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The map label for this gene is prlC [H]

Identifier: 213158799

GI number: 213158799

Start: 3610852

End: 3612891

Strand: Direct

Name: prlC [H]

Synonym: AB57_3494

Alternate gene names: 213158799

Gene position: 3610852-3612891 (Clockwise)

Preceding gene: 213158798

Following gene: 213158800

Centisome position: 89.15

GC content: 41.32

Gene sequence:

>2040_bases
ATGACTTTACAGCAAGCGACTCTACCTACTCCCCGCTTTGATCAAATTACATTAGATAATTTAAAACAAGATATTCAACA
AGCGATTCAAGCAGGACAAGAGTTTTTAAACACCCTTACGGCTGCACCATCCGAGACAGACCAGCAACTTGCCGTACTTG
AACAAATTGATGCACTTGAAAATAACCTCAGTGAATCATGGGGAGTGTTGTCTCATTTAAATGCTGTAATGAACAATGCT
GAAACCAGAGAAGTCTATCAATCACTATTACCCGCTTTAAGTGAATATTACACTCAGCTTGGCCAACACACGGCGTTATA
TCAGACCTATCAACTCATTCATGATGGTCAGAGCTATTCAACGCTAAGCCCTGCGCAACAAAGTGCCATCCGTCTCGCTT
TACGTGATTTTAAACTTTCTGGTGTTGCTTTAGAGGGTGAAGACAAAAAACGTTACGCTGAAATTTCTGCACGTCTTTCA
CAGCTTTCTTCTGACTTCTCAAACCATGTACTTGATGCGACACAGGCTTATTTTAAACCACTGACAGAAGACGAATTAAA
AGGTCTTCCGGAAAGTAATGTTGAGTTATTAAAACAGTACGGCAAACAGCGTGAGCTTGATCAAGCGGTCGCAACTTTAG
ATTTTCCAGCTTATTTTGCCATCATGACCTATGCCGATGATCGTGCCTTGCGAGAAGAGCTTTATAAAGCTTATGTCACA
CGTGCATCAGATCAGTCTGAGCAAACAGAATTTGACAACAGCAAAATTATGGAAGAAATCCTGAGTCTTCGCCAAGAGAT
GGCAAAACTACTCGGTTTTAATAACTATGCTGAATATTCTCTTGCCAGCAAAATGGCGCCTGATGTCAAAACAGTTCATG
ACTTTTTGGTCGACCTAGCTGAACATGCACGTACCCCTGCACTTCAGGAAGTTGCCGAACTCCAAGCTATTGCCAAACAA
GATGGTATTGATGAGCTTAAACCTTGGGATACCACTTACTATTCTGAAAAGCTTAAACAACAACAATTCAACTTATCACA
AGAAGCTTTAAAACCTTACTTCCCTGCACCAAAAGTGATTCAGGGATTATTCCAGATCGTACAGCGTCTATATGGTATTA
ACATCGTTGAACGTGAAGCTCCTGTTTGGCATCCAGATGCACGTTATTTTGAGTTAGAAGACCAAGGTGAAGTTGTTGGC
GGCTTCTTCTTTGATTTATATGCGCGCACAGGGAAACGTGGTGGAGCATGGATGAGTGGTTTCCGCTCACGTATGCAAAC
TGTTCATGGTTTACAAAAACCAATTTGCTATATGGTGTGTAACTTCACTCCACCTGTAGGCAACCAACCAGCCTTACTCA
CCCATGATGAAGTCATTACCTTATTCCACGAGTTTGGTCATGGCTTACACCATATGCTTACTGAAGTAGATAATATCTCA
GTTGCAGGTACTCACGGCGTTGCTTGGGATGCAGTCGAGTTACCAAGTCAGTTCATGGAATTCTGGTCATGGGATAAAGA
AAGTCTTGATGTTTTAAGTGAGCATATTGAGAGTAAGCAGACTTTACCTCAAGAGTTACTTGATGCTTTATTAAATGCAC
GTTTCTTCCAGTCTGGTATGCAAACTTTACGTCAGCTTGAATTTGCCTTATTTGACTTAACTATTCACACCAAAACTCCT
GCGTTGAATAGTGAACAAATTCAGCAGACCTTAAATGATATTCGCAAACAATATGCGGTAGTTCCAACCGTCGACTACAA
CCGTTTCCAACATAGCTTTAGTCATATTTTTGCAGGCGGCTATGCAGCAGGTTACTACTCTTACAAATGGGCAGAAGTTT
TAGCAAGTGATGCCTTTGACCGTTTTGAAAATGAAGGTATTTTCAATACTCAAACGGGTAAAGAATTCCGTCAGGCAATT
TTAGCGGTGGGTGGGAAAGATACTGCTCTTGAAGCATTTGTGAATTTCCGCGGTCGTGAGCCAAAAATTGATGCATTGTT
ACGTCATCAAGGTTGGACGAACGATAACAAAACCGCTTAA

Upstream 100 bases:

>100_bases
TAATGTTTTTAAAACGTTTATTTTTTAAATTAAGCTTGATTTCCTACCTAACAATACCTACATCTAATACTATGTTTAAA
AAATAATGTGGCTATTAGCA

Downstream 100 bases:

>100_bases
ACTATGGGCCTAAATTGATCGTGTGGTTAGGGTGATAAAGATGAAGAAACGTTTCATTGCTGGGGCTAAATGTCCAAAAT
GTGAAGCCATAGATCGGATT

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MTLQQATLPTPRFDQITLDNLKQDIQQAIQAGQEFLNTLTAAPSETDQQLAVLEQIDALENNLSESWGVLSHLNAVMNNA
ETREVYQSLLPALSEYYTQLGQHTALYQTYQLIHDGQSYSTLSPAQQSAIRLALRDFKLSGVALEGEDKKRYAEISARLS
QLSSDFSNHVLDATQAYFKPLTEDELKGLPESNVELLKQYGKQRELDQAVATLDFPAYFAIMTYADDRALREELYKAYVT
RASDQSEQTEFDNSKIMEEILSLRQEMAKLLGFNNYAEYSLASKMAPDVKTVHDFLVDLAEHARTPALQEVAELQAIAKQ
DGIDELKPWDTTYYSEKLKQQQFNLSQEALKPYFPAPKVIQGLFQIVQRLYGINIVEREAPVWHPDARYFELEDQGEVVG
GFFFDLYARTGKRGGAWMSGFRSRMQTVHGLQKPICYMVCNFTPPVGNQPALLTHDEVITLFHEFGHGLHHMLTEVDNIS
VAGTHGVAWDAVELPSQFMEFWSWDKESLDVLSEHIESKQTLPQELLDALLNARFFQSGMQTLRQLEFALFDLTIHTKTP
ALNSEQIQQTLNDIRKQYAVVPTVDYNRFQHSFSHIFAGGYAAGYYSYKWAEVLASDAFDRFENEGIFNTQTGKEFRQAI
LAVGGKDTALEAFVNFRGREPKIDALLRHQGWTNDNKTA

Sequences:

>Translated_679_residues
MTLQQATLPTPRFDQITLDNLKQDIQQAIQAGQEFLNTLTAAPSETDQQLAVLEQIDALENNLSESWGVLSHLNAVMNNA
ETREVYQSLLPALSEYYTQLGQHTALYQTYQLIHDGQSYSTLSPAQQSAIRLALRDFKLSGVALEGEDKKRYAEISARLS
QLSSDFSNHVLDATQAYFKPLTEDELKGLPESNVELLKQYGKQRELDQAVATLDFPAYFAIMTYADDRALREELYKAYVT
RASDQSEQTEFDNSKIMEEILSLRQEMAKLLGFNNYAEYSLASKMAPDVKTVHDFLVDLAEHARTPALQEVAELQAIAKQ
DGIDELKPWDTTYYSEKLKQQQFNLSQEALKPYFPAPKVIQGLFQIVQRLYGINIVEREAPVWHPDARYFELEDQGEVVG
GFFFDLYARTGKRGGAWMSGFRSRMQTVHGLQKPICYMVCNFTPPVGNQPALLTHDEVITLFHEFGHGLHHMLTEVDNIS
VAGTHGVAWDAVELPSQFMEFWSWDKESLDVLSEHIESKQTLPQELLDALLNARFFQSGMQTLRQLEFALFDLTIHTKTP
ALNSEQIQQTLNDIRKQYAVVPTVDYNRFQHSFSHIFAGGYAAGYYSYKWAEVLASDAFDRFENEGIFNTQTGKEFRQAI
LAVGGKDTALEAFVNFRGREPKIDALLRHQGWTNDNKTA
>Mature_678_residues
TLQQATLPTPRFDQITLDNLKQDIQQAIQAGQEFLNTLTAAPSETDQQLAVLEQIDALENNLSESWGVLSHLNAVMNNAE
TREVYQSLLPALSEYYTQLGQHTALYQTYQLIHDGQSYSTLSPAQQSAIRLALRDFKLSGVALEGEDKKRYAEISARLSQ
LSSDFSNHVLDATQAYFKPLTEDELKGLPESNVELLKQYGKQRELDQAVATLDFPAYFAIMTYADDRALREELYKAYVTR
ASDQSEQTEFDNSKIMEEILSLRQEMAKLLGFNNYAEYSLASKMAPDVKTVHDFLVDLAEHARTPALQEVAELQAIAKQD
GIDELKPWDTTYYSEKLKQQQFNLSQEALKPYFPAPKVIQGLFQIVQRLYGINIVEREAPVWHPDARYFELEDQGEVVGG
FFFDLYARTGKRGGAWMSGFRSRMQTVHGLQKPICYMVCNFTPPVGNQPALLTHDEVITLFHEFGHGLHHMLTEVDNISV
AGTHGVAWDAVELPSQFMEFWSWDKESLDVLSEHIESKQTLPQELLDALLNARFFQSGMQTLRQLEFALFDLTIHTKTPA
LNSEQIQQTLNDIRKQYAVVPTVDYNRFQHSFSHIFAGGYAAGYYSYKWAEVLASDAFDRFENEGIFNTQTGKEFRQAIL
AVGGKDTALEAFVNFRGREPKIDALLRHQGWTNDNKTA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=591, Percent_Identity=33.3333333333333, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI14149738, Length=615, Percent_Identity=29.2682926829268, Blast_Score=247, Evalue=3e-65,
Organism=Homo sapiens, GI156105687, Length=597, Percent_Identity=25.7956448911223, Blast_Score=183, Evalue=6e-46,
Organism=Escherichia coli, GI1789913, Length=669, Percent_Identity=50.9715994020927, Blast_Score=674, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=690, Percent_Identity=30.7246376811594, Blast_Score=282, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI71999758, Length=468, Percent_Identity=26.7094017094017, Blast_Score=130, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI32565901, Length=639, Percent_Identity=23.0046948356808, Blast_Score=119, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319793, Length=671, Percent_Identity=29.3591654247392, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6322715, Length=678, Percent_Identity=24.6312684365782, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21356111, Length=687, Percent_Identity=27.3653566229985, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI20129717, Length=569, Percent_Identity=24.9560632688928, Blast_Score=173, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77152; Mature: 77021

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQQATLPTPRFDQITLDNLKQDIQQAIQAGQEFLNTLTAAPSETDQQLAVLEQIDALE
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
NNLSESWGVLSHLNAVMNNAETREVYQSLLPALSEYYTQLGQHTALYQTYQLIHDGQSYS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCC
TLSPAQQSAIRLALRDFKLSGVALEGEDKKRYAEISARLSQLSSDFSNHVLDATQAYFKP
CCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTEDELKGLPESNVELLKQYGKQRELDQAVATLDFPAYFAIMTYADDRALREELYKAYVT
CCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
RASDQSEQTEFDNSKIMEEILSLRQEMAKLLGFNNYAEYSLASKMAPDVKTVHDFLVDLA
HCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
EHARTPALQEVAELQAIAKQDGIDELKPWDTTYYSEKLKQQQFNLSQEALKPYFPAPKVI
HHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCHHHH
QGLFQIVQRLYGINIVEREAPVWHPDARYFELEDQGEVVGGFFFDLYARTGKRGGAWMSG
HHHHHHHHHHHCCCEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHH
FRSRMQTVHGLQKPICYMVCNFTPPVGNQPALLTHDEVITLFHEFGHGLHHMLTEVDNIS
HHHHHHHHHHHHCCHHHEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCE
VAGTHGVAWDAVELPSQFMEFWSWDKESLDVLSEHIESKQTLPQELLDALLNARFFQSGM
EECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
QTLRQLEFALFDLTIHTKTPALNSEQIQQTLNDIRKQYAVVPTVDYNRFQHSFSHIFAGG
HHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
YAAGYYSYKWAEVLASDAFDRFENEGIFNTQTGKEFRQAILAVGGKDTALEAFVNFRGRE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCC
PKIDALLRHQGWTNDNKTA
CHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TLQQATLPTPRFDQITLDNLKQDIQQAIQAGQEFLNTLTAAPSETDQQLAVLEQIDALE
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
NNLSESWGVLSHLNAVMNNAETREVYQSLLPALSEYYTQLGQHTALYQTYQLIHDGQSYS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCC
TLSPAQQSAIRLALRDFKLSGVALEGEDKKRYAEISARLSQLSSDFSNHVLDATQAYFKP
CCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTEDELKGLPESNVELLKQYGKQRELDQAVATLDFPAYFAIMTYADDRALREELYKAYVT
CCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
RASDQSEQTEFDNSKIMEEILSLRQEMAKLLGFNNYAEYSLASKMAPDVKTVHDFLVDLA
HCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
EHARTPALQEVAELQAIAKQDGIDELKPWDTTYYSEKLKQQQFNLSQEALKPYFPAPKVI
HHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCHHHH
QGLFQIVQRLYGINIVEREAPVWHPDARYFELEDQGEVVGGFFFDLYARTGKRGGAWMSG
HHHHHHHHHHHCCCEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHH
FRSRMQTVHGLQKPICYMVCNFTPPVGNQPALLTHDEVITLFHEFGHGLHHMLTEVDNIS
HHHHHHHHHHHHCCHHHEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCE
VAGTHGVAWDAVELPSQFMEFWSWDKESLDVLSEHIESKQTLPQELLDALLNARFFQSGM
EECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
QTLRQLEFALFDLTIHTKTPALNSEQIQQTLNDIRKQYAVVPTVDYNRFQHSFSHIFAGG
HHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
YAAGYYSYKWAEVLASDAFDRFENEGIFNTQTGKEFRQAILAVGGKDTALEAFVNFRGRE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCC
PKIDALLRHQGWTNDNKTA
CHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]