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The map label for this gene is dxr [H]

Identifier: 213158370

GI number: 213158370

Start: 2401016

End: 2402212

Strand: Reverse

Name: dxr [H]

Synonym: AB57_2316

Alternate gene names: 213158370

Gene position: 2402212-2401016 (Counterclockwise)

Preceding gene: 213158371

Following gene: 213158369

Centisome position: 59.31

GC content: 39.1

Gene sequence:

>1197_bases
ATGACACAATCTGTTTGCATATTGGGTGTAACCGGTTCTATTGGACGAAGTACCTTAAAAATTTTAGGTCAACATCCAGA
TAAGTATTCAGTCTTTGCAGTTTCGGCGCATAGTCGAATTTCTGAACTTGTTGAAATCTGCAAACAGTTTCGACCTAAAG
TTGTTGTTGTTCCTGAACAGAAAATAGCTGAACTAAAAACACTATTTGCTCAGCAAAATATATCGGATATTGATGTTTTA
GCTGGGCAAGAGGGTTTAGTCGATATCGCATCTCATACAGATGTGGATATTGTTATGGCTGCAATTGTAGGGGCAGCTGG
GCTGTTGCCAACTTTAGCGGCTGTTAAGGCAGGTAAAAGAGTACTACTTGCCAACAAAGAAGCATTAGTTATGTCTGGTG
AAATCATGATGCAAGCTGCTCGTGATCATCAGGCATTGTTATTGCCAGTTGATTCGGAACATAATGCAATTTTCCAATCA
TTGCCTCATAATTATTTACAAGCAGATAGAACAGGGCAACCACAGCTAGGTGTATCTAAAATATTGCTTACAGCATCTGG
TGGTCCTTTTTTAAATCATTCCCTAGAACAATTGGTTCATGTAACACCGCAACAAGCATGTAAACATCCAAACTGGTCAA
TGGGACAAAAAATTTCGGTTGACTCGGCTACTCTTATGAATAAAGGGTTAGAGTTAATTGAGGCTTGTCATTTATTTTCA
ATATCTGAACATTTTGTTACAGTTGTTGTTCATCCACAAAGTATCATTCACTCTATGGTGCAGTATGTTGATGGCTCAAC
ATTAGCACAAATGGGTAACCCGGATATGTGTACTCCGATTGCACATGCATTGGCATGGCCTGAGCGTTTACAAACTAATG
TTCCTGCTTTAGATTTATTTGAGTATTCTCAACTTAATTTTCAGGCACCGGATACCCAAAAATTTCCTGCATTAAATTTG
GCTAGACAAGCAATGCGTGCGGGAGGTTTGGCACCAACCATTTTGAATGCAGCTAATGAAATTGCAGTTGAAGCATTCTT
AATGGAAAGGATTGGATTTACAAGTATTCCGCAAGTGGTAGAGCATACTTTGGAAAAATTAGAGAATGCAGCGGCTGAAA
GCATCGAGTGCATTTTAGATAAAGATAAAGTGGCCCGATCTGTAGCTCAGCAATATATATCAAGTATTGGAGGCTGA

Upstream 100 bases:

>100_bases
TCATGGTGGTGTATTGGACCGTATTGATTCTTTACTCGCAGCAGCCCCGATTTTTGCAACGGGAATGTATATATTAAAGC
TTATTGGTGTAGATTTATAG

Downstream 100 bases:

>100_bases
AATGAATGCACTGTTTATGATTGCAGCGGCAGCTCTTTTACTTGGGCCTCTAATTGCAATCCATGAGTTTGGCCATTACT
GGGTTGCGCGAAAACTTGGT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTQSVCILGVTGSIGRSTLKILGQHPDKYSVFAVSAHSRISELVEICKQFRPKVVVVPEQKIAELKTLFAQQNISDIDVL
AGQEGLVDIASHTDVDIVMAAIVGAAGLLPTLAAVKAGKRVLLANKEALVMSGEIMMQAARDHQALLLPVDSEHNAIFQS
LPHNYLQADRTGQPQLGVSKILLTASGGPFLNHSLEQLVHVTPQQACKHPNWSMGQKISVDSATLMNKGLELIEACHLFS
ISEHFVTVVVHPQSIIHSMVQYVDGSTLAQMGNPDMCTPIAHALAWPERLQTNVPALDLFEYSQLNFQAPDTQKFPALNL
ARQAMRAGGLAPTILNAANEIAVEAFLMERIGFTSIPQVVEHTLEKLENAAAESIECILDKDKVARSVAQQYISSIGG

Sequences:

>Translated_398_residues
MTQSVCILGVTGSIGRSTLKILGQHPDKYSVFAVSAHSRISELVEICKQFRPKVVVVPEQKIAELKTLFAQQNISDIDVL
AGQEGLVDIASHTDVDIVMAAIVGAAGLLPTLAAVKAGKRVLLANKEALVMSGEIMMQAARDHQALLLPVDSEHNAIFQS
LPHNYLQADRTGQPQLGVSKILLTASGGPFLNHSLEQLVHVTPQQACKHPNWSMGQKISVDSATLMNKGLELIEACHLFS
ISEHFVTVVVHPQSIIHSMVQYVDGSTLAQMGNPDMCTPIAHALAWPERLQTNVPALDLFEYSQLNFQAPDTQKFPALNL
ARQAMRAGGLAPTILNAANEIAVEAFLMERIGFTSIPQVVEHTLEKLENAAAESIECILDKDKVARSVAQQYISSIGG
>Mature_397_residues
TQSVCILGVTGSIGRSTLKILGQHPDKYSVFAVSAHSRISELVEICKQFRPKVVVVPEQKIAELKTLFAQQNISDIDVLA
GQEGLVDIASHTDVDIVMAAIVGAAGLLPTLAAVKAGKRVLLANKEALVMSGEIMMQAARDHQALLLPVDSEHNAIFQSL
PHNYLQADRTGQPQLGVSKILLTASGGPFLNHSLEQLVHVTPQQACKHPNWSMGQKISVDSATLMNKGLELIEACHLFSI
SEHFVTVVVHPQSIIHSMVQYVDGSTLAQMGNPDMCTPIAHALAWPERLQTNVPALDLFEYSQLNFQAPDTQKFPALNLA
RQAMRAGGLAPTILNAANEIAVEAFLMERIGFTSIPQVVEHTLEKLENAAAESIECILDKDKVARSVAQQYISSIGG

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=395, Percent_Identity=51.6455696202532, Blast_Score=373, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 43022; Mature: 42891

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSVCILGVTGSIGRSTLKILGQHPDKYSVFAVSAHSRISELVEICKQFRPKVVVVPEQ
CCCCEEEEECCCCCCHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCEEEECHH
KIAELKTLFAQQNISDIDVLAGQEGLVDIASHTDVDIVMAAIVGAAGLLPTLAAVKAGKR
HHHHHHHHHHHCCCCHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCE
VLLANKEALVMSGEIMMQAARDHQALLLPVDSEHNAIFQSLPHNYLQADRTGQPQLGVSK
EEEECCCEEEEEHHHHHHHHCCCCEEEEEECCCCHHHHHHCCHHHHHCCCCCCCCCCCEE
ILLTASGGPFLNHSLEQLVHVTPQQACKHPNWSMGQKISVDSATLMNKGLELIEACHLFS
EEEEECCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHE
ISEHFVTVVVHPQSIIHSMVQYVDGSTLAQMGNPDMCTPIAHALAWPERLQTNVPALDLF
ECCCEEEEEECCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHCHHHHHCCCCCEEHE
EYSQLNFQAPDTQKFPALNLARQAMRAGGLAPTILNAANEIAVEAFLMERIGFTSIPQVV
HHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
EHTLEKLENAAAESIECILDKDKVARSVAQQYISSIGG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQSVCILGVTGSIGRSTLKILGQHPDKYSVFAVSAHSRISELVEICKQFRPKVVVVPEQ
CCCEEEEECCCCCCHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCEEEECHH
KIAELKTLFAQQNISDIDVLAGQEGLVDIASHTDVDIVMAAIVGAAGLLPTLAAVKAGKR
HHHHHHHHHHHCCCCHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCE
VLLANKEALVMSGEIMMQAARDHQALLLPVDSEHNAIFQSLPHNYLQADRTGQPQLGVSK
EEEECCCEEEEEHHHHHHHHCCCCEEEEEECCCCHHHHHHCCHHHHHCCCCCCCCCCCEE
ILLTASGGPFLNHSLEQLVHVTPQQACKHPNWSMGQKISVDSATLMNKGLELIEACHLFS
EEEEECCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHE
ISEHFVTVVVHPQSIIHSMVQYVDGSTLAQMGNPDMCTPIAHALAWPERLQTNVPALDLF
ECCCEEEEEECCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHCHHHHHCCCCCEEHE
EYSQLNFQAPDTQKFPALNLARQAMRAGGLAPTILNAANEIAVEAFLMERIGFTSIPQVV
HHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
EHTLEKLENAAAESIECILDKDKVARSVAQQYISSIGG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA