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The map label for this gene is ilvD [H]

Identifier: 213158777

GI number: 213158777

Start: 4036258

End: 4038087

Strand: Reverse

Name: ilvD [H]

Synonym: AB57_3911

Alternate gene names: 213158777

Gene position: 4038087-4036258 (Counterclockwise)

Preceding gene: 213158780

Following gene: 213158776

Centisome position: 99.69

GC content: 43.83

Gene sequence:

>1830_bases
ATGCCTGACTATCGTTCAAAAACATCGACACACGGAAGAAATATGGCTGGCGCACGTGGCTTATGGCGTGCAACAGGAAT
GAAAGATGAAGATTTCGGCAAACCGATTATTGCAGTGGTCAATTCATTTACCCAATTTGTTCCGGGCCACGTCCATCTGA
AAGATTTAGGACAGCTTGTCGCGGCAGAAATTCAGGCAGCAGGTGGTGTTGCTAAAGAGTTCAATACCATCGCGGTGGAT
GACGGTATCGCAATGGGGCATGACGGCATGCTTTATTCATTACCATCACGTGATTTAATTGCGGACTCGGTTGAATATAT
GGTGAATGCACATTGCGCCGATGCGATGGTGTGTATTTCGAACTGTGACAAAATTACTCCGGGAATGTTGATGGCTGCGA
TGCGTCTAAATATTCCTGTGGTGTTTGTGTCTGGCGGACCAATGGAAGCAGGTAAGGTTAAATTCCGCGGTGATGAAAAA
GCAATTGACCTTGTAGATGCTATGGTTGTTGCAGCTGATGACAGCTACACAGACGAAGAAGTTGCAGAATTTGAACGTTC
AGCATGTCCAACCTGTGGTTCGTGTTCAGGTATGTTTACTGCGAACTCAATGAACTGTTTAACAGAAGCGCTAGGTTTAT
CGTTACCGGGCAATGGTTCTATCGTTGCAACGCATGCAAACCGTAAAAAATTATTCTTAAAAGCAGGTCAGCTTATTGTT
GAATTGGCTAAACGCTACTATGAGCAAAATGATGCAAGTATTTTGCCTCGTTCAATTGCCACTAAAGCTGCCTTTAAAAA
TGCGATGACACTTGATATTGCAATGGGTGGATCAACCAATACAGTTCTTCACTTGTTAGCTGCGGCAAATGAAGCTGAAG
TTGACTTTACGATGGACGATATTGATGAGTTGTCACGTCGAGTACCAGTGCTTTCAAAAGTAGCACCAGCAAAACAAGAC
GTACATATGGAAGATGTACATCGTGCAGGCGGTATCATGGCCATTTTAGGCGAGCTTGATCGTGCGAATCTACTTGATGT
ATCTGTACCAACTGTACATGAGAAAACATTAAAAGATGCGTTAGATAAGTGGGATATTATCCGTACTGAAGATCCAGATG
TATATGAGTTCTATCGCTCGTCTCCGGGTGGCGTTCCAACTCAAGTTGCATTCTCACAAAACCGTTACTACTCAACTTTA
GATGGCGACCGTGAAAAGGGTGTGATTCGTAATGCAGAGCATGCATTCTCTAAAGATGGTGGTTTAGCTGTTCTTTACGG
CAACATTGCGCTTGATGGATGTATTGTAAAAACTGCGGGCGTTGACGAATCTATTTTAAAATTCACAGGTTCAGCACGAG
TTTTTGAGAGCCAAGATGCAGCGGTAGAAGCAATTTTAGGCAATGAAATTAAAGCTGGTGATGTGGTTGTTATTCGCTAC
GAAGGTCCACGTGGTGGTCCGGGCATGCAAGAAATGCTTTACCCAACCAGCTATCTTAAATCGAAAGGTTTAGGAAAAGA
CTGTGCGTTAGTTACAGATGGCCGTTTCTCTGGTGGTTCATCAGGTCTTTCAATTGGTCACGTTTCACCAGAAGCCGCTG
AAGGCGGTGCGATTGGTTTAGTTGAAGATGGTGATACCATCGAAATTGATATTCCAAACCGTACCATTCACTTGAATATT
GATGATGCGACTTTGGCGCACCGTCGTACAGTTCAAGAAGCGAAAGGTTGGCATCCGAAGGAAGAACGTAAACGTAAGGT
ATCAAAAGCGTTAAAAGTTTATGCAATGCATACCACAAGTGCAGCAAAAGGAGCTGTACGCGTCCTATAA

Upstream 100 bases:

>100_bases
ATGATGATGAGTCAATATTCCGACTGATCTAACGCTATATCAGTATCATTCAGCCAGAGTGGAAGTCATTTCACTCAAGC
ACAACTTGTTGGAAACACAA

Downstream 100 bases:

>100_bases
AATATTCAATTTTAATAATTGAGTAGGAAACATGCACCCATTAACACGATGAATTGTTATCATGTTAAGGGTGCATTTTT
TATGTCTGGTAAAAAAAATC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 1 [H]

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MPDYRSKTSTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAAEIQAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVKFRGDEK
AIDLVDAMVVAADDSYTDEEVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSIVATHANRKKLFLKAGQLIV
ELAKRYYEQNDASILPRSIATKAAFKNAMTLDIAMGGSTNTVLHLLAAANEAEVDFTMDDIDELSRRVPVLSKVAPAKQD
VHMEDVHRAGGIMAILGELDRANLLDVSVPTVHEKTLKDALDKWDIIRTEDPDVYEFYRSSPGGVPTQVAFSQNRYYSTL
DGDREKGVIRNAEHAFSKDGGLAVLYGNIALDGCIVKTAGVDESILKFTGSARVFESQDAAVEAILGNEIKAGDVVVIRY
EGPRGGPGMQEMLYPTSYLKSKGLGKDCALVTDGRFSGGSSGLSIGHVSPEAAEGGAIGLVEDGDTIEIDIPNRTIHLNI
DDATLAHRRTVQEAKGWHPKEERKRKVSKALKVYAMHTTSAAKGAVRVL

Sequences:

>Translated_609_residues
MPDYRSKTSTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAAEIQAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVKFRGDEK
AIDLVDAMVVAADDSYTDEEVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSIVATHANRKKLFLKAGQLIV
ELAKRYYEQNDASILPRSIATKAAFKNAMTLDIAMGGSTNTVLHLLAAANEAEVDFTMDDIDELSRRVPVLSKVAPAKQD
VHMEDVHRAGGIMAILGELDRANLLDVSVPTVHEKTLKDALDKWDIIRTEDPDVYEFYRSSPGGVPTQVAFSQNRYYSTL
DGDREKGVIRNAEHAFSKDGGLAVLYGNIALDGCIVKTAGVDESILKFTGSARVFESQDAAVEAILGNEIKAGDVVVIRY
EGPRGGPGMQEMLYPTSYLKSKGLGKDCALVTDGRFSGGSSGLSIGHVSPEAAEGGAIGLVEDGDTIEIDIPNRTIHLNI
DDATLAHRRTVQEAKGWHPKEERKRKVSKALKVYAMHTTSAAKGAVRVL
>Mature_608_residues
PDYRSKTSTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAAEIQAAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVKFRGDEKA
IDLVDAMVVAADDSYTDEEVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSIVATHANRKKLFLKAGQLIVE
LAKRYYEQNDASILPRSIATKAAFKNAMTLDIAMGGSTNTVLHLLAAANEAEVDFTMDDIDELSRRVPVLSKVAPAKQDV
HMEDVHRAGGIMAILGELDRANLLDVSVPTVHEKTLKDALDKWDIIRTEDPDVYEFYRSSPGGVPTQVAFSQNRYYSTLD
GDREKGVIRNAEHAFSKDGGLAVLYGNIALDGCIVKTAGVDESILKFTGSARVFESQDAAVEAILGNEIKAGDVVVIRYE
GPRGGPGMQEMLYPTSYLKSKGLGKDCALVTDGRFSGGSSGLSIGHVSPEAAEGGAIGLVEDGDTIEIDIPNRTIHLNID
DATLAHRRTVQEAKGWHPKEERKRKVSKALKVYAMHTTSAAKGAVRVL

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=610, Percent_Identity=73.9344262295082, Blast_Score=926, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=553, Percent_Identity=31.1030741410488, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1786464, Length=535, Percent_Identity=31.214953271028, Blast_Score=182, Evalue=6e-47,
Organism=Escherichia coli, GI1788157, Length=543, Percent_Identity=29.8342541436464, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322476, Length=604, Percent_Identity=38.9072847682119, Blast_Score=355, Evalue=1e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65314; Mature: 65183

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDYRSKTSTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AAEIQAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCIS
HHHHHHCCCCHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHCCHHHHHHHHH
NCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVKFRGDEKAIDLVDAMVVAADDSYTDEE
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCHHHHHHHEEEEECCCCCCHHH
VAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSIVATHANRKKLFLKAGQLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCCCEEHHHHHHHHH
ELAKRYYEQNDASILPRSIATKAAFKNAMTLDIAMGGSTNTVLHLLAAANEAEVDFTMDD
HHHHHHHCCCCCHHCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEHHH
IDELSRRVPVLSKVAPAKQDVHMEDVHRAGGIMAILGELDRANLLDVSVPTVHEKTLKDA
HHHHHHHCCHHHHCCCCCCCCCHHHHHHCCCCEEEECCCCCCCEEEECCCCHHHHHHHHH
LDKWDIIRTEDPDVYEFYRSSPGGVPTQVAFSQNRYYSTLDGDREKGVIRNAEHAFSKDG
HHHCCEEECCCCHHHHHHHCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCCHHHHCCCC
GLAVLYGNIALDGCIVKTAGVDESILKFTGSARVFESQDAAVEAILGNEIKAGDVVVIRY
CEEEEECCEEECCEEEEECCCCHHHHHHCCCCEEECCCCHHHHHHHCCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGLGKDCALVTDGRFSGGSSGLSIGHVSPEAAEGGAIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCEEEE
VEDGDTIEIDIPNRTIHLNIDDATLAHRRTVQEAKGWHPKEERKRKVSKALKVYAMHTTS
EECCCEEEEECCCEEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEECCC
AAKGAVRVL
CCCCCEECC
>Mature Secondary Structure 
PDYRSKTSTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AAEIQAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCIS
HHHHHHCCCCHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHCCHHHHHHHHH
NCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVKFRGDEKAIDLVDAMVVAADDSYTDEE
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCHHHHHHHEEEEECCCCCCHHH
VAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSIVATHANRKKLFLKAGQLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCCCEEHHHHHHHHH
ELAKRYYEQNDASILPRSIATKAAFKNAMTLDIAMGGSTNTVLHLLAAANEAEVDFTMDD
HHHHHHHCCCCCHHCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEHHH
IDELSRRVPVLSKVAPAKQDVHMEDVHRAGGIMAILGELDRANLLDVSVPTVHEKTLKDA
HHHHHHHCCHHHHCCCCCCCCCHHHHHHCCCCEEEECCCCCCCEEEECCCCHHHHHHHHH
LDKWDIIRTEDPDVYEFYRSSPGGVPTQVAFSQNRYYSTLDGDREKGVIRNAEHAFSKDG
HHHCCEEECCCCHHHHHHHCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCCHHHHCCCC
GLAVLYGNIALDGCIVKTAGVDESILKFTGSARVFESQDAAVEAILGNEIKAGDVVVIRY
CEEEEECCEEECCEEEEECCCCHHHHHHCCCCEEECCCCHHHHHHHCCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGLGKDCALVTDGRFSGGSSGLSIGHVSPEAAEGGAIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCEEEE
VEDGDTIEIDIPNRTIHLNIDDATLAHRRTVQEAKGWHPKEERKRKVSKALKVYAMHTTS
EECCCEEEEECCCEEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEECCC
AAKGAVRVL
CCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA