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The map label for this gene is dapA [H]

Identifier: 213158742

GI number: 213158742

Start: 4002172

End: 4003065

Strand: Direct

Name: dapA [H]

Synonym: AB57_3876

Alternate gene names: 213158742

Gene position: 4002172-4003065 (Clockwise)

Preceding gene: 213158738

Following gene: 213158743

Centisome position: 98.81

GC content: 43.62

Gene sequence:

>894_bases
ATGACTCAGCAAGCACAGACCATTCAAGGCTCAATCGTCGCAATCGTCACTCCCATGTTGAAAGATGGCGGTGTAGATTG
GAAGAGTCTTGAGAAGCTGGTTGAGTGGCACATAGAACAAGGTACAAACAGTATTGTAGCCGTCGGTACAACCGGCGAAG
CCTCAACATTGAGCATGGAAGAGCACACACAGGTTATTAAAGAAATTATTCGTGTAGCCAACAAACGTATTCCAATTATT
GCCGGTACTGGTGCAAACTCAACCCGTGAAGCAATCGAATTAACTAAAGCTGCCAAAGACCTTGGCGCAGATGCAGCTTT
ACTTGTAACCCCATACTATAACAAGCCGACTCAAGAAGGCCTTTACCAACACTATAAAGCGATTGCTGAAGCTGTTGAAT
TACCGCTTATTCTTTACAACGTACCTGGTCGTACAGGTGTAGATTTGTCAAACGATACAGCTGTTCGTTTAGCGGAAATT
CCAAATATTGTCGGCATTAAAGATGCAACAGGTGACGTACCACGCGGTAAAGCTTTAATCGATGCTTTAAACGGCAAGAT
GGCTGTGTACTCAGGTGACGATGAAACTGCATGGGAACTTATGCTTCTTGGCGCAGACGGTAATATCTCGGTTACTGCAA
ACATTGCACCTAAAGCAATGAGCGAAGTATGTGCGGTTGCAATTGCAAAAGATGAGCAACAAGCAAAGACGCTTAACAAT
AAGATTGCAAATTTACACAATATTCTATTTTGCGAATCAAACCCAATTCCTGTGAAATGGGCACTACATGAGATGGGACT
GATTGATACTGGTATTCGTTTACCACTCACTCCTCTCGCTGAGCAATATCGCGAACCTCTCCGCAATGCCCTAAAAGATG
CGGGAATTATTTAA

Upstream 100 bases:

>100_bases
ATCTGTTATTGTTAGAACTGGACAATCAAAATACTGCAACCATCCCACATTTTGTTTTTCTTACCTCAGATTCGGATGGA
TAAATAGGATATTTTTTAAA

Downstream 100 bases:

>100_bases
TAAGAGCAATTTATGATGCAATTACGTCTTGGTTTAGTCCTTGCAGTTTCAGCCTTAAGTTTAGCTGGCTGTGGTCGCTT
CGCACTCAATAATCACTCTT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MTQQAQTIQGSIVAIVTPMLKDGGVDWKSLEKLVEWHIEQGTNSIVAVGTTGEASTLSMEEHTQVIKEIIRVANKRIPII
AGTGANSTREAIELTKAAKDLGADAALLVTPYYNKPTQEGLYQHYKAIAEAVELPLILYNVPGRTGVDLSNDTAVRLAEI
PNIVGIKDATGDVPRGKALIDALNGKMAVYSGDDETAWELMLLGADGNISVTANIAPKAMSEVCAVAIAKDEQQAKTLNN
KIANLHNILFCESNPIPVKWALHEMGLIDTGIRLPLTPLAEQYREPLRNALKDAGII

Sequences:

>Translated_297_residues
MTQQAQTIQGSIVAIVTPMLKDGGVDWKSLEKLVEWHIEQGTNSIVAVGTTGEASTLSMEEHTQVIKEIIRVANKRIPII
AGTGANSTREAIELTKAAKDLGADAALLVTPYYNKPTQEGLYQHYKAIAEAVELPLILYNVPGRTGVDLSNDTAVRLAEI
PNIVGIKDATGDVPRGKALIDALNGKMAVYSGDDETAWELMLLGADGNISVTANIAPKAMSEVCAVAIAKDEQQAKTLNN
KIANLHNILFCESNPIPVKWALHEMGLIDTGIRLPLTPLAEQYREPLRNALKDAGII
>Mature_296_residues
TQQAQTIQGSIVAIVTPMLKDGGVDWKSLEKLVEWHIEQGTNSIVAVGTTGEASTLSMEEHTQVIKEIIRVANKRIPIIA
GTGANSTREAIELTKAAKDLGADAALLVTPYYNKPTQEGLYQHYKAIAEAVELPLILYNVPGRTGVDLSNDTAVRLAEIP
NIVGIKDATGDVPRGKALIDALNGKMAVYSGDDETAWELMLLGADGNISVTANIAPKAMSEVCAVAIAKDEQQAKTLNNK
IANLHNILFCESNPIPVKWALHEMGLIDTGIRLPLTPLAEQYREPLRNALKDAGII

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=292, Percent_Identity=28.4246575342466, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI13540533, Length=299, Percent_Identity=28.4280936454849, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=51.2027491408935, Blast_Score=303, Evalue=8e-84,
Organism=Escherichia coli, GI87082415, Length=298, Percent_Identity=30.8724832214765, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1789620, Length=286, Percent_Identity=30.7692307692308, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1786463, Length=222, Percent_Identity=32.8828828828829, Blast_Score=132, Evalue=3e-32,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31936; Mature: 31805

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQAQTIQGSIVAIVTPMLKDGGVDWKSLEKLVEWHIEQGTNSIVAVGTTGEASTLSME
CCCCCHHHCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEECHH
EHTQVIKEIIRVANKRIPIIAGTGANSTREAIELTKAAKDLGADAALLVTPYYNKPTQEG
HHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHH
LYQHYKAIAEAVELPLILYNVPGRTGVDLSNDTAVRLAEIPNIVGIKDATGDVPRGKALI
HHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCEEEEECCCCEEECCCCCCCCCCCHHHH
DALNGKMAVYSGDDETAWELMLLGADGNISVTANIAPKAMSEVCAVAIAKDEQQAKTLNN
HHHCCCEEEEECCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHH
KIANLHNILFCESNPIPVKWALHEMGLIDTGIRLPLTPLAEQYREPLRNALKDAGII
HHHHHHEEEEECCCCCCEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQQAQTIQGSIVAIVTPMLKDGGVDWKSLEKLVEWHIEQGTNSIVAVGTTGEASTLSME
CCCCHHHCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEECHH
EHTQVIKEIIRVANKRIPIIAGTGANSTREAIELTKAAKDLGADAALLVTPYYNKPTQEG
HHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHH
LYQHYKAIAEAVELPLILYNVPGRTGVDLSNDTAVRLAEIPNIVGIKDATGDVPRGKALI
HHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCEEEEECCCCEEECCCCCCCCCCCHHHH
DALNGKMAVYSGDDETAWELMLLGADGNISVTANIAPKAMSEVCAVAIAKDEQQAKTLNN
HHHCCCEEEEECCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHH
KIANLHNILFCESNPIPVKWALHEMGLIDTGIRLPLTPLAEQYREPLRNALKDAGII
HHHHHHEEEEECCCCCCEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA