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The map label for this gene is gsk [C]

Identifier: 213157567

GI number: 213157567

Start: 2346620

End: 2347624

Strand: Direct

Name: gsk [C]

Synonym: AB57_2259

Alternate gene names: 213157567

Gene position: 2346620-2347624 (Clockwise)

Preceding gene: 213157562

Following gene: 213157568

Centisome position: 57.93

GC content: 40.5

Gene sequence:

>1005_bases
ATGGCAACTGTAGATCTTTTTGCAATTGGTAATGCATTAATCGACCAAGAATTTAAAGTTTCTGATGATTTTCTTAGTCA
GCAAGGCTTACAAAAAGGCACCATGCAGTTGTCTGATGGTGAAACACAATCTGCCCTTTATGAAAAATTAAAACAAACTC
AAGATTACAAAGGTCAAGCAAGTGGCGGTTCTGCTGCAAATACAACTGTGGCATTTAGTGCATTAGGTGGTAGCGCATTT
TATGGTTGCCGCGTTGGTCATGATGAATTAGGTGGAATTTACCTGCAAGGGCTAAATGATGCAGGCATCCAGACTACACC
AAAGTCCATCAGTGAAGGTGTGACTGGTACCTGTATGGTCCTGATTAGCCCAGATTCTGAGCGTACTATGCATACCTATT
TAGGTATTACCGCTGAGCTCTCTCAAGACCAAATCGATTTTGAACCATTAAAAACAGCAAAATGGCTTTATATTGAAGGC
TATCTTTCTACAAGTGAAACAGCACGTAAAGCGGTAAAACAAGCTAGAGAAATTGCAAAAGCTCACGGCGTTAAAATTGC
CCTATCTTTATCAGATCCTGCAATGGTTCAATACGCTCGTGAAGGCCTAGAAGAGCTTATGGATGATGGTGTGGATTTAT
TGTTCTGTAATGAACAAGAAGCCTTAATGTATACCCATACCACTACTGTTGAAGATGCACTTACTCAATTACGTTTTAAA
AACCATACCGTTGTGATTACACAAAGTGCAAAAGGTGCTTTAGTTGCAAATCCAACTCACCATTTTCACGTCGCAGGCCG
TCATGTTGAAGCTGTAGATACAAATGGCGCGGGTGATGCTTTTGCAGGTGCCTTCCTCTACGCATTAAACCATCATGAAG
ATTTAACTGCTGCTGCACAGTTAGCCATCTTAATTTCAAGTGAAGTCGTGTCTCAATTTGGTCCTCGTTTAGCCATTAAT
GACTATGCTAAACTTCTCGAAAATTTTCAGAAGGAATGTGCTTGA

Upstream 100 bases:

>100_bases
GCTAGCCGCTGAATAACCTGAATTTTATTCAACAAACTACAGCAAATGTGAGCAATGGTGTAAACTTATCGACCTGATTT
TTTATTCTGTGACAACACAT

Downstream 100 bases:

>100_bases
AATGGAAAGGATCTGTATGACGGAAGAAGTTCCTGAGCGTGAAGCTAGAGCTTTTGACACTTTACAAGGAACTACTATTT
TCATTACACAGCGTGATGGC

Product: sugar kinase, ribokinase family

Products: ADP; H+; IMP [C]

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MATVDLFAIGNALIDQEFKVSDDFLSQQGLQKGTMQLSDGETQSALYEKLKQTQDYKGQASGGSAANTTVAFSALGGSAF
YGCRVGHDELGGIYLQGLNDAGIQTTPKSISEGVTGTCMVLISPDSERTMHTYLGITAELSQDQIDFEPLKTAKWLYIEG
YLSTSETARKAVKQAREIAKAHGVKIALSLSDPAMVQYAREGLEELMDDGVDLLFCNEQEALMYTHTTTVEDALTQLRFK
NHTVVITQSAKGALVANPTHHFHVAGRHVEAVDTNGAGDAFAGAFLYALNHHEDLTAAAQLAILISSEVVSQFGPRLAIN
DYAKLLENFQKECA

Sequences:

>Translated_334_residues
MATVDLFAIGNALIDQEFKVSDDFLSQQGLQKGTMQLSDGETQSALYEKLKQTQDYKGQASGGSAANTTVAFSALGGSAF
YGCRVGHDELGGIYLQGLNDAGIQTTPKSISEGVTGTCMVLISPDSERTMHTYLGITAELSQDQIDFEPLKTAKWLYIEG
YLSTSETARKAVKQAREIAKAHGVKIALSLSDPAMVQYAREGLEELMDDGVDLLFCNEQEALMYTHTTTVEDALTQLRFK
NHTVVITQSAKGALVANPTHHFHVAGRHVEAVDTNGAGDAFAGAFLYALNHHEDLTAAAQLAILISSEVVSQFGPRLAIN
DYAKLLENFQKECA
>Mature_333_residues
ATVDLFAIGNALIDQEFKVSDDFLