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The map label for this gene is pyrD

Identifier: 213158655

GI number: 213158655

Start: 2702053

End: 2703057

Strand: Reverse

Name: pyrD

Synonym: AB57_2609

Alternate gene names: 213158655

Gene position: 2703057-2702053 (Counterclockwise)

Preceding gene: 213158656

Following gene: 213158654

Centisome position: 66.73

GC content: 39.2

Gene sequence:

>1005_bases
ATGTTATATTCACTTGCTCGCCCGATGTTGTTTAGTTTAGCACCAGAGCGTGCCCATGAATTAACATTATCCATGCTTGA
TAAAGCGCATAAGCTAGGCATGATGCGCCAGACCGTAGAAGCGAAGCCAACTACATGTATGGGAATCGAATTTCCTAATC
CGGTAGGGTTGGCAGCCGGTCTAGATAAAAATGGTGCTCATATTGATGCATTAGCTGGGTTGGGTTTCGGCTTCATTGAA
ATTGGTACAATTACACCTCGCCCGCAATCTGGTAACCCAAAACCACGTTTATTCCGTATTCCTGAAGCTAAAGCTATTAT
TAACCGTATGGGTTTTAATAATGATGGCGTTGATAAGCTAATCGAGAATGTTAAAGCATCAAAATTTAGAGGCATTTTAG
GTATTAATATTGGTAAAAATGCTGATACACCTGTCGAAAAAGCCGTTGATGATTATTTGATTTGTCTTGAGAAAGTTTAT
AACTACGCTTCATACATTACGGTTAATATTTCGTCTCCAAATACTAAAAATTTGCGTAGTTTGCAAAGTGGTGATGCATT
AACTGAATTATTGCAAACCTTAAAAGCACGTCAACTTGAGTTGGCAGAGCAATATAATCACTATGTACCTTTAGTTCTTA
AAGTCGCTCCAGACTTAACAGCTGAAGATGTTGAATTTATTTCGGCACAATTATTAGATTTTAAAATTGATGGTCTTATT
GTGACGAACACGACCTTATCGAGAGAAGGGGTAGAGAACCTGCCTTACGGTAATGAGTCAGGTGGTTTGTCGGGTGCACC
TGTATTTGAAAAAAGTACGGAATGTTTACGTTTATTTGCTCAAACATTAAAAGGACAAATTCCTTTAATTGGTGTGGGCG
GAATTTTGTCGGGTGAACAAGCTGCAGCGAAACAACAGGCTGGAGCAACGCTTGTACAAATTTATAGTGGTCTGATTTAT
ACGGGACCAACGCTTGTGAAGCAATGTGTTGAAGCCATGACTTAA

Upstream 100 bases:

>100_bases
CAGTTCAATAACATATCAAAATATGCTTGTGTCAAGCATGGTGTTTTGTGCTGCCTGTGCCTATAATATGCGTACCTAAA
ATCAGTAGACTGTGATTGGT

Downstream 100 bases:

>100_bases
TTGAACATGAACACCATTGATATCATCATTCTGATACTTTTGCTCATTGGGGGGCTAAACGGTTTGCGACAAGGATTTAT
AAAAGCCTTTGCGAACTTGG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MLYSLARPMLFSLAPERAHELTLSMLDKAHKLGMMRQTVEAKPTTCMGIEFPNPVGLAAGLDKNGAHIDALAGLGFGFIE
IGTITPRPQSGNPKPRLFRIPEAKAIINRMGFNNDGVDKLIENVKASKFRGILGINIGKNADTPVEKAVDDYLICLEKVY
NYASYITVNISSPNTKNLRSLQSGDALTELLQTLKARQLELAEQYNHYVPLVLKVAPDLTAEDVEFISAQLLDFKIDGLI
VTNTTLSREGVENLPYGNESGGLSGAPVFEKSTECLRLFAQTLKGQIPLIGVGGILSGEQAAAKQQAGATLVQIYSGLIY
TGPTLVKQCVEAMT

Sequences:

>Translated_334_residues
MLYSLARPMLFSLAPERAHELTLSMLDKAHKLGMMRQTVEAKPTTCMGIEFPNPVGLAAGLDKNGAHIDALAGLGFGFIE
IGTITPRPQSGNPKPRLFRIPEAKAIINRMGFNNDGVDKLIENVKASKFRGILGINIGKNADTPVEKAVDDYLICLEKVY
NYASYITVNISSPNTKNLRSLQSGDALTELLQTLKARQLELAEQYNHYVPLVLKVAPDLTAEDVEFISAQLLDFKIDGLI
VTNTTLSREGVENLPYGNESGGLSGAPVFEKSTECLRLFAQTLKGQIPLIGVGGILSGEQAAAKQQAGATLVQIYSGLIY
TGPTLVKQCVEAMT
>Mature_334_residues
MLYSLARPMLFSLAPERAHELTLSMLDKAHKLGMMRQTVEAKPTTCMGIEFPNPVGLAAGLDKNGAHIDALAGLGFGFIE
IGTITPRPQSGNPKPRLFRIPEAKAIINRMGFNNDGVDKLIENVKASKFRGILGINIGKNADTPVEKAVDDYLICLEKVY
NYASYITVNISSPNTKNLRSLQSGDALTELLQTLKARQLELAEQYNHYVPLVLKVAPDLTAEDVEFISAQLLDFKIDGLI
VTNTTLSREGVENLPYGNESGGLSGAPVFEKSTECLRLFAQTLKGQIPLIGVGGILSGEQAAAKQQAGATLVQIYSGLIY
TGPTLVKQCVEAMT

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=337, Percent_Identity=41.839762611276, Blast_Score=239, Evalue=3e-63,
Organism=Escherichia coli, GI1787177, Length=333, Percent_Identity=54.954954954955, Blast_Score=369, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17509475, Length=305, Percent_Identity=42.6229508196721, Blast_Score=224, Evalue=4e-59,
Organism=Drosophila melanogaster, GI281361352, Length=335, Percent_Identity=41.7910447761194, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI17137316, Length=335, Percent_Identity=41.7910447761194, Blast_Score=251, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_ACIB3 (B7GZW7)

Other databases:

- EMBL:   CP001172
- RefSeq:   YP_002325094.1
- ProteinModelPortal:   B7GZW7
- SMR:   B7GZW7
- GeneID:   7057397
- GenomeReviews:   CP001172_GR
- KEGG:   abb:ABBFA_001187
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- ProtClustDB:   PRK05286
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 36093; Mature: 36093

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYSLARPMLFSLAPERAHELTLSMLDKAHKLGMMRQTVEAKPTTCMGIEFPNPVGLAAG
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
LDKNGAHIDALAGLGFGFIEIGTITPRPQSGNPKPRLFRIPEAKAIINRMGFNNDGVDKL
CCCCCCEEHHHHHCCCCEEEECCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCHHHH
IENVKASKFRGILGINIGKNADTPVEKAVDDYLICLEKVYNYASYITVNISSPNTKNLRS
HHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHH
LQSGDALTELLQTLKARQLELAEQYNHYVPLVLKVAPDLTAEDVEFISAQLLDFKIDGLI
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHEEEECCEE
VTNTTLSREGVENLPYGNESGGLSGAPVFEKSTECLRLFAQTLKGQIPLIGVGGILSGEQ
EECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHH
AAAKQQAGATLVQIYSGLIYTGPTLVKQCVEAMT
HHHHHHHCHHHHHHHHCHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MLYSLARPMLFSLAPERAHELTLSMLDKAHKLGMMRQTVEAKPTTCMGIEFPNPVGLAAG
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
LDKNGAHIDALAGLGFGFIEIGTITPRPQSGNPKPRLFRIPEAKAIINRMGFNNDGVDKL
CCCCCCEEHHHHHCCCCEEEECCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCHHHH
IENVKASKFRGILGINIGKNADTPVEKAVDDYLICLEKVYNYASYITVNISSPNTKNLRS
HHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHH
LQSGDALTELLQTLKARQLELAEQYNHYVPLVLKVAPDLTAEDVEFISAQLLDFKIDGLI
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHEEEECCEE
VTNTTLSREGVENLPYGNESGGLSGAPVFEKSTECLRLFAQTLKGQIPLIGVGGILSGEQ
EECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHH
AAAKQQAGATLVQIYSGLIYTGPTLVKQCVEAMT
HHHHHHHCHHHHHHHHCHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA