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The map label for this gene is trpF [H]

Identifier: 213157888

GI number: 213157888

Start: 3484550

End: 3485209

Strand: Reverse

Name: trpF [H]

Synonym: AB57_3380

Alternate gene names: 213157888

Gene position: 3485209-3484550 (Counterclockwise)

Preceding gene: 213157892

Following gene: 213157887

Centisome position: 86.04

GC content: 42.88

Gene sequence:

>660_bases
ATGAGCCAATCAAACCAAAAACGTACACGAGCAAAAATCTGTGGAATTACTCGCAAGCAAGATGTTCAGGCAGTAGTTGC
AGCGGGAGCAGATGCGATAGGCTTTGTTTTTTTCCCGCCGAGTCCAAGAAATGTAACAGTTGAACAGGCAGAAGAATTAG
CAAAACTCGTTCCGCCTTATGTACAAATGGTAGGTTTGTTTGTAAATGCGAGTGTTACTGAAATTCAGGATATACTTGAT
TGTGTTCCCCTAGATGTATTACAACTACATGGCGATGAAACTCCAGAACAATGTCAGGAAATAGCGCGTCATTGTAAACG
TCGCTGGTATAAAGCGATTCAGGTTAAACCTGATCTGGATGTAATTGCTGAAATTCAAAAATATCAGGCAGCTGGTGCCA
GTGCTGTATTGCTCGATGCATGGCATCCTGAGCTTAAAGGGGGCACAGGACATCAGTTTGACTGGTCTAAATTCCCGAAA
CTTGATATTCCATTAATCTTGGCAGGTGGTTTAACCCCTGACAATGTCATTGACGCTATTCATACTACCGGTGCTTTTGC
AGTAGATGTGAGCGGAGGCGTAGAGTCCGCAAAAGGTATAAAAGACCAACAACTCATTGAACGATTTATGCAAGGAGTCC
AACGTGGATCAGCAAAATAA

Upstream 100 bases:

>100_bases
AATGTCATTTAAAGCAATTCCCTGAGAACTTTTACGCAAGGGGCAAAAATTGCATTACAATGGCGCTTATTTTAAGAAAT
GGTTGTAGTTTAAGCAGCTC

Downstream 100 bases:

>100_bases
TATGATTGACTATACCCAATTCCCAGATGCAAATGGGCATTTCGGTATCCATGGCGGACGTTTTGTGTCAGAAACTTTAA
TGGCGGCATTAGAAGATTTG

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MSQSNQKRTRAKICGITRKQDVQAVVAAGADAIGFVFFPPSPRNVTVEQAEELAKLVPPYVQMVGLFVNASVTEIQDILD
CVPLDVLQLHGDETPEQCQEIARHCKRRWYKAIQVKPDLDVIAEIQKYQAAGASAVLLDAWHPELKGGTGHQFDWSKFPK
LDIPLILAGGLTPDNVIDAIHTTGAFAVDVSGGVESAKGIKDQQLIERFMQGVQRGSAK

Sequences:

>Translated_219_residues
MSQSNQKRTRAKICGITRKQDVQAVVAAGADAIGFVFFPPSPRNVTVEQAEELAKLVPPYVQMVGLFVNASVTEIQDILD
CVPLDVLQLHGDETPEQCQEIARHCKRRWYKAIQVKPDLDVIAEIQKYQAAGASAVLLDAWHPELKGGTGHQFDWSKFPK
LDIPLILAGGLTPDNVIDAIHTTGAFAVDVSGGVESAKGIKDQQLIERFMQGVQRGSAK
>Mature_218_residues
SQSNQKRTRAKICGITRKQDVQAVVAAGADAIGFVFFPPSPRNVTVEQAEELAKLVPPYVQMVGLFVNASVTEIQDILDC
VPLDVLQLHGDETPEQCQEIARHCKRRWYKAIQVKPDLDVIAEIQKYQAAGASAVLLDAWHPELKGGTGHQFDWSKFPKL
DIPLILAGGLTPDNVIDAIHTTGAFAVDVSGGVESAKGIKDQQLIERFMQGVQRGSAK

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=208, Percent_Identity=34.1346153846154, Blast_Score=98, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320210, Length=219, Percent_Identity=27.8538812785388, Blast_Score=85, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 23899; Mature: 23767

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSNQKRTRAKICGITRKQDVQAVVAAGADAIGFVFFPPSPRNVTVEQAEELAKLVPPY
CCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCHH
VQMVGLFVNASVTEIQDILDCVPLDVLQLHGDETPEQCQEIARHCKRRWYKAIQVKPDLD
HHHHHHHHCCCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHH
VIAEIQKYQAAGASAVLLDAWHPELKGGTGHQFDWSKFPKLDIPLILAGGLTPDNVIDAI
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHH
HTTGAFAVDVSGGVESAKGIKDQQLIERFMQGVQRGSAK
HCCCCEEEEECCCCCHHCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SQSNQKRTRAKICGITRKQDVQAVVAAGADAIGFVFFPPSPRNVTVEQAEELAKLVPPY
CCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCHH
VQMVGLFVNASVTEIQDILDCVPLDVLQLHGDETPEQCQEIARHCKRRWYKAIQVKPDLD
HHHHHHHHCCCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHH
VIAEIQKYQAAGASAVLLDAWHPELKGGTGHQFDWSKFPKLDIPLILAGGLTPDNVIDAI
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHH
HTTGAFAVDVSGGVESAKGIKDQQLIERFMQGVQRGSAK
HCCCCEEEEECCCCCHHCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2299982; 2211532 [H]