Click here to switch to the map view.

The map label for this gene is cusR [H]

Identifier: 213158589

GI number: 213158589

Start: 2635517

End: 2636212

Strand: Direct

Name: cusR [H]

Synonym: AB57_2543

Alternate gene names: 213158589

Gene position: 2635517-2636212 (Clockwise)

Preceding gene: 213158587

Following gene: 213158598

Centisome position: 65.07

GC content: 39.8

Gene sequence:

>696_bases
ATGGGTAATCACTTTATCCTCATGGTTGAGGACCATTTTGAACTTGCAGCAACGGTCTGCGAATTTCTTGAAGTGCATGG
TTATGTTGTCGATCATGCACGTAATTTAGAGGCTGCACGGACTTTTCTCAAATCTCAGCATTATCATCTTTTGTTGCTAG
ATATAAATTTGCCCGATGGCTCGGGTTATGACCTATGCAACTGGCTACGCACCGAACAAGGCGTTGATATTCCTGTTCTT
ATGCTCACAGCAAGAGATACTTTAGATGACAAACTTAAAGGTTTTACCGCTGGAACAGATGATTATTTGGTAAAACCTTT
TGATTTTAATGAACTAGTGATGCGGATTCGTGCATTAATAAAAAGAGCAGCTGGCGAAGTCACTCACCATAAAATTCAAA
TTCACGACTTAATTCTTGATAGCGCAACTCAAACCGTGGTTCGTGCTGGAAATAATATCGAGTTACCCCCTATTCAATTC
AAACTATTAAAAATTTTGATGCGCCAGTCTCCAAAAGTGGTGACCAAGCAAGAACTGATGATGGAATTATGGGGCGACGA
AGAGCCTGAAAGTGATGCGTTACGCAGTCATATCTATAACTTAAGAAAAATGGTTGATAAACCTTTTGACCCAAAGCTAT
TACATACAGTGGCAGGTGTTGGTTTAAAAATTGCTTTGGAAGATTCCGCGACTTAA

Upstream 100 bases:

>100_bases
ATCCGAATGCAAATCAATATTTTAAAATCTGGTTTGGTAGTGAACCGTTTAATGCTAAATTAAAACAACAATTATTAAAT
TAATGGCTTAATAAAATCTC

Downstream 100 bases:

>100_bases
CTTAAATAGACCACAACAATTAAGCCTGTGGTTGGCTCCAAATCGAGTTCAGGATGAGTGGTTAAATAATATTGTCGATC
AAACAGCTCCACTCTCCATC

Product: two-component system response regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MGNHFILMVEDHFELAATVCEFLEVHGYVVDHARNLEAARTFLKSQHYHLLLLDINLPDGSGYDLCNWLRTEQGVDIPVL
MLTARDTLDDKLKGFTAGTDDYLVKPFDFNELVMRIRALIKRAAGEVTHHKIQIHDLILDSATQTVVRAGNNIELPPIQF
KLLKILMRQSPKVVTKQELMMELWGDEEPESDALRSHIYNLRKMVDKPFDPKLLHTVAGVGLKIALEDSAT

Sequences:

>Translated_231_residues
MGNHFILMVEDHFELAATVCEFLEVHGYVVDHARNLEAARTFLKSQHYHLLLLDINLPDGSGYDLCNWLRTEQGVDIPVL
MLTARDTLDDKLKGFTAGTDDYLVKPFDFNELVMRIRALIKRAAGEVTHHKIQIHDLILDSATQTVVRAGNNIELPPIQF
KLLKILMRQSPKVVTKQELMMELWGDEEPESDALRSHIYNLRKMVDKPFDPKLLHTVAGVGLKIALEDSAT
>Mature_230_residues
GNHFILMVEDHFELAATVCEFLEVHGYVVDHARNLEAARTFLKSQHYHLLLLDINLPDGSGYDLCNWLRTEQGVDIPVLM
LTARDTLDDKLKGFTAGTDDYLVKPFDFNELVMRIRALIKRAAGEVTHHKIQIHDLILDSATQTVVRAGNNIELPPIQFK
LLKILMRQSPKVVTKQELMMELWGDEEPESDALRSHIYNLRKMVDKPFDPKLLHTVAGVGLKIALEDSAT

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=34.2222222222222, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=33.4841628959276, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=33.7837837837838, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1790552, Length=217, Percent_Identity=35.9447004608295, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=32.1266968325792, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=32.1428571428571, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=31.2775330396476, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787375, Length=217, Percent_Identity=29.9539170506912, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=29.4642857142857, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=29.3859649122807, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=33.7777777777778, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=28.5106382978723, Blast_Score=87, Evalue=6e-19,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=27.1929824561404, Blast_Score=80, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26252; Mature: 26121

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNHFILMVEDHFELAATVCEFLEVHGYVVDHARNLEAARTFLKSQHYHLLLLDINLPDG
CCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEEECCCC
SGYDLCNWLRTEQGVDIPVLMLTARDTLDDKLKGFTAGTDDYLVKPFDFNELVMRIRALI
CCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHH
KRAAGEVTHHKIQIHDLILDSATQTVVRAGNNIELPPIQFKLLKILMRQSPKVVTKQELM
HHHHCHHHHHEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHH
MELWGDEEPESDALRSHIYNLRKMVDKPFDPKLLHTVAGVGLKIALEDSAT
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCCC
>Mature Secondary Structure 
GNHFILMVEDHFELAATVCEFLEVHGYVVDHARNLEAARTFLKSQHYHLLLLDINLPDG
CCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEEECCCC
SGYDLCNWLRTEQGVDIPVLMLTARDTLDDKLKGFTAGTDDYLVKPFDFNELVMRIRALI
CCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHH
KRAAGEVTHHKIQIHDLILDSATQTVVRAGNNIELPPIQFKLLKILMRQSPKVVTKQELM
HHHHCHHHHHEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHH
MELWGDEEPESDALRSHIYNLRKMVDKPFDPKLLHTVAGVGLKIALEDSAT
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]