGAACGGAGGCCGCCGGCGGAAC
GGAAGAGGATGTCCGCACGCGCTTCGGCCTGCTGCAGCCGGACGAGATGGCATCCTACGTGTCCATCGACGGCCGATTGA
TCGCACGCATCGTGCTGCGTGATGTGCCGCGCGCCAATGCCGGGACGGCGCTCGCCAAACTGCATGCGCTGGGCGTCGCC
AGACTCGCCATGCTCACCGGCGACAAGCGCGCCTCGGCCGACATCATCGCGAACGAGGTCGGCATTGACGAGGTCCACGC
CGAACTCTTCCCCGAAGACAAGGTCGCCGCCGTCAAGTCCGCCGCGGAAGACGGCAACGCCGTCACGATGATGGTCGGTG
ACGGCGTGAACGACGCCCCGGTGCTCGCCGTCGCCGACATCGGCGTGGCCATGACCGACGGCACCTCCACCGCCGCCTCC
GAAAGCGCCCAGGTGGTCATCATGACCGATGACATCGCGGCCGTGCCGCGCGCCATCGCCATCGCCCGCCGCACCAAGCG
TGTGATGCTGCAAGCCGTTATCGTCGGTCTTGCGCTCGCCGTGATCGGCATGATCGCCGCCGCGTTCGATCTCATTCCGG
TCGTCGTCGGCGCATTCCTCCAGGAGGCCATCGACGTGGTGAGCATCCTCTGGGGCCTCACCGCCCTGATCGATCGAGAT
TAG

Upstream 100 bases:

>100_bases
AGGCATGGACGCCGGTGGGTTAACAAGGCGTGACCACAGCGCCGATTGCGCGGGCCACGCTTGCCGCAATCGACTCCGTA
TACGAGCGTAAGGAGCAATG

Downstream 100 bases:

>100_bases
GGGACACGGCCCGCCGCGTACCGCGACATGGAGCCGGCCGCCGCACCGATCGCATATCGGTGCGGCGGCCGGCTTGTTTT
TTGTCGTCGCTCTTCTTGCG

Product: ATPase P

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 720; Mature: 719

Protein sequence:

>720_residues
MSALIRFFTKILDICRLVPMLPVVVIAAIPLALLGDWHPWGHAADIAMLGDPGFGQWLIIALVLIIVADTVRGMIDDLRH
GQVGVDLLAVVAILSTVAVHEYWASWAVMLMVTSGEAIEEYAQAKAEHSLTALMEAAPRTAHVVSLPGVGRDSAGDAGDA
SEGFRRVGQFATASAAHRFDTVPVEQVRLGDVLMVLPGETVPVDGELLSGSATLDLSDINGEPVPREVFAGARVMSGAVN
GSTALTMRATQVAADSQYQRILELVASAQESRPAVVKTADRLAVPFTVLSLVIAGVAWAVSGVPTRFAQVLVLATPCPLL
IAAPVAYIAGTGRLAAAGVLIKAQDVLENLGRVTQVFFDKTGTLTVKQPQVVRVEMLPGAATQFDGDHVLMMAGVVESYS
VHILSKGIAKAGTEAMARLRRQSENDGRPCPESDAVWFGVGREHPVVKGINEEAGKGVSGEVNGHVVRVGRLSFAAAGKD
GFLTAGNADPTGPRHDPRPGTEAAGGTEEDVRTRFGLLQPDEMASYVSIDGRLIARIVLRDVPRANAGTALAKLHALGVA
RLAMLTGDKRASADIIANEVGIDEVHAELFPEDKVAAVKSAAEDGNAVTMMVGDGVNDAPVLAVADIGVAMTDGTSTAAS
ESAQVVIMTDDIAAVPRAIAIARRTKRVMLQAVIVGLALAVIGMIAAAFDLIPVVVGAFLQEAIDVVSILWGLTALIDRD

Sequences:

>Translated_720_residues
MSALIRFFTKILDICRLVPMLPVVVIAAIPLALLGDWHPWGHAADIAMLGDPGFGQWLIIALVLIIVADTVRGMIDDLRH
GQVGVDLLAVVAILSTVAVHEYWASWAVMLMVTSGEAIEEYAQAKAEHSLTALMEAAPRTAHVVSLPGVGRDSAGDAGDA
SEGFRRVGQFATASAAHRFDTVPVEQVRLGDVLMVLPGETVPVDGELLSGSATLDLSDINGEPVPREVFAGARVMSGAVN
GSTALTMRATQVAADSQYQRILELVASAQESRPAVVKTADRLAVPFTVLSLVIAGVAWAVSGVPTRFAQVLVLATPCPLL
IAAPVAYIAGTGRLAAAGVLIKAQDVLENLGRVTQVFFDKTGTLTVKQPQVVRVEMLPGAATQFDGDHVLMMAGVVESYS
VHILSKGIAKAGTEAMARLRRQSENDGRPCPESDAVWFGVGREHPVVKGINEEAGKGVSGEVNGHVVRVGRLSFAAAGKD
GFLTAGNADPTGPRHDPRPGTEAAGGTEEDVRTRFGLLQPDEMASYVSIDGRLIARIVLRDVPRANAGTALAKLHALGVA
RLAMLTGDKRASADIIANEVGIDEVHAELFPEDKVAAVKSAAEDGNAVTMMVGDGVNDAPVLAVADIGVAMTDGTSTAAS
ESAQVVIMTDDIAAVPRAIAIARRTKRVMLQAVIVGLALAVIGMIAAAFDLIPVVVGAFLQEAIDVVSILWGLTALIDRD
>Mature_719_residues
SALIRFFTKILDICRLVPMLPVVVIAAIPLALLGDWHPWGHAADIAMLGDPGFGQWLIIALVLIIVADTVRGMIDDLRHG
QVGVDLLAVVAILSTVAVHEYWASWAVMLMVTSGEAIEEYAQAKAEHSLTALMEAAPRTAHVVSLPGVGRDSAGDAGDAS
EGFRRVGQFATASAAHRFDTVPVEQVRLGDVLMVLPGETVPVDGELLSGSATLDLSDINGEPVPREVFAGARVMSGAVNG
STALTMRATQVAADSQYQRILELVASAQESRPAVVKTADRLAVPFTVLSLVIAGVAWAVSGVPTRFAQVLVLATPCPLLI
AAPVAYIAGTGRLAAAGVLIKAQDVLENLGRVTQVFFDKTGTLTVKQPQVVRVEMLPGAATQFDGDHVLMMAGVVESYSV
HILSKGIAKAGTEAMARLRRQSENDGRPCPESDAVWFGVGREHPVVKGINEEAGKGVSGEVNGHVVRVGRLSFAAAGKDG
FLTAGNADPTGPRHDPRPGTEAAGGTEEDVRTRFGLLQPDEMASYVSIDGRLIARIVLRDVPRANAGTALAKLHALGVAR
LAMLTGDKRASADIIANEVGIDEVHAELFPEDKVAAVKSAAEDGNAVTMMVGDGVNDAPVLAVADIGVAMTDGTSTAASE
SAQVVIMTDDIAAVPRAIAIARRTKRVMLQAVIVGLALAVIGMIAAAFDLIPVVVGAFLQEAIDVVSILWGLTALIDRD

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=673, Percent_Identity=31.3521545319465, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI55743073, Length=525, Percent_Identity=33.3333333333333, Blast_Score=199, Evalue=1e-50,
Organism=Homo sapiens, GI115529486, Length=267, Percent_Identity=33.7078651685393, Blast_Score=127, Evalue=5e-29,
Organism=Homo sapiens, GI28373107, Length=226, Percent_Identity=26.9911504424779, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI28373105, Length=226, Percent_Identity=26.9911504424779, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI28373115, Length=226, Percent_Identity=27.4336283185841, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI28373111, Length=226, Percent_Identity=27.4336283185841, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI28373109, Length=226, Percent_Identity=27.4336283185841, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI28373103, Length=226, Percent_Identity=27.4336283185841, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI28373113, Length=226, Percent_Identity=27.4336283185841, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1786691, Length=713, Percent_Identity=30.5750350631136, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1789879, Length=686, Percent_Identity=28.4256559766764, Blast_Score=186, Evalue=6e-48,
Organism=Escherichia coli, GI1786914, Length=115, Percent_Identity=40.8695652173913, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17556548, Length=697, Percent_Identity=27.9770444763271, Blast_Score=182, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6320475, Length=640, Percent_Identity=26.09375, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319772, Length=513, Percent_Identity=24.7563352826511, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321271, Length=202, Percent_Identity=28.7128712871287, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI221329854, Length=446, Percent_Identity=26.457399103139, Blast_Score=110, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24762455, Length=231, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24762453, Length=231, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24762447, Length=231, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24762457, Length=231, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24762449, Length=231, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24762445, Length=231, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24762451, Length=231, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17136664, Length=231, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 75249; Mature: 75118

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALIRFFTKILDICRLVPMLPVVVIAAIPLALLGDWHPWGHAADIAMLGDPGFGQWLII
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHH
ALVLIIVADTVRGMIDDLRHGQVGVDLLAVVAILSTVAVHEYWASWAVMLMVTSGEAIEE
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHH
YAQAKAEHSLTALMEAAPRTAHVVSLPGVGRDSAGDAGDASEGFRRVGQFATASAAHRFD
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
TVPVEQVRLGDVLMVLPGETVPVDGELLSGSATLDLSDINGEPVPREVFAGARVMSGAVN
CCCHHHEECCCEEEEECCCCCCCCCCEECCCEEEEEECCCCCCCCHHHHHCHHHHHCCCC
GSTALTMRATQVAADSQYQRILELVASAQESRPAVVKTADRLAVPFTVLSLVIAGVAWAV
CCEEEEEEHHHHHCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHHH
SGVPTRFAQVLVLATPCPLLIAAPVAYIAGTGRLAAAGVLIKAQDVLENLGRVTQVFFDK
CCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHEEEHHHHHHHHHHHHHHHHCC
TGTLTVKQPQVVRVEMLPGAATQFDGDHVLMMAGVVESYSVHILSKGIAKAGTEAMARLR
CCEEEECCCCEEEEEECCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHH
RQSENDGRPCPESDAVWFGVGREHPVVKGINEEAGKGVSGEVNGHVVRVGRLSFAAAGKD
HCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHCCCCCCCCCCEEEEEECEEEEECCCC
GFLTAGNADPTGPRHDPRPGTEAAGGTEEDVRTRFGLLQPDEMASYVSIDGRLIARIVLR
CEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHH
DVPRANAGTALAKLHALGVARLAMLTGDKRASADIIANEVGIDEVHAELFPEDKVAAVKS
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHH
AAEDGNAVTMMVGDGVNDAPVLAVADIGVAMTDGTSTAASESAQVVIMTDDIAAVPRAIA
HCCCCCEEEEEECCCCCCCCEEEEEECCEEEECCCCCCCCCCCEEEEEECCHHHHHHHHH
IARRTKRVMLQAVIVGLALAVIGMIAAAFDLIPVVVGAFLQEAIDVVSILWGLTALIDRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SALIRFFTKILDICRLVPMLPVVVIAAIPLALLGDWHPWGHAADIAMLGDPGFGQWLII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHH
ALVLIIVADTVRGMIDDLRHGQVGVDLLAVVAILSTVAVHEYWASWAVMLMVTSGEAIEE
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHH
YAQAKAEHSLTALMEAAPRTAHVVSLPGVGRDSAGDAGDASEGFRRVGQFATASAAHRFD
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
TVPVEQVRLGDVLMVLPGETVPVDGELLSGSATLDLSDINGEPVPREVFAGARVMSGAVN
CCCHHHEECCCEEEEECCCCCCCCCCEECCCEEEEEECCCCCCCCHHHHHCHHHHHCCCC
GSTALTMRATQVAADSQYQRILELVASAQESRPAVVKTADRLAVPFTVLSLVIAGVAWAV
CCEEEEEEHHHHHCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHHH
SGVPTRFAQVLVLATPCPLLIAAPVAYIAGTGRLAAAGVLIKAQDVLENLGRVTQVFFDK
CCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHEEEHHHHHHHHHHHHHHHHCC
TGTLTVKQPQVVRVEMLPGAATQFDGDHVLMMAGVVESYSVHILSKGIAKAGTEAMARLR
CCEEEECCCCEEEEEECCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHH
RQSENDGRPCPESDAVWFGVGREHPVVKGINEEAGKGVSGEVNGHVVRVGRLSFAAAGKD
HCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHCCCCCCCCCCEEEEEECEEEEECCCC
GFLTAGNADPTGPRHDPRPGTEAAGGTEEDVRTRFGLLQPDEMASYVSIDGRLIARIVLR
CEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHH
DVPRANAGTALAKLHALGVARLAMLTGDKRASADIIANEVGIDEVHAELFPEDKVAAVKS
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHH
AAEDGNAVTMMVGDGVNDAPVLAVADIGVAMTDGTSTAASESAQVVIMTDDIAAVPRAIA
HCCCCCEEEEEECCCCCCCCEEEEEECCEEEECCCCCCCCCCCEEEEEECCHHHHHHHHH
IARRTKRVMLQAVIVGLALAVIGMIAAAFDLIPVVVGAFLQEAIDVVSILWGLTALIDRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]