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The map label for this gene is xdhB [H]

Identifier: 213158081

GI number: 213158081

Start: 2868452

End: 2870827

Strand: Reverse

Name: xdhB [H]

Synonym: AB57_2793

Alternate gene names: 213158081

Gene position: 2870827-2868452 (Counterclockwise)

Preceding gene: 213158082

Following gene: 213158080

Centisome position: 70.88

GC content: 44.4

Gene sequence:

>2376_bases
ATGAATCAAACCATTGACCTAAATATTTCTAAAAAATCAGCTAAAGCAGGCGACTCGATTCCACACGAAAGTGCACATTT
ACATGTGACCGGGCAGGCAACTTATATTGATGATTTACCCGAGCTTGAAAATACCATGCACCTAGCTGTCGGATTTTCAA
ATTGTGCCAAAGGCAAAATCAGTAAGTTTGATTTGGATGCAGTACGTCAGGCTGAGGGTGTTTATGCAGTTTTTTCGGCA
AAGGATATTGAGGTTGAAAATAATTGGGGACCAATTGTAAAAGATGACCCAATTTTTGCCGAAGAGCAGGTCGAATTTTA
TGGACAAGCCTTATTTGTGGTCGTTGCTGAGAGTTATCAGCAAGCCCGTCAGGCAGTTCGCTTGGCAAAAATTGAGTATG
TGCCTGGAACTCCGATTTTAACGATTCAAGATGCGATTGAAAAAGAATCATGGGTGTTGCCGCCTGTTGAATTTAGCCAT
GGTGAAGTTGAACAGGCATTTCAAAATGCAGCCCATCAACTTTCAGGTGCTATTGAGCTAGGCGGGCAAGAGCATTTTTA
TCTTGAAGGGCAAATTTCCTATGCGATTCCACAAGAAAATCAGAGTTTAAAAGTCTATTGCTCGACACAACATCCAACCG
AAATGCAGTTACTGATTTGTCATGCATTAGGCATGAATATGCATCAGGTCAGCGTGGAAAGTCGCCGTATGGGTGGCGGT
TTTGGTGGTAAAGAGTCACAGTCAGCGCAGTGGGCATGTATTGCCTCTTTGGCAGCACAAAAAACTGGCCGTCCGTGTAA
ATTACGCTTAGATCGTGATGATGACATGAGTGCTACAGGCAAACGTCACGGTTTTGCTTATGAGTGGTCTGTGGCTTTTG
ATGACAGTGGTGTTTTGCAAGGCTTAAAGGTACAACTGGCTTCAAACTGTGGTTTTTCGGCTGATCTTTCTGGGCCAGTG
AATGAACGTGCGATTTGCCATATTGGCAATGCCTATTATCTAAATGCAGTTGAGCTACGTAACTTGCGTTGTAAAACTAA
TACTGTTTCCAATACGGCATATCGTGGTTTTGGTGGACCGCAAGGTATGTTTGTCATTGAAAATATTATTGATGACATTG
CGCGTTATTTAGGTTGTGATCCAGTTGAAATTCGTCAGCGCAATTTCTTTGCCGAGCAGCCCGGTGGTGGACGTGACCGT
ATGCACTATGGGGCAGAAGTCCGTGATAATGTTGCGCCAAAATTGGTAGCCGAACTATTGCAAAGTAGTGATTACGCGAA
GCGTAGACAGACTATTCATGCCTTTAATCAGAACAATGACATCATTAAGCGTGGTATTGCGTTAACACCATTAATGTTCG
GTATTTCATTTAACGCCGTGCATTACAATCAGGCAGGTGCACTGGTCTATGTGTACATGGATGGCACTGTCGCGATTACA
CACGGTGGTACAGAAATGGGACAGGGGCTATATACCAAAGTACGGCAGGTTGCTGCACATGAGTTGGGTTTACCAATCGA
TAGCGTTCGTTTAATTGCAACCGATACTTCTCGTGTGCCAAATACTTCGGCAACTGCAGCATCGAGTGGCGCAGATCTAA
ACGGTAAAGCTGTTCAAAATGCCTGTATTAAAATTCGTGAGCGTCTGGCAAAACTTGCAGTCGAAATAAGTCAAAGTGAA
GCTGACCAAGTCCAGTTTGAAGATAGTATGGTTTCAACAGCGAATGGTCATTCATGGACATTTCCTGACTTGGTTCAACG
GGCATATATGGCACGTGTACAACTATGGGACAGTGGTTTTTATAAAACACCAGAAATTCATTATGATCAGGTCAACCATT
TAGGGCGTCCATTTTTCTATTATGCCTATGGTGCGGCAGTTAGTGAGGTCGCAATAGATACCTTAACTGGAGAAATGAAA
GTATTACGTGCCGACATTTTGCATGACGTCGGGCGGTCAATTAACCCTGCAATTGATATTGGGCAAATTGAAGGCGGGTT
TGTGCAAGGGATGGGGTGGCTCACGACAGAAGAGTTGTATTGGCAGCCGCAGGGGCCACACGCAGGCCGTTTGTTTACCC
ATGCACCTTCAACTTACAAAATCCCGACCAGTGTGGACATTCCTCATATTTTTAATGTCAAACTGTTTAATAACCAAAAT
CAGGCAGACACCATCTACCGCTCCAAAGCTGTAGGTGAACCGCCATTTATGTTGGCATTATCGGTTTTCTCTGCAATTCG
TCAGGCAGTACAGGCGGCTATTCCAGAAAATGCACCGCTCGTACTCAATGCTCCGGCAACTGCCGAGGAAATTTTACGTG
CAATTGCTATTGGACGGGGACAAGCTTTGGCTGCTCGCCCACAGGCTAAAATGTAG

Upstream 100 bases:

>100_bases
CACGTCGCGAAAAACTGTTTACAGCGTTTTTATGTAGAAAAAATCCTGTCTCAAACGATCACTCGTGTGAATGACTTGAT
CGCTATGGTGGAGATCTAAA

Downstream 100 bases:

>100_bases
AAGATTATGCAACATTTACAATGGTGGACTGATTTTGTAGCGTGGCAAGCCGATGCGTTGCCTATGGTATTAGTCACAGT
GGTCCGTGCAGATGGTTCAA

Product: xanthine dehydrogenase, molybdopterin binding subunit

Products: NA

Alternate protein names: XDHase subunit D [H]

Number of amino acids: Translated: 791; Mature: 791

Protein sequence:

>791_residues
MNQTIDLNISKKSAKAGDSIPHESAHLHVTGQATYIDDLPELENTMHLAVGFSNCAKGKISKFDLDAVRQAEGVYAVFSA
KDIEVENNWGPIVKDDPIFAEEQVEFYGQALFVVVAESYQQARQAVRLAKIEYVPGTPILTIQDAIEKESWVLPPVEFSH
GEVEQAFQNAAHQLSGAIELGGQEHFYLEGQISYAIPQENQSLKVYCSTQHPTEMQLLICHALGMNMHQVSVESRRMGGG
FGGKESQSAQWACIASLAAQKTGRPCKLRLDRDDDMSATGKRHGFAYEWSVAFDDSGVLQGLKVQLASNCGFSADLSGPV
NERAICHIGNAYYLNAVELRNLRCKTNTVSNTAYRGFGGPQGMFVIENIIDDIARYLGCDPVEIRQRNFFAEQPGGGRDR
MHYGAEVRDNVAPKLVAELLQSSDYAKRRQTIHAFNQNNDIIKRGIALTPLMFGISFNAVHYNQAGALVYVYMDGTVAIT
HGGTEMGQGLYTKVRQVAAHELGLPIDSVRLIATDTSRVPNTSATAASSGADLNGKAVQNACIKIRERLAKLAVEISQSE
ADQVQFEDSMVSTANGHSWTFPDLVQRAYMARVQLWDSGFYKTPEIHYDQVNHLGRPFFYYAYGAAVSEVAIDTLTGEMK
VLRADILHDVGRSINPAIDIGQIEGGFVQGMGWLTTEELYWQPQGPHAGRLFTHAPSTYKIPTSVDIPHIFNVKLFNNQN
QADTIYRSKAVGEPPFMLALSVFSAIRQAVQAAIPENAPLVLNAPATAEEILRAIAIGRGQALAARPQAKM

Sequences:

>Translated_791_residues
MNQTIDLNISKKSAKAGDSIPHESAHLHVTGQATYIDDLPELENTMHLAVGFSNCAKGKISKFDLDAVRQAEGVYAVFSA
KDIEVENNWGPIVKDDPIFAEEQVEFYGQALFVVVAESYQQARQAVRLAKIEYVPGTPILTIQDAIEKESWVLPPVEFSH
GEVEQAFQNAAHQLSGAIELGGQEHFYLEGQISYAIPQENQSLKVYCSTQHPTEMQLLICHALGMNMHQVSVESRRMGGG
FGGKESQSAQWACIASLAAQKTGRPCKLRLDRDDDMSATGKRHGFAYEWSVAFDDSGVLQGLKVQLASNCGFSADLSGPV
NERAICHIGNAYYLNAVELRNLRCKTNTVSNTAYRGFGGPQGMFVIENIIDDIARYLGCDPVEIRQRNFFAEQPGGGRDR
MHYGAEVRDNVAPKLVAELLQSSDYAKRRQTIHAFNQNNDIIKRGIALTPLMFGISFNAVHYNQAGALVYVYMDGTVAIT
HGGTEMGQGLYTKVRQVAAHELGLPIDSVRLIATDTSRVPNTSATAASSGADLNGKAVQNACIKIRERLAKLAVEISQSE
ADQVQFEDSMVSTANGHSWTFPDLVQRAYMARVQLWDSGFYKTPEIHYDQVNHLGRPFFYYAYGAAVSEVAIDTLTGEMK
VLRADILHDVGRSINPAIDIGQIEGGFVQGMGWLTTEELYWQPQGPHAGRLFTHAPSTYKIPTSVDIPHIFNVKLFNNQN
QADTIYRSKAVGEPPFMLALSVFSAIRQAVQAAIPENAPLVLNAPATAEEILRAIAIGRGQALAARPQAKM
>Mature_791_residues
MNQTIDLNISKKSAKAGDSIPHESAHLHVTGQATYIDDLPELENTMHLAVGFSNCAKGKISKFDLDAVRQAEGVYAVFSA
KDIEVENNWGPIVKDDPIFAEEQVEFYGQALFVVVAESYQQARQAVRLAKIEYVPGTPILTIQDAIEKESWVLPPVEFSH
GEVEQAFQNAAHQLSGAIELGGQEHFYLEGQISYAIPQENQSLKVYCSTQHPTEMQLLICHALGMNMHQVSVESRRMGGG
FGGKESQSAQWACIASLAAQKTGRPCKLRLDRDDDMSATGKRHGFAYEWSVAFDDSGVLQGLKVQLASNCGFSADLSGPV
NERAICHIGNAYYLNAVELRNLRCKTNTVSNTAYRGFGGPQGMFVIENIIDDIARYLGCDPVEIRQRNFFAEQPGGGRDR
MHYGAEVRDNVAPKLVAELLQSSDYAKRRQTIHAFNQNNDIIKRGIALTPLMFGISFNAVHYNQAGALVYVYMDGTVAIT
HGGTEMGQGLYTKVRQVAAHELGLPIDSVRLIATDTSRVPNTSATAASSGADLNGKAVQNACIKIRERLAKLAVEISQSE
ADQVQFEDSMVSTANGHSWTFPDLVQRAYMARVQLWDSGFYKTPEIHYDQVNHLGRPFFYYAYGAAVSEVAIDTLTGEMK
VLRADILHDVGRSINPAIDIGQIEGGFVQGMGWLTTEELYWQPQGPHAGRLFTHAPSTYKIPTSVDIPHIFNVKLFNNQN
QADTIYRSKAVGEPPFMLALSVFSAIRQAVQAAIPENAPLVLNAPATAEEILRAIAIGRGQALAARPQAKM

Specific function: Oxidizes hypoxanthine and xanthine to uric acid [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=765, Percent_Identity=41.3071895424837, Blast_Score=566, Evalue=1e-161,
Organism=Homo sapiens, GI71773480, Length=763, Percent_Identity=36.959370904325, Blast_Score=473, Evalue=1e-133,
Organism=Escherichia coli, GI1789230, Length=750, Percent_Identity=26.8, Blast_Score=213, Evalue=4e-56,
Organism=Escherichia coli, GI1789246, Length=692, Percent_Identity=24.7109826589595, Blast_Score=172, Evalue=7e-44,
Organism=Escherichia coli, GI1786478, Length=727, Percent_Identity=26.8225584594223, Blast_Score=151, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17540638, Length=768, Percent_Identity=41.015625, Blast_Score=543, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI32566215, Length=757, Percent_Identity=32.3645970937913, Blast_Score=358, Evalue=5e-99,
Organism=Caenorhabditis elegans, GI17539860, Length=745, Percent_Identity=32.0805369127517, Blast_Score=347, Evalue=2e-95,
Organism=Drosophila melanogaster, GI17737937, Length=758, Percent_Identity=41.1609498680739, Blast_Score=577, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24647199, Length=786, Percent_Identity=30.7888040712468, Blast_Score=327, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24647193, Length=772, Percent_Identity=30.9585492227979, Blast_Score=326, Evalue=4e-89,
Organism=Drosophila melanogaster, GI24647201, Length=767, Percent_Identity=31.4211212516297, Blast_Score=297, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24647195, Length=791, Percent_Identity=29.0771175726928, Blast_Score=291, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24647197, Length=775, Percent_Identity=29.4193548387097, Blast_Score=290, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR017609 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 86802; Mature: 86802

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTIDLNISKKSAKAGDSIPHESAHLHVTGQATYIDDLPELENTMHLAVGFSNCAKGKI
CCCEEEEEEECCCCCCCCCCCCCCCEEEEEECEEECCCCHHHHCCEEEEEECCCCCCCCC
SKFDLDAVRQAEGVYAVFSAKDIEVENNWGPIVKDDPIFAEEQVEFYGQALFVVVAESYQ
CCCCHHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHEEEEHHHHHHH
QARQAVRLAKIEYVPGTPILTIQDAIEKESWVLPPVEFSHGEVEQAFQNAAHQLSGAIEL
HHHHHHHHHEEEECCCCCEEEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEE
GGQEHFYLEGQISYAIPQENQSLKVYCSTQHPTEMQLLICHALGMNMHQVSVESRRMGGG
CCCEEEEEEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEHHHHHCCCC
FGGKESQSAQWACIASLAAQKTGRPCKLRLDRDDDMSATGKRHGFAYEWSVAFDDSGVLQ
CCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCHHC
GLKVQLASNCGFSADLSGPVNERAICHIGNAYYLNAVELRNLRCKTNTVSNTAYRGFGGP
CEEEEEECCCCCCCCCCCCCCCCEEEEECCEEEEEEEEECCEEEECCCCCCCCCCCCCCC
QGMFVIENIIDDIARYLGCDPVEIRQRNFFAEQPGGGRDRMHYGAEVRDNVAPKLVAELL
CCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHH
QSSDYAKRRQTIHAFNQNNDIIKRGIALTPLMFGISFNAVHYNQAGALVYVYMDGTVAIT
HCCCHHHHHHHHHHCCCCCHHHHCCCHHHHHEECEEEEEEEECCCCEEEEEEECCEEEEE
HGGTEMGQGLYTKVRQVAAHELGLPIDSVRLIATDTSRVPNTSATAASSGADLNGKAVQN
ECCHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHH
ACIKIRERLAKLAVEISQSEADQVQFEDSMVSTANGHSWTFPDLVQRAYMARVQLWDSGF
HHHHHHHHHHHHHHHHCCCCCHHEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCCC
YKTPEIHYDQVNHLGRPFFYYAYGAAVSEVAIDTLTGEMKVLRADILHDVGRSINPAIDI
CCCCCCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEE
GQIEGGFVQGMGWLTTEELYWQPQGPHAGRLFTHAPSTYKIPTSVDIPHIFNVKLFNNQN
ECCCCCCEECCCCEEEHHEEECCCCCCCCCEEEECCCCEECCCCCCCCCEEEEEEECCCC
QADTIYRSKAVGEPPFMLALSVFSAIRQAVQAAIPENAPLVLNAPATAEEILRAIAIGRG
CHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCC
QALAARPQAKM
CEEECCCCCCC
>Mature Secondary Structure
MNQTIDLNISKKSAKAGDSIPHESAHLHVTGQATYIDDLPELENTMHLAVGFSNCAKGKI
CCCEEEEEEECCCCCCCCCCCCCCCEEEEEECEEECCCCHHHHCCEEEEEECCCCCCCCC
SKFDLDAVRQAEGVYAVFSAKDIEVENNWGPIVKDDPIFAEEQVEFYGQALFVVVAESYQ
CCCCHHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHEEEEHHHHHHH
QARQAVRLAKIEYVPGTPILTIQDAIEKESWVLPPVEFSHGEVEQAFQNAAHQLSGAIEL
HHHHHHHHHEEEECCCCCEEEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEE
GGQEHFYLEGQISYAIPQENQSLKVYCSTQHPTEMQLLICHALGMNMHQVSVESRRMGGG
CCCEEEEEEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEHHHHHCCCC
FGGKESQSAQWACIASLAAQKTGRPCKLRLDRDDDMSATGKRHGFAYEWSVAFDDSGVLQ
CCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCHHC
GLKVQLASNCGFSADLSGPVNERAICHIGNAYYLNAVELRNLRCKTNTVSNTAYRGFGGP
CEEEEEECCCCCCCCCCCCCCCCEEEEECCEEEEEEEEECCEEEECCCCCCCCCCCCCCC
QGMFVIENIIDDIARYLGCDPVEIRQRNFFAEQPGGGRDRMHYGAEVRDNVAPKLVAELL
CCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHH
QSSDYAKRRQTIHAFNQNNDIIKRGIALTPLMFGISFNAVHYNQAGALVYVYMDGTVAIT
HCCCHHHHHHHHHHCCCCCHHHHCCCHHHHHEECEEEEEEEECCCCEEEEEEECCEEEEE
HGGTEMGQGLYTKVRQVAAHELGLPIDSVRLIATDTSRVPNTSATAASSGADLNGKAVQN
ECCHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHH
ACIKIRERLAKLAVEISQSEADQVQFEDSMVSTANGHSWTFPDLVQRAYMARVQLWDSGF
HHHHHHHHHHHHHHHHCCCCCHHEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCCC
YKTPEIHYDQVNHLGRPFFYYAYGAAVSEVAIDTLTGEMKVLRADILHDVGRSINPAIDI
CCCCCCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEE
GQIEGGFVQGMGWLTTEELYWQPQGPHAGRLFTHAPSTYKIPTSVDIPHIFNVKLFNNQN
ECCCCCCEECCCCEEEHHEEECCCCCCCCCEEEECCCCEECCCCCCCCCEEEEEEECCCC
QADTIYRSKAVGEPPFMLALSVFSAIRQAVQAAIPENAPLVLNAPATAEEILRAIAIGRG
CHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCC
QALAARPQAKM
CEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 11344136 [H]