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The map label for this gene is rnz [H]

Identifier: 213158673

GI number: 213158673

Start: 2714113

End: 2715069

Strand: Direct

Name: rnz [H]

Synonym: AB57_2627

Alternate gene names: 213158673

Gene position: 2714113-2715069 (Clockwise)

Preceding gene: 213158672

Following gene: 213158678

Centisome position: 67.01

GC content: 37.62

Gene sequence:

>957_bases
ATGCTTCATTTTACCTTTTTAGGCACATCATCAGGTGTACCCACGCTTTCACGCAATGTTTCAGGATTAGCTGTTCGTAA
CAGTAAAAATAAGGACTGGATTTTAGTTGATGCTGGTGAAGGTACACAGCATCGTATTCAGCAAGCTAGACTCTCACTAC
AAAACTTAATTGCCATTTGTATTACACACGTTCACGGCGATCATTGTTATGGTCTAGTTGGTTTACTGGCAAGTGCAGGC
ATGAATGCACGCAGCAAACCATTAATCGTGATTGCACCCAAAGAAATTCAACAATGGTTTGAAATCACTGCTCAACTTAC
AGACTTACATTTGCCTTATTCAATAAAATTTATTGATGTTAATGAAGCAACTCGGCCACAGCAGCTCACCGATGAACTCT
TTATTCAAGCACATCCACTAAGTCATCGTGTTCCGAGTTTTGCATTTAGTATTTATATAAAATCCACCCAGAAGAAGATA
GATATTCAAGTTTTAACTCAGCTTGGCGTACCTAAAGGCGATATTTGGGGGCATTTAAAACGAGGCTACGATGTAGAGTT
TGAGGGGCGAATTTTAAAATCTCAAGACTTTATCAAAATTCAAAATCAGCAGATTCATGCAATTATAGGTGGTGATAATG
ATCGGCCAGAATTATTAGCCGATGCTTGTAAGGATGCTCAATTACTTATTCATGAAGCAACTTATTTGCAAACAGTCTTA
GATAAAGTAGGTAAAGGACCAATGCACAGCTCAGCAAAAATGGTGGCTGAATTTGCTGAGCAGCAATCTCTAGACAATTT
AATTCTGACACACTTTAGCCCTAGACATCAGGATAAAACTGGGCAGCAAGCTATTACCGAAGAAGTTCGCCAGTTTTATA
AAGGTCATTTTTATTTAGCGAATGATTTTGATGAATTTACTTTAAATGAAACAGGACAACTTTTAAAAATCGAGTAA

Upstream 100 bases:

>100_bases
TTTTTTCACTTGGTCGCTACCCTGCACCATAATTTTTATAAAATTTTAATAAGTGTCTATAATATAAAAATTACGCATTT
GACTAAAAAATTCCAAGAAT

Downstream 100 bases:

>100_bases
AAATCATATTTGTTGTGAGATCGAATTAGCTACATATCATTTCCATATAAAAGTTTAAGAAGCTCATAATTGAGCTTCTT
ATCTCTTAAAAAACTACTCT

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MLHFTFLGTSSGVPTLSRNVSGLAVRNSKNKDWILVDAGEGTQHRIQQARLSLQNLIAICITHVHGDHCYGLVGLLASAG
MNARSKPLIVIAPKEIQQWFEITAQLTDLHLPYSIKFIDVNEATRPQQLTDELFIQAHPLSHRVPSFAFSIYIKSTQKKI
DIQVLTQLGVPKGDIWGHLKRGYDVEFEGRILKSQDFIKIQNQQIHAIIGGDNDRPELLADACKDAQLLIHEATYLQTVL
DKVGKGPMHSSAKMVAEFAEQQSLDNLILTHFSPRHQDKTGQQAITEEVRQFYKGHFYLANDFDEFTLNETGQLLKIE

Sequences:

