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The map label for this gene is kdtA [H]

Identifier: 213159052

GI number: 213159052

Start: 3877389

End: 3878681

Strand: Reverse

Name: kdtA [H]

Synonym: AB57_3761

Alternate gene names: 213159052

Gene position: 3878681-3877389 (Counterclockwise)

Preceding gene: 213159053

Following gene: 213159050

Centisome position: 95.76

GC content: 41.61

Gene sequence:

>1293_bases
TTGGCGACCCCATTTTGGTACAACACCGCACTTCATTTATTAAAACCGTTTTATCGTTGGCGGATAAAAAGACGTGCAGA
AAGTCTAGAATTATATCAGCAGGAATGTCTGGAAAGATTTGGGCCGTTTGAAGCACCGAAGAATGTAAAAGCGATCTGGT
TTCATGCTGTTTCAGTCGGGGAAACCAATGCTGCACAGCCTTTAATTGAATATTACCTAAAACTTGGGCAGCCAGTCTTA
GTGACCAATACCACGAAAACAGGTCAGGCTCGTGCCAAGTCACTTTTTCTAAAAGAACCTTATTTAGATTTATTTCAAGC
CGTTTATTTGCCTGTAGACCAGAAGCCTCTTTTAAAAAAATTTTTTGAGTTATATCAGCCAAAGCTTTTAGCACTGGTTG
AAACTGAACTTTGGCCAAATTTAATCGATCAAGCCAAGTTACAGCATGTACCTTGTTTGCTGCTTAATGCTCGGTTGTCA
GAAAAATCTGCAAAAGGATATGGCAAAGTCTCGGGTTTAACCGCAGGTATGTTAAAACAGCTGGACTGGGTGTTAGCGCA
AGATAGTGCAACTCGTCAGCGTTATGTTGAGCTTGGTTTAGACGAACACAAAAGTCAGGTCGTTGGTAATATTAAATTTG
ATATTCATGCGCCAGAGGCTTTTATTAAACAAGCAGCGCAATTGCGTCAGCAGTGGTATCTGGAAAATCGGCAGGTTGTG
ACAATTGCCAGTACACATGCACCCGAAGAACAACAGATTTTGGAAGCACTCGCACCTTATTTAAATTCAGATCGTGAGTT
GGTGTGTATTGTGGTGCCTCGTCATCCTGAGCGTTTCGATGAAGTATTCGAAATTTGCCAAAATTTAAATTTAATTACGC
ATCGTAGAAGTATGGGCCAAAGTATTCATGCCAGCACGCAAGTTTATCTCGCTGACAGTATGGGTGAGCTCTGGTTATGG
TATGCCTTAAGTCAGGTGTGTTTTGTAGGCGGTTCTTTAAATGAGCCGGGTGGGGGGCATAATATTTTAGAACCTATGGT
TTTAAATGTACCTACTGTAGTTGGACCGCGTTATTTTAACTTTCAAACGATTGTCGATGAGTTCATTGATGAAAATGCTG
TGCTTATTGCTCAAGATGCACAGCAGGTCGTTGATATCTGGTTAGCATGTCTGGCAGAACCTGAGGCGACTGAACAGTTA
GTGGTACAGGCGCATAAAGTGTTGCAACGTAATCAAGGTTCCTTACAAAAACATATCGGGGTGATTAATCGCTATCTGGC
CGAAAAATCATGA

Upstream 100 bases:

>100_bases
CTTGTATATGGTAGAGTTTAGGTATCGAAACTCTGCCATTTTTTTTATCTATGTTATATTTTCCGCAGTTTTTGAATTTT
GACTATTTGAGGCAAACCGC

Downstream 100 bases:

>100_bases
ATATTGTTTTACTAGAGTCTGAAGATGTTCAATCGGATACATGGTCTATCCATTCAAAACGTCAATTACAGCATTTGCGT
GAACATCTTGAGATTACAGT

Product: 3-deoxy-D-manno-2-octulosonate transferase

Products: NA

Alternate protein names: KDO transferase [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MATPFWYNTALHLLKPFYRWRIKRRAESLELYQQECLERFGPFEAPKNVKAIWFHAVSVGETNAAQPLIEYYLKLGQPVL
VTNTTKTGQARAKSLFLKEPYLDLFQAVYLPVDQKPLLKKFFELYQPKLLALVETELWPNLIDQAKLQHVPCLLLNARLS
EKSAKGYGKVSGLTAGMLKQLDWVLAQDSATRQRYVELGLDEHKSQVVGNIKFDIHAPEAFIKQAAQLRQQWYLENRQVV
TIASTHAPEEQQILEALAPYLNSDRELVCIVVPRHPERFDEVFEICQNLNLITHRRSMGQSIHASTQVYLADSMGELWLW
YALSQVCFVGGSLNEPGGGHNILEPMVLNVPTVVGPRYFNFQTIVDEFIDENAVLIAQDAQQVVDIWLACLAEPEATEQL
VVQAHKVLQRNQGSLQKHIGVINRYLAEKS

Sequences:

>Translated_430_residues
MATPFWYNTALHLLKPFYRWRIKRRAESLELYQQECLERFGPFEAPKNVKAIWFHAVSVGETNAAQPLIEYYLKLGQPVL
VTNTTKTGQARAKSLFLKEPYLDLFQAVYLPVDQKPLLKKFFELYQPKLLALVETELWPNLIDQAKLQHVPCLLLNARLS
EKSAKGYGKVSGLTAGMLKQLDWVLAQDSATRQRYVELGLDEHKSQVVGNIKFDIHAPEAFIKQAAQLRQQWYLENRQVV
TIASTHAPEEQQILEALAPYLNSDRELVCIVVPRHPERFDEVFEICQNLNLITHRRSMGQSIHASTQVYLADSMGELWLW
YALSQVCFVGGSLNEPGGGHNILEPMVLNVPTVVGPRYFNFQTIVDEFIDENAVLIAQDAQQVVDIWLACLAEPEATEQL
VVQAHKVLQRNQGSLQKHIGVINRYLAEKS
>Mature_429_residues
ATPFWYNTALHLLKPFYRWRIKRRAESLELYQQECLERFGPFEAPKNVKAIWFHAVSVGETNAAQPLIEYYLKLGQPVLV
TNTTKTGQARAKSLFLKEPYLDLFQAVYLPVDQKPLLKKFFELYQPKLLALVETELWPNLIDQAKLQHVPCLLLNARLSE
KSAKGYGKVSGLTAGMLKQLDWVLAQDSATRQRYVELGLDEHKSQVVGNIKFDIHAPEAFIKQAAQLRQQWYLENRQVVT
IASTHAPEEQQILEALAPYLNSDRELVCIVVPRHPERFDEVFEICQNLNLITHRRSMGQSIHASTQVYLADSMGELWLWY
ALSQVCFVGGSLNEPGGGHNILEPMVLNVPTVVGPRYFNFQTIVDEFIDENAVLIAQDAQQVVDIWLACLAEPEATEQLV
VQAHKVLQRNQGSLQKHIGVINRYLAEKS

Specific function: Essential step in lipopolysaccharides biosynthesis. Acts at transfer of 3-deoxy-D-mono octulonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1,4'-bisphosphate precursor of lipid A (lipid IVA). Transfers two molecules of KDO to lipid IVA [H]

COG id: COG1519

COG function: function code M; 3-deoxy-D-manno-octulosonic-acid transferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 1 family [H]

Homologues:

Organism=Escherichia coli, GI1790064, Length=428, Percent_Identity=35.5140186915888, Blast_Score=246, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001296
- InterPro:   IPR007507 [H]

Pfam domain/function: PF00534 Glycos_transf_1; PF04413 Glycos_transf_N [H]

EC number: 2.-.-.-

Molecular weight: Translated: 49060; Mature: 48929

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPFWYNTALHLLKPFYRWRIKRRAESLELYQQECLERFGPFEAPKNVKAIWFHAVSVG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECC
ETNAAQPLIEYYLKLGQPVLVTNTTKTGQARAKSLFLKEPYLDLFQAVYLPVDQKPLLKK
CCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHH
FFELYQPKLLALVETELWPNLIDQAKLQHVPCLLLNARLSEKSAKGYGKVSGLTAGMLKQ
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LDWVLAQDSATRQRYVELGLDEHKSQVVGNIKFDIHAPEAFIKQAAQLRQQWYLENRQVV
HHHHHHCCCHHHHHHHHHCCHHHHHHHEECEEEEEECCHHHHHHHHHHHHHHHHCCCEEE
TIASTHAPEEQQILEALAPYLNSDRELVCIVVPRHPERFDEVFEICQNLNLITHRRSMGQ
EEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHCC
SIHASTQVYLADSMGELWLWYALSQVCFVGGSLNEPGGGHNILEPMVLNVPTVVGPRYFN
HHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCC
FQTIVDEFIDENAVLIAQDAQQVVDIWLACLAEPEATEQLVVQAHKVLQRNQGSLQKHIG
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
VINRYLAEKS
HHHHHHHCCC
>Mature Secondary Structure 
ATPFWYNTALHLLKPFYRWRIKRRAESLELYQQECLERFGPFEAPKNVKAIWFHAVSVG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECC
ETNAAQPLIEYYLKLGQPVLVTNTTKTGQARAKSLFLKEPYLDLFQAVYLPVDQKPLLKK
CCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHH
FFELYQPKLLALVETELWPNLIDQAKLQHVPCLLLNARLSEKSAKGYGKVSGLTAGMLKQ
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LDWVLAQDSATRQRYVELGLDEHKSQVVGNIKFDIHAPEAFIKQAAQLRQQWYLENRQVV
HHHHHHCCCHHHHHHHHHCCHHHHHHHEECEEEEEECCHHHHHHHHHHHHHHHHCCCEEE
TIASTHAPEEQQILEALAPYLNSDRELVCIVVPRHPERFDEVFEICQNLNLITHRRSMGQ
EEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHCC
SIHASTQVYLADSMGELWLWYALSQVCFVGGSLNEPGGGHNILEPMVLNVPTVVGPRYFN
HHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCC
FQTIVDEFIDENAVLIAQDAQQVVDIWLACLAEPEATEQLVVQAHKVLQRNQGSLQKHIG
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
VINRYLAEKS
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]