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The map label for this gene is hisB [H]

Identifier: 213158980

GI number: 213158980

Start: 3802189

End: 3802782

Strand: Direct

Name: hisB [H]

Synonym: AB57_3682

Alternate gene names: 213158980

Gene position: 3802189-3802782 (Clockwise)

Preceding gene: 213158978

Following gene: 213158981

Centisome position: 93.87

GC content: 40.4

Gene sequence:

>594_bases
ATGACGCAACGTATCAGTGAAGTGGTTAGAAATACCAATGAAACCAAAATTCGAGTTCGTTTAAATCTCGATGGTACTGG
TCAAGGCACACTAAACACCGGAGTTCCATTTTTAGACCATATGATTGATCAAATCAAGCGACATGGCTTATTTGATATCG
ATATTCATTGTGATGGAGACTTAGAGATTGATGATCACCATACCGTAGAAGACTGCGGTATCACGCTTGGACAAGCTTTT
GCACAAGCTTTAGGTGATAAAAAAGGTTTACGTCGTTATGGGCATTTTTACGCACCATTAGACGAAGCTTTATCTCGTGT
GGTTGTAGATTTGTCTGGTCGTCCGGGTTTATTTATGGATATTCCATTTACTCGCGCGCGCATTGGTACCTTTGACGTAG
ATTTATTTTCCGAGTTTTTCCAAGGTTTCGTAAACCATGCGCTTATGACCTTACACATCGATAACTTGAAAGGTAAAAAT
AGCCACCATCAAATCGAGAGTGTATTTAAAGCACTAGCTCGTGCTTTACGTATGGCATGTGAAATTGATCCACGTGCTGA
AAACACGATTGCATCGACAAAAGGTAGCCTCTAA

Upstream 100 bases:

>100_bases
ATTAACCCTCCTGAGCAAACTATGATGCTGTCACGAATTCGTCACAGCGAAATTGTCGTTAACATCCAATCATTTTTGAC
GTTTTTTGAGGAACGTGTCC

Downstream 100 bases:

>100_bases
TGACACGTATCGCATTGCTTGATTATGGCATGGGTAATCTGCACTCAGCCGCTAAAGCACTTGAATATGTAGGTGCAACC
GTCGATGTGACAAATGATCC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MTQRISEVVRNTNETKIRVRLNLDGTGQGTLNTGVPFLDHMIDQIKRHGLFDIDIHCDGDLEIDDHHTVEDCGITLGQAF
AQALGDKKGLRRYGHFYAPLDEALSRVVVDLSGRPGLFMDIPFTRARIGTFDVDLFSEFFQGFVNHALMTLHIDNLKGKN
SHHQIESVFKALARALRMACEIDPRAENTIASTKGSL

Sequences:

>Translated_197_residues
MTQRISEVVRNTNETKIRVRLNLDGTGQGTLNTGVPFLDHMIDQIKRHGLFDIDIHCDGDLEIDDHHTVEDCGITLGQAF
AQALGDKKGLRRYGHFYAPLDEALSRVVVDLSGRPGLFMDIPFTRARIGTFDVDLFSEFFQGFVNHALMTLHIDNLKGKN
SHHQIESVFKALARALRMACEIDPRAENTIASTKGSL
>Mature_196_residues
TQRISEVVRNTNETKIRVRLNLDGTGQGTLNTGVPFLDHMIDQIKRHGLFDIDIHCDGDLEIDDHHTVEDCGITLGQAFA
QALGDKKGLRRYGHFYAPLDEALSRVVVDLSGRPGLFMDIPFTRARIGTFDVDLFSEFFQGFVNHALMTLHIDNLKGKNS
HHQIESVFKALARALRMACEIDPRAENTIASTKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=47.9381443298969, Blast_Score=176, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6324776, Length=221, Percent_Identity=43.4389140271493, Blast_Score=182, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 22031; Mature: 21900

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRISEVVRNTNETKIRVRLNLDGTGQGTLNTGVPFLDHMIDQIKRHGLFDIDIHCDGD
CCHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCC
LEIDDHHTVEDCGITLGQAFAQALGDKKGLRRYGHFYAPLDEALSRVVVDLSGRPGLFMD
CEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEE
IPFTRARIGTFDVDLFSEFFQGFVNHALMTLHIDNLKGKNSHHQIESVFKALARALRMAC
CCCHHHHCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
EIDPRAENTIASTKGSL
CCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
TQRISEVVRNTNETKIRVRLNLDGTGQGTLNTGVPFLDHMIDQIKRHGLFDIDIHCDGD
CHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCC
LEIDDHHTVEDCGITLGQAFAQALGDKKGLRRYGHFYAPLDEALSRVVVDLSGRPGLFMD
CEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEE
IPFTRARIGTFDVDLFSEFFQGFVNHALMTLHIDNLKGKNSHHQIESVFKALARALRMAC
CCCHHHHCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
EIDPRAENTIASTKGSL
CCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA