Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 213158906

GI number: 213158906

Start: 3713921

End: 3715153

Strand: Direct

Name: serA [H]

Synonym: AB57_3607

Alternate gene names: 213158906

Gene position: 3713921-3715153 (Clockwise)

Preceding gene: 213158903

Following gene: 213158907

Centisome position: 91.69

GC content: 42.09

Gene sequence:

>1233_bases
ATGAGCCAACATCTTTCACTACCTAAAGATAAAATCCGTTTCCTTTTGTTAGAAGGCGTTCACCAAAACGCAGTCGATAC
TTTAAACGCTGCGGGTTATACCAACATTGACTATCGCAAAACTGCTCTTGAAGGCGAAGCGCTTAAAGAAGCAATTAAAG
ATGCTCACTTTATTGGTATTCGTTCGCGTACCCAATTGACTGAAGAAGTTTTCGAAGCTGCAAATAAATTGATCGCAGTA
GGTTGTTTCTGTATCGGAACAAACCAAGTAGATCTTAAAGCAGCGATGGCACGTGGTATTCCTGTATTTAACGCACCATA
TTCAAATACGCGTTCGGTTGCAGAGCTCGTACTTGCTGAAACTATTCTTCTTCTTCGCCGTGTTCCTGAAAAGTCAGCGG
CTTGTCATCGTGGTGGTTGGGACAAATCTGCTGTGGGTTCTTTTGAAACTCGTGGCAAAACTTTAGGTATTGTGGGTTAC
GGTTCCATCGGTTCTCAACTTTCAGTTCTTGCTGAAAGTATGGGTATGCATGTCATTTATTATGATGCAGTCACTAAATT
ACCAATGGGTAATGCTCGCCAAGTTGGTTCTTTAGATGAACTTTTAGCAACTGCTGATGTTGTGACTTTGCATGTACCGG
ATGTTCCGTCTACACGTAACTTCTTCACTAAAGAACAATTTGCAAAAATGAAAGAAGGCGCGATCTTCTTAAATGCTGCA
CGTGGTACATGTGTAGTGATCGAAGATTTAGCTGATGCAATCAAATCTGGTCACCTTGCAGGTGCGGCAGTTGATGTATT
CCCGAAAGAACCAAAAGCAAATGGTGAAGAATTCCAGTCTCCACTTCGTGGTTTAGACAACGTGATCTTGACTCCTCACG
TTGGTGGTTCAACGATGGAAGCTCAAGCAAACATCGGTTTAGAAGTAGCAGAGAAATTTGTTGCTTACTCTGATAAGGGT
ATGACACTTTCTGCGGTAAACTTCCCAGAAATCGCGTTGCCATTGACAGCGGGTCAACACCGTTTACTACATATCCACAA
AAACGTACCGGGTGTATTGTCTAAAATCAACAACTTGTTTGCTGAACAAGGCATTAACATTTCAGGTCAGTCACTTATGA
CTAAAGGCGACATCGGTTACCTTGTAATGGACGTAGATGCTTCTGCTTCTCAAGAAGCTTTAGATATGTTGCATGAAGTT
GAAGGCACAATTCGCGTACGCGTATTGTTTTAA

Upstream 100 bases:

>100_bases
ATAAAATTGCCATAAGGCGATGGTATAAACGAAATATCTATAGCGCTGCCCAGTATGTTATTATACCGCCACCAAATTTG
GCCTTTGTAGCGGAGCCGTA

Downstream 100 bases:

>100_bases
TACAGACTGTAAATTTAAAAGCCACAGCATTGTCTGTGGCTTTTTTATAGGTATTTACATTATCATGTGAAAAGTATACC
AATTGATCAAATAATAAAAT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSQHLSLPKDKIRFLLLEGVHQNAVDTLNAAGYTNIDYRKTALEGEALKEAIKDAHFIGIRSRTQLTEEVFEAANKLIAV
GCFCIGTNQVDLKAAMARGIPVFNAPYSNTRSVAELVLAETILLLRRVPEKSAACHRGGWDKSAVGSFETRGKTLGIVGY
GSIGSQLSVLAESMGMHVIYYDAVTKLPMGNARQVGSLDELLATADVVTLHVPDVPSTRNFFTKEQFAKMKEGAIFLNAA
RGTCVVIEDLADAIKSGHLAGAAVDVFPKEPKANGEEFQSPLRGLDNVILTPHVGGSTMEAQANIGLEVAEKFVAYSDKG
MTLSAVNFPEIALPLTAGQHRLLHIHKNVPGVLSKINNLFAEQGINISGQSLMTKGDIGYLVMDVDASASQEALDMLHEV
EGTIRVRVLF

Sequences:

>Translated_410_residues
MSQHLSLPKDKIRFLLLEGVHQNAVDTLNAAGYTNIDYRKTALEGEALKEAIKDAHFIGIRSRTQLTEEVFEAANKLIAV
GCFCIGTNQVDLKAAMARGIPVFNAPYSNTRSVAELVLAETILLLRRVPEKSAACHRGGWDKSAVGSFETRGKTLGIVGY
GSIGSQLSVLAESMGMHVIYYDAVTKLPMGNARQVGSLDELLATADVVTLHVPDVPSTRNFFTKEQFAKMKEGAIFLNAA
RGTCVVIEDLADAIKSGHLAGAAVDVFPKEPKANGEEFQSPLRGLDNVILTPHVGGSTMEAQANIGLEVAEKFVAYSDKG
MTLSAVNFPEIALPLTAGQHRLLHIHKNVPGVLSKINNLFAEQGINISGQSLMTKGDIGYLVMDVDASASQEALDMLHEV
EGTIRVRVLF
>Mature_409_residues
SQHLSLPKDKIRFLLLEGVHQNAVDTLNAAGYTNIDYRKTALEGEALKEAIKDAHFIGIRSRTQLTEEVFEAANKLIAVG
CFCIGTNQVDLKAAMARGIPVFNAPYSNTRSVAELVLAETILLLRRVPEKSAACHRGGWDKSAVGSFETRGKTLGIVGYG
SIGSQLSVLAESMGMHVIYYDAVTKLPMGNARQVGSLDELLATADVVTLHVPDVPSTRNFFTKEQFAKMKEGAIFLNAAR
GTCVVIEDLADAIKSGHLAGAAVDVFPKEPKANGEEFQSPLRGLDNVILTPHVGGSTMEAQANIGLEVAEKFVAYSDKGM
TLSAVNFPEIALPLTAGQHRLLHIHKNVPGVLSKINNLFAEQGINISGQSLMTKGDIGYLVMDVDASASQEALDMLHEVE
GTIRVRVLF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=290, Percent_Identity=37.9310344827586, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI61743967, Length=255, Percent_Identity=30.5882352941176, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI4557497, Length=255, Percent_Identity=30.5882352941176, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI145580578, Length=245, Percent_Identity=32.6530612244898, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI4557499, Length=245, Percent_Identity=32.6530612244898, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI145580575, Length=245, Percent_Identity=32.6530612244898, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI6912396, Length=280, Percent_Identity=27.1428571428571, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1789279, Length=408, Percent_Identity=61.2745098039216, Blast_Score=516, Evalue=1e-148,
Organism=Escherichia coli, GI87082289, Length=247, Percent_Identity=33.6032388663968, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787645, Length=251, Percent_Identity=27.0916334661355, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081824, Length=211, Percent_Identity=27.0142180094787, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788660, Length=323, Percent_Identity=29.1021671826625, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=331, Percent_Identity=35.0453172205438, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI25147481, Length=262, Percent_Identity=30.1526717557252, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=49.5169082125604, Blast_Score=400, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=48.0676328502416, Blast_Score=393, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324964, Length=242, Percent_Identity=33.4710743801653, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=272, Percent_Identity=27.5735294117647, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324980, Length=194, Percent_Identity=31.4432989690722, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=184, Percent_Identity=31.5217391304348, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921140, Length=314, Percent_Identity=33.7579617834395, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI28574286, Length=264, Percent_Identity=30.3030303030303, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24646446, Length=237, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646448, Length=237, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646452, Length=237, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646450, Length=237, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI62472511, Length=237, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28571528, Length=271, Percent_Identity=29.1512915129151, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585514, Length=249, Percent_Identity=27.710843373494, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28574282, Length=249, Percent_Identity=27.710843373494, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI45552429, Length=249, Percent_Identity=27.710843373494, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28574284, Length=249, Percent_Identity=27.710843373494, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI45551003, Length=249, Percent_Identity=27.3092369477912, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24585516, Length=273, Percent_Identity=28.2051282051282, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44154; Mature: 44023

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQHLSLPKDKIRFLLLEGVHQNAVDTLNAAGYTNIDYRKTALEGEALKEAIKDAHFIGI
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHEEEC
RSRTQLTEEVFEAANKLIAVGCFCIGTNQVDLKAAMARGIPVFNAPYSNTRSVAELVLAE
CHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHH
TILLLRRVPEKSAACHRGGWDKSAVGSFETRGKTLGIVGYGSIGSQLSVLAESMGMHVIY
HHHHHHHCCCHHHHHHCCCCCCHHCCCHHCCCCEEEEEEECCCCHHHHHHHHHHCCEEEE
YDAVTKLPMGNARQVGSLDELLATADVVTLHVPDVPSTRNFFTKEQFAKMKEGAIFLNAA
EEHHHHCCCCCCCCCCCHHHHHHHHCEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEEC
RGTCVVIEDLADAIKSGHLAGAAVDVFPKEPKANGEEFQSPLRGLDNVILTPHVGGSTME
CCCEEEHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCEE
AQANIGLEVAEKFVAYSDKGMTLSAVNFPEIALPLTAGQHRLLHIHKNVPGVLSKINNLF
HHCCCCHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHH
AEQGINISGQSLMTKGDIGYLVMDVDASASQEALDMLHEVEGTIRVRVLF
HHCCCCCCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEEEC
>Mature Secondary Structure 
SQHLSLPKDKIRFLLLEGVHQNAVDTLNAAGYTNIDYRKTALEGEALKEAIKDAHFIGI
CCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHEEEC
RSRTQLTEEVFEAANKLIAVGCFCIGTNQVDLKAAMARGIPVFNAPYSNTRSVAELVLAE
CHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHH
TILLLRRVPEKSAACHRGGWDKSAVGSFETRGKTLGIVGYGSIGSQLSVLAESMGMHVIY
HHHHHHHCCCHHHHHHCCCCCCHHCCCHHCCCCEEEEEEECCCCHHHHHHHHHHCCEEEE
YDAVTKLPMGNARQVGSLDELLATADVVTLHVPDVPSTRNFFTKEQFAKMKEGAIFLNAA
EEHHHHCCCCCCCCCCCHHHHHHHHCEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEEC
RGTCVVIEDLADAIKSGHLAGAAVDVFPKEPKANGEEFQSPLRGLDNVILTPHVGGSTME
CCCEEEHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCEE
AQANIGLEVAEKFVAYSDKGMTLSAVNFPEIALPLTAGQHRLLHIHKNVPGVLSKINNLF
HHCCCCHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHH
AEQGINISGQSLMTKGDIGYLVMDVDASASQEALDMLHEVEGTIRVRVLF
HHCCCCCCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]