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The map label for this gene is dxs [H]

Identifier: 213158861

GI number: 213158861

Start: 3662073

End: 3663977

Strand: Reverse

Name: dxs [H]

Synonym: AB57_3558

Alternate gene names: 213158861

Gene position: 3663977-3662073 (Counterclockwise)

Preceding gene: 213158865

Following gene: 213158860

Centisome position: 90.46

GC content: 44.2

Gene sequence:

>1905_bases
ATGTTGTATACCGAAATTCCAACTCAACGCCCTGTTACGCCATTGTTAGATGCGATTGATCATCCTCAACAATTACGTCA
GCTCGAGCATAGCCAATTACTACAAGTGGCTGATGAGTTGCGTCAATATATTTTATATGCAGCAGGCCAGAGTGGTGGCC
ATTTCGGTGCTAACCTCGGCGTGGTTGAGCTGACGGTAGCGCTGCATTATTGCTTTAATACACCAAATGACCGTTTAGTT
TGGGATGTGGGACACCAAGCATACCCACATAAAATCCTGACTGGACGCCGTGAACAAATTACGACCATTCGCGCTAAAAA
TGGATTGGCTGCTTTCCCAGCCAGAGAAGAGTCCGTTTTTGATACCTTTGGGGTAGGGCATTCTTCAACTGCTATTTCAG
CTGGTTTGGGTATGTCTTTGGCACGTCGCTATCAGAAAGACCCATGTGAAGTCGTTTGTATTGTGGGTGATGGTGCAATG
ACTGCGGGCATGGCATTTGAAGCAATGAATGATGCTGTTGCTCATGATGCAGATTTAATTGTTGTACTCAATGACAACGA
TATGTCGATTTCTTGCAGTACAGGTGGCTTTGCCAAACATTTAGCTGCAATTTGGGAAAAAGGTCATTTAGTTAATGTCA
ATGAACATGGTGAAGCTTATATCCAGCCACACCCAAAATGGACATATAACTCTCGATTACACCAATCGGCAACCGATGCG
GCAGATAATTTATTTAAAGCAATTGGTTTTGATTATTTCGGGCCTTTTGATGGACACGATGTCACTCAGTTGGTTCAGGT
GTTCAACGCGCTCAAAAAACGTAAAGGTCCACGTTTAGTTCACGTTTATACCAAGAAAGGTAAAGGCTTTGCTCCTGCTG
AAGCAGACCCGATTACTTACCATGCGATTGGCAAAATTAATGCTGCTTCGGGCGGGAAAACACCACCAAAATACTCTGAT
GTGTTTGGTGAGTGGTTATGTGATGAAGCTGCACAAGATGAGCGTTTGCTTGCGATCACGCCTGCAATGTGTGAAGGCTC
GGGCATGGTTAAATTTGCTAAGCAATTTCCTCAGCGTTTCTTCGATGTCGCGATTGCAGAGCAGCATGCTGTAACACTTG
CAGCAGGAATGGCATGCGAAGGGCTAAAACCTGTTGTCGCCATTTATTCAACATTCCTGCAGCGTGGTTACGATCAGCTT
ATTCATGATGTCGCATTGCAAAATCTTGACGTGACTTTTGGTATTGACCGTGCAGGCTTGGTTGGTGAAGATGGTCCAAC
GCATGCAGGTGCATATGACTATGCTTATATGCGTACTGTGCCTAATATGGTGATCATGGCACCGAAAGATGAAAATGAAT
GCCGTCAAATGCTTCATACGGCTTATGCCTATAATGGCCCGGCTGCGGTACGCTATCCGCGTGGTGCAGGTGTGGGCGTC
GAAATCCAAAAAGAGATGACTGTTCTTGAATTGGGTAAAGCTGAAATTGTTGCAGAAATTAAAGCAAACAGTGATGAGCA
GATTACGGTTTTAGCATTTGGTAGTCGTGTCATGGTTGCTCTGGAAGCAGCTGAGCAATTTGCGCAAAAACATGACGTCA
GTGTGTGTATTGTAAATATGCGCTTCGTAAAACCGCTTGATGAACAAATGATTCGAGACTTGGCTGAGCATACTCATTTA
TTCGTGACAGTTGAAGAACACGCGATTATGGGTGGTGCGGGTAGTGCAGTGAATGAGTTTATGGCTCAAGAACAAATTGT
TAAACCTATCATTAATTTAGGTCTACCTGACTCGTTCTTGCATCAGGCGACACATAATCAAATGCTACAAGATTGTGGTT
TAGATGCTAAGGGTATTTTGAACTCGATTGAGCGAGCATGGCTTAAGGTAAATCAGGTGGTTTAA

Upstream 100 bases:

>100_bases
TCGCAAATGTGGCTGATTGAAGGTGACTTCATTCGATTGTATGATCGACCCATTTTGACCCAGCTTAGGATTTGCCAGGC
TTATAAAGGCTTTGCCACAT

Downstream 100 bases:

