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The map label for this gene is moaC [H]

Identifier: 213158397

GI number: 213158397

Start: 2425268

End: 2426191

Strand: Reverse

Name: moaC [H]

Synonym: AB57_2345

Alternate gene names: 213158397

Gene position: 2426191-2425268 (Counterclockwise)

Preceding gene: 213158398

Following gene: 213158396

Centisome position: 59.9

GC content: 43.07

Gene sequence:

>924_bases
ATGAAAAACGTAGGAATGAAGCCGGAAAGTTATCGTGTTGCTGAAGCACAAGCGATTTTATATGCACCACCACACTGTAT
TGAATTATTAAGACAAGGAAATACCGAAAAAGGGGATGCATTAAAAACCGCACGTGTAGCAGGAATCTTGGCAGCAAAAC
GAACTGATGAGCTGATTCCTTTGTGTCATCCACTGCCGATTTATCGTGCAGATGTTGAATATGAATTAGAACATGATTTT
GTAAAGATTATTACCGTGGTGGAAACCATTGGTCCAACTGGCGTAGAAATGGAAGCCTTAACGGCTGCAAGTCTTGCAGG
GTTAACCATTTACGACATGTTAAAACCGCATTGTGAACCAGAAGAACTCTGGATGGATCAATGTAAATTGCTTAAGAAAA
AAGGTGGCAAATCACACTTTAAGCGAGTTCTTCGTCAGCCTGTTTCGGCTGCTGTTATTGTGTTGTCAGACACCGTAGCA
GCAGGTAGAAAGCCCGATACTGCCGGAAAATCTGTGGTTGAAACTTTAACCGAGGCAGGATTTGATCCAATTCATTACCA
AATTTTGCCAGATGAAGCGGATACTTTGAAAAACTTAGTGCTTGAGTTGAGCAAATCATATGCTTGCATTATGACCGTGG
GTGGGACAGGAATTGGTAAGCGTGACATTACAGTTGATACGCTAGAGCCTCTTTTAGAACGTAAATTAGATGGCTTAATG
GAAGCTGCTCGCTCATTTGGACAAAAACGCACGCCATATGCTGCTATGTCACGCGGAGTAGCAGGGTTTATTGACCGTTC
GTTAGTAGTGACGTTACCGGGAAGCCGTGGTGGAGCAAGCGAATCAATGGCCGCTATTTTACCCGCATTAGTCCATATTT
TTGATGTTTGCCGTGATTTACCGCATCCAGGAGGCTATGAATAA

Upstream 100 bases:

>100_bases
AGGGCTGTTGTATTCGTAAGGATGCACCGCACGACCACAAACATCACCATCATACCGGCCATGAACACTCACACTGAAAT
AAGCAAGACTAGGATAAATA

Downstream 100 bases:

>100_bases
TGTCAGGTTGTGGTGCTGAGCGTGGATTAATCAGTATAGATGAAGCGCTAGATTTAGTTATTAATAAGCCTAAAAACTTA
AGCTCTATTCAAAAGACTCT

Product: bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA

Products: NA

Alternate protein names: Molybdenum cofactor biosynthesis protein C; Molybdenum cofactor biosynthesis protein B [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYELEHDF
VKIITVVETIGPTGVEMEALTAASLAGLTIYDMLKPHCEPEELWMDQCKLLKKKGGKSHFKRVLRQPVSAAVIVLSDTVA
AGRKPDTAGKSVVETLTEAGFDPIHYQILPDEADTLKNLVLELSKSYACIMTVGGTGIGKRDITVDTLEPLLERKLDGLM
EAARSFGQKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAILPALVHIFDVCRDLPHPGGYE

Sequences:

>Translated_307_residues
MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYELEHDF
VKIITVVETIGPTGVEMEALTAASLAGLTIYDMLKPHCEPEELWMDQCKLLKKKGGKSHFKRVLRQPVSAAVIVLSDTVA
AGRKPDTAGKSVVETLTEAGFDPIHYQILPDEADTLKNLVLELSKSYACIMTVGGTGIGKRDITVDTLEPLLERKLDGLM
EAARSFGQKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAILPALVHIFDVCRDLPHPGGYE
>Mature_307_residues
MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYELEHDF
VKIITVVETIGPTGVEMEALTAASLAGLTIYDMLKPHCEPEELWMDQCKLLKKKGGKSHFKRVLRQPVSAAVIVLSDTVA
AGRKPDTAGKSVVETLTEAGFDPIHYQILPDEADTLKNLVLELSKSYACIMTVGGTGIGKRDITVDTLEPLLERKLDGLM
EAARSFGQKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAILPALVHIFDVCRDLPHPGGYE

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=157, Percent_Identity=31.8471337579618, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI66932975, Length=157, Percent_Identity=31.8471337579618, Blast_Score=81, Evalue=9e-16,
Organism=Escherichia coli, GI1787001, Length=140, Percent_Identity=47.1428571428571, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786190, Length=139, Percent_Identity=27.3381294964029, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI32566331, Length=140, Percent_Identity=35, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17564954, Length=153, Percent_Identity=30.0653594771242, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574492, Length=144, Percent_Identity=41.6666666666667, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28574490, Length=144, Percent_Identity=41.6666666666667, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17136978, Length=157, Percent_Identity=31.2101910828025, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24638841, Length=157, Percent_Identity=31.2101910828025, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR020817
- InterPro:   IPR012247
- InterPro:   IPR001453
- InterPro:   IPR002820 [H]

Pfam domain/function: PF01967 MoaC; PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 33332; Mature: 33332

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIP
CCCCCCCCCCCCHHHHCEEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
LCHPLPIYRADVEYELEHDFVKIITVVETIGPTGVEMEALTAASLAGLTIYDMLKPHCEP
CCCCCCCEECCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
EELWMDQCKLLKKKGGKSHFKRVLRQPVSAAVIVLSDTVAAGRKPDTAGKSVVETLTEAG
HHHHHHHHHHHHHCCCHHHHHHHHHCCHHHEEEEEECHHHCCCCCCCHHHHHHHHHHHCC
FDPIHYQILPDEADTLKNLVLELSKSYACIMTVGGTGIGKRDITVDTLEPLLERKLDGLM
CCCEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
EAARSFGQKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAILPALVHIFDVCRDL
HHHHHHCCCCCCHHHHHCCHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
PHPGGYE
CCCCCCC
>Mature Secondary Structure
MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIP
CCCCCCCCCCCCHHHHCEEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
LCHPLPIYRADVEYELEHDFVKIITVVETIGPTGVEMEALTAASLAGLTIYDMLKPHCEP
CCCCCCCEECCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
EELWMDQCKLLKKKGGKSHFKRVLRQPVSAAVIVLSDTVAAGRKPDTAGKSVVETLTEAG
HHHHHHHHHHHHHCCCHHHHHHHHHCCHHHEEEEEECHHHCCCCCCCHHHHHHHHHHHCC
FDPIHYQILPDEADTLKNLVLELSKSYACIMTVGGTGIGKRDITVDTLEPLLERKLDGLM
CCCEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
EAARSFGQKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAILPALVHIFDVCRDL
HHHHHHCCCCCCHHHHHCCHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
PHPGGYE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]