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The map label for this gene is map [H]

Identifier: 213157585

GI number: 213157585

Start: 2361271

End: 2362065

Strand: Reverse

Name: map [H]

Synonym: AB57_2278

Alternate gene names: 213157585

Gene position: 2362065-2361271 (Counterclockwise)

Preceding gene: 213157589

Following gene: 213157583

Centisome position: 58.32

GC content: 37.11

Gene sequence:

>795_bases
ATGAGAGCTTCTACTGTTACAATTAAAACTGAACAAGATCTAGAAAAATTAAGAGTTTCTGGGCGTTTGGCTGCACAAGT
TTTAGAAATGATAGGGGAGTATGTCAAGCCAGGTGTAACAACTGAATATTTAGACAATATTTGTAATGATTACATCGTAA
ATACTTTAAAAGTTATACCGGCTAATGTGGGTTATCATGGATTCACAAAAACAATATGTACTTCAGTCAATGAAGTGGTA
TGTCACGGTATCCCTTCTCAAAATAAAATTTTAAAAGATGGCGATATTATTAATATTGATGTAGCAATTATTAAAGACGG
CTATTTTGGTGATACGAGCCGTATGTATTATGTCGGTAACGTAAATCCACATGCTAAAAAATTAGTTGAAACTACTTATG
AAGCAATGGTCGCTGGTATACATGCAGTTAAACCAGGAGCGACTTTAGGGGATATTGGTTACGCTATTCAATCGGTCGCT
CATCGCGAAGGATATAGCATTGTTCGTGAATATTGCGGGCATGGTATTGGTAAAGTTTATCATGAACAACCTAATATTCT
GCATTATGGACAACGCGGCCAAGGTCTTGTTTTGAAAAAAGGGATGGTCTTTACAATTGAACCTATGGTTAATGCAGGCA
AACCTCAGGTAAAAGAGCTAAATGACGGCTGGACCGTAATTACTCAGGATCATTCATTATCTGCTCAATGGGAACACATG
GTTGCTGTTACAGATACTGGATTTGAATTATTAACGCCGTGGCCCGAAGGTGTGGGAAATTATCCAGAAATTTAA

Upstream 100 bases:

>100_bases
TAAAAGCTTTCCGCCTATCCTATATCCATTCTAAAATATTCTAAATTAACTAACATTTTTGTAGGCGTGGTAAAAGCAGT
GCCTACGAGGATAAAATTGA

Downstream 100 bases:

>100_bases
TATGCATAAAAAAAGTTCGATAATCTATCGAACTTTTTTATGCGGCTTTGATTTATGGATGTTCTGAAAGATGTTCTACC
AAATAATCAATAAATACACG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MRASTVTIKTEQDLEKLRVSGRLAAQVLEMIGEYVKPGVTTEYLDNICNDYIVNTLKVIPANVGYHGFTKTICTSVNEVV
CHGIPSQNKILKDGDIINIDVAIIKDGYFGDTSRMYYVGNVNPHAKKLVETTYEAMVAGIHAVKPGATLGDIGYAIQSVA
HREGYSIVREYCGHGIGKVYHEQPNILHYGQRGQGLVLKKGMVFTIEPMVNAGKPQVKELNDGWTVITQDHSLSAQWEHM
VAVTDTGFELLTPWPEGVGNYPEI

Sequences:

>Translated_264_residues
MRASTVTIKTEQDLEKLRVSGRLAAQVLEMIGEYVKPGVTTEYLDNICNDYIVNTLKVIPANVGYHGFTKTICTSVNEVV
CHGIPSQNKILKDGDIINIDVAIIKDGYFGDTSRMYYVGNVNPHAKKLVETTYEAMVAGIHAVKPGATLGDIGYAIQSVA
HREGYSIVREYCGHGIGKVYHEQPNILHYGQRGQGLVLKKGMVFTIEPMVNAGKPQVKELNDGWTVITQDHSLSAQWEHM
VAVTDTGFELLTPWPEGVGNYPEI
>Mature_264_residues
MRASTVTIKTEQDLEKLRVSGRLAAQVLEMIGEYVKPGVTTEYLDNICNDYIVNTLKVIPANVGYHGFTKTICTSVNEVV
CHGIPSQNKILKDGDIINIDVAIIKDGYFGDTSRMYYVGNVNPHAKKLVETTYEAMVAGIHAVKPGATLGDIGYAIQSVA
HREGYSIVREYCGHGIGKVYHEQPNILHYGQRGQGLVLKKGMVFTIEPMVNAGKPQVKELNDGWTVITQDHSLSAQWEHM
VAVTDTGFELLTPWPEGVGNYPEI

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=249, Percent_Identity=44.578313253012, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI40385867, Length=251, Percent_Identity=40.6374501992032, Blast_Score=201, Evalue=8e-52,
Organism=Escherichia coli, GI1786364, Length=247, Percent_Identity=58.2995951417004, Blast_Score=314, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI71996291, Length=256, Percent_Identity=40.234375, Blast_Score=204, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6323273, Length=252, Percent_Identity=41.2698412698413, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI21355531, Length=260, Percent_Identity=40, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=40.4081632653061, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29093; Mature: 29093

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRASTVTIKTEQDLEKLRVSGRLAAQVLEMIGEYVKPGVTTEYLDNICNDYIVNTLKVIP
CCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEE
ANVGYHGFTKTICTSVNEVVCHGIPSQNKILKDGDIINIDVAIIKDGYFGDTSRMYYVGN
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEECCCCEEEEEEEEEECCCCCCCCCEEEEEC
VNPHAKKLVETTYEAMVAGIHAVKPGATLGDIGYAIQSVAHREGYSIVREYCGHGIGKVY
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHH
HEQPNILHYGQRGQGLVLKKGMVFTIEPMVNAGKPQVKELNDGWTVITQDHSLSAQWEHM
HCCCCEEEECCCCCEEEEECCEEEEEECCCCCCCCCHHCCCCCEEEEEECCCCCCCEEEE
VAVTDTGFELLTPWPEGVGNYPEI
EEEECCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure
MRASTVTIKTEQDLEKLRVSGRLAAQVLEMIGEYVKPGVTTEYLDNICNDYIVNTLKVIP
CCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEE
ANVGYHGFTKTICTSVNEVVCHGIPSQNKILKDGDIINIDVAIIKDGYFGDTSRMYYVGN
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEECCCCEEEEEEEEEECCCCCCCCCEEEEEC
VNPHAKKLVETTYEAMVAGIHAVKPGATLGDIGYAIQSVAHREGYSIVREYCGHGIGKVY
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHH
HEQPNILHYGQRGQGLVLKKGMVFTIEPMVNAGKPQVKELNDGWTVITQDHSLSAQWEHM
HCCCCEEEECCCCCEEEEECCEEEEEECCCCCCCCCHHCCCCCEEEEEECCCCCCCEEEE
VAVTDTGFELLTPWPEGVGNYPEI
EEEECCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]