Click here to switch to the map view.

The map label for this gene is sthA [H]

Identifier: 213158050

GI number: 213158050

Start: 2827439

End: 2828851

Strand: Reverse

Name: sthA [H]

Synonym: AB57_2762

Alternate gene names: 213158050

Gene position: 2828851-2827439 (Counterclockwise)

Preceding gene: 213158054

Following gene: 213158045

Centisome position: 69.84

GC content: 40.48

Gene sequence:

>1413_bases
ATGCCACGTAAAAAAGAGGTCGTTAGTGGGAATTTCGTTAAGTACGATGCGGTAGTTCTCGGTTCTGGACCTGCAGGTGA
AGGCGCGGCAATGAAGCTTGCAAAAGCTGGTAAGCGTGTTGCAATTGTAGATGTACGTGATCAACTCGGTGGTAACTGTG
CACACGTAGGAACCATTCCAAGTAAAGCATTACGTCAAACAGTTTCTAGCATTATTCGCTATCAGCGTGATCCAATGTTT
CAAAAAGTAGGTGAATGGAAGCAGTTCACTATGAAACAGGTCTTGCGTAATGCGCACAAAGTGATTCAACAACAGGTTGA
TACGCATACGCGCTTTTATGACCGTAACAAAATTGGTGTCTTCCACGGTCGTGCATATATTCAAGACAAAAATACAGTTT
TAGTTTTTAGCCACGAAGGCATTAAAGAAACAATTATCTGTAAGCAAATCGTGATTGCGACAGGTAGCCGTCCTTATCAT
CCGCAAGGTCTTGATTTTGACCACCCGCGCGTATTTGATTCGGACAAAATTCTTGATCTTGATTACTCAATTCAAAAAAT
CATTATTTACGGCGCAGGTGTTATTGGCTGTGAATATGCCTCAATCTTTATTGGTTTAGATCATAAAGTTGACTTGATCA
ATACTCAACAAAAACTCTTAAGCTATCTAGATGATGAAATCGCCGATGCTTTGTCTTATCACTTACGTGAACAGGGCGTT
TTGATTCGTCACAATGAACAAATGGATCATCTTGAAACATTTGATGACCACGTTGTTCTACATTTACAAAGTGGTAAAAA
GATTAAAGCTGATGCGATTCTTTGGTGTAATGGTCGTTCAGGTAACACAGAAGGTTTAGGTCTTGAAAATGTTGGGTTGG
TACCAAATAGCCGTGGTCAACTTTCTGTAAATGATCAATATCAAACTGAAGTTGAAAACATCTATGCGGCTGGTGACGTG
ATTGGTTGGCCTTCACTTGCTTCGGCTGCCTATGACCAAGGGCGCTGTGCTGGTGCAAACATGAGTGGTGAAGACGCTAA
GCCAGTACGTGATATCCCTACAGGTATTTATACCATTCCGGAAATCTCATCTATTGGTAAGAATGAACAGGAATTAACGG
AAGAGAAAATTCCGTATGAAGTCGGTCAGGCTTCTTTCCGTCATTTGGCTCGTGCACAAATTACCGGTGATACAGTAGGT
GAGTTGAAGATTCTTTTCCATCGAGACACTTTGGAAATTTTAGGTATTCACTGTTTTGGTAATAATGCTGCTGAAATTAT
CCACATTGGACAAGCAGTTATGCACAGCCCAAACAATACTTTGAAATATTTTGTTGAAACGACTTTTAACTATCCAACAA
TGGCTGAAGCATACCGTGTAGCTGCACTTAATGGTATGAATCGTTTATTTTGA

Upstream 100 bases:

>100_bases
GGCTATTCAGAAATATAGGGTTGAGAAATACATAAATTCACCGCATATTAGCCATAATTTATTATAAAATATGGTCATTC
AACAGAGGAAGGAGCTTTCA

Downstream 100 bases:

>100_bases
TTTTAAATAAGTTTTTCATAAAAAAGCCCGCAAACTTGCGGGCTTTTTTATTTTTATTAGACCATATGTTTTTTATATTT
TTATGACAATGTACAGAGTG

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MPRKKEVVSGNFVKYDAVVLGSGPAGEGAAMKLAKAGKRVAIVDVRDQLGGNCAHVGTIPSKALRQTVSSIIRYQRDPMF
QKVGEWKQFTMKQVLRNAHKVIQQQVDTHTRFYDRNKIGVFHGRAYIQDKNTVLVFSHEGIKETIICKQIVIATGSRPYH
PQGLDFDHPRVFDSDKILDLDYSIQKIIIYGAGVIGCEYASIFIGLDHKVDLINTQQKLLSYLDDEIADALSYHLREQGV
LIRHNEQMDHLETFDDHVVLHLQSGKKIKADAILWCNGRSGNTEGLGLENVGLVPNSRGQLSVNDQYQTEVENIYAAGDV
IGWPSLASAAYDQGRCAGANMSGEDAKPVRDIPTGIYTIPEISSIGKNEQELTEEKIPYEVGQASFRHLARAQITGDTVG
ELKILFHRDTLEILGIHCFGNNAAEIIHIGQAVMHSPNNTLKYFVETTFNYPTMAEAYRVAALNGMNRLF

Sequences:

>Translated_470_residues
MPRKKEVVSGNFVKYDAVVLGSGPAGEGAAMKLAKAGKRVAIVDVRDQLGGNCAHVGTIPSKALRQTVSSIIRYQRDPMF
QKVGEWKQFTMKQVLRNAHKVIQQQVDTHTRFYDRNKIGVFHGRAYIQDKNTVLVFSHEGIKETIICKQIVIATGSRPYH
PQGLDFDHPRVFDSDKILDLDYSIQKIIIYGAGVIGCEYASIFIGLDHKVDLINTQQKLLSYLDDEIADALSYHLREQGV
LIRHNEQMDHLETFDDHVVLHLQSGKKIKADAILWCNGRSGNTEGLGLENVGLVPNSRGQLSVNDQYQTEVENIYAAGDV
IGWPSLASAAYDQGRCAGANMSGEDAKPVRDIPTGIYTIPEISSIGKNEQELTEEKIPYEVGQASFRHLARAQITGDTVG
ELKILFHRDTLEILGIHCFGNNAAEIIHIGQAVMHSPNNTLKYFVETTFNYPTMAEAYRVAALNGMNRLF
>Mature_469_residues
PRKKEVVSGNFVKYDAVVLGSGPAGEGAAMKLAKAGKRVAIVDVRDQLGGNCAHVGTIPSKALRQTVSSIIRYQRDPMFQ
KVGEWKQFTMKQVLRNAHKVIQQQVDTHTRFYDRNKIGVFHGRAYIQDKNTVLVFSHEGIKETIICKQIVIATGSRPYHP
QGLDFDHPRVFDSDKILDLDYSIQKIIIYGAGVIGCEYASIFIGLDHKVDLINTQQKLLSYLDDEIADALSYHLREQGVL
IRHNEQMDHLETFDDHVVLHLQSGKKIKADAILWCNGRSGNTEGLGLENVGLVPNSRGQLSVNDQYQTEVENIYAAGDVI
GWPSLASAAYDQGRCAGANMSGEDAKPVRDIPTGIYTIPEISSIGKNEQELTEEKIPYEVGQASFRHLARAQITGDTVGE
LKILFHRDTLEILGIHCFGNNAAEIIHIGQAVMHSPNNTLKYFVETTFNYPTMAEAYRVAALNGMNRLF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=470, Percent_Identity=32.5531914893617, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI50301238, Length=468, Percent_Identity=26.0683760683761, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI291045266, Length=488, Percent_Identity=24.1803278688525, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI33519430, Length=488, Percent_Identity=26.0245901639344, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI33519428, Length=488, Percent_Identity=26.0245901639344, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI33519426, Length=488, Percent_Identity=26.0245901639344, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI148277065, Length=488, Percent_Identity=26.0245901639344, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI148277071, Length=482, Percent_Identity=26.3485477178423, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=58.4782608695652, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI1786307, Length=462, Percent_Identity=28.3549783549784, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI87081717, Length=452, Percent_Identity=29.2035398230088, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=26.879271070615, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=30.9368191721133, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17557007, Length=473, Percent_Identity=23.4672304439746, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI71983429, Length=336, Percent_Identity=25.297619047619, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71983419, Length=336, Percent_Identity=25.297619047619, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321091, Length=473, Percent_Identity=29.8097251585624, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6325240, Length=477, Percent_Identity=28.5115303983228, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6325166, Length=472, Percent_Identity=27.3305084745763, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI21358499, Length=456, Percent_Identity=31.5789473684211, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24640551, Length=509, Percent_Identity=25.7367387033399, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24640549, Length=503, Percent_Identity=25.844930417495, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24640553, Length=496, Percent_Identity=25.8064516129032, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 52265; Mature: 52134

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRKKEVVSGNFVKYDAVVLGSGPAGEGAAMKLAKAGKRVAIVDVRDQLGGNCAHVGTIP
CCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHCCCEEEEEEEHHHHCCCEEEECCCC
SKALRQTVSSIIRYQRDPMFQKVGEWKQFTMKQVLRNAHKVIQQQVDTHTRFYDRNKIGV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEE
FHGRAYIQDKNTVLVFSHEGIKETIICKQIVIATGSRPYHPQGLDFDHPRVFDSDKILDL
EECEEEEECCCEEEEEECCCCHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCEEEC
DYSIQKIIIYGAGVIGCEYASIFIGLDHKVDLINTQQKLLSYLDDEIADALSYHLREQGV
CCCEEEEEEEECCEEEEEEEEEEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCE
LIRHNEQMDHLETFDDHVVLHLQSGKKIKADAILWCNGRSGNTEGLGLENVGLVPNSRGQ
EEEECCCHHHHHCCCCEEEEEECCCCEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
LSVNDQYQTEVENIYAAGDVIGWPSLASAAYDQGRCAGANMSGEDAKPVRDIPTGIYTIP
EEECCHHHHHHHHHEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCEEECC
EISSIGKNEQELTEEKIPYEVGQASFRHLARAQITGDTVGELKILFHRDTLEILGIHCFG
CHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEEEEEEC
NNAAEIIHIGQAVMHSPNNTLKYFVETTFNYPTMAEAYRVAALNGMNRLF
CCCHHHEEHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHCC
>Mature Secondary Structure 
PRKKEVVSGNFVKYDAVVLGSGPAGEGAAMKLAKAGKRVAIVDVRDQLGGNCAHVGTIP
CCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHCCCEEEEEEEHHHHCCCEEEECCCC
SKALRQTVSSIIRYQRDPMFQKVGEWKQFTMKQVLRNAHKVIQQQVDTHTRFYDRNKIGV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEE
FHGRAYIQDKNTVLVFSHEGIKETIICKQIVIATGSRPYHPQGLDFDHPRVFDSDKILDL
EECEEEEECCCEEEEEECCCCHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCEEEC
DYSIQKIIIYGAGVIGCEYASIFIGLDHKVDLINTQQKLLSYLDDEIADALSYHLREQGV
CCCEEEEEEEECCEEEEEEEEEEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCE
LIRHNEQMDHLETFDDHVVLHLQSGKKIKADAILWCNGRSGNTEGLGLENVGLVPNSRGQ
EEEECCCHHHHHCCCCEEEEEECCCCEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
LSVNDQYQTEVENIYAAGDVIGWPSLASAAYDQGRCAGANMSGEDAKPVRDIPTGIYTIP
EEECCHHHHHHHHHEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCEEECC
EISSIGKNEQELTEEKIPYEVGQASFRHLARAQITGDTVGELKILFHRDTLEILGIHCFG
CHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEEEEEEC
NNAAEIIHIGQAVMHSPNNTLKYFVETTFNYPTMAEAYRVAALNGMNRLF
CCCHHHEEHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA