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The map label for this gene is pepQ [H]

Identifier: 213158073

GI number: 213158073

Start: 2856232

End: 2858037

Strand: Direct

Name: pepQ [H]

Synonym: AB57_2785

Alternate gene names: 213158073

Gene position: 2856232-2858037 (Clockwise)

Preceding gene: 213158072

Following gene: 213158074

Centisome position: 70.52

GC content: 41.03

Gene sequence:

>1806_bases
ATGAACGACTTAACTGTTCCAGAAAAACTAGCGAAACTTCGTGAACTCATGACCAATCAAAGTATTGATGCTTTGGTTGT
CATGAGTGCAGACCCCCATATGTCTGAATATTTACCAGACTATTGGAAAGCAAGGCAGTGGTTAAGCGGTTTTAGTGGCT
CTGTTGGCACTTTATTTGTGACCCAAAACTTTGCAGGACTCTGGGCCGATGGACGCTATTGGGTACAAGCCGAACAACAA
CTCGCTGGAACTGGCTTTCAGTTACAAAAACTGACCAGTGATGAATCTTCTACACATCTCGCATGGATTGAGAAAAATCT
ACCGGCTGGTTCGGTTATTTCAGTAAATGGGCAAACACTTTCAATCCAGCAATTTAAAAGTCGTTGGAAAATAACAGCAA
AGCAACGTGGCTTTAAGCTTGAAACACAGCAAGATTTAATTGGTTTGATCTGGTTAAACCGCCCTGAGCTTCCTTTAGAG
CAGATTCATTTAATGCCTGAAGGGTTAAATGCCCTCTCTCGTAAAGAAAAAATTCAGGCAATTCGCAAGAGCTTAGCTAA
CAAGAATATTGCGGGTCATTTTATTTCATCTTTAGATGATATTGCTTGGGTTTTAAATGCACGTGGACAAGATGTAGAGT
ACAACCCTGTATTCCTTTCACATTTATATATCAGTGCTCAACAGGCTGTTTTATTCATTGATAGTAACAAAGTTGATTTA
ACCACCCAACAGGCTTTTAAAGCTGATGGCATTGAGATTCGTGACTATCAAGATTCAGCTCAGTTTTTAGCAAATATTTC
TAATGCATCTGTGCTGTTAGATCCAGCCAAAGTCTCGATTTTTCATGAACAGGCTATCGCAAAAGATATTCAGGTTGTAT
ATGACATCAATCCGAGTACACTTTTTAAATCGCGTAAGCATGAAAGCGAAATTGCGCATATCCGTCACGCAATGGTTAAA
GATGGAGTCGCGCTTTGTCACTTTTTCTATTGGCTAGAAAAAGCACTTCATCAGGGTGAACGTATTTCAGAATTGACTAT
CGATGAGAAAATTACTGCCTACCGCGCTCAACAAGAAGGTTTTATAGGCCCAAGCTTTTCAACGATTGCCGGCTTTAATG
CCAATGGTGCTCTACCTCACTACCGTGCAACTGAAGAACATTACTCATTCATTGAAGGCGATGGCCTATTACTCATTGAC
TCTGGCGGCCAGTATGTTGATGGAACAACGGATATTACCCGTGTTGTTCCTGTAGGAACACCAACAGAGCAACAAAAACG
TGACTATACTCTGGTTTTAAAATGTCATATTGCTTTGGCAAAAACGATTTATCCAGAAGGTTTAGCTGCCCCACTACTCG
ATTCAATTTGTCGCCATACGTTATGGCAACATGGTTTAGATTATCGCCACGGTACAGGTCATGGCGTAGGCTTTGCGCTT
AACGTGCATGAAGGACCACAAGTGCTTTCTTATTACGCGCCTATTCATGCCTATAGTAAGTTGCGTGAAGGTATGATTCT
TTCTAACGAGCCGGGCTTATACCATGAGGGACAATACGGTATTCGTATTGAGAATCTGGTTGCAAACAGACTTCACTCAG
GGTTTGAGAAAACCTACGGCGATTTCTTAGAGTTTGAAACGCTGACCCTTTGCCCGATTCATTTAGATTGTATCGTCGTT
GACATGCTAACGGATGAAGAGAAAGACTGGTTAAATGGTTATCATCAAACTGTTCAAGAAAGACTGGCCGAACATTTATC
TGGCGATGTTTTAGATTGGCTGATTTATAACACACGTAAGATTTAA

Upstream 100 bases:

>100_bases
CCTTGGTTATTGGCGCAATCGTGTTATTTTTATTAAAGAAACCAATGAATAAATTAATGGACAAAAGTACCAACAAAGTT
CAACCTGATTTGGAAACGAT

Downstream 100 bases:

>100_bases
TCTTCTTGTATGACCAAGGCAGAATAGTTTTTTATTTACAATAGAAGCTTATTCTGCCTTATTTGTACTTATCTATAATT
TCAAAAAACCTCACTTTTTA

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MNDLTVPEKLAKLRELMTNQSIDALVVMSADPHMSEYLPDYWKARQWLSGFSGSVGTLFVTQNFAGLWADGRYWVQAEQQ
LAGTGFQLQKLTSDESSTHLAWIEKNLPAGSVISVNGQTLSIQQFKSRWKITAKQRGFKLETQQDLIGLIWLNRPELPLE
QIHLMPEGLNALSRKEKIQAIRKSLANKNIAGHFISSLDDIAWVLNARGQDVEYNPVFLSHLYISAQQAVLFIDSNKVDL
TTQQAFKADGIEIRDYQDSAQFLANISNASVLLDPAKVSIFHEQAIAKDIQVVYDINPSTLFKSRKHESEIAHIRHAMVK
DGVALCHFFYWLEKALHQGERISELTIDEKITAYRAQQEGFIGPSFSTIAGFNANGALPHYRATEEHYSFIEGDGLLLID
SGGQYVDGTTDITRVVPVGTPTEQQKRDYTLVLKCHIALAKTIYPEGLAAPLLDSICRHTLWQHGLDYRHGTGHGVGFAL
NVHEGPQVLSYYAPIHAYSKLREGMILSNEPGLYHEGQYGIRIENLVANRLHSGFEKTYGDFLEFETLTLCPIHLDCIVV
DMLTDEEKDWLNGYHQTVQERLAEHLSGDVLDWLIYNTRKI

Sequences:

>Translated_601_residues
MNDLTVPEKLAKLRELMTNQSIDALVVMSADPHMSEYLPDYWKARQWLSGFSGSVGTLFVTQNFAGLWADGRYWVQAEQQ
LAGTGFQLQKLTSDESSTHLAWIEKNLPAGSVISVNGQTLSIQQFKSRWKITAKQRGFKLETQQDLIGLIWLNRPELPLE
QIHLMPEGLNALSRKEKIQAIRKSLANKNIAGHFISSLDDIAWVLNARGQDVEYNPVFLSHLYISAQQAVLFIDSNKVDL
TTQQAFKADGIEIRDYQDSAQFLANISNASVLLDPAKVSIFHEQAIAKDIQVVYDINPSTLFKSRKHESEIAHIRHAMVK
DGVALCHFFYWLEKALHQGERISELTIDEKITAYRAQQEGFIGPSFSTIAGFNANGALPHYRATEEHYSFIEGDGLLLID
SGGQYVDGTTDITRVVPVGTPTEQQKRDYTLVLKCHIALAKTIYPEGLAAPLLDSICRHTLWQHGLDYRHGTGHGVGFAL
NVHEGPQVLSYYAPIHAYSKLREGMILSNEPGLYHEGQYGIRIENLVANRLHSGFEKTYGDFLEFETLTLCPIHLDCIVV
DMLTDEEKDWLNGYHQTVQERLAEHLSGDVLDWLIYNTRKI
>Mature_601_residues
MNDLTVPEKLAKLRELMTNQSIDALVVMSADPHMSEYLPDYWKARQWLSGFSGSVGTLFVTQNFAGLWADGRYWVQAEQQ
LAGTGFQLQKLTSDESSTHLAWIEKNLPAGSVISVNGQTLSIQQFKSRWKITAKQRGFKLETQQDLIGLIWLNRPELPLE
QIHLMPEGLNALSRKEKIQAIRKSLANKNIAGHFISSLDDIAWVLNARGQDVEYNPVFLSHLYISAQQAVLFIDSNKVDL
TTQQAFKADGIEIRDYQDSAQFLANISNASVLLDPAKVSIFHEQAIAKDIQVVYDINPSTLFKSRKHESEIAHIRHAMVK
DGVALCHFFYWLEKALHQGERISELTIDEKITAYRAQQEGFIGPSFSTIAGFNANGALPHYRATEEHYSFIEGDGLLLID
SGGQYVDGTTDITRVVPVGTPTEQQKRDYTLVLKCHIALAKTIYPEGLAAPLLDSICRHTLWQHGLDYRHGTGHGVGFAL
NVHEGPQVLSYYAPIHAYSKLREGMILSNEPGLYHEGQYGIRIENLVANRLHSGFEKTYGDFLEFETLTLCPIHLDCIVV
DMLTDEEKDWLNGYHQTVQERLAEHLSGDVLDWLIYNTRKI

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=616, Percent_Identity=36.3636363636364, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI264681565, Length=616, Percent_Identity=34.9025974025974, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI93141226, Length=589, Percent_Identity=31.748726655348, Blast_Score=307, Evalue=2e-83,
Organism=Escherichia coli, GI1788728, Length=234, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=619, Percent_Identity=34.0872374798061, Blast_Score=337, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI25149105, Length=589, Percent_Identity=28.5229202037351, Blast_Score=248, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6322999, Length=633, Percent_Identity=32.7014218009479, Blast_Score=298, Evalue=1e-81,
Organism=Drosophila melanogaster, GI17137632, Length=602, Percent_Identity=35.0498338870432, Blast_Score=331, Evalue=1e-90,
Organism=Drosophila melanogaster, GI161078230, Length=619, Percent_Identity=26.9789983844911, Blast_Score=222, Evalue=5e-58,
Organism=Drosophila melanogaster, GI21357287, Length=619, Percent_Identity=26.9789983844911, Blast_Score=222, Evalue=5e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 67793; Mature: 67793

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLTVPEKLAKLRELMTNQSIDALVVMSADPHMSEYLPDYWKARQWLSGFSGSVGTLFV
CCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCHHHHHHHHHHCCCCCCEEEEE
TQNFAGLWADGRYWVQAEQQLAGTGFQLQKLTSDESSTHLAWIEKNLPAGSVISVNGQTL
ECCCCEEECCCEEEEEEHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCEEEECCCEE
SIQQFKSRWKITAKQRGFKLETQQDLIGLIWLNRPELPLEQIHLMPEGLNALSRKEKIQA
EHHHHHHHHEEEHHHCCCCCCCHHCEEEEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHH
IRKSLANKNIAGHFISSLDDIAWVLNARGQDVEYNPVFLSHLYISAQQAVLFIDSNKVDL
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHEEEECEEEEEEECCCEEE
TTQQAFKADGIEIRDYQDSAQFLANISNASVLLDPAKVSIFHEQAIAKDIQVVYDINPST
EHHHHHCCCCEEEECCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCEEEEEECCHHH
LFKSRKHESEIAHIRHAMVKDGVALCHFFYWLEKALHQGERISELTIDEKITAYRAQQEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
FIGPSFSTIAGFNANGALPHYRATEEHYSFIEGDGLLLIDSGGQYVDGTTDITRVVPVGT
CCCCCCHHHCCCCCCCCCCCCCCCHHHHCEECCCCEEEECCCCCEECCCCCEEEEEECCC
PTEQQKRDYTLVLKCHIALAKTIYPEGLAAPLLDSICRHTLWQHGLDYRHGTGHGVGFAL
CCHHHCCCEEEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
NVHEGPQVLSYYAPIHAYSKLREGMILSNEPGLYHEGQYGIRIENLVANRLHSGFEKTYG
EECCCCHHHHHHHHHHHHHHHHCCEEECCCCCCEECCCCCEEHHHHHHHHHHHHHHHHHH
DFLEFETLTLCPIHLDCIVVDMLTDEEKDWLNGYHQTVQERLAEHLSGDVLDWLIYNTRK
HHHCCCEEEEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
I
C
>Mature Secondary Structure
MNDLTVPEKLAKLRELMTNQSIDALVVMSADPHMSEYLPDYWKARQWLSGFSGSVGTLFV
CCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCHHHHHHHHHHCCCCCCEEEEE
TQNFAGLWADGRYWVQAEQQLAGTGFQLQKLTSDESSTHLAWIEKNLPAGSVISVNGQTL
ECCCCEEECCCEEEEEEHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCEEEECCCEE
SIQQFKSRWKITAKQRGFKLETQQDLIGLIWLNRPELPLEQIHLMPEGLNALSRKEKIQA
EHHHHHHHHEEEHHHCCCCCCCHHCEEEEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHH
IRKSLANKNIAGHFISSLDDIAWVLNARGQDVEYNPVFLSHLYISAQQAVLFIDSNKVDL
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHEEEECEEEEEEECCCEEE
TTQQAFKADGIEIRDYQDSAQFLANISNASVLLDPAKVSIFHEQAIAKDIQVVYDINPST
EHHHHHCCCCEEEECCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCEEEEEECCHHH
LFKSRKHESEIAHIRHAMVKDGVALCHFFYWLEKALHQGERISELTIDEKITAYRAQQEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
FIGPSFSTIAGFNANGALPHYRATEEHYSFIEGDGLLLIDSGGQYVDGTTDITRVVPVGT
CCCCCCHHHCCCCCCCCCCCCCCCHHHHCEECCCCEEEECCCCCEECCCCCEEEEEECCC
PTEQQKRDYTLVLKCHIALAKTIYPEGLAAPLLDSICRHTLWQHGLDYRHGTGHGVGFAL
CCHHHCCCEEEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
NVHEGPQVLSYYAPIHAYSKLREGMILSNEPGLYHEGQYGIRIENLVANRLHSGFEKTYG
EECCCCHHHHHHHHHHHHHHHHCCEEECCCCCCEECCCCCEEHHHHHHHHHHHHHHHHHH
DFLEFETLTLCPIHLDCIVVDMLTDEEKDWLNGYHQTVQERLAEHLSGDVLDWLIYNTRK
HHHCCCEEEEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]