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The map label for this gene is wecB [H]

Identifier: 213158214

GI number: 213158214

Start: 3029429

End: 3030565

Strand: Reverse

Name: wecB [H]

Synonym: AB57_2933

Alternate gene names: 213158214

Gene position: 3030565-3029429 (Counterclockwise)

Preceding gene: 213158215

Following gene: 213158203

Centisome position: 74.82

GC content: 37.91

Gene sequence:

>1137_bases
ATGAAGAAAATTTTTATTTCAATTGTATTTGGTACTCGTCCAGAGCTCATAAAGTTGGCTCCGGTAATTTTATTAGCAAA
ACAAGACTCACGATTTCAGGTAGAAGTTATTTTTACAGGACAACATGATGAATTAGTTCGAGATGCGATAGATTTCTTTG
GGGTTGAAATTGATCATCGCCTTAAAATTATGAATGCTGGACAAAGCCTAAATCAGCTTTTAATTCATGGCTTAACGCAA
CTTGAAAATATTTACACAGATGGTCAAAAAAGAGATGCAATTGTTATTCAAGGTGATACTACAACCGTGTTAGCTGCTGG
GCTAGTTGCATTTTCAATGAAGATTCCTGTTGCCCATGTCGAAGCGGGTTTACGTTCTTATGATTTAGATCATCCATTTC
CTGAAGAAGGCAACCGCCAGTTAGTTTCTCGTATTACCAAATGGCATTTTGCCCCTACAGAACAATCAAAGCGTAACTTG
TTAAATGAGCAGATTCCACCTTCATTGATTACAGTGACAGGGAATACGGTAGTCGATGCTGTGTATTTAGGAAGGAAACT
CATAGCTGAAAAGACGGGTTTGAAAAATCAACTTGAGCCTTACGGAATTGAATTAAAACAAAATGATAAAGTTGTACTTA
TAACTGCTCACCGCCGTGAGAATTTTGGCGAAGGAATTCAGAATATTTGTAATGCTGTTGAGTATTTAGCAAAACATCAT
CCTGATTTACATTTTATTTGGCCTGTACATTTAAATCCTGCTGTACATAATGTAGTGCACGATAAGTTTAAAAATCATGC
TCAAATTCATCTTGTGAAGCCACTCGATTATCCAAGTTTATTGGCCGTTATCGACCGCTCCACCTTTATTTTAACGGACT
CTGGTGGTTTACAAGAAGAAAGCCCATCATTTAATAAGCCTGTCTTAATTTTAAGAGACACGACTGAACGCCCGGAAGTG
GTAGAGGTGGGAGCAGGGGTATTGGTTGGAACAAATCAGCAGAAAATTATTGAAGAGGCTGAGAAACTTTTAACGGATTC
GCAGCATTACCAAAAAATGGCTCATGTTGAAAATCCGTTTGGTGATGGATGTGCTGCCCAGCGAATATTAGATGAAATTG
CCAGAACTTATAACTAG

Upstream 100 bases:

>100_bases
AACGTCTATATGGCAATTATTTTAAAGACGTACCGGTTAATACAAAAGATCATTACAACAATACTCGTGTAGAACTTGTT
TTTTATAAGGATTTCTAATA

Downstream 100 bases:

>100_bases
AGATCATTTATTTTGAGTTTTCTGGTTCGTTTATGGTGGCGGGTGTGCTGCCATAAACGAATCGATACCATAGACCGACA
ATATAAACGGACCATCGGCC

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MKKIFISIVFGTRPELIKLAPVILLAKQDSRFQVEVIFTGQHDELVRDAIDFFGVEIDHRLKIMNAGQSLNQLLIHGLTQ
LENIYTDGQKRDAIVIQGDTTTVLAAGLVAFSMKIPVAHVEAGLRSYDLDHPFPEEGNRQLVSRITKWHFAPTEQSKRNL
LNEQIPPSLITVTGNTVVDAVYLGRKLIAEKTGLKNQLEPYGIELKQNDKVVLITAHRRENFGEGIQNICNAVEYLAKHH
PDLHFIWPVHLNPAVHNVVHDKFKNHAQIHLVKPLDYPSLLAVIDRSTFILTDSGGLQEESPSFNKPVLILRDTTERPEV
VEVGAGVLVGTNQQKIIEEAEKLLTDSQHYQKMAHVENPFGDGCAAQRILDEIARTYN

Sequences:

>Translated_378_residues
MKKIFISIVFGTRPELIKLAPVILLAKQDSRFQVEVIFTGQHDELVRDAIDFFGVEIDHRLKIMNAGQSLNQLLIHGLTQ
LENIYTDGQKRDAIVIQGDTTTVLAAGLVAFSMKIPVAHVEAGLRSYDLDHPFPEEGNRQLVSRITKWHFAPTEQSKRNL
LNEQIPPSLITVTGNTVVDAVYLGRKLIAEKTGLKNQLEPYGIELKQNDKVVLITAHRRENFGEGIQNICNAVEYLAKHH
PDLHFIWPVHLNPAVHNVVHDKFKNHAQIHLVKPLDYPSLLAVIDRSTFILTDSGGLQEESPSFNKPVLILRDTTERPEV
VEVGAGVLVGTNQQKIIEEAEKLLTDSQHYQKMAHVENPFGDGCAAQRILDEIARTYN
>Mature_378_residues
MKKIFISIVFGTRPELIKLAPVILLAKQDSRFQVEVIFTGQHDELVRDAIDFFGVEIDHRLKIMNAGQSLNQLLIHGLTQ
LENIYTDGQKRDAIVIQGDTTTVLAAGLVAFSMKIPVAHVEAGLRSYDLDHPFPEEGNRQLVSRITKWHFAPTEQSKRNL
LNEQIPPSLITVTGNTVVDAVYLGRKLIAEKTGLKNQLEPYGIELKQNDKVVLITAHRRENFGEGIQNICNAVEYLAKHH
PDLHFIWPVHLNPAVHNVVHDKFKNHAQIHLVKPLDYPSLLAVIDRSTFILTDSGGLQEESPSFNKPVLILRDTTERPEV
VEVGAGVLVGTNQQKIIEEAEKLLTDSQHYQKMAHVENPFGDGCAAQRILDEIARTYN

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=365, Percent_Identity=43.2876712328767, Blast_Score=303, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 42460; Mature: 42460

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIFISIVFGTRPELIKLAPVILLAKQDSRFQVEVIFTGQHDELVRDAIDFFGVEIDHR
CCEEEEEEEECCCCCHHHHCEEEEEEECCCCEEEEEEEECCHHHHHHHHHHHHCCCCHHE
LKIMNAGQSLNQLLIHGLTQLENIYTDGQKRDAIVIQGDTTTVLAAGLVAFSMKIPVAHV
EEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHH
EAGLRSYDLDHPFPEEGNRQLVSRITKWHFAPTEQSKRNLLNEQIPPSLITVTGNTVVDA
HHCHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHH
VYLGRKLIAEKTGLKNQLEPYGIELKQNDKVVLITAHRRENFGEGIQNICNAVEYLAKHH
HHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCC
PDLHFIWPVHLNPAVHNVVHDKFKNHAQIHLVKPLDYPSLLAVIDRSTFILTDSGGLQEE
CCEEEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCEEEEECCCCCCCC
SPSFNKPVLILRDTTERPEVVEVGAGVLVGTNQQKIIEEAEKLLTDSQHYQKMAHVENPF
CCCCCCCEEEEECCCCCCCEEEECCCEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCC
GDGCAAQRILDEIARTYN
CCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKIFISIVFGTRPELIKLAPVILLAKQDSRFQVEVIFTGQHDELVRDAIDFFGVEIDHR
CCEEEEEEEECCCCCHHHHCEEEEEEECCCCEEEEEEEECCHHHHHHHHHHHHCCCCHHE
LKIMNAGQSLNQLLIHGLTQLENIYTDGQKRDAIVIQGDTTTVLAAGLVAFSMKIPVAHV
EEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHH
EAGLRSYDLDHPFPEEGNRQLVSRITKWHFAPTEQSKRNLLNEQIPPSLITVTGNTVVDA
HHCHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHH
VYLGRKLIAEKTGLKNQLEPYGIELKQNDKVVLITAHRRENFGEGIQNICNAVEYLAKHH
HHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCC
PDLHFIWPVHLNPAVHNVVHDKFKNHAQIHLVKPLDYPSLLAVIDRSTFILTDSGGLQEE
CCEEEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCEEEEECCCCCCCC
SPSFNKPVLILRDTTERPEVVEVGAGVLVGTNQQKIIEEAEKLLTDSQHYQKMAHVENPF
CCCCCCCEEEEECCCCCCCEEEECCCEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCC
GDGCAAQRILDEIARTYN
CCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]