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The map label for this gene is lysA [H]

Identifier: 213158317

GI number: 213158317

Start: 3138581

End: 3139831

Strand: Reverse

Name: lysA [H]

Synonym: AB57_3044

Alternate gene names: 213158317

Gene position: 3139831-3138581 (Counterclockwise)

Preceding gene: 213158318

Following gene: 213158316

Centisome position: 77.52

GC content: 39.01

Gene sequence:

>1251_bases
ATGAGTTTCACCCGCATTAATGGAGTATTGCATGCAGAGCAATGTTCTCTAGAGCAGCTTGCGCAGCAATTTGGCACACC
GTTATATGTTTATTCAAAAGCAGCTTTTGAAAAACATTATTTAGATATGGATCGTGCTTTTGACTTTATTGATCATCAAA
TCTGTTTTGCGGTGAAGTCGAACTCAAATATAGCTGTTCTTAATGTCTTGGCAAAACTTGGTGCGGGTTTTGACATTGTG
TCTGGTGGTGAGCTAGCACGTGTTTTAAAAGCAGGTGGCGATGCTTCTAAAATTGTTTTTTCAGGTTTAGGTAAAACTGA
AGCTGATATTGAAACGTCATTAAATGTAGGTATTGCCTGTTTTAATGTCGAGTCTTATGCAGAGTTGGACCGTATTCAAA
AAGTAGCAGCTCGCCTAGGCAAAAAAGCGCCTATTTCTTTACGTGTAAATCCTGATGTCGATGCAAAAACGCATCCTTAT
ATTTCAACAGGATTAAAAGAAAATAAATTTGGTATTCCAAGTGATGCAGTTTATGAAACTTATCAATATGCTGCATCTTT
ACCTAACCTTGAAATCGTAGGTATTGATTGCCACATTGGTTCACAGCTCACTGAAACTAAACCATTTGTTGATGCTTTAG
ACCGTGTCATTGTGATGATTGATGAGTTGAAAAAACTAGGCATTAATCTGAAACATATCGATATCGGTGGTGGTTTAGGG
GTTTGTTATAAAGATGAAACACCGCCAAGTGTTGAAGAATATGCAAACTCTATGAAGCCGGCTTTAGAAAAATTAGGCTT
GAAAGTTTATATGGAGCCAGGTCGTAGCATCAGTGCAAATGCAGGTGTACTTTTAACGAAAGTTGATTTGCTTAAACCAA
CGACGCATCGTAACTTCGCGATTATTGATGCAGCAATGAATGATTTAATTCGTCCTGCTTTATATGAAGCTTGGATGGAT
ATTCAACCTGTTGTACCACGTACAGATACCGAAGAAAAAACTTGGGATTTAGTTGGTGCAATTTGTGAGACAGGTGATTT
CATTGGTAAAGACCGCTCACTCGCATTACAAGAAAATGACTTGTTGACTGTACTGGGTGCCGGGGCTTATGGTTTTGTCA
TGAGCTCAAATTACAACACGCGTGGCCGTGCAGCAGAAGTCATGGTATCAGGTGAAAAAAGCTATTTAATTCGTGAACGT
GAAACGGTTGAGTCGCTTTGGGAAAAAGAACGTTTATTGCCTGAGGAGTAA

Upstream 100 bases:

>100_bases
CAAGTTGTGCAACAAGATGAACAGGCTGAACAGTCAGTCGAATCATCAGCAGCTCAACCACAAACTACATCACCTTAAGC
TTTGAAATAAGGACACCTTC

Downstream 100 bases:

>100_bases
ATGAGATGTTATTAGAATTTACCAAAATGCATGGTTTAGGCAATGATTTCATGGTGGTTGATCTAATTAGCCAAAGAGCT
TATTTAGATACTGCAACAAT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSFTRINGVLHAEQCSLEQLAQQFGTPLYVYSKAAFEKHYLDMDRAFDFIDHQICFAVKSNSNIAVLNVLAKLGAGFDIV
SGGELARVLKAGGDASKIVFSGLGKTEADIETSLNVGIACFNVESYAELDRIQKVAARLGKKAPISLRVNPDVDAKTHPY
ISTGLKENKFGIPSDAVYETYQYAASLPNLEIVGIDCHIGSQLTETKPFVDALDRVIVMIDELKKLGINLKHIDIGGGLG
VCYKDETPPSVEEYANSMKPALEKLGLKVYMEPGRSISANAGVLLTKVDLLKPTTHRNFAIIDAAMNDLIRPALYEAWMD
IQPVVPRTDTEEKTWDLVGAICETGDFIGKDRSLALQENDLLTVLGAGAYGFVMSSNYNTRGRAAEVMVSGEKSYLIRER
ETVESLWEKERLLPEE

Sequences:

>Translated_416_residues
MSFTRINGVLHAEQCSLEQLAQQFGTPLYVYSKAAFEKHYLDMDRAFDFIDHQICFAVKSNSNIAVLNVLAKLGAGFDIV
SGGELARVLKAGGDASKIVFSGLGKTEADIETSLNVGIACFNVESYAELDRIQKVAARLGKKAPISLRVNPDVDAKTHPY
ISTGLKENKFGIPSDAVYETYQYAASLPNLEIVGIDCHIGSQLTETKPFVDALDRVIVMIDELKKLGINLKHIDIGGGLG
VCYKDETPPSVEEYANSMKPALEKLGLKVYMEPGRSISANAGVLLTKVDLLKPTTHRNFAIIDAAMNDLIRPALYEAWMD
IQPVVPRTDTEEKTWDLVGAICETGDFIGKDRSLALQENDLLTVLGAGAYGFVMSSNYNTRGRAAEVMVSGEKSYLIRER
ETVESLWEKERLLPEE
>Mature_415_residues
SFTRINGVLHAEQCSLEQLAQQFGTPLYVYSKAAFEKHYLDMDRAFDFIDHQICFAVKSNSNIAVLNVLAKLGAGFDIVS
GGELARVLKAGGDASKIVFSGLGKTEADIETSLNVGIACFNVESYAELDRIQKVAARLGKKAPISLRVNPDVDAKTHPYI
STGLKENKFGIPSDAVYETYQYAASLPNLEIVGIDCHIGSQLTETKPFVDALDRVIVMIDELKKLGINLKHIDIGGGLGV
CYKDETPPSVEEYANSMKPALEKLGLKVYMEPGRSISANAGVLLTKVDLLKPTTHRNFAIIDAAMNDLIRPALYEAWMDI
QPVVPRTDTEEKTWDLVGAICETGDFIGKDRSLALQENDLLTVLGAGAYGFVMSSNYNTRGRAAEVMVSGEKSYLIRERE
TVESLWEKERLLPEE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=238, Percent_Identity=28.9915966386555, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI22538418, Length=238, Percent_Identity=27.3109243697479, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI21361583, Length=238, Percent_Identity=27.3109243697479, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789203, Length=421, Percent_Identity=31.1163895486936, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789307, Length=317, Percent_Identity=25.8675078864353, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562780, Length=362, Percent_Identity=23.7569060773481, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45693; Mature: 45562

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTRINGVLHAEQCSLEQLAQQFGTPLYVYSKAAFEKHYLDMDRAFDFIDHQICFAVKS
CCCCCCCCEEEHHHCCHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCCEEEEEEEC
NSNIAVLNVLAKLGAGFDIVSGGELARVLKAGGDASKIVFSGLGKTEADIETSLNVGIAC
CCCCHHHHHHHHHCCCCEEECCHHHHHHHHCCCCHHHHHEECCCCCCCCHHHCCCCCEEE
FNVESYAELDRIQKVAARLGKKAPISLRVNPDVDAKTHPYISTGLKENKFGIPSDAVYET
ECCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCCCHHHHHH
YQYAASLPNLEIVGIDCHIGSQLTETKPFVDALDRVIVMIDELKKLGINLKHIDIGGGLG
HHHHHCCCCEEEEEEEEECCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEE
VCYKDETPPSVEEYANSMKPALEKLGLKVYMEPGRSISANAGVLLTKVDLLKPTTHRNFA
EEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEHHCCCCCCCCEE
IIDAAMNDLIRPALYEAWMDIQPVVPRTDTEEKTWDLVGAICETGDFIGKDRSLALQEND
EEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCC
LLTVLGAGAYGFVMSSNYNTRGRAAEVMVSGEKSYLIRERETVESLWEKERLLPEE
EEEEEECCEEEEEEECCCCCCCCEEEEEEECCHHEEEHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SFTRINGVLHAEQCSLEQLAQQFGTPLYVYSKAAFEKHYLDMDRAFDFIDHQICFAVKS
CCCCCCCEEEHHHCCHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCCEEEEEEEC
NSNIAVLNVLAKLGAGFDIVSGGELARVLKAGGDASKIVFSGLGKTEADIETSLNVGIAC
CCCCHHHHHHHHHCCCCEEECCHHHHHHHHCCCCHHHHHEECCCCCCCCHHHCCCCCEEE
FNVESYAELDRIQKVAARLGKKAPISLRVNPDVDAKTHPYISTGLKENKFGIPSDAVYET
ECCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCCCHHHHHH
YQYAASLPNLEIVGIDCHIGSQLTETKPFVDALDRVIVMIDELKKLGINLKHIDIGGGLG
HHHHHCCCCEEEEEEEEECCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEE
VCYKDETPPSVEEYANSMKPALEKLGLKVYMEPGRSISANAGVLLTKVDLLKPTTHRNFA
EEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEHHCCCCCCCCEE
IIDAAMNDLIRPALYEAWMDIQPVVPRTDTEEKTWDLVGAICETGDFIGKDRSLALQEND
EEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCC
LLTVLGAGAYGFVMSSNYNTRGRAAEVMVSGEKSYLIRERETVESLWEKERLLPEE
EEEEEECCEEEEEEECCCCCCCCEEEEEEECCHHEEEHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]