>Translated_318_residues
MLHFTFLGTSSGVPTLSRNVSGLAVRNSKNKDWILVDAGEGTQHRIQQARLSLQNLIAICITHVHGDHCYGLVGLLASAG
MNARSKPLIVIAPKEIQQWFEITAQLTDLHLPYSIKFIDVNEATRPQQLTDELFIQAHPLSHRVPSFAFSIYIKSTQKKI
DIQVLTQLGVPKGDIWGHLKRGYDVEFEGRILKSQDFIKIQNQQIHAIIGGDNDRPELLADACKDAQLLIHEATYLQTVL
DKVGKGPMHSSAKMVAEFAEQQSLDNLILTHFSPRHQDKTGQQAITEEVRQFYKGHFYLANDFDEFTLNETGQLLKIE
>Mature_318_residues
MLHFTFLGTSSGVPTLSRNVSGLAVRNSKNKDWILVDAGEGTQHRIQQARLSLQNLIAICITHVHGDHCYGLVGLLASAG
MNARSKPLIVIAPKEIQQWFEITAQLTDLHLPYSIKFIDVNEATRPQQLTDELFIQAHPLSHRVPSFAFSIYIKSTQKKI
DIQVLTQLGVPKGDIWGHLKRGYDVEFEGRILKSQDFIKIQNQQIHAIIGGDNDRPELLADACKDAQLLIHEATYLQTVL
DKVGKGPMHSSAKMVAEFAEQQSLDNLILTHFSPRHQDKTGQQAITEEVRQFYKGHFYLANDFDEFTLNETGQLLKIE

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=324, Percent_Identity=32.7160493827161, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI87082078, Length=311, Percent_Identity=30.8681672025724, Blast_Score=147, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24652403, Length=279, Percent_Identity=26.8817204301075, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 35786; Mature: 35786

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHFTFLGTSSGVPTLSRNVSGLAVRNSKNKDWILVDAGEGTQHRIQQARLSLQNLIAIC
CEEEEEEECCCCCCHHHCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
ITHVHGDHCYGLVGLLASAGMNARSKPLIVIAPKEIQQWFEITAQLTDLHLPYSIKFIDV
HHHCCCCHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHEEECCEEEEEEEC
NEATRPQQLTDELFIQAHPLSHRVPSFAFSIYIKSTQKKIDIQVLTQLGVPKGDIWGHLK
CCCCCCHHHHHHHEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHH
RGYDVEFEGRILKSQDFIKIQNQQIHAIIGGDNDRPELLADACKDAQLLIHEATYLQTVL
CCCCEEECCEEECCCCEEEECCCEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
DKVGKGPMHSSAKMVAEFAEQQSLDNLILTHFSPRHQDKTGQQAITEEVRQFYKGHFYLA
HHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEE
NDFDEFTLNETGQLLKIE
CCCCCCCCCCCCCEEEEC
>Mature Secondary Structure
MLHFTFLGTSSGVPTLSRNVSGLAVRNSKNKDWILVDAGEGTQHRIQQARLSLQNLIAIC
CEEEEEEECCCCCCHHHCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
ITHVHGDHCYGLVGLLASAGMNARSKPLIVIAPKEIQQWFEITAQLTDLHLPYSIKFIDV
HHHCCCCHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHEEECCEEEEEEEC
NEATRPQQLTDELFIQAHPLSHRVPSFAFSIYIKSTQKKIDIQVLTQLGVPKGDIWGHLK
CCCCCCHHHHHHHEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHH
RGYDVEFEGRILKSQDFIKIQNQQIHAIIGGDNDRPELLADACKDAQLLIHEATYLQTVL
CCCCEEECCEEECCCCEEEECCCEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
DKVGKGPMHSSAKMVAEFAEQQSLDNLILTHFSPRHQDKTGQQAITEEVRQFYKGHFYLA
HHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEE
NDFDEFTLNETGQLLKIE
CCCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA