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The map label for this gene is thiED [H]

Identifier: 213159029

GI number: 213159029

Start: 3848817

End: 3849491

Strand: Direct

Name: thiED [H]

Synonym: AB57_3737

Alternate gene names: 213159029

Gene position: 3848817-3849491 (Clockwise)

Preceding gene: 213159025

Following gene: 213159034

Centisome position: 95.02

GC content: 40.59

Gene sequence:

>675_bases
ATGCTTTTTTCTCAAGAACTCTGGCAACGTAATTTAAATTTATATCAAAAAATTCTCGACCTACCTTTTAATCAGGAACT
TGCTAACGGTACTTTAGATAAAGAAGCTTTTTGTCATTATGTTATTCAAGATGCTCAATATTTAGTGGCCTATGGCCGTG
TGCTGGCTGTTGCAGCAGCTAAAGCTTTTGATGCTGACGATATTATGCAGTTCTCTGATGCAGCTAAAATTGCAATTGTG
GTCGAGCGCAGTTTGCATGACGACTTTATGAAAAACTTTGGTGTCACCAAAGAAGAATTTAAAAATACCCCATTGACCTT
GGCCGGCCATCATTACACTTCATTTTTGACAGCAACTGCTTGGTCTGAAAGCTACCCTGTTGTACTTGCTGCACTTTTAC
CTTGCTTCTGGATTTATGCCGAAGTCGGTAAAGACATTGTGAGTAAGTCTGTCCCGAACAATCCTTATCAGGCATGGATC
GATACCTACGCAGGTGAAGAATTCCATACCGCCGTTCGTAATGTGATTGCGACGGTAGATAAAGTTGCCGCACGTTGTGA
TGCAGATACTTTAGAGAAAATGCATGCAGCCTATACCATGGGTGCAAAACTTGAATGGTTATTTTGGGATAGTGCCTACC
ATCAAAGACAATGGTTAGGTTTAGATCAGATCTAA

Upstream 100 bases:

>100_bases
ATTAAATATTTTCTTGCGATATATCTATCATTATTATTTTTGTATTTTAAAATTGATTTAAAATCGGGTTTAGCTGTCTT
ATTTTAAATGGAATGTTTTT

Downstream 100 bases:

>100_bases
AATAAGATGAGTTCTGACCATTTAGTTCATTAAATGGTCAGTGTTTAATTTAACTTTGAAACAATTGCCAGCCGTAAATC
AAACCTGCCGCAGCCACAAC

Product: transcriptional regulator, TenA family

Products: NA

Alternate protein names: Thiamine-phosphate pyrophosphorylase; TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate synthase; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MLFSQELWQRNLNLYQKILDLPFNQELANGTLDKEAFCHYVIQDAQYLVAYGRVLAVAAAKAFDADDIMQFSDAAKIAIV
VERSLHDDFMKNFGVTKEEFKNTPLTLAGHHYTSFLTATAWSESYPVVLAALLPCFWIYAEVGKDIVSKSVPNNPYQAWI
DTYAGEEFHTAVRNVIATVDKVAARCDADTLEKMHAAYTMGAKLEWLFWDSAYHQRQWLGLDQI

Sequences:

>Translated_224_residues
MLFSQELWQRNLNLYQKILDLPFNQELANGTLDKEAFCHYVIQDAQYLVAYGRVLAVAAAKAFDADDIMQFSDAAKIAIV
VERSLHDDFMKNFGVTKEEFKNTPLTLAGHHYTSFLTATAWSESYPVVLAALLPCFWIYAEVGKDIVSKSVPNNPYQAWI
DTYAGEEFHTAVRNVIATVDKVAARCDADTLEKMHAAYTMGAKLEWLFWDSAYHQRQWLGLDQI
>Mature_224_residues
MLFSQELWQRNLNLYQKILDLPFNQELANGTLDKEAFCHYVIQDAQYLVAYGRVLAVAAAKAFDADDIMQFSDAAKIAIV
VERSLHDDFMKNFGVTKEEFKNTPLTLAGHHYTSFLTATAWSESYPVVLAALLPCFWIYAEVGKDIVSKSVPNNPYQAWI
DTYAGEEFHTAVRNVIATVDKVAARCDADTLEKMHAAYTMGAKLEWLFWDSAYHQRQWLGLDQI

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0819

COG function: function code K; Putative transcription activator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the thiaminase-2 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR016084
- InterPro:   IPR013749
- InterPro:   IPR004399
- InterPro:   IPR004305
- InterPro:   IPR022998
- InterPro:   IPR003733 [H]

Pfam domain/function: PF08543 Phos_pyr_kin; PF03070 TENA_THI-4; PF02581 TMP-TENI [H]

EC number: =2.5.1.3; =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 25486; Mature: 25486

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFSQELWQRNLNLYQKILDLPFNQELANGTLDKEAFCHYVIQDAQYLVAYGRVLAVAAA
CCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAFDADDIMQFSDAAKIAIVVERSLHDDFMKNFGVTKEEFKNTPLTLAGHHYTSFLTATA
HHCCHHHHHHHHCCCEEEEEEEHHHHHHHHHHCCCCHHHHCCCCEEEECCHHHHHHHHHH
WSESYPVVLAALLPCFWIYAEVGKDIVSKSVPNNPYQAWIDTYAGEEFHTAVRNVIATVD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
KVAARCDADTLEKMHAAYTMGAKLEWLFWDSAYHQRQWLGLDQI
HHHHHCCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHCCCCCC
>Mature Secondary Structure
MLFSQELWQRNLNLYQKILDLPFNQELANGTLDKEAFCHYVIQDAQYLVAYGRVLAVAAA
CCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAFDADDIMQFSDAAKIAIVVERSLHDDFMKNFGVTKEEFKNTPLTLAGHHYTSFLTATA
HHCCHHHHHHHHCCCEEEEEEEHHHHHHHHHHCCCCHHHHCCCCEEEECCHHHHHHHHHH
WSESYPVVLAALLPCFWIYAEVGKDIVSKSVPNNPYQAWIDTYAGEEFHTAVRNVIATVD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
KVAARCDADTLEKMHAAYTMGAKLEWLFWDSAYHQRQWLGLDQI
HHHHHCCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]