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The map label for this gene is fruA [H]

Identifier: 213157594

GI number: 213157594

Start: 2370356

End: 2372074

Strand: Direct

Name: fruA [H]

Synonym: AB57_2287

Alternate gene names: 213157594

Gene position: 2370356-2372074 (Clockwise)

Preceding gene: 213157593

Following gene: 213157596

Centisome position: 58.52

GC content: 39.67

Gene sequence:

>1719_bases
ATGCAAACTGCTAAACATTTATTATTTGTCACTAATGATCCGCAACAGCAAGTCAATACTTTAATCTTGGCTCGTAAACT
TGCTTTAGTCGCAACCCAACACGGCTATAAACATAGTGTCATTTCACTCGATGAGTTTGAATCAAGCGATCATTTTGATC
ATGTCATTATTATTGGACAGCAACCTAAAAATCTAAATATTTTTGGTCAAAACGCTTTATCTTTAGTTTCTATTGAAGAT
ATTAAAGATGATGCAGACAAAGCACTTTTAACGGCACTTGAACACTCAAAACCAGCAAATGAGTGGGAACAAAAACCTAA
GCAAGCTTCAAATACCGCAACTCATTTTGTTGCCATTACTGCTTGCCCAACTGGAGTTGCCCATACATTTATGGCAGCTG
AAGCGTTACAACAAGGTGCAGAAAGACTTGGGTATCAAATCGATGTAGAAACTCAAGGTTCTGTAGGTGCGAAGAATATT
TTATCACCTCAAGCGATTGCTGATGCCGATATTGTTATTCTTGCTACTGACATTGAAGTCAACACTGACCGCTTTATAGG
TAAGCGTGTCTATAGATGTAGCACTGGTTTTGCTTTAAAACAAACCGACAAGGCTTTTGCTGAGGCAATTGCTAATGCTC
AGGTTTTAGAACAAGGTAAACAGCAAGCAACAACGGAAAATAAGGATAAAACTGAAAAAGTTGGTGTATATAAACACTTA
TTAACTGGCGTTTCTTATATGCTACCTATGGTTGTTGCGGGTGGCTTGCTAATTGCACTTTCTTTATGTTTTGGCCTAAA
TGCAGCAGAACAAGCTGGTAGTCTGCCAGCCATATTAAAACAGATTGGCGCAGCAGCATTTACCCTCATGGTACCCATGC
TGTCGGGTTATATTGCATATTCCATTGCAGATCGCCCCGGTCTTGCGCCAGGTTTAATCGGGGGATTATTGGCAGCACAG
TTACAAGCAGGTTTTTTAGGCGGTATTGTTTCTGGTTTCCTTGCAGGTTATATCGCGTTATTTATTGCTAAAAAAGTTAA
GCTCCCAACTAGCTTAGAGTCTCTTAAGCCCATTTTGATTATTCCATTATTAGGAACATTATCTGTTGGGCTGATTATGT
TCTATGTGGTAGGTCAACCTGTAGCGCATATTTTTGAGTTAATGAAAGATTTCCTCAACAACATGGGCACAACAAATGCT
GTATTAATGGGAATTATTCTGGCAAGTATGATGTGTATTGATTTGGGCGGACCAATTAATAAAGCTGCTTATGCTTTTAC
AGTTGGACTACTTACCACCAATACCTATATGCCAATGGCAGCCACGATGGCAGGCGGTATGGTTCCTGCAATTGGGATGG
CAATTGCAACCTTCCTCGCTAGAAATAAATTTAGTACTGGTGAAAAAGATGCAGGTAAAGCTGCGTTTGTGCTTGGTTTA
TGCTTTATTTCAGAAGGTGCAATTCCATTTGCAGCAAAAGATCCAATGCGCGTTATTCCAACCTGTATTCTAGGTGGCGC
AGTAACTGGTGCATTAGTTGCTTTATTTCACTGTGAGCTTGTGACTCCACACGGCGGTGTATTTGTACTACTGATTCCAA
ATGCAATCAATCATGCGTGGTTGTATCTTGCAGCAATTGCGGCTGGAAGTATCGTAACGGGAGTAAGTTATGCCATCATT
AAAAAGAATCAAGAAGAAAAATTATTAACAAACTCATAA

Upstream 100 bases:

>100_bases
GCAAGCCATGCTGTAACACAAATTGGTTTTCGAATCCCTACTTCTGAGGTTCTAAACCAATTAAAAGCACAAACTATTAT
CAATTCATTGAGTGAATCTG

Downstream 100 bases:

>100_bases
TTTAAAAAGGGAGAATATAAATTCTCCCTTTTTTATTACTATTTTTATTTATTAATTTGTACTGCACGGGCCATCATTTG
CTCAGGAATATCTTGAGCCA

Product: PTS system fructose-specific EIIBC component

Products: NA

Alternate protein names: EIIBC-Fru; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 572; Mature: 572

Protein sequence:

>572_residues
MQTAKHLLFVTNDPQQQVNTLILARKLALVATQHGYKHSVISLDEFESSDHFDHVIIIGQQPKNLNIFGQNALSLVSIED
IKDDADKALLTALEHSKPANEWEQKPKQASNTATHFVAITACPTGVAHTFMAAEALQQGAERLGYQIDVETQGSVGAKNI
LSPQAIADADIVILATDIEVNTDRFIGKRVYRCSTGFALKQTDKAFAEAIANAQVLEQGKQQATTENKDKTEKVGVYKHL
LTGVSYMLPMVVAGGLLIALSLCFGLNAAEQAGSLPAILKQIGAAAFTLMVPMLSGYIAYSIADRPGLAPGLIGGLLAAQ
LQAGFLGGIVSGFLAGYIALFIAKKVKLPTSLESLKPILIIPLLGTLSVGLIMFYVVGQPVAHIFELMKDFLNNMGTTNA
VLMGIILASMMCIDLGGPINKAAYAFTVGLLTTNTYMPMAATMAGGMVPAIGMAIATFLARNKFSTGEKDAGKAAFVLGL
CFISEGAIPFAAKDPMRVIPTCILGGAVTGALVALFHCELVTPHGGVFVLLIPNAINHAWLYLAAIAAGSIVTGVSYAII
KKNQEEKLLTNS

Sequences:

>Translated_572_residues
MQTAKHLLFVTNDPQQQVNTLILARKLALVATQHGYKHSVISLDEFESSDHFDHVIIIGQQPKNLNIFGQNALSLVSIED
IKDDADKALLTALEHSKPANEWEQKPKQASNTATHFVAITACPTGVAHTFMAAEALQQGAERLGYQIDVETQGSVGAKNI
LSPQAIADADIVILATDIEVNTDRFIGKRVYRCSTGFALKQTDKAFAEAIANAQVLEQGKQQATTENKDKTEKVGVYKHL
LTGVSYMLPMVVAGGLLIALSLCFGLNAAEQAGSLPAILKQIGAAAFTLMVPMLSGYIAYSIADRPGLAPGLIGGLLAAQ
LQAGFLGGIVSGFLAGYIALFIAKKVKLPTSLESLKPILIIPLLGTLSVGLIMFYVVGQPVAHIFELMKDFLNNMGTTNA
VLMGIILASMMCIDLGGPINKAAYAFTVGLLTTNTYMPMAATMAGGMVPAIGMAIATFLARNKFSTGEKDAGKAAFVLGL
CFISEGAIPFAAKDPMRVIPTCILGGAVTGALVALFHCELVTPHGGVFVLLIPNAINHAWLYLAAIAAGSIVTGVSYAII
KKNQEEKLLTNS
>Mature_572_residues
MQTAKHLLFVTNDPQQQVNTLILARKLALVATQHGYKHSVISLDEFESSDHFDHVIIIGQQPKNLNIFGQNALSLVSIED
IKDDADKALLTALEHSKPANEWEQKPKQASNTATHFVAITACPTGVAHTFMAAEALQQGAERLGYQIDVETQGSVGAKNI
LSPQAIADADIVILATDIEVNTDRFIGKRVYRCSTGFALKQTDKAFAEAIANAQVLEQGKQQATTENKDKTEKVGVYKHL
LTGVSYMLPMVVAGGLLIALSLCFGLNAAEQAGSLPAILKQIGAAAFTLMVPMLSGYIAYSIADRPGLAPGLIGGLLAAQ
LQAGFLGGIVSGFLAGYIALFIAKKVKLPTSLESLKPILIIPLLGTLSVGLIMFYVVGQPVAHIFELMKDFLNNMGTTNA
VLMGIILASMMCIDLGGPINKAAYAFTVGLLTTNTYMPMAATMAGGMVPAIGMAIATFLARNKFSTGEKDAGKAAFVLGL
CFISEGAIPFAAKDPMRVIPTCILGGAVTGALVALFHCELVTPHGGVFVLLIPNAINHAWLYLAAIAAGSIVTGVSYAII
KKNQEEKLLTNS

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=525, Percent_Identity=53.3333333333333, Blast_Score=542, Evalue=1e-155,
Organism=Escherichia coli, GI1786951, Length=435, Percent_Identity=37.0114942528736, Blast_Score=272, Evalue=4e-74,
Organism=Escherichia coli, GI87082348, Length=438, Percent_Identity=37.2146118721461, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI1790386, Length=282, Percent_Identity=42.1985815602837, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI1788729, Length=391, Percent_Identity=27.3657289002558, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790387, Length=91, Percent_Identity=48.3516483516484, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788730, Length=103, Percent_Identity=39.8058252427184, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790390, Length=94, Percent_Identity=38.2978723404255, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 60524; Mature: 60524

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTAKHLLFVTNDPQQQVNTLILARKLALVATQHGYKHSVISLDEFESSDHFDHVIIIGQ
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCCCCCCEEEEEEC
QPKNLNIFGQNALSLVSIEDIKDDADKALLTALEHSKPANEWEQKPKQASNTATHFVAIT
CCCCCEEECCCCEEEEEHHHHHCHHHHHHHHHHHCCCCCHHHHHCHHHCCCCCEEEEEEE
ACPTGVAHTFMAAEALQQGAERLGYQIDVETQGSVGAKNILSPQAIADADIVILATDIEV
ECCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHCCCCHHHCCCCEEEEEECCEE
NTDRFIGKRVYRCSTGFALKQTDKAFAEAIANAQVLEQGKQQATTENKDKTEKVGVYKHL
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LTGVSYMLPMVVAGGLLIALSLCFGLNAAEQAGSLPAILKQIGAAAFTLMVPMLSGYIAY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEE
SIADRPGLAPGLIGGLLAAQLQAGFLGGIVSGFLAGYIALFIAKKVKLPTSLESLKPILI
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEE
IPLLGTLSVGLIMFYVVGQPVAHIFELMKDFLNNMGTTNAVLMGIILASMMCIDLGGPIN
EHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCC
KAAYAFTVGLLTTNTYMPMAATMAGGMVPAIGMAIATFLARNKFSTGEKDAGKAAFVLGL
HHHHHEEEEHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
CFISEGAIPFAAKDPMRVIPTCILGGAVTGALVALFHCELVTPHGGVFVLLIPNAINHAW
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCCCHHHHH
LYLAAIAAGSIVTGVSYAIIKKNQEEKLLTNS
HHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MQTAKHLLFVTNDPQQQVNTLILARKLALVATQHGYKHSVISLDEFESSDHFDHVIIIGQ
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCCCCCCEEEEEEC
QPKNLNIFGQNALSLVSIEDIKDDADKALLTALEHSKPANEWEQKPKQASNTATHFVAIT
CCCCCEEECCCCEEEEEHHHHHCHHHHHHHHHHHCCCCCHHHHHCHHHCCCCCEEEEEEE
ACPTGVAHTFMAAEALQQGAERLGYQIDVETQGSVGAKNILSPQAIADADIVILATDIEV
ECCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHCCCCHHHCCCCEEEEEECCEE
NTDRFIGKRVYRCSTGFALKQTDKAFAEAIANAQVLEQGKQQATTENKDKTEKVGVYKHL
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LTGVSYMLPMVVAGGLLIALSLCFGLNAAEQAGSLPAILKQIGAAAFTLMVPMLSGYIAY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEE
SIADRPGLAPGLIGGLLAAQLQAGFLGGIVSGFLAGYIALFIAKKVKLPTSLESLKPILI
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEE
IPLLGTLSVGLIMFYVVGQPVAHIFELMKDFLNNMGTTNAVLMGIILASMMCIDLGGPIN
EHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCC
KAAYAFTVGLLTTNTYMPMAATMAGGMVPAIGMAIATFLARNKFSTGEKDAGKAAFVLGL
HHHHHEEEEHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
CFISEGAIPFAAKDPMRVIPTCILGGAVTGALVALFHCELVTPHGGVFVLLIPNAINHAW
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCCCHHHHH
LYLAAIAAGSIVTGVSYAIIKKNQEEKLLTNS
HHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3076173; 9278503; 9097040; 1981619 [H]