>100_bases
TACCTCAATAAAATTTTTCGAAACATTTTTTCCCAAAAAGCGTATTCATTTGCTAAAATGGATACGCTTTTATGCATTAT
TCTTTGTCAAAATCTTCAAA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MLYTEIPTQRPVTPLLDAIDHPQQLRQLEHSQLLQVADELRQYILYAAGQSGGHFGANLGVVELTVALHYCFNTPNDRLV
WDVGHQAYPHKILTGRREQITTIRAKNGLAAFPAREESVFDTFGVGHSSTAISAGLGMSLARRYQKDPCEVVCIVGDGAM
TAGMAFEAMNDAVAHDADLIVVLNDNDMSISCSTGGFAKHLAAIWEKGHLVNVNEHGEAYIQPHPKWTYNSRLHQSATDA
ADNLFKAIGFDYFGPFDGHDVTQLVQVFNALKKRKGPRLVHVYTKKGKGFAPAEADPITYHAIGKINAASGGKTPPKYSD
VFGEWLCDEAAQDERLLAITPAMCEGSGMVKFAKQFPQRFFDVAIAEQHAVTLAAGMACEGLKPVVAIYSTFLQRGYDQL
IHDVALQNLDVTFGIDRAGLVGEDGPTHAGAYDYAYMRTVPNMVIMAPKDENECRQMLHTAYAYNGPAAVRYPRGAGVGV
EIQKEMTVLELGKAEIVAEIKANSDEQITVLAFGSRVMVALEAAEQFAQKHDVSVCIVNMRFVKPLDEQMIRDLAEHTHL
FVTVEEHAIMGGAGSAVNEFMAQEQIVKPIINLGLPDSFLHQATHNQMLQDCGLDAKGILNSIERAWLKVNQVV

Sequences:

>Translated_634_residues
MLYTEIPTQRPVTPLLDAIDHPQQLRQLEHSQLLQVADELRQYILYAAGQSGGHFGANLGVVELTVALHYCFNTPNDRLV
WDVGHQAYPHKILTGRREQITTIRAKNGLAAFPAREESVFDTFGVGHSSTAISAGLGMSLARRYQKDPCEVVCIVGDGAM
TAGMAFEAMNDAVAHDADLIVVLNDNDMSISCSTGGFAKHLAAIWEKGHLVNVNEHGEAYIQPHPKWTYNSRLHQSATDA
ADNLFKAIGFDYFGPFDGHDVTQLVQVFNALKKRKGPRLVHVYTKKGKGFAPAEADPITYHAIGKINAASGGKTPPKYSD
VFGEWLCDEAAQDERLLAITPAMCEGSGMVKFAKQFPQRFFDVAIAEQHAVTLAAGMACEGLKPVVAIYSTFLQRGYDQL
IHDVALQNLDVTFGIDRAGLVGEDGPTHAGAYDYAYMRTVPNMVIMAPKDENECRQMLHTAYAYNGPAAVRYPRGAGVGV
EIQKEMTVLELGKAEIVAEIKANSDEQITVLAFGSRVMVALEAAEQFAQKHDVSVCIVNMRFVKPLDEQMIRDLAEHTHL
FVTVEEHAIMGGAGSAVNEFMAQEQIVKPIINLGLPDSFLHQATHNQMLQDCGLDAKGILNSIERAWLKVNQVV
>Mature_634_residues
MLYTEIPTQRPVTPLLDAIDHPQQLRQLEHSQLLQVADELRQYILYAAGQSGGHFGANLGVVELTVALHYCFNTPNDRLV
WDVGHQAYPHKILTGRREQITTIRAKNGLAAFPAREESVFDTFGVGHSSTAISAGLGMSLARRYQKDPCEVVCIVGDGAM
TAGMAFEAMNDAVAHDADLIVVLNDNDMSISCSTGGFAKHLAAIWEKGHLVNVNEHGEAYIQPHPKWTYNSRLHQSATDA
ADNLFKAIGFDYFGPFDGHDVTQLVQVFNALKKRKGPRLVHVYTKKGKGFAPAEADPITYHAIGKINAASGGKTPPKYSD
VFGEWLCDEAAQDERLLAITPAMCEGSGMVKFAKQFPQRFFDVAIAEQHAVTLAAGMACEGLKPVVAIYSTFLQRGYDQL
IHDVALQNLDVTFGIDRAGLVGEDGPTHAGAYDYAYMRTVPNMVIMAPKDENECRQMLHTAYAYNGPAAVRYPRGAGVGV
EIQKEMTVLELGKAEIVAEIKANSDEQITVLAFGSRVMVALEAAEQFAQKHDVSVCIVNMRFVKPLDEQMIRDLAEHTHL
FVTVEEHAIMGGAGSAVNEFMAQEQIVKPIINLGLPDSFLHQATHNQMLQDCGLDAKGILNSIERAWLKVNQVV

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=564, Percent_Identity=24.290780141844, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI4507521, Length=564, Percent_Identity=24.290780141844, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI133778974, Length=631, Percent_Identity=22.8209191759113, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI225637463, Length=553, Percent_Identity=22.9656419529837, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI225637459, Length=553, Percent_Identity=22.9656419529837, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI225637461, Length=553, Percent_Identity=22.9656419529837, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI1786622, Length=624, Percent_Identity=51.1217948717949, Blast_Score=636, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=585, Percent_Identity=22.9059829059829, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17538422, Length=277, Percent_Identity=24.187725631769, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319698, Length=278, Percent_Identity=25.1798561151079, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45551847, Length=624, Percent_Identity=23.3974358974359, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI45550715, Length=624, Percent_Identity=23.3974358974359, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24645119, Length=624, Percent_Identity=23.3974358974359, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24666278, Length=601, Percent_Identity=23.4608985024958, Blast_Score=99, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69470; Mature: 69470

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYTEIPTQRPVTPLLDAIDHPQQLRQLEHSQLLQVADELRQYILYAAGQSGGHFGANLG
CCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
VVELTVALHYCFNTPNDRLVWDVGHQAYPHKILTGRREQITTIRAKNGLAAFPAREESVF
HHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHCCCHHHHEEEEECCCCEECCCCCCHHH
DTFGVGHSSTAISAGLGMSLARRYQKDPCEVVCIVGDGAMTAGMAFEAMNDAVAHDADLI
HHHCCCCCCHHHHHHCCHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEE
VVLNDNDMSISCSTGGFAKHLAAIWEKGHLVNVNEHGEAYIQPHPKWTYNSRLHQSATDA
EEECCCCCEEEECCCHHHHHHHHHHCCCCEEEECCCCCEEECCCCCCCCCCHHHHHHHHH
ADNLFKAIGFDYFGPFDGHDVTQLVQVFNALKKRKGPRLVHVYTKKGKGFAPAEADPITY
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEE
HAIGKINAASGGKTPPKYSDVFGEWLCDEAAQDERLLAITPAMCEGSGMVKFAKQFPQRF
EEECEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
FDVAIAEQHAVTLAAGMACEGLKPVVAIYSTFLQRGYDQLIHDVALQNLDVTFGIDRAGL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCC
VGEDGPTHAGAYDYAYMRTVPNMVIMAPKDENECRQMLHTAYAYNGPAAVRYPRGAGVGV
CCCCCCCCCCCCHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCE
EIQKEMTVLELGKAEIVAEIKANSDEQITVLAFGSRVMVALEAAEQFAQKHDVSVCIVNM
EECCCHHHHHCCCHHEEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEE
RFVKPLDEQMIRDLAEHTHLFVTVEEHAIMGGAGSAVNEFMAQEQIVKPIINLGLPDSFL
HHHCCHHHHHHHHHHHCCEEEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
HQATHNQMLQDCGLDAKGILNSIERAWLKVNQVV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLYTEIPTQRPVTPLLDAIDHPQQLRQLEHSQLLQVADELRQYILYAAGQSGGHFGANLG
CCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
VVELTVALHYCFNTPNDRLVWDVGHQAYPHKILTGRREQITTIRAKNGLAAFPAREESVF
HHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHCCCHHHHEEEEECCCCEECCCCCCHHH
DTFGVGHSSTAISAGLGMSLARRYQKDPCEVVCIVGDGAMTAGMAFEAMNDAVAHDADLI
HHHCCCCCCHHHHHHCCHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEE
VVLNDNDMSISCSTGGFAKHLAAIWEKGHLVNVNEHGEAYIQPHPKWTYNSRLHQSATDA
EEECCCCCEEEECCCHHHHHHHHHHCCCCEEEECCCCCEEECCCCCCCCCCHHHHHHHHH
ADNLFKAIGFDYFGPFDGHDVTQLVQVFNALKKRKGPRLVHVYTKKGKGFAPAEADPITY
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEE
HAIGKINAASGGKTPPKYSDVFGEWLCDEAAQDERLLAITPAMCEGSGMVKFAKQFPQRF
EEECEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
FDVAIAEQHAVTLAAGMACEGLKPVVAIYSTFLQRGYDQLIHDVALQNLDVTFGIDRAGL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCC
VGEDGPTHAGAYDYAYMRTVPNMVIMAPKDENECRQMLHTAYAYNGPAAVRYPRGAGVGV
CCCCCCCCCCCCHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCE
EIQKEMTVLELGKAEIVAEIKANSDEQITVLAFGSRVMVALEAAEQFAQKHDVSVCIVNM
EECCCHHHHHCCCHHEEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEE
RFVKPLDEQMIRDLAEHTHLFVTVEEHAIMGGAGSAVNEFMAQEQIVKPIINLGLPDSFL
HHHCCHHHHHHHHHHHCCEEEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
HQATHNQMLQDCGLDAKGILNSIERAWLKVNQVV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA