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The map label for this gene is gap [H]

Identifier: 213158225

GI number: 213158225

Start: 3041015

End: 3042472

Strand: Reverse

Name: gap [H]

Synonym: AB57_2944

Alternate gene names: 213158225

Gene position: 3042472-3041015 (Counterclockwise)

Preceding gene: 213158226

Following gene: 213158224

Centisome position: 75.11

GC content: 39.57

Gene sequence:

>1458_bases
GTGAGCAAAGACACTATCATCGCCCTGCACGCTGAACACCAAGGCCGTTGGAAAAACCGTGAAGAAATCGCGGAACGTAT
GATTGCATTAATCGGTCAATTATACCGTGAAAAAAATATTGTCGTATCTGTTTACGGTCGCTCTTTAATTAACCGTTCTG
TTATTCAAATTTTGAAAACTCACCGTCGTACACGTGTTGTAGATGTTGAGCTTTCTGTAGTAAATACTTTCCCAATTTTA
GAAGCTTTAGCAAAAGTTGAAAATATCGGTTCTGCAGAAGTTGATATCGGTAAACTTGCAGTTGAATATAAAGAAAAAGG
CGGTGATGTTGACGCTTTTGTTGCTCAAGCTGTTGAGTCAATTAAAGGTAGCGCAACTTCTGAACAACCTAAAGATGTAG
TTCTTTACGGTTTTGGTCGTATTGGCCGTATCTTGGCTCGTTTAATCATTAGCCAATCAGGTTTAGGTCGTGGTTTAAGC
CTTAAAGCGATTGTTGTTCGTAAGTCTTCTGACGGTGACTTGGCTAAACGTGCTTCTTTACTTCGTCGTGACTCTATTCA
CGGTACTTTCGCTGGTACAATTTCTGTTGATGAAGAAAACGAAGCAATTATCGCTAACGGTAACTTCATCAAAGTAATCT
ATGCATCTAGCCCAAGCGAAGTAGACTATACTCAATACGGTATTGAAAACGCGCTTTTAATCGACAACACTGGTAAATGG
CGTGATGCTGAAGGCCTAAGCCAACACTTGAAATGCCCAGGTGTTGCACGTGTTGTATTAACTGCACCAAGTAAAGGCGA
AATGAAAAACGTTGTATTTGGTGTAAACAACTCTGACATTTTAGATGAAGACAAAATCATCTCTGCTGCAAGTTGTACAA
CAAATGCGATCACTCCAATTCTTAAAGTATTGGATGACAAATATAAAGTTCTTAATGGTCACGTTGAGACAGTTCACTCA
TTTACAAATGACCAGAACTTGATCGATAACTACCACAAAGCTGATCGTCGTGGTCGTGCTGCTACATTGAACATGGTTAT
TACTGAAACTGGTGCTGCTAAAGCTGTTGCTAAAGCATTGCCTGCGTTAAAAGGTAAGTTAACTGGTAACTCTGTACGTG
TTCCAACACCAAACGTATCTCTTGCGATTTTAAACTTAACGCTTGATAAAGAAGTTGATCGTGAAGAAGTGAACGAATAC
ATTCGTCAAATTTCGATCAACTCTAACCTTCAAGGTCAAATCGGTTATACCAACTCTACAGAAGTGGTATCAAGCGACTT
TATCGGTTCTCGTACTGCTGGTGTATATGATGCTCAAGCAACGATTACTTCTGGTAACCGCTTAACTGCATATGTTTGGT
ACGATAATGAAGTAGGTTATAGCTGCCAAGTATTACGTATTGCTGAGCAAATGTGTGGCGTAAGCTATAAAAAAATTCCT
GCAGAAACTAACGCTTAA

Upstream 100 bases:

>100_bases
CCACTAACGTCAGCTTTTGATTCATTCTTGCCAATAATTCCATTACAATTACGGGGTTTTAAAAATCACGCCTAGATATA
ATTAATTAGAGGACGTATCT

Downstream 100 bases:

>100_bases
TCTGTTTTAACGTTAGATAAAAGAATGTGACAAAAAGACCCAGTTTAGACTGGGTTTTTTTACAACCGTACAAAATATAT
GCTGATTATTTTTTAGAAAT

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSKDTIIALHAEHQGRWKNREEIAERMIALIGQLYREKNIVVSVYGRSLINRSVIQILKTHRRTRVVDVELSVVNTFPIL
EALAKVENIGSAEVDIGKLAVEYKEKGGDVDAFVAQAVESIKGSATSEQPKDVVLYGFGRIGRILARLIISQSGLGRGLS
LKAIVVRKSSDGDLAKRASLLRRDSIHGTFAGTISVDEENEAIIANGNFIKVIYASSPSEVDYTQYGIENALLIDNTGKW
RDAEGLSQHLKCPGVARVVLTAPSKGEMKNVVFGVNNSDILDEDKIISAASCTTNAITPILKVLDDKYKVLNGHVETVHS
FTNDQNLIDNYHKADRRGRAATLNMVITETGAAKAVAKALPALKGKLTGNSVRVPTPNVSLAILNLTLDKEVDREEVNEY
IRQISINSNLQGQIGYTNSTEVVSSDFIGSRTAGVYDAQATITSGNRLTAYVWYDNEVGYSCQVLRIAEQMCGVSYKKIP
AETNA

Sequences:

>Translated_485_residues
MSKDTIIALHAEHQGRWKNREEIAERMIALIGQLYREKNIVVSVYGRSLINRSVIQILKTHRRTRVVDVELSVVNTFPIL
EALAKVENIGSAEVDIGKLAVEYKEKGGDVDAFVAQAVESIKGSATSEQPKDVVLYGFGRIGRILARLIISQSGLGRGLS
LKAIVVRKSSDGDLAKRASLLRRDSIHGTFAGTISVDEENEAIIANGNFIKVIYASSPSEVDYTQYGIENALLIDNTGKW
RDAEGLSQHLKCPGVARVVLTAPSKGEMKNVVFGVNNSDILDEDKIISAASCTTNAITPILKVLDDKYKVLNGHVETVHS
FTNDQNLIDNYHKADRRGRAATLNMVITETGAAKAVAKALPALKGKLTGNSVRVPTPNVSLAILNLTLDKEVDREEVNEY
IRQISINSNLQGQIGYTNSTEVVSSDFIGSRTAGVYDAQATITSGNRLTAYVWYDNEVGYSCQVLRIAEQMCGVSYKKIP
AETNA
>Mature_484_residues
SKDTIIALHAEHQGRWKNREEIAERMIALIGQLYREKNIVVSVYGRSLINRSVIQILKTHRRTRVVDVELSVVNTFPILE
ALAKVENIGSAEVDIGKLAVEYKEKGGDVDAFVAQAVESIKGSATSEQPKDVVLYGFGRIGRILARLIISQSGLGRGLSL
KAIVVRKSSDGDLAKRASLLRRDSIHGTFAGTISVDEENEAIIANGNFIKVIYASSPSEVDYTQYGIENALLIDNTGKWR
DAEGLSQHLKCPGVARVVLTAPSKGEMKNVVFGVNNSDILDEDKIISAASCTTNAITPILKVLDDKYKVLNGHVETVHSF
TNDQNLIDNYHKADRRGRAATLNMVITETGAAKAVAKALPALKGKLTGNSVRVPTPNVSLAILNLTLDKEVDREEVNEYI
RQISINSNLQGQIGYTNSTEVVSSDFIGSRTAGVYDAQATITSGNRLTAYVWYDNEVGYSCQVLRIAEQMCGVSYKKIPA
ETNA

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=338, Percent_Identity=36.6863905325444, Blast_Score=192, Evalue=9e-49,
Organism=Homo sapiens, GI7657116, Length=338, Percent_Identity=34.0236686390533, Blast_Score=180, Evalue=3e-45,
Organism=Escherichia coli, GI1788079, Length=333, Percent_Identity=37.2372372372372, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1789295, Length=347, Percent_Identity=31.9884726224784, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17568413, Length=346, Percent_Identity=33.8150289017341, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI32566163, Length=337, Percent_Identity=33.8278931750742, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17534677, Length=337, Percent_Identity=32.6409495548961, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17534679, Length=337, Percent_Identity=32.6409495548961, Blast_Score=171, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6322468, Length=344, Percent_Identity=36.6279069767442, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6321631, Length=342, Percent_Identity=36.5497076023392, Blast_Score=199, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6322409, Length=344, Percent_Identity=36.6279069767442, Blast_Score=197, Evalue=3e-51,
Organism=Drosophila melanogaster, GI19922412, Length=335, Percent_Identity=37.3134328358209, Blast_Score=198, Evalue=8e-51,
Organism=Drosophila melanogaster, GI17933600, Length=337, Percent_Identity=36.2017804154303, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI18110149, Length=337, Percent_Identity=36.2017804154303, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI85725000, Length=337, Percent_Identity=36.2017804154303, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI22023983, Length=337, Percent_Identity=36.2017804154303, Blast_Score=196, Evalue=4e-50,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 52907; Mature: 52776

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKDTIIALHAEHQGRWKNREEIAERMIALIGQLYREKNIVVSVYGRSLINRSVIQILKT
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
HRRTRVVDVELSVVNTFPILEALAKVENIGSAEVDIGKLAVEYKEKGGDVDAFVAQAVES
CCCCEEEEEEEEEEHHHHHHHHHHHHHCCCCCCEEHHHEEEEEHHCCCCHHHHHHHHHHH
IKGSATSEQPKDVVLYGFGRIGRILARLIISQSGLGRGLSLKAIVVRKSSDGDLAKRASL
HCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCHHHHHHH
LRRDSIHGTFAGTISVDEENEAIIANGNFIKVIYASSPSEVDYTQYGIENALLIDNTGKW
HHHCCCCEEEEEEEEECCCCCEEEECCCEEEEEEECCCCCCCHHHHCCCCEEEEECCCCC
RDAEGLSQHLKCPGVARVVLTAPSKGEMKNVVFGVNNSDILDEDKIISAASCTTNAITPI
CCHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCCEEEHHCCCHHHHHHH
LKVLDDKYKVLNGHVETVHSFTNDQNLIDNYHKADRRGRAATLNMVITETGAAKAVAKAL
HHHHCCHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHH
PALKGKLTGNSVRVPTPNVSLAILNLTLDKEVDREEVNEYIRQISINSNLQGQIGYTNST
HHHHCCCCCCEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHEECCCCCCEEECCCCCC
EVVSSDFIGSRTAGVYDAQATITSGNRLTAYVWYDNEVGYSCQVLRIAEQMCGVSYKKIP
HHHHHCCCCCCCCCEEECEEEEECCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
AETNA
CCCCC
>Mature Secondary Structure 
SKDTIIALHAEHQGRWKNREEIAERMIALIGQLYREKNIVVSVYGRSLINRSVIQILKT
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
HRRTRVVDVELSVVNTFPILEALAKVENIGSAEVDIGKLAVEYKEKGGDVDAFVAQAVES
CCCCEEEEEEEEEEHHHHHHHHHHHHHCCCCCCEEHHHEEEEEHHCCCCHHHHHHHHHHH
IKGSATSEQPKDVVLYGFGRIGRILARLIISQSGLGRGLSLKAIVVRKSSDGDLAKRASL
HCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCHHHHHHH
LRRDSIHGTFAGTISVDEENEAIIANGNFIKVIYASSPSEVDYTQYGIENALLIDNTGKW
HHHCCCCEEEEEEEEECCCCCEEEECCCEEEEEEECCCCCCCHHHHCCCCEEEEECCCCC
RDAEGLSQHLKCPGVARVVLTAPSKGEMKNVVFGVNNSDILDEDKIISAASCTTNAITPI
CCHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCCEEEHHCCCHHHHHHH
LKVLDDKYKVLNGHVETVHSFTNDQNLIDNYHKADRRGRAATLNMVITETGAAKAVAKAL
HHHHCCHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHH
PALKGKLTGNSVRVPTPNVSLAILNLTLDKEVDREEVNEYIRQISINSNLQGQIGYTNST
HHHHCCCCCCEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHEECCCCCCEEECCCCCC
EVVSSDFIGSRTAGVYDAQATITSGNRLTAYVWYDNEVGYSCQVLRIAEQMCGVSYKKIP
HHHHHCCCCCCCCCEEECEEEEECCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
AETNA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8508805; 10360571; 2401296; 7877172 [H]