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The map label for this gene is ykoW [H]

Identifier: 213157598

GI number: 213157598

Start: 2374737

End: 2376830

Strand: Direct

Name: ykoW [H]

Synonym: AB57_2291

Alternate gene names: 213157598

Gene position: 2374737-2376830 (Clockwise)

Preceding gene: 213157597

Following gene: 213157599

Centisome position: 58.63

GC content: 38.11

Gene sequence:

>2094_bases
ATGACTTCAATGTCGAACACTACCCAAAAGCATTTTATTGTTGAGCAGTTTCCTTTACCGACTTGGGTCAGTGATGAAAA
AGGCTTAATTTTATACTGCAATACGGAGTGCACAAAGTACTGGCGCGATACTTCTCCTCCATTGTTTCAACAATGGCTAG
ATTTCGTGTACCCTGCCGATTTAGAAGAAGTTAAAAACAAATGGTTAGATGCGATACGACTCCGATCAAGAATTGAATTT
AAATGCCGTCTTTTGCATAAAACCCATTATTATCGATGGTGTAAAATTTCTATTCAATTGTCGAAATACCATGAATCTTC
TCAAGAAAATGAATGGTTTATTAGTTTTCTAGATATTGACCAAGATATACAAGAGCAGCAAAGCTTACGAAAAGATATCG
ATATACAAAATCAAATGCTCGATATCAGTGTCGATTGTATTAAGGTTTTAAATACAGATGGCACTGTATCTCATATGAAT
AAATCAGGATGCCTTGCATTAGGTATACCTGTAGATGAAAAAAAATTCGGTATGCGATGGTTAGATCTTTTACCACCCCA
TATTCGTAAACGCGGAAGAGTTGCCTTAAAAAAAGCCTTACAGGGTAAAGTGGCCCGATTCGCTGGCATGAGTTGCTTAC
CAAATCAAGATCCAGAATATTGGGATAACATGCTTACCCCAATTCAACATACAAACGGCGAAATTATTCAGATATTGTGT
GTTTCGCGAAATGTCACTCAACAGTATCTTACCGAAAACCGTCTAAGAGATATTAGCGAGAGAGATGAACTCACAGGATT
ATTTAATAGACGTTCATTTAAGCTACAACTAAAACGCACCCTAGCCTACTCAAGAGAAACCCAAACTAGTGTAGGGCTAC
TTTTAATTGATCTAGATCATTTCAAGCATATTAATGACACTATAGGTCATAGTGCTGGTGACCACTTATTAAAAATACTT
TCTAAACGTTTTAATCAGTGCGTAGATCCTGAAAGATGTTCAGTTGCCAGATTAGGTGGTGATGAGTTTGCAGTTATTGT
TAGCCATTTAGAAAATGAGAATGATGTTCGTGAACTTGCAGAAGTATTGCTTCAACAACTCAATCAACCCATTACATATG
CTGGGAATGTGCTCAACGGCGGCATGAGCATCGGCTGCGCCATTTATCCTCAAGATGCAGTTGATCAATCGAGCTTATTA
AGTTGTGCCGATATGGCATTACATGACTTAAAAGCCCGTGGTCGTGGCGGCATACGTATGTATAACCCAAGTATGATGCA
GTTAACCGAGGCAATCGCCTCTCAACTCAACATTGCTCGCCAGCTTATTCGTCATCATACCATTCAGCCCTACTATCAAC
CCAAAGTCGATCTAAAAACTCATGCTGTAGTGGGCTTTGAAGCATTACTCCGCTGGCATACGACTTCGGCCCAAAGAGGT
TTGCCTTCTCAGATTGCTGAAGCTTTTAAAGACTACGATTTAGCCAGTAAAATTGGTGAAATCATGCAACAACAAGTTTT
GCATGATATTGCTAAATGGATAAAGTTAGGTTTTGAGCCGCTTCCTGTTTCTCTAAATGCCGCACCGGTTGAGTTTTTAA
GAGATAACTATGCTGAACGTTTATTAAAAAAGATTAATCAACTTGAAATTCCTACCCATTTAATTGAAATAGAAGTTACT
GAACATATGCTGGGTGACCGTGGTTCTGAATATGTTATTCGCGCGCTCAATAAACTAAAACAGCATGGGGTACGCATTGC
TTTAGATGACTTCGGAACAGGTTTCTCTTCATTAACACATATAAGAGACTATCCGATTGATTGCTTAAAAGTTGATTGTA
GCTTTATACAAAAGATGCAACATGATCCATCCATTTATGCAATTGTTCAGGCAATTGGCTTACTTGCTCCAAATCTCTCA
CTCGGATTAATTGCAGAAGGTATTGAAACACCAGAACAAGAAGAATTACTTCTTCAATTTGGATACAACATAGGGCAAGG
TTTTTTATTTGAATCAGCTATTGACGCTAATCAGGTGATTTCTATTCTTAAACAGGGTCAGGCTTATCTAGAAAGTCACT
ATTCTATGAATTAA

Upstream 100 bases:

>100_bases
AAACATCAAATATTAATTTTTTATAGCTTTTGTGGTGACGACACAACTATTACAATACAGTTTATAAATAGTTTAACTCT
TCAGCAGTTTTAGGCATGTT

Downstream 100 bases:

>100_bases
TCATTTATCTTACACACTAAAAACAAACAATAAAAATTATAAAATTGGCGATAATATAACCATAACGATAACAAGTTTAG
GTTCTTCAACAATAAATATT

Product: GGDEF family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 697; Mature: 696

Protein sequence:

>697_residues
MTSMSNTTQKHFIVEQFPLPTWVSDEKGLILYCNTECTKYWRDTSPPLFQQWLDFVYPADLEEVKNKWLDAIRLRSRIEF
KCRLLHKTHYYRWCKISIQLSKYHESSQENEWFISFLDIDQDIQEQQSLRKDIDIQNQMLDISVDCIKVLNTDGTVSHMN
KSGCLALGIPVDEKKFGMRWLDLLPPHIRKRGRVALKKALQGKVARFAGMSCLPNQDPEYWDNMLTPIQHTNGEIIQILC
VSRNVTQQYLTENRLRDISERDELTGLFNRRSFKLQLKRTLAYSRETQTSVGLLLIDLDHFKHINDTIGHSAGDHLLKIL
SKRFNQCVDPERCSVARLGGDEFAVIVSHLENENDVRELAEVLLQQLNQPITYAGNVLNGGMSIGCAIYPQDAVDQSSLL
SCADMALHDLKARGRGGIRMYNPSMMQLTEAIASQLNIARQLIRHHTIQPYYQPKVDLKTHAVVGFEALLRWHTTSAQRG
LPSQIAEAFKDYDLASKIGEIMQQQVLHDIAKWIKLGFEPLPVSLNAAPVEFLRDNYAERLLKKINQLEIPTHLIEIEVT
EHMLGDRGSEYVIRALNKLKQHGVRIALDDFGTGFSSLTHIRDYPIDCLKVDCSFIQKMQHDPSIYAIVQAIGLLAPNLS
LGLIAEGIETPEQEELLLQFGYNIGQGFLFESAIDANQVISILKQGQAYLESHYSMN

Sequences:

>Translated_697_residues
MTSMSNTTQKHFIVEQFPLPTWVSDEKGLILYCNTECTKYWRDTSPPLFQQWLDFVYPADLEEVKNKWLDAIRLRSRIEF
KCRLLHKTHYYRWCKISIQLSKYHESSQENEWFISFLDIDQDIQEQQSLRKDIDIQNQMLDISVDCIKVLNTDGTVSHMN
KSGCLALGIPVDEKKFGMRWLDLLPPHIRKRGRVALKKALQGKVARFAGMSCLPNQDPEYWDNMLTPIQHTNGEIIQILC
VSRNVTQQYLTENRLRDISERDELTGLFNRRSFKLQLKRTLAYSRETQTSVGLLLIDLDHFKHINDTIGHSAGDHLLKIL
SKRFNQCVDPERCSVARLGGDEFAVIVSHLENENDVRELAEVLLQQLNQPITYAGNVLNGGMSIGCAIYPQDAVDQSSLL
SCADMALHDLKARGRGGIRMYNPSMMQLTEAIASQLNIARQLIRHHTIQPYYQPKVDLKTHAVVGFEALLRWHTTSAQRG
LPSQIAEAFKDYDLASKIGEIMQQQVLHDIAKWIKLGFEPLPVSLNAAPVEFLRDNYAERLLKKINQLEIPTHLIEIEVT
EHMLGDRGSEYVIRALNKLKQHGVRIALDDFGTGFSSLTHIRDYPIDCLKVDCSFIQKMQHDPSIYAIVQAIGLLAPNLS
LGLIAEGIETPEQEELLLQFGYNIGQGFLFESAIDANQVISILKQGQAYLESHYSMN
>Mature_696_residues
TSMSNTTQKHFIVEQFPLPTWVSDEKGLILYCNTECTKYWRDTSPPLFQQWLDFVYPADLEEVKNKWLDAIRLRSRIEFK
CRLLHKTHYYRWCKISIQLSKYHESSQENEWFISFLDIDQDIQEQQSLRKDIDIQNQMLDISVDCIKVLNTDGTVSHMNK
SGCLALGIPVDEKKFGMRWLDLLPPHIRKRGRVALKKALQGKVARFAGMSCLPNQDPEYWDNMLTPIQHTNGEIIQILCV
SRNVTQQYLTENRLRDISERDELTGLFNRRSFKLQLKRTLAYSRETQTSVGLLLIDLDHFKHINDTIGHSAGDHLLKILS
KRFNQCVDPERCSVARLGGDEFAVIVSHLENENDVRELAEVLLQQLNQPITYAGNVLNGGMSIGCAIYPQDAVDQSSLLS
CADMALHDLKARGRGGIRMYNPSMMQLTEAIASQLNIARQLIRHHTIQPYYQPKVDLKTHAVVGFEALLRWHTTSAQRGL
PSQIAEAFKDYDLASKIGEIMQQQVLHDIAKWIKLGFEPLPVSLNAAPVEFLRDNYAERLLKKINQLEIPTHLIEIEVTE
HMLGDRGSEYVIRALNKLKQHGVRIALDDFGTGFSSLTHIRDYPIDCLKVDCSFIQKMQHDPSIYAIVQAIGLLAPNLSL
GLIAEGIETPEQEELLLQFGYNIGQGFLFESAIDANQVISILKQGQAYLESHYSMN

Specific function: Probable signaling protein whose physiological role is not yet known [H]

COG id: COG5001

COG function: function code T; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=444, Percent_Identity=29.7297297297297, Blast_Score=198, Evalue=1e-51,
Organism=Escherichia coli, GI87081921, Length=434, Percent_Identity=25.3456221198157, Blast_Score=155, Evalue=1e-38,
Organism=Escherichia coli, GI226510982, Length=453, Percent_Identity=26.4900662251656, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI87081743, Length=224, Percent_Identity=30.8035714285714, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1790496, Length=240, Percent_Identity=30, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786507, Length=251, Percent_Identity=29.4820717131474, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI87081845, Length=288, Percent_Identity=27.7777777777778, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788502, Length=239, Percent_Identity=30.1255230125523, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788381, Length=648, Percent_Identity=22.5308641975309, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI145693134, Length=202, Percent_Identity=33.6633663366337, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1787055, Length=224, Percent_Identity=27.6785714285714, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1786584, Length=166, Percent_Identity=33.7349397590361, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI87081980, Length=251, Percent_Identity=27.0916334661355, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1787262, Length=174, Percent_Identity=28.735632183908, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788956, Length=150, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87082096, Length=193, Percent_Identity=27.979274611399, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI87081977, Length=223, Percent_Identity=30.4932735426009, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081881, Length=182, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1787410, Length=228, Percent_Identity=28.0701754385965, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87081974, Length=86, Percent_Identity=37.2093023255814, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787802, Length=162, Percent_Identity=32.0987654320988, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788849, Length=240, Percent_Identity=25, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR005330
- InterPro:   IPR000014 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF03707 MHYT [H]

EC number: NA

Molecular weight: Translated: 79691; Mature: 79559

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSMSNTTQKHFIVEQFPLPTWVSDEKGLILYCNTECTKYWRDTSPPLFQQWLDFVYPAD
CCCCCCCHHHHEEHCCCCCCCCCCCCCCEEEEECCHHHHHHCCCCCHHHHHHHHHHCCCC
LEEVKNKWLDAIRLRSRIEFKCRLLHKTHYYRWCKISIQLSKYHESSQENEWFISFLDID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEHHHHCCCCCCCEEEEEECCC
QDIQEQQSLRKDIDIQNQMLDISVDCIKVLNTDGTVSHMNKSGCLALGIPVDEKKFGMRW
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEECCCCCHHHCCHH
LDLLPPHIRKRGRVALKKALQGKVARFAGMSCLPNQDPEYWDNMLTPIQHTNGEIIQILC
HHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCEEEEEE
VSRNVTQQYLTENRLRDISERDELTGLFNRRSFKLQLKRTLAYSRETQTSVGLLLIDLDH
ECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEHHH
FKHINDTIGHSAGDHLLKILSKRFNQCVDPERCSVARLGGDEFAVIVSHLENENDVRELA
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHCCCCHHHHHH
EVLLQQLNQPITYAGNVLNGGMSIGCAIYPQDAVDQSSLLSCADMALHDLKARGRGGIRM
HHHHHHCCCCCCCCCCHHCCCCEEEEEECCCHHCCHHHHHHHHHHHHHHHHHCCCCCEEE
YNPSMMQLTEAIASQLNIARQLIRHHTIQPYYQPKVDLKTHAVVGFEALLRWHTTSAQRG
ECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
LPSQIAEAFKDYDLASKIGEIMQQQVLHDIAKWIKLGFEPLPVSLNAAPVEFLRDNYAER
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
LLKKINQLEIPTHLIEIEVTEHMLGDRGSEYVIRALNKLKQHGVRIALDDFGTGFSSLTH
HHHHHHHCCCCCEEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
IRDYPIDCLKVDCSFIQKMQHDPSIYAIVQAIGLLAPNLSLGLIAEGIETPEQEELLLQF
HHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHH
GYNIGQGFLFESAIDANQVISILKQGQAYLESHYSMN
CCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSMSNTTQKHFIVEQFPLPTWVSDEKGLILYCNTECTKYWRDTSPPLFQQWLDFVYPAD
CCCCCCHHHHEEHCCCCCCCCCCCCCCEEEEECCHHHHHHCCCCCHHHHHHHHHHCCCC
LEEVKNKWLDAIRLRSRIEFKCRLLHKTHYYRWCKISIQLSKYHESSQENEWFISFLDID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEHHHHCCCCCCCEEEEEECCC
QDIQEQQSLRKDIDIQNQMLDISVDCIKVLNTDGTVSHMNKSGCLALGIPVDEKKFGMRW
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEECCCCCHHHCCHH
LDLLPPHIRKRGRVALKKALQGKVARFAGMSCLPNQDPEYWDNMLTPIQHTNGEIIQILC
HHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCEEEEEE
VSRNVTQQYLTENRLRDISERDELTGLFNRRSFKLQLKRTLAYSRETQTSVGLLLIDLDH
ECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEHHH
FKHINDTIGHSAGDHLLKILSKRFNQCVDPERCSVARLGGDEFAVIVSHLENENDVRELA
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHCCCCHHHHHH
EVLLQQLNQPITYAGNVLNGGMSIGCAIYPQDAVDQSSLLSCADMALHDLKARGRGGIRM
HHHHHHCCCCCCCCCCHHCCCCEEEEEECCCHHCCHHHHHHHHHHHHHHHHHCCCCCEEE
YNPSMMQLTEAIASQLNIARQLIRHHTIQPYYQPKVDLKTHAVVGFEALLRWHTTSAQRG
ECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
LPSQIAEAFKDYDLASKIGEIMQQQVLHDIAKWIKLGFEPLPVSLNAAPVEFLRDNYAER
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
LLKKINQLEIPTHLIEIEVTEHMLGDRGSEYVIRALNKLKQHGVRIALDDFGTGFSSLTH
HHHHHHHCCCCCEEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
IRDYPIDCLKVDCSFIQKMQHDPSIYAIVQAIGLLAPNLSLGLIAEGIETPEQEELLLQF
HHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHH
GYNIGQGFLFESAIDANQVISILKQGQAYLESHYSMN
CCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 11728710 [H]