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The map label for this gene is groEL [H]

Identifier: 213158349

GI number: 213158349

Start: 3176051

End: 3177685

Strand: Reverse

Name: groEL [H]

Synonym: AB57_3079

Alternate gene names: 213158349

Gene position: 3177685-3176051 (Counterclockwise)

Preceding gene: 213158350

Following gene: 213158347

Centisome position: 78.45

GC content: 42.02

Gene sequence:

>1635_bases
ATGTCAGCTAAAGACGTAAAATTTGGTGATTCAGCTCGCTCAAAAATGATTGCAGGGGTAAACGTACTTGCAGATGCGGT
TAAAGTGACTTTAGGTCCTAAAGGCCGTAATGTTGTGATCGACCGCTCTTTCGGCGCGCCGCACATCACTAAAGACGGTG
TAACTGTTGCAAAAGAAATTTCATTAAAAGACAAGTTTGAAAACATGGGTGCTCAACTTGTTCGTGAAGTTTCAAGCAAA
ACTAACGACATCGCAGGTGACGGTACAACAACTGCAACTGTACTTGCTCAAGCAATTTTAAATGAAGGTATCAAATCAGT
AACTGCTGGTATGAACCCAATGGATTTAAAACGCGGTATCGACATTGCAGTAAAAACTGTAGTTGAAAATATCCGTTCTA
TTGCTAAACCAGCTGATGATTTCAAAGCAATTGAACAAGTAGGTTCAATCTCTGCTAACTCTGATACTACTGTTGGTAAA
CTTATTGCTCAAGCAATGGAAAAAGTAGGTAAAGAAGGCGTAATCACTGTAGAAGAAGGTTCTGGCTTCGAAGACGCATT
AGACGTTGTAGAAGGTATGCAGTTTGACCGTGGTTATATCTCTCCGTACTTTGCAAACAAACAAGATACTTTAACTGCTG
AACTTGAAAATCCGTTCATTCTTCTTGTTGATAAAAAAATCAGCAACATTCGTGAATTGATTTCTGTTTTAGAAGCAGTT
GCTAAAACTGGTAAACCACTTCTTATCATCGCTGAAGATGTTGAAGGTGAAGCGCTTGCAACTCTTGTTGTAAACAACAT
GCGCGGTATCATCAAAGTATGTGCTGTTAAAGCTCCTGGTTTCGGTGACCGTCGTAAAGCAATGCTTCAAGATATCGCGA
TCTTGACTGGCGCAACAGTTATTTCTGAAGAAGTTGGTATGTCTTTAGAACAAGCAACTCTTCAAGATTTAGGTACAGCG
CACAAAATCACTGTTTCTAAAGAAAACACAGTTATTGTTGACGGTGCTGGTGATGCTGCTGCTATCGCTGAGCGTGTTCA
ACAAATCCGTGCTCAAATCGAAGAGTCTACTTCAGAATATGACCGTGAAAAATTACAAGAACGTGTTGCTAAGTTAGCAG
GCGGTGTTGCTGTAATTAAAATCGGTGCAGCAACTGAAGTTGAAATGAAAGAGAAGAAAGACCGCGTAGACGACGCACTT
CACGCAACTCGTGCAGCAGTTGAAGAAGGTGTTGTTGCTGGTGGTGGTGTTGCTCTTGTTCGCGCTGTAAATGCTCTTGA
AGGCTTAAAAGGCGCTAACGAAGATCAAACAGCTGGTATCAACATTTTACGCCGTGCGATCGAAGCTCCACTTCGTCAAA
TCGTTGCGAATGCTGGTGATGAGCCATCTGTAGTTATCAACGCTGTTAAGAATGGTGAAGGTAACTTCGGTTACAACGCT
GCAACTGGCGAATATGGTGATATGTTAGAAATGGGTATCCTTGACCCAGCTAAAGTAACTCGTTCTGCACTTGAGCACGC
TGCTTCTGTTGCTGGCTTAATGTTAACTACAGAATGTATGATTACTGACATTCCTGAAGACAAACCAGCTGCTCCAGATA
TGGGCGGTATGGGTGGTATGGGCGGAATGATGTAA

Upstream 100 bases:

>100_bases
ATCATGAAAGAGTCAGACATCTTAGCTGTATTAGAAGGCTAATCGATCCATAACTCAATTCATTATCAGATTCAGTATTT
AAAAAGATTCGGAGTTTAAT

Downstream 100 bases:

>100_bases
TAACGCATCAACGCTTTAACCCAAAAAAATCCCTGCATTCGCAGGGATTTTTTTTATTTTTCCAGTAATTTTAAGGATAA
GTTAAGTTCAGAACCCTAAA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MSAKDVKFGDSARSKMIAGVNVLADAVKVTLGPKGRNVVIDRSFGAPHITKDGVTVAKEISLKDKFENMGAQLVREVSSK
TNDIAGDGTTTATVLAQAILNEGIKSVTAGMNPMDLKRGIDIAVKTVVENIRSIAKPADDFKAIEQVGSISANSDTTVGK
LIAQAMEKVGKEGVITVEEGSGFEDALDVVEGMQFDRGYISPYFANKQDTLTAELENPFILLVDKKISNIRELISVLEAV
AKTGKPLLIIAEDVEGEALATLVVNNMRGIIKVCAVKAPGFGDRRKAMLQDIAILTGATVISEEVGMSLEQATLQDLGTA
HKITVSKENTVIVDGAGDAAAIAERVQQIRAQIEESTSEYDREKLQERVAKLAGGVAVIKIGAATEVEMKEKKDRVDDAL
HATRAAVEEGVVAGGGVALVRAVNALEGLKGANEDQTAGINILRRAIEAPLRQIVANAGDEPSVVINAVKNGEGNFGYNA
ATGEYGDMLEMGILDPAKVTRSALEHAASVAGLMLTTECMITDIPEDKPAAPDMGGMGGMGGMM

Sequences:

>Translated_544_residues
MSAKDVKFGDSARSKMIAGVNVLADAVKVTLGPKGRNVVIDRSFGAPHITKDGVTVAKEISLKDKFENMGAQLVREVSSK
TNDIAGDGTTTATVLAQAILNEGIKSVTAGMNPMDLKRGIDIAVKTVVENIRSIAKPADDFKAIEQVGSISANSDTTVGK
LIAQAMEKVGKEGVITVEEGSGFEDALDVVEGMQFDRGYISPYFANKQDTLTAELENPFILLVDKKISNIRELISVLEAV
AKTGKPLLIIAEDVEGEALATLVVNNMRGIIKVCAVKAPGFGDRRKAMLQDIAILTGATVISEEVGMSLEQATLQDLGTA
HKITVSKENTVIVDGAGDAAAIAERVQQIRAQIEESTSEYDREKLQERVAKLAGGVAVIKIGAATEVEMKEKKDRVDDAL
HATRAAVEEGVVAGGGVALVRAVNALEGLKGANEDQTAGINILRRAIEAPLRQIVANAGDEPSVVINAVKNGEGNFGYNA
ATGEYGDMLEMGILDPAKVTRSALEHAASVAGLMLTTECMITDIPEDKPAAPDMGGMGGMGGMM
>Mature_543_residues
SAKDVKFGDSARSKMIAGVNVLADAVKVTLGPKGRNVVIDRSFGAPHITKDGVTVAKEISLKDKFENMGAQLVREVSSKT
NDIAGDGTTTATVLAQAILNEGIKSVTAGMNPMDLKRGIDIAVKTVVENIRSIAKPADDFKAIEQVGSISANSDTTVGKL
IAQAMEKVGKEGVITVEEGSGFEDALDVVEGMQFDRGYISPYFANKQDTLTAELENPFILLVDKKISNIRELISVLEAVA
KTGKPLLIIAEDVEGEALATLVVNNMRGIIKVCAVKAPGFGDRRKAMLQDIAILTGATVISEEVGMSLEQATLQDLGTAH
KITVSKENTVIVDGAGDAAAIAERVQQIRAQIEESTSEYDREKLQERVAKLAGGVAVIKIGAATEVEMKEKKDRVDDALH
ATRAAVEEGVVAGGGVALVRAVNALEGLKGANEDQTAGINILRRAIEAPLRQIVANAGDEPSVVINAVKNGEGNFGYNAA
TGEYGDMLEMGILDPAKVTRSALEHAASVAGLMLTTECMITDIPEDKPAAPDMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=50.4743833017078, Blast_Score=534, Evalue=1e-152,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=50.4743833017078, Blast_Score=534, Evalue=1e-152,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=75.4716981132076, Blast_Score=810, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=52.4621212121212, Blast_Score=553, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=52.8571428571429, Blast_Score=229, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=55.893536121673, Blast_Score=574, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6322524, Length=162, Percent_Identity=27.1604938271605, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=51.3307984790874, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=51.3307984790874, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=51.5267175572519, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=51.5267175572519, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=51.5267175572519, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI17864606, Length=542, Percent_Identity=43.9114391143911, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24584129, Length=533, Percent_Identity=38.0863039399625, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI19921262, Length=533, Percent_Identity=38.0863039399625, Blast_Score=345, Evalue=4e-95,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57167; Mature: 57036

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKDVKFGDSARSKMIAGVNVLADAVKVTLGPKGRNVVIDRSFGAPHITKDGVTVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCCHHHHHH
SLKDKFENMGAQLVREVSSKTNDIAGDGTTTATVLAQAILNEGIKSVTAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DIAVKTVVENIRSIAKPADDFKAIEQVGSISANSDTTVGKLIAQAMEKVGKEGVITVEEG
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC
SGFEDALDVVEGMQFDRGYISPYFANKQDTLTAELENPFILLVDKKISNIRELISVLEAV
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHHHHH
AKTGKPLLIIAEDVEGEALATLVVNNMRGIIKVCAVKAPGFGDRRKAMLQDIAILTGATV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
ISEEVGMSLEQATLQDLGTAHKITVSKENTVIVDGAGDAAAIAERVQQIRAQIEESTSEY
HHHHHCCHHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKIGAATEVEMKEKKDRVDDALHATRAAVEEGVVAGGGVALV
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAVNALEGLKGANEDQTAGINILRRAIEAPLRQIVANAGDEPSVVINAVKNGEGNFGYNA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
ATGEYGDMLEMGILDPAKVTRSALEHAASVAGLMLTTECMITDIPEDKPAAPDMGGMGGM
CCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCC
GGMM
CCCC
>Mature Secondary Structure 
SAKDVKFGDSARSKMIAGVNVLADAVKVTLGPKGRNVVIDRSFGAPHITKDGVTVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCCHHHHHH
SLKDKFENMGAQLVREVSSKTNDIAGDGTTTATVLAQAILNEGIKSVTAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DIAVKTVVENIRSIAKPADDFKAIEQVGSISANSDTTVGKLIAQAMEKVGKEGVITVEEG
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC
SGFEDALDVVEGMQFDRGYISPYFANKQDTLTAELENPFILLVDKKISNIRELISVLEAV
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHHHHH
AKTGKPLLIIAEDVEGEALATLVVNNMRGIIKVCAVKAPGFGDRRKAMLQDIAILTGATV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
ISEEVGMSLEQATLQDLGTAHKITVSKENTVIVDGAGDAAAIAERVQQIRAQIEESTSEY
HHHHHCCHHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKIGAATEVEMKEKKDRVDDALHATRAAVEEGVVAGGGVALV
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAVNALEGLKGANEDQTAGINILRRAIEAPLRQIVANAGDEPSVVINAVKNGEGNFGYNA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
ATGEYGDMLEMGILDPAKVTRSALEHAASVAGLMLTTECMITDIPEDKPAAPDMGGMGGM
CCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCC
GGMM
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA