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The map label for this gene is fadE [H]

Identifier: 213158052

GI number: 213158052

Start: 2830345

End: 2832810

Strand: Direct

Name: fadE [H]

Synonym: AB57_2764

Alternate gene names: 213158052

Gene position: 2830345-2832810 (Clockwise)

Preceding gene: 213158051

Following gene: 213158053

Centisome position: 69.88

GC content: 41.65

Gene sequence:

>2466_bases
ATGATTTTCCTACTCTTTGTTTTAAGTATTGTCATTCAGCTTGTTGCAATATGGGCAATTTTCTTTTTTAACCTAAATAG
AGTCGCTGGTAGTGTTATTACGATTGCTGTAGCCATACTTACTGCTTTCATTTTAACGCCGTGGGCATTACTTTTAGGGA
TTCCCCTTATTGCACTTAGCATTATTATTTTGTTTAAACCTTTACGGTTTAACTTAATTACCCAACCTGCATATAAAACT
CTGGCCAACTCAATGCCGAGCATCAGTACCACTGAACAAGAAGCCTTAGAAGCAGGAACAAGCTGGTGGGAAAAAGAGTT
ATTTATGGGGGCTCCAGATTGGTCGCAATTTGAAAAATATCCCTATCCTACACTTTCACCAGAAGAACAAAGTTTTATCG
ATAATGAAGTTGAAGTGCTATGTAGCATGCTTGATGAATGGGAAATTCACCATCAATTAAAAGACCTTCCTCCTGAAGTT
TGGCAGTTCATTAAAGATAAAGGCTTCTTGGGTCTTATTATTCCAAAATCCTTTGGCGGTAAAGAGTTCAGCTCATTTGC
TCAAAGTCGCATTATGAGCAAAATTGCCTCACGTTCATTAACTGCTGCGGTGAGTTGTATGGTTCCTAACTCATTAGGAC
CCGGTGAATTACTCATGCATTACGGTACAGATGCGCAAAAGCAGCAATATCTACCGGGACTTGCTAAAGGTGAAGAAATT
CCATGCTTTGGTTTAACCAGTCCGGAAGCAGGTTCAGATGCAGGTGCAATTCCAGATTCGGGTGTAGTCTGCTATGGCGA
ATATGAAGGTGCTCAAGTTCTTGGGCTGCGCATGAATTTCTCTAAACGTTGGATTACGCTCGCTCCAATTGCCACAGTGG
TCGGTCTAGCATTTAAACTTTATGACCCCGAAGGTTTACTTGGAGATAAAACTAAAACTGAGTACGGGATTACCTGTGCT
TTAATTCCAGCCAATCATGCAGGCGTAAAAATAGGTGCACGACATTATCCGGGCTCTCCATTCATGAATGGGACAGTAGA
GGGTGAAGATGTCTTCATTCCAATTGACTGGATTATTGGCGGACAAGAAAATGCCGGTAAAGGCTGGCGCATGCTGATGG
AATGCCTAGGTGTTGGCCGAGGTATTTCACTGCCCGCATTAGCCACAGCCGCAGGTGAAATGAGCTATCTCACTGTCGGT
GCATTTGCAAGAATTCGTCAACAGTTCAATATTTCTGTCGGCAAATTTGAAGGTGTACAAGAAGCAAGCAGTGAAATTGC
CAGCGATGCCTATATGCTTGAAGCATTCCGTTATTTAGTGACGTGTGGTCTAAACCAAGGTGGAACCCCTGCTGTAATGA
CTGCCATGGCAAAATACTATGCAACTGAAACGATGCGTAAAGTGGTTAATCACGGGATGGATATTGCTGGAGGACGTGCA
ATTCAACTTGGGCCACGCAATTTCCTTGCTCTCACCTATCAAGCGATTCCAATTGCTATTACAGTAGAAGGTGCAAATAT
TTTAACCCGCTCGTTGATGATTTTTGGTCAAGGCTCAATGCGCTGTCACCCTTATCTTTTTGAAGAATTGCAATTACTTC
AGTCTGACGACAAAGCCAATGCCGTACAAAAATTCGATGATTTGTTGTTTAAACATTTAGCCTATACCTTTAACCGCGGT
GCTAGATCATTTGCTTATGGTTGGACGGGAGGTTCGAGTGATGCACCTCAATCAGCAGATCAATTCACTGCAAGTTACTA
TAAAACCATCAATCGTTTTAGCGCCAATTTTTCACTTGTTTCCGATATGGCACTTGGCTTACTCGCAGGAGACCTAAAGC
GTAAAGAAATGCTATCAGGCCGCTTGGCAGATATTCACGCGCACTTGTTTATTGCCACTGCAATTTTAAAATATTATGAG
GCTGGACAAAAAACTGAAGCTGAACAACTTCATGCCAAACTAGCACTGCAAAAAGCATTTTTGAATATTCAGGAAGCATT
TTGGGGACTATTTGACAACTTCCCAGCCAAGCTTCCAGCAGCATTTGTCAAATGGATATGCTTCCCGTTAGGTCGTGTGA
TTTCAAAACCTGACGATGAGTTAAAACAACAAGTTGCTGAACTCATGATGGAAGAACATCCGTTTAGAGAGCAACTCAAA
CGCCATGTGTACTATTCAACTGAACCTAATGATGTCACTGGCCGTCTAGAGCACACGTTCCAAATGTTAAGAACCATTGA
ACCGCTTTGGGATAAGTTTAAGAAAGCTGAATCCAAAGGCAAGTTTACGGGTCTTACTTTTAAAGAGAATATTGCGCAAG
CGATAAAAGAAGGCTTTATTTCTGAAAGCGAAGCTCAACAATTATTGCAGTACAACGCAATTCGATTCGATAGCATGCTT
ACCGATGTTTTTGATGAAAAGCTAAATAAAGTCCTGCCTTTATCAAATCCTCATCAAATAGTGTGA

Upstream 100 bases:

>100_bases
CAAATTTAAACAGCATTAAAAAATTCGCTAGTTAAGCCTTAAATCTCTCCTCGCTTTTTTATTATTTCTAACTTGAGGGC
TTATCTAGCAAGGAGCAAGT

Downstream 100 bases:

>100_bases
CTGATGCCTCCACTAATTCACTATTGCAATCATTTTTGATTCGCATTAATTAATAAACAGCCATAAAAGCGTCACTCGAC
GCTTTTATTTTTAGGAGAAA

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 821; Mature: 821

Protein sequence:

>821_residues
MIFLLFVLSIVIQLVAIWAIFFFNLNRVAGSVITIAVAILTAFILTPWALLLGIPLIALSIIILFKPLRFNLITQPAYKT
LANSMPSISTTEQEALEAGTSWWEKELFMGAPDWSQFEKYPYPTLSPEEQSFIDNEVEVLCSMLDEWEIHHQLKDLPPEV
WQFIKDKGFLGLIIPKSFGGKEFSSFAQSRIMSKIASRSLTAAVSCMVPNSLGPGELLMHYGTDAQKQQYLPGLAKGEEI
PCFGLTSPEAGSDAGAIPDSGVVCYGEYEGAQVLGLRMNFSKRWITLAPIATVVGLAFKLYDPEGLLGDKTKTEYGITCA
LIPANHAGVKIGARHYPGSPFMNGTVEGEDVFIPIDWIIGGQENAGKGWRMLMECLGVGRGISLPALATAAGEMSYLTVG
AFARIRQQFNISVGKFEGVQEASSEIASDAYMLEAFRYLVTCGLNQGGTPAVMTAMAKYYATETMRKVVNHGMDIAGGRA
IQLGPRNFLALTYQAIPIAITVEGANILTRSLMIFGQGSMRCHPYLFEELQLLQSDDKANAVQKFDDLLFKHLAYTFNRG
ARSFAYGWTGGSSDAPQSADQFTASYYKTINRFSANFSLVSDMALGLLAGDLKRKEMLSGRLADIHAHLFIATAILKYYE
AGQKTEAEQLHAKLALQKAFLNIQEAFWGLFDNFPAKLPAAFVKWICFPLGRVISKPDDELKQQVAELMMEEHPFREQLK
RHVYYSTEPNDVTGRLEHTFQMLRTIEPLWDKFKKAESKGKFTGLTFKENIAQAIKEGFISESEAQQLLQYNAIRFDSML
TDVFDEKLNKVLPLSNPHQIV

Sequences:

>Translated_821_residues
MIFLLFVLSIVIQLVAIWAIFFFNLNRVAGSVITIAVAILTAFILTPWALLLGIPLIALSIIILFKPLRFNLITQPAYKT
LANSMPSISTTEQEALEAGTSWWEKELFMGAPDWSQFEKYPYPTLSPEEQSFIDNEVEVLCSMLDEWEIHHQLKDLPPEV
WQFIKDKGFLGLIIPKSFGGKEFSSFAQSRIMSKIASRSLTAAVSCMVPNSLGPGELLMHYGTDAQKQQYLPGLAKGEEI
PCFGLTSPEAGSDAGAIPDSGVVCYGEYEGAQVLGLRMNFSKRWITLAPIATVVGLAFKLYDPEGLLGDKTKTEYGITCA
LIPANHAGVKIGARHYPGSPFMNGTVEGEDVFIPIDWIIGGQENAGKGWRMLMECLGVGRGISLPALATAAGEMSYLTVG
AFARIRQQFNISVGKFEGVQEASSEIASDAYMLEAFRYLVTCGLNQGGTPAVMTAMAKYYATETMRKVVNHGMDIAGGRA
IQLGPRNFLALTYQAIPIAITVEGANILTRSLMIFGQGSMRCHPYLFEELQLLQSDDKANAVQKFDDLLFKHLAYTFNRG
ARSFAYGWTGGSSDAPQSADQFTASYYKTINRFSANFSLVSDMALGLLAGDLKRKEMLSGRLADIHAHLFIATAILKYYE
AGQKTEAEQLHAKLALQKAFLNIQEAFWGLFDNFPAKLPAAFVKWICFPLGRVISKPDDELKQQVAELMMEEHPFREQLK
RHVYYSTEPNDVTGRLEHTFQMLRTIEPLWDKFKKAESKGKFTGLTFKENIAQAIKEGFISESEAQQLLQYNAIRFDSML
TDVFDEKLNKVLPLSNPHQIV
>Mature_821_residues
MIFLLFVLSIVIQLVAIWAIFFFNLNRVAGSVITIAVAILTAFILTPWALLLGIPLIALSIIILFKPLRFNLITQPAYKT
LANSMPSISTTEQEALEAGTSWWEKELFMGAPDWSQFEKYPYPTLSPEEQSFIDNEVEVLCSMLDEWEIHHQLKDLPPEV
WQFIKDKGFLGLIIPKSFGGKEFSSFAQSRIMSKIASRSLTAAVSCMVPNSLGPGELLMHYGTDAQKQQYLPGLAKGEEI
PCFGLTSPEAGSDAGAIPDSGVVCYGEYEGAQVLGLRMNFSKRWITLAPIATVVGLAFKLYDPEGLLGDKTKTEYGITCA
LIPANHAGVKIGARHYPGSPFMNGTVEGEDVFIPIDWIIGGQENAGKGWRMLMECLGVGRGISLPALATAAGEMSYLTVG
AFARIRQQFNISVGKFEGVQEASSEIASDAYMLEAFRYLVTCGLNQGGTPAVMTAMAKYYATETMRKVVNHGMDIAGGRA
IQLGPRNFLALTYQAIPIAITVEGANILTRSLMIFGQGSMRCHPYLFEELQLLQSDDKANAVQKFDDLLFKHLAYTFNRG
ARSFAYGWTGGSSDAPQSADQFTASYYKTINRFSANFSLVSDMALGLLAGDLKRKEMLSGRLADIHAHLFIATAILKYYE
AGQKTEAEQLHAKLALQKAFLNIQEAFWGLFDNFPAKLPAAFVKWICFPLGRVISKPDDELKQQVAELMMEEHPFREQLK
RHVYYSTEPNDVTGRLEHTFQMLRTIEPLWDKFKKAESKGKFTGLTFKENIAQAIKEGFISESEAQQLLQYNAIRFDSML
TDVFDEKLNKVLPLSNPHQIV

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=395, Percent_Identity=30.379746835443, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI4557235, Length=452, Percent_Identity=26.7699115044248, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI76496475, Length=414, Percent_Identity=27.2946859903382, Blast_Score=112, Evalue=2e-24,
Organism=Homo sapiens, GI4501859, Length=376, Percent_Identity=27.9255319148936, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI4557233, Length=326, Percent_Identity=28.8343558282209, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI226958412, Length=348, Percent_Identity=24.4252873563218, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI226958414, Length=329, Percent_Identity=24.3161094224924, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI87081702, Length=820, Percent_Identity=44.6341463414634, Blast_Score=725, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985184, Length=430, Percent_Identity=24.4186046511628, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71985192, Length=347, Percent_Identity=24.7838616714697, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=28.3018867924528, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17538396, Length=390, Percent_Identity=23.8461538461538, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17506239, Length=339, Percent_Identity=25.3687315634218, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281363737, Length=413, Percent_Identity=24.6973365617433, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24646207, Length=335, Percent_Identity=26.5671641791045, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21356377, Length=362, Percent_Identity=25.414364640884, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355753, Length=357, Percent_Identity=25.2100840336134, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24666513, Length=348, Percent_Identity=26.7241379310345, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: 1.3.99.3

Molecular weight: Translated: 91106; Mature: 91106

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFLLFVLSIVIQLVAIWAIFFFNLNRVAGSVITIAVAILTAFILTPWALLLGIPLIALS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIILFKPLRFNLITQPAYKTLANSMPSISTTEQEALEAGTSWWEKELFMGAPDWSQFEKY
HHHHHCCHHHHEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCC
PYPTLSPEEQSFIDNEVEVLCSMLDEWEIHHQLKDLPPEVWQFIKDKGFLGLIIPKSFGG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCC
KEFSSFAQSRIMSKIASRSLTAAVSCMVPNSLGPGELLMHYGTDAQKQQYLPGLAKGEEI
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHCCCCCHHHHHCCCCCCCCCCC
PCFGLTSPEAGSDAGAIPDSGVVCYGEYEGAQVLGLRMNFSKRWITLAPIATVVGLAFKL
CEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHE
YDPEGLLGDKTKTEYGITCALIPANHAGVKIGARHYPGSPFMNGTVEGEDVFIPIDWIIG
ECCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCEECCCEEEEEEEEEEC
GQENAGKGWRMLMECLGVGRGISLPALATAAGEMSYLTVGAFARIRQQFNISVGKFEGVQ
CCCCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHCCHH
EASSEIASDAYMLEAFRYLVTCGLNQGGTPAVMTAMAKYYATETMRKVVNHGMDIAGGRA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
IQLGPRNFLALTYQAIPIAITVEGANILTRSLMIFGQGSMRCHPYLFEELQLLQSDDKAN
EEECCCCEEEEEEEEEEEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHH
AVQKFDDLLFKHLAYTFNRGARSFAYGWTGGSSDAPQSADQFTASYYKTINRFSANFSLV
HHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHH
SDMALGLLAGDLKRKEMLSGRLADIHAHLFIATAILKYYEAGQKTEAEQLHAKLALQKAF
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LNIQEAFWGLFDNFPAKLPAAFVKWICFPLGRVISKPDDELKQQVAELMMEEHPFREQLK
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHH
RHVYYSTEPNDVTGRLEHTFQMLRTIEPLWDKFKKAESKGKFTGLTFKENIAQAIKEGFI
HHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHCC
SESEAQQLLQYNAIRFDSMLTDVFDEKLNKVLPLSNPHQIV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MIFLLFVLSIVIQLVAIWAIFFFNLNRVAGSVITIAVAILTAFILTPWALLLGIPLIALS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIILFKPLRFNLITQPAYKTLANSMPSISTTEQEALEAGTSWWEKELFMGAPDWSQFEKY
HHHHHCCHHHHEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCC
PYPTLSPEEQSFIDNEVEVLCSMLDEWEIHHQLKDLPPEVWQFIKDKGFLGLIIPKSFGG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCC
KEFSSFAQSRIMSKIASRSLTAAVSCMVPNSLGPGELLMHYGTDAQKQQYLPGLAKGEEI
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHCCCCCHHHHHCCCCCCCCCCC
PCFGLTSPEAGSDAGAIPDSGVVCYGEYEGAQVLGLRMNFSKRWITLAPIATVVGLAFKL
CEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHE
YDPEGLLGDKTKTEYGITCALIPANHAGVKIGARHYPGSPFMNGTVEGEDVFIPIDWIIG
ECCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCEECCCEEEEEEEEEEC
GQENAGKGWRMLMECLGVGRGISLPALATAAGEMSYLTVGAFARIRQQFNISVGKFEGVQ
CCCCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHCCHH
EASSEIASDAYMLEAFRYLVTCGLNQGGTPAVMTAMAKYYATETMRKVVNHGMDIAGGRA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
IQLGPRNFLALTYQAIPIAITVEGANILTRSLMIFGQGSMRCHPYLFEELQLLQSDDKAN
EEECCCCEEEEEEEEEEEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHH
AVQKFDDLLFKHLAYTFNRGARSFAYGWTGGSSDAPQSADQFTASYYKTINRFSANFSLV
HHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHH
SDMALGLLAGDLKRKEMLSGRLADIHAHLFIATAILKYYEAGQKTEAEQLHAKLALQKAF
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LNIQEAFWGLFDNFPAKLPAAFVKWICFPLGRVISKPDDELKQQVAELMMEEHPFREQLK
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHH
RHVYYSTEPNDVTGRLEHTFQMLRTIEPLWDKFKKAESKGKFTGLTFKENIAQAIKEGFI
HHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHCC
SESEAQQLLQYNAIRFDSMLTDVFDEKLNKVLPLSNPHQIV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]