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The map label for this gene is hisA [H]

Identifier: 213158983

GI number: 213158983

Start: 3804923

End: 3805654

Strand: Direct

Name: hisA [H]

Synonym: AB57_3687

Alternate gene names: 213158983

Gene position: 3804923-3805654 (Clockwise)

Preceding gene: 213158982

Following gene: 213158985

Centisome position: 93.94

GC content: 43.99

Gene sequence:

>732_bases
ATGCTAATCATTCCAGCAATTGACCTGAAAGATGGTAAATGTGTGCGTTTAAAACAAGGGCGTATGGAAGACGATACCGT
TTTCTCTGACGATCCGGTTGCAACTGCCCAGCATTGGGTAAATGAAGGCGCACGACGTTTGCATTTGGTCGATTTGAATG
GTGCTTTCGCAGGTACGCCTATTCATAAACCTGTTGTTGAAGCAATTGCAAAAGCTCAGCCAGAATTACCAATTCAAATT
GGTGGCGGTATCCGCTCATTAGAAACCATTGAACACTATTTAGAAGCTGGCGTGACTTTTGTCATTATCGGTACTAAAGC
CGTTCAAGAGCCTGAATTTGTAGAAGAAGCTTGTAAACGTTTTGCAGGCCACATCATTGTTGGTATTGATGCCATGAATG
GTATGGTTGCAACTGACGGCTGGGCAAACGTTACTGATGTGAAAGCAACTGATTTAGCAAAACGCTTTGCAGATGCAGGC
GTGTCTAGCATTGTTTACACGGACATTGCGCGTGACGGCATGATGCAAGGTGTAAATGTTGAGCAGACTGTAAACTTGGC
TCAATACTCAGGCTTACCAGTCATTGCGTCAGGTGGTGTAACCAACCTTGATGACGTTCGTAACTTAAAAGGCCAACCAG
GTATTTTAGGCGCGATCACAGGCCGTGCAATTTATGAAGGTACTTTAAACCTTCGTGAAGCTCAGCTTTTGTTAGATGAA
AACCGTCTTTAA

Upstream 100 bases:

>100_bases
AGGTAAAGTTATAAAAGTCTTTTCTAAGGCTTAGCTATTGATCAATACTTTGCTAAGATGTGCACAATTTCATAAACATG
ATGAAGCAAGGAGCGAAAGC

Downstream 100 bases:

>100_bases
TTTTTAAGATGTAAAAAAGAGCTGCTTTAGGCTCTTTTTTATTGCTGATATGAAAATATATTTCGAATCAATAAACCACA
TTACGAATAAATTTAAGTAC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MLIIPAIDLKDGKCVRLKQGRMEDDTVFSDDPVATAQHWVNEGARRLHLVDLNGAFAGTPIHKPVVEAIAKAQPELPIQI
GGGIRSLETIEHYLEAGVTFVIIGTKAVQEPEFVEEACKRFAGHIIVGIDAMNGMVATDGWANVTDVKATDLAKRFADAG
VSSIVYTDIARDGMMQGVNVEQTVNLAQYSGLPVIASGGVTNLDDVRNLKGQPGILGAITGRAIYEGTLNLREAQLLLDE
NRL

Sequences:

>Translated_243_residues
MLIIPAIDLKDGKCVRLKQGRMEDDTVFSDDPVATAQHWVNEGARRLHLVDLNGAFAGTPIHKPVVEAIAKAQPELPIQI
GGGIRSLETIEHYLEAGVTFVIIGTKAVQEPEFVEEACKRFAGHIIVGIDAMNGMVATDGWANVTDVKATDLAKRFADAG
VSSIVYTDIARDGMMQGVNVEQTVNLAQYSGLPVIASGGVTNLDDVRNLKGQPGILGAITGRAIYEGTLNLREAQLLLDE
NRL
>Mature_243_residues
MLIIPAIDLKDGKCVRLKQGRMEDDTVFSDDPVATAQHWVNEGARRLHLVDLNGAFAGTPIHKPVVEAIAKAQPELPIQI
GGGIRSLETIEHYLEAGVTFVIIGTKAVQEPEFVEEACKRFAGHIIVGIDAMNGMVATDGWANVTDVKATDLAKRFADAG
VSSIVYTDIARDGMMQGVNVEQTVNLAQYSGLPVIASGGVTNLDDVRNLKGQPGILGAITGRAIYEGTLNLREAQLLLDE
NRL

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=240, Percent_Identity=36.25, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788336, Length=247, Percent_Identity=25.5060728744939, Blast_Score=81, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26083; Mature: 26083

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIIPAIDLKDGKCVRLKQGRMEDDTVFSDDPVATAQHWVNEGARRLHLVDLNGAFAGTP
CEEEEEEECCCCCEEEEECCCCCCCCEECCCCHHHHHHHHCCCCEEEEEEEECCCCCCCC
IHKPVVEAIAKAQPELPIQIGGGIRSLETIEHYLEAGVTFVIIGTKAVQEPEFVEEACKR
CHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
FAGHIIVGIDAMNGMVATDGWANVTDVKATDLAKRFADAGVSSIVYTDIARDGMMQGVNV
HHCEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCH
EQTVNLAQYSGLPVIASGGVTNLDDVRNLKGQPGILGAITGRAIYEGTLNLREAQLLLDE
HHHHHHHHHCCCCEEECCCCCCHHHHHHCCCCCCEEEEECCCEEEECCCCHHHHHHHHCC
NRL
CCC
>Mature Secondary Structure
MLIIPAIDLKDGKCVRLKQGRMEDDTVFSDDPVATAQHWVNEGARRLHLVDLNGAFAGTP
CEEEEEEECCCCCEEEEECCCCCCCCEECCCCHHHHHHHHCCCCEEEEEEEECCCCCCCC
IHKPVVEAIAKAQPELPIQIGGGIRSLETIEHYLEAGVTFVIIGTKAVQEPEFVEEACKR
CHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
FAGHIIVGIDAMNGMVATDGWANVTDVKATDLAKRFADAGVSSIVYTDIARDGMMQGVNV
HHCEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCH
EQTVNLAQYSGLPVIASGGVTNLDDVRNLKGQPGILGAITGRAIYEGTLNLREAQLLLDE
HHHHHHHHHCCCCEEECCCCCCHHHHHHCCCCCCEEEEECCCEEEECCCCHHHHHHHHCC
NRL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA