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The map label for this gene is acsA [H]

Identifier: 213159048

GI number: 213159048

Start: 3872793

End: 3874742

Strand: Reverse

Name: acsA [H]

Synonym: AB57_3756

Alternate gene names: 213159048

Gene position: 3874742-3872793 (Counterclockwise)

Preceding gene: 213159050

Following gene: 213159046

Centisome position: 95.66

GC content: 44.92

Gene sequence:

>1950_bases
ATGAATGAGATCTATCCAGTACCAGAGGAATTTAAAAAAACAGCTCGTACTGTTGAAGCAGACTACTTTAAACGTTATCA
ACACTCTATCGAGAACCCAGATGAATTCTGGGCAGAGCAAGCTAAAATTGTCGATTGGATAAAGCCATTTACCCAAGTTA
AAAATACCAGTTTTGACAAAGACAATTTCAAGATTGAATGGTTTGCTGATGGTGAGTTGAACGTATCAGCAAACTGCTTG
GACAGGCATCTTAAAGAACACCCTCACAAACCTGCAATTATTTGGGAAGGTGACCATCCTTCTCGTCATAAAATCGTTTC
TTATAAAGAATTACACGACGAAGTCTGCCGTTTCGCCAACGTTTTAAAGAAATATGGCATTGGTAAAGGTGACCGCGTTG
TGCTGTATATGCCAATGGTGACTGAGGCTGCAATTGCCATGTTAGCCTGTGCCCGTATTGGTGCGGTGCACTGCGTGGTA
TTTGGTGGTTTCTCACCAGACTCGTTGGCGAGTCGTATTGAAGATAGCCAAGCTAAACTTGTGATTACGGCTGACTCAAG
CCTACGTGCCGGTAAGTTGTTACCACTTAAAGAAAATGTTGATTTGGCTCTAGCATTGCCGGGCACAGAGTGCGTTGAAA
ACGTGATTGTGGTTTACCGTAATGCAAACCCAATCGAGATGAAGCCGGGTCGTGATTTGTGGTATCACCTTATTATTATG
GAGGTGGATGCAAACTGTCCTCCAGAACCAATGAAGGCCGAAGACCCTTTATTTATTCTTTATACCTCTGGCTCGACAGG
TAAACCTAAAGGAGTGTTGCATACTACAGGTGGTTATCTGGTGTATGTGGCGAGTACCTTTAAAGAAGTTTTTGATTTAA
AACAAGATGATGTGTACTGGTGTACCGCTGATGTCGGCTGGATTACAGGCCATAGTTATCTAATCTATGGACCATTGGCA
AATGGTACGACGACCTTAATGTTTGAAGGTGTGCCTCAGTATCCAACATGGGCACGTCTTGGTCATGTGGTCGATAAACA
TAAAGTCTCTATTTTATATACAGCGCCAACCGCGATTCGAGCCATGATGCGAGAAGGTGATTCGTATGTACGTGAAAGTA
ACCGTAGTAGTTTGCGTTTGTTAGGTTCAGTGGGTGAACCTATTAACCCTGAGGCTTGGAACTGGTACTACAATGTTGTC
GGCGAAGGCCGCTGCCCGATTGTTGATACATGGTGGCAAACCGAAACAGGTGGTATTTTGATTGCGCCATTACCGGGGGC
AACAGCTTTAAAACCAGGTTCGGCAACGCGACCTTTATTTGGTATTCAACCAGCTATTGTAGATGGTGAAGGCAATGAAC
TAGAAGGCGCTGCCGAAGGTAATCTTGTGATTAAAGATTCATGGCCGGGCCAGATGCGTACCATTTGGGGTGACCCAGAT
CGCTTTATTGAAGCTTACTTCTCGACCTTTAAAAATACTTATTTTACAGGTGATGGCGCCCGCCGTGATGAAGATGGCTA
TTACTGGATCACGGGTCGTGTTGACGATGTCTTAAACGTTTCAGGCCACCGTCTAGGTACGGCTGAAATTGAAAGTGCTC
TTGTATCGCATGAATCGGTGGCAGAGGCTGCTGTTGTAGGTATGCCGCATGATATTAAAGGGCAGGGTATTTGTACTTTT
GTGACTTTGCAGGCGGGTGTTCCGGAGTCGGAAGAACTGCGAAAAGAGTTAATTAGCTGGGTACGTAAAGTACTTGGACC
AGTGGCTTCACCAGATGCACTGCACTGGGCGCCGGCATTACCTAAAACCCGTTCGGGTAAAATCATGCGCCGTATTTTAA
GAAAAATTGCAGCGAATGAACTGGATAGTTTGGGCGATACCTCAACCCTAGCTGAACCGGCAGTGGTGGATCAACTGATT
GCGACAGTTTATCCTGATAGACAAAAATAA

Upstream 100 bases:

>100_bases
CTTTGAAAGAGTCATCATACTGAAAAGGCAAACAAATAAGATCCAGTAAAATAATAGCCACAGTCTCGAGATGGGATGCA
CAAGATCAAGGAAGTTGCGT

Downstream 100 bases:

>100_bases
CGTTTTAATAAAAAAGCCCCGTTAGGGGCTTTTTTATTAAACCTGTTTAAAATTTTGCTAGAAATTCAGCAGTATTTTGT
ACGCTTGCAAACATGCCAAG

Product: acetate--CoA ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 649; Mature: 649

Protein sequence:

>649_residues
MNEIYPVPEEFKKTARTVEADYFKRYQHSIENPDEFWAEQAKIVDWIKPFTQVKNTSFDKDNFKIEWFADGELNVSANCL
DRHLKEHPHKPAIIWEGDHPSRHKIVSYKELHDEVCRFANVLKKYGIGKGDRVVLYMPMVTEAAIAMLACARIGAVHCVV
FGGFSPDSLASRIEDSQAKLVITADSSLRAGKLLPLKENVDLALALPGTECVENVIVVYRNANPIEMKPGRDLWYHLIIM
EVDANCPPEPMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYVASTFKEVFDLKQDDVYWCTADVGWITGHSYLIYGPLA
NGTTTLMFEGVPQYPTWARLGHVVDKHKVSILYTAPTAIRAMMREGDSYVRESNRSSLRLLGSVGEPINPEAWNWYYNVV
GEGRCPIVDTWWQTETGGILIAPLPGATALKPGSATRPLFGIQPAIVDGEGNELEGAAEGNLVIKDSWPGQMRTIWGDPD
RFIEAYFSTFKNTYFTGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVSHESVAEAAVVGMPHDIKGQGICTF
VTLQAGVPESEELRKELISWVRKVLGPVASPDALHWAPALPKTRSGKIMRRILRKIAANELDSLGDTSTLAEPAVVDQLI
ATVYPDRQK

Sequences:

>Translated_649_residues
MNEIYPVPEEFKKTARTVEADYFKRYQHSIENPDEFWAEQAKIVDWIKPFTQVKNTSFDKDNFKIEWFADGELNVSANCL
DRHLKEHPHKPAIIWEGDHPSRHKIVSYKELHDEVCRFANVLKKYGIGKGDRVVLYMPMVTEAAIAMLACARIGAVHCVV
FGGFSPDSLASRIEDSQAKLVITADSSLRAGKLLPLKENVDLALALPGTECVENVIVVYRNANPIEMKPGRDLWYHLIIM
EVDANCPPEPMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYVASTFKEVFDLKQDDVYWCTADVGWITGHSYLIYGPLA
NGTTTLMFEGVPQYPTWARLGHVVDKHKVSILYTAPTAIRAMMREGDSYVRESNRSSLRLLGSVGEPINPEAWNWYYNVV
GEGRCPIVDTWWQTETGGILIAPLPGATALKPGSATRPLFGIQPAIVDGEGNELEGAAEGNLVIKDSWPGQMRTIWGDPD
RFIEAYFSTFKNTYFTGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVSHESVAEAAVVGMPHDIKGQGICTF
VTLQAGVPESEELRKELISWVRKVLGPVASPDALHWAPALPKTRSGKIMRRILRKIAANELDSLGDTSTLAEPAVVDQLI
ATVYPDRQK
>Mature_649_residues
MNEIYPVPEEFKKTARTVEADYFKRYQHSIENPDEFWAEQAKIVDWIKPFTQVKNTSFDKDNFKIEWFADGELNVSANCL
DRHLKEHPHKPAIIWEGDHPSRHKIVSYKELHDEVCRFANVLKKYGIGKGDRVVLYMPMVTEAAIAMLACARIGAVHCVV
FGGFSPDSLASRIEDSQAKLVITADSSLRAGKLLPLKENVDLALALPGTECVENVIVVYRNANPIEMKPGRDLWYHLIIM
EVDANCPPEPMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYVASTFKEVFDLKQDDVYWCTADVGWITGHSYLIYGPLA
NGTTTLMFEGVPQYPTWARLGHVVDKHKVSILYTAPTAIRAMMREGDSYVRESNRSSLRLLGSVGEPINPEAWNWYYNVV
GEGRCPIVDTWWQTETGGILIAPLPGATALKPGSATRPLFGIQPAIVDGEGNELEGAAEGNLVIKDSWPGQMRTIWGDPD
RFIEAYFSTFKNTYFTGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVSHESVAEAAVVGMPHDIKGQGICTF
VTLQAGVPESEELRKELISWVRKVLGPVASPDALHWAPALPKTRSGKIMRRILRKIAANELDSLGDTSTLAEPAVVDQLI
ATVYPDRQK

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=665, Percent_Identity=52.4812030075188, Blast_Score=660, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=678, Percent_Identity=51.622418879056, Blast_Score=657, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=627, Percent_Identity=48.6443381180223, Blast_Score=610, Evalue=1e-174,
Organism=Homo sapiens, GI13375727, Length=631, Percent_Identity=36.2916006339144, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI38505220, Length=562, Percent_Identity=30.6049822064057, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI42544132, Length=572, Percent_Identity=29.3706293706294, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI115511026, Length=526, Percent_Identity=28.7072243346008, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI122937307, Length=561, Percent_Identity=26.7379679144385, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI31982927, Length=632, Percent_Identity=25.4746835443038, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI58082049, Length=535, Percent_Identity=26.1682242990654, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI157311624, Length=540, Percent_Identity=25.9259259259259, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI157311622, Length=540, Percent_Identity=25.9259259259259, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI187761345, Length=551, Percent_Identity=26.1343012704174, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI187761343, Length=551, Percent_Identity=26.1343012704174, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI42544134, Length=357, Percent_Identity=26.0504201680672, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI195947378, Length=407, Percent_Identity=25.3071253071253, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI156151445, Length=588, Percent_Identity=21.5986394557823, Blast_Score=90, Evalue=8e-18,
Organism=Escherichia coli, GI1790505, Length=619, Percent_Identity=67.5282714054927, Blast_Score=881, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=628, Percent_Identity=38.5350318471338, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI221142682, Length=542, Percent_Identity=24.169741697417, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788107, Length=587, Percent_Identity=23.3390119250426, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI145693145, Length=510, Percent_Identity=22.7450980392157, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786810, Length=542, Percent_Identity=22.6937269372694, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71983001, Length=636, Percent_Identity=50, Blast_Score=603, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI71982997, Length=636, Percent_Identity=50, Blast_Score=603, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI17569507, Length=648, Percent_Identity=22.2222222222222, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17558820, Length=510, Percent_Identity=23.3333333333333, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17557194, Length=563, Percent_Identity=22.202486678508, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560140, Length=377, Percent_Identity=21.7506631299735, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17538037, Length=142, Percent_Identity=32.3943661971831, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323182, Length=638, Percent_Identity=48.9028213166144, Blast_Score=613, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6319264, Length=640, Percent_Identity=48.4375, Blast_Score=589, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6319699, Length=374, Percent_Identity=23.7967914438503, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24667955, Length=641, Percent_Identity=53.3541341653666, Blast_Score=660, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=561, Percent_Identity=56.1497326203209, Blast_Score=619, Evalue=1e-177,
Organism=Drosophila melanogaster, GI24667959, Length=519, Percent_Identity=56.0693641618497, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI21355225, Length=616, Percent_Identity=36.038961038961, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI21355181, Length=519, Percent_Identity=24.0847784200385, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI18859661, Length=537, Percent_Identity=24.2085661080074, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24656500, Length=388, Percent_Identity=24.4845360824742, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24648260, Length=365, Percent_Identity=24.3835616438356, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581924, Length=250, Percent_Identity=26.8, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21358303, Length=491, Percent_Identity=21.9959266802444, Blast_Score=66, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72182; Mature: 72182

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIYPVPEEFKKTARTVEADYFKRYQHSIENPDEFWAEQAKIVDWIKPFTQVKNTSFDK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DNFKIEWFADGELNVSANCLDRHLKEHPHKPAIIWEGDHPSRHKIVSYKELHDEVCRFAN
CCEEEEEEECCCCEEEHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEHHHHHHHHHHHHH
VLKKYGIGKGDRVVLYMPMVTEAAIAMLACARIGAVHCVVFGGFSPDSLASRIEDSQAKL
HHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHCCCCCEE
VITADSSLRAGKLLPLKENVDLALALPGTECVENVIVVYRNANPIEMKPGRDLWYHLIIM
EEEECCCCCCCCEEEECCCCCEEEECCCHHHHCCEEEEEECCCCCEECCCCCEEEEEEEE
EVDANCPPEPMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYVASTFKEVFDLKQDDVYW
EECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEHHHHHHHHHCCCCCCEEE
CTADVGWITGHSYLIYGPLANGTTTLMFEGVPQYPTWARLGHVVDKHKVSILYTAPTAIR
EECCCCEEECCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEEEEECHHHHH
AMMREGDSYVRESNRSSLRLLGSVGEPINPEAWNWYYNVVGEGRCPIVDTWWQTETGGIL
HHHHCCHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCEEECCCCCCCCCEE
IAPLPGATALKPGSATRPLFGIQPAIVDGEGNELEGAAEGNLVIKDSWPGQMRTIWGDPD
EECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEECCCCCCEEEECCCHH
RFIEAYFSTFKNTYFTGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVSHESV
HHHHHHHHHHCCCEECCCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHH
AEAAVVGMPHDIKGQGICTFVTLQAGVPESEELRKELISWVRKVLGPVASPDALHWAPAL
HHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PKTRSGKIMRRILRKIAANELDSLGDTSTLAEPAVVDQLIATVYPDRQK
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNEIYPVPEEFKKTARTVEADYFKRYQHSIENPDEFWAEQAKIVDWIKPFTQVKNTSFDK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DNFKIEWFADGELNVSANCLDRHLKEHPHKPAIIWEGDHPSRHKIVSYKELHDEVCRFAN
CCEEEEEEECCCCEEEHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEHHHHHHHHHHHHH
VLKKYGIGKGDRVVLYMPMVTEAAIAMLACARIGAVHCVVFGGFSPDSLASRIEDSQAKL
HHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHCCCCCEE
VITADSSLRAGKLLPLKENVDLALALPGTECVENVIVVYRNANPIEMKPGRDLWYHLIIM
EEEECCCCCCCCEEEECCCCCEEEECCCHHHHCCEEEEEECCCCCEECCCCCEEEEEEEE
EVDANCPPEPMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYVASTFKEVFDLKQDDVYW
EECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEHHHHHHHHHCCCCCCEEE
CTADVGWITGHSYLIYGPLANGTTTLMFEGVPQYPTWARLGHVVDKHKVSILYTAPTAIR
EECCCCEEECCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEEEEECHHHHH
AMMREGDSYVRESNRSSLRLLGSVGEPINPEAWNWYYNVVGEGRCPIVDTWWQTETGGIL
HHHHCCHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCEEECCCCCCCCCEE
IAPLPGATALKPGSATRPLFGIQPAIVDGEGNELEGAAEGNLVIKDSWPGQMRTIWGDPD
EECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEECCCCCCEEEECCCHH
RFIEAYFSTFKNTYFTGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVSHESV
HHHHHHHHHHCCCEECCCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHH
AEAAVVGMPHDIKGQGICTFVTLQAGVPESEELRKELISWVRKVLGPVASPDALHWAPAL
HHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PKTRSGKIMRRILRKIAANELDSLGDTSTLAEPAVVDQLIATVYPDRQK
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA