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The map label for this gene is xanP [H]

Identifier: 213157851

GI number: 213157851

Start: 3442080

End: 3443438

Strand: Direct

Name: xanP [H]

Synonym: AB57_3338

Alternate gene names: 213157851

Gene position: 3442080-3443438 (Clockwise)

Preceding gene: 213157847

Following gene: 213157852

Centisome position: 84.98

GC content: 40.77

Gene sequence:

>1359_bases
ATGTCCAATCAACCATCACAAGACCGTCTTGACCTCGTTTATGGGCTAGATGACCGACCAAAACCGTTCGTGGCTTTTTT
GGCAGCCTTTCAACATTTGCTTGCAATTATTGTCCCGATTGTTACTCCCGGGCTTCTAATTTGCTTAGCATTAGGCGTTC
CACGAAATGAAACCAATATGATTTTATCCATGTCTTTGGTCATTTCAGGAATCGCGACTTTCTTACAATGTAAAAAAGTT
GGTCCGTTTGGTGCAGGCTTACTTATTGTTCAAGGTACAAGTTTTAACTTTATTGGCCCGATTATCGGTATTGGCAGTGC
AATGGTTGCTGCAGGTACACCAGTCAATCAAGTTATGGCTGCTATTTTTGGTGTTGTGATTGCAGGTTCATTTATTGAAA
TGGGCGTATCACAAATTCTCCCATGGGTAAAAAAGCTAATTACTCCCCTTGTGACAGGTATTGTGGTACTCCTGATTGGC
CTAACGCTCATTAAAGAAGGTTTGATTAGTATGGGCGGTGGTTATCAAGCCATGCAGGACCATACTTTTGCCAGTGCTGA
TAACCTTATAATGTCGTGTACGGTTCTTGCTATTATTATTGTCCTAAACCGTATTCGTATTGTCTGGATTAAAAGTTCAG
CTATTTTAATTGCTTTAGTGATTGGCTACATTCTTGCCGGCTTTATGGGATATCTAGACTTCTCTGGTCTAAAAGATGCG
CCCGTGATTCAAATTCCGACACCGATGCATTTTGGCTTAAGCTTCTCATGGGGCTTATTTATTCCAATGGCATTTATTTA
TTTGGTTACGTCTTTAGAAGCAATTGGTGACGTAACGGCAACCAGTAAACTATCAAACCAACCTGTAGATGGTCCTCAGT
GGATGCAACGTATTAAGGGTGGTGTGTTAGTAAATGGTGCAAATTCACTACTTGCTGGCCTATTCAATACTTTCCCAAGC
TCCGTGTTTGCCCAAAATAATGGTGTTATCCAATTAACTGGCGTAGCAAGTCGTTATGTAGGAATCTGGATTGCTGCTTT
ACTCATTTTATTAGGTCTATTCCCTGCTGTAGCTGGTGTAATACAAGCTGTTCCACAAGCCGTATTAGGTGGAGCAGTCA
TGGTAATGTTCGGCGCCGTTGCTGCTTCAGGTATTAATATACTTTCATCAATTCATTTAGATCGCCGTGCCCTTTTAATT
ATTGCGATTTCACTTGCATTAGGTTTGGGTGTTGCTCAGGTGCCACAAATTTTGGAGCATCTGCCAGAATTATTTAAAAA
TATTTTTAGTTCCGGCGTAGCAACAGGCGGTATTGCAGCATTAATTTTAAATGTTGTACTCCCAGAAACACATAAATAA

Upstream 100 bases:

>100_bases
TTGACAAAAAAATTTTCCAATAGTCTGTATTTCGTTTTGTAAAGATAGGTATCTCGATTAGAATAGCGCCAATTTGCGAA
ATTGCGGCGTATTTACTCCC

Downstream 100 bases:

>100_bases
CCAATTTTAATTTTGATTACTGCCCAGTTTTCACTGGGCATTCTTCTTCATGAGAGATGTACATGGACCCTAGAAGTGAA
GTGATATTAAGACAACAAGA

Product: uracil-xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSNQPSQDRLDLVYGLDDRPKPFVAFLAAFQHLLAIIVPIVTPGLLICLALGVPRNETNMILSMSLVISGIATFLQCKKV
GPFGAGLLIVQGTSFNFIGPIIGIGSAMVAAGTPVNQVMAAIFGVVIAGSFIEMGVSQILPWVKKLITPLVTGIVVLLIG
LTLIKEGLISMGGGYQAMQDHTFASADNLIMSCTVLAIIIVLNRIRIVWIKSSAILIALVIGYILAGFMGYLDFSGLKDA
PVIQIPTPMHFGLSFSWGLFIPMAFIYLVTSLEAIGDVTATSKLSNQPVDGPQWMQRIKGGVLVNGANSLLAGLFNTFPS
SVFAQNNGVIQLTGVASRYVGIWIAALLILLGLFPAVAGVIQAVPQAVLGGAVMVMFGAVAASGINILSSIHLDRRALLI
IAISLALGLGVAQVPQILEHLPELFKNIFSSGVATGGIAALILNVVLPETHK

Sequences:

>Translated_452_residues
MSNQPSQDRLDLVYGLDDRPKPFVAFLAAFQHLLAIIVPIVTPGLLICLALGVPRNETNMILSMSLVISGIATFLQCKKV
GPFGAGLLIVQGTSFNFIGPIIGIGSAMVAAGTPVNQVMAAIFGVVIAGSFIEMGVSQILPWVKKLITPLVTGIVVLLIG
LTLIKEGLISMGGGYQAMQDHTFASADNLIMSCTVLAIIIVLNRIRIVWIKSSAILIALVIGYILAGFMGYLDFSGLKDA
PVIQIPTPMHFGLSFSWGLFIPMAFIYLVTSLEAIGDVTATSKLSNQPVDGPQWMQRIKGGVLVNGANSLLAGLFNTFPS
SVFAQNNGVIQLTGVASRYVGIWIAALLILLGLFPAVAGVIQAVPQAVLGGAVMVMFGAVAASGINILSSIHLDRRALLI
IAISLALGLGVAQVPQILEHLPELFKNIFSSGVATGGIAALILNVVLPETHK
>Mature_451_residues
SNQPSQDRLDLVYGLDDRPKPFVAFLAAFQHLLAIIVPIVTPGLLICLALGVPRNETNMILSMSLVISGIATFLQCKKVG
PFGAGLLIVQGTSFNFIGPIIGIGSAMVAAGTPVNQVMAAIFGVVIAGSFIEMGVSQILPWVKKLITPLVTGIVVLLIGL
TLIKEGLISMGGGYQAMQDHTFASADNLIMSCTVLAIIIVLNRIRIVWIKSSAILIALVIGYILAGFMGYLDFSGLKDAP
VIQIPTPMHFGLSFSWGLFIPMAFIYLVTSLEAIGDVTATSKLSNQPVDGPQWMQRIKGGVLVNGANSLLAGLFNTFPSS
VFAQNNGVIQLTGVASRYVGIWIAALLILLGLFPAVAGVIQAVPQAVLGGAVMVMFGAVAASGINILSSIHLDRRALLII
AISLALGLGVAQVPQILEHLPELFKNIFSSGVATGGIAALILNVVLPETHK

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=516, Percent_Identity=23.062015503876, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI44680143, Length=520, Percent_Identity=23.0769230769231, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI44680148, Length=513, Percent_Identity=25.5360623781676, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI40316845, Length=513, Percent_Identity=25.5360623781676, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1790087, Length=446, Percent_Identity=52.6905829596413, Blast_Score=457, Evalue=1e-130,
Organism=Escherichia coli, GI87082178, Length=442, Percent_Identity=42.9864253393665, Blast_Score=352, Evalue=4e-98,
Organism=Escherichia coli, GI87082181, Length=441, Percent_Identity=31.5192743764172, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1788843, Length=276, Percent_Identity=26.0869565217391, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87081818, Length=280, Percent_Identity=27.8571428571429, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=454, Percent_Identity=22.0264317180617, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71993493, Length=222, Percent_Identity=26.1261261261261, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17542260, Length=222, Percent_Identity=26.1261261261261, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 47483; Mature: 47351

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQPSQDRLDLVYGLDDRPKPFVAFLAAFQHLLAIIVPIVTPGLLICLALGVPRNETNM
CCCCCCCCCHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ILSMSLVISGIATFLQCKKVGPFGAGLLIVQGTSFNFIGPIIGIGSAMVAAGTPVNQVMA
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHCHHHHHCCCCHHHHHH
AIFGVVIAGSFIEMGVSQILPWVKKLITPLVTGIVVLLIGLTLIKEGLISMGGGYQAMQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHC
HTFASADNLIMSCTVLAIIIVLNRIRIVWIKSSAILIALVIGYILAGFMGYLDFSGLKDA
CCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PVIQIPTPMHFGLSFSWGLFIPMAFIYLVTSLEAIGDVTATSKLSNQPVDGPQWMQRIKG
CEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCHHHHHHHCC
GVLVNGANSLLAGLFNTFPSSVFAQNNGVIQLTGVASRYVGIWIAALLILLGLFPAVAGV
CEEEECHHHHHHHHHHHCCHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
IQAVPQAVLGGAVMVMFGAVAASGINILSSIHLDRRALLIIAISLALGLGVAQVPQILEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LPELFKNIFSSGVATGGIAALILNVVLPETHK
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SNQPSQDRLDLVYGLDDRPKPFVAFLAAFQHLLAIIVPIVTPGLLICLALGVPRNETNM
CCCCCCCCHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ILSMSLVISGIATFLQCKKVGPFGAGLLIVQGTSFNFIGPIIGIGSAMVAAGTPVNQVMA
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHCHHHHHCCCCHHHHHH
AIFGVVIAGSFIEMGVSQILPWVKKLITPLVTGIVVLLIGLTLIKEGLISMGGGYQAMQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHC
HTFASADNLIMSCTVLAIIIVLNRIRIVWIKSSAILIALVIGYILAGFMGYLDFSGLKDA
CCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PVIQIPTPMHFGLSFSWGLFIPMAFIYLVTSLEAIGDVTATSKLSNQPVDGPQWMQRIKG
CEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCHHHHHHHCC
GVLVNGANSLLAGLFNTFPSSVFAQNNGVIQLTGVASRYVGIWIAALLILLGLFPAVAGV
CEEEECHHHHHHHHHHHCCHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
IQAVPQAVLGGAVMVMFGAVAASGINILSSIHLDRRALLIIAISLALGLGVAQVPQILEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LPELFKNIFSSGVATGGIAALILNVVLPETHK
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]