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The map label for this gene is mutT [C]

Identifier: 213158851

GI number: 213158851

Start: 3652980

End: 3653381

Strand: Reverse

Name: mutT [C]

Synonym: AB57_3546

Alternate gene names: 213158851

Gene position: 3653381-3652980 (Counterclockwise)

Preceding gene: 213158852

Following gene: 213158848

Centisome position: 90.2

GC content: 39.55

Gene sequence:

>402_bases
GTGAAAACAATTACGGTTGCCGCTGCGGTGATCTTAAATGAACAAAATGAATTATTGCTTGTCAGAAAGCGTAATACACA
AGCTTTTATGCAGGTAGGCGGTAAACTGGAGCCGAATGAGGCTCCAGAAAGTGCTATACAGCGTGAAATCTTGGAAGAAA
TAGGCAGCCCGTGTGTAATAGAACAGTTTATAGGGCGTTTTGAGACAGCAGCTGCCAATGAACCGGATCATACGCTTATT
AGCCATTTATATTTGGTTCGATTAAAACAATCTCCACAAATTGCAGCTGAAATTGCTGAAATGAAGTGGGTGAAATTTAA
TGATTCCGAGACAAAACTTGCACCATTAACCAAAGAAATTGTAATTCCGTGGTGTGAGCAGAACTTATCTATAACTCTAT
AA

Upstream 100 bases:

>100_bases
CAGACAAAATTGAAGATATTCTTCAACAATTTGAGCAATATCAGGCTCCTGCTCCGAAATGGACAAATGCCGACGTTCAA
CCATAAATGAGGTTAAATAG

Downstream 100 bases:

>100_bases
TTTTAATATGATGTAGATGAAGCAGCAGCTAGGCAACTGGCATGAATAGATGTACACCCTAGCTGTTTTAGCGCCTGACT
TAAAGCGTGAATTGAACTTC

Product: hydrolase, NUDIX family protein

Products: 8-Oxo-Dgmp; Pyrophosphate. [C]

Alternate protein names: NTP Pyrophosphohydrolase Including Oxidative Damage Repair; MutT/Nudix Family Protein; Phosphohydrolase; MutT Family NTP Pyrophosphatase; NUDIX Family Protein; Phosphatase; NUDIX Family Hydrolase; NTP Pyrophosphohydrolase; MutT/Nudix Family Hydrolase; Uridine Kinase; MutT/Nudix Family Phosphohydrolase; Hydrolase Nudix Family; NUDIX Protein; Hydrolase Nudix Family Protein

Number of amino acids: Translated: 133; Mature: 133

Protein sequence:

>133_residues
MKTITVAAAVILNEQNELLLVRKRNTQAFMQVGGKLEPNEAPESAIQREILEEIGSPCVIEQFIGRFETAAANEPDHTLI
SHLYLVRLKQSPQIAAEIAEMKWVKFNDSETKLAPLTKEIVIPWCEQNLSITL

Sequences:

>Translated_133_residues
MKTITVAAAVILNEQNELLLVRKRNTQAFMQVGGKLEPNEAPESAIQREILEEIGSPCVIEQFIGRFETAAANEPDHTLI
SHLYLVRLKQSPQIAAEIAEMKWVKFNDSETKLAPLTKEIVIPWCEQNLSITL
>Mature_133_residues
MKTITVAAAVILNEQNELLLVRKRNTQAFMQVGGKLEPNEAPESAIQREILEEIGSPCVIEQFIGRFETAAANEPDHTLI
SHLYLVRLKQSPQIAAEIAEMKWVKFNDSETKLAPLTKEIVIPWCEQNLSITL

Specific function: Involved In The Go System Responsible For Removing An Oxidatively Damaged Form Of Guanine (7,8-Dihydro-8-Oxoguanine) From DNA And The Nucleotide Pool. 8-Oxo-Dgtp Is Inserted Opposite Da And Dc Residues Of Template DNA With Almost Equal Efficiency Thus Le

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.6.1.- [C]

Molecular weight: Translated: 14954; Mature: 14954

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTITVAAAVILNEQNELLLVRKRNTQAFMQVGGKLEPNEAPESAIQREILEEIGSPCVI
CCHHHEEHEEEECCCCCEEEEEECCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHH
EQFIGRFETAAANEPDHTLISHLYLVRLKQSPQIAAEIAEMKWVKFNDSETKLAPLTKEI
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCCHHHH
VIPWCEQNLSITL
EEEECCCCCEEEC
>Mature Secondary Structure
MKTITVAAAVILNEQNELLLVRKRNTQAFMQVGGKLEPNEAPESAIQREILEEIGSPCVI
CCHHHEEHEEEECCCCCEEEEEECCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHH
EQFIGRFETAAANEPDHTLISHLYLVRLKQSPQIAAEIAEMKWVKFNDSETKLAPLTKEI
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCCHHHH
VIPWCEQNLSITL
EEEECCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Oxo-Dgtp; H2O [C]

Specific reaction: 8-Oxo-Dgtp + H2O = 8-Oxo-Dgmp + Pyrophosphate. [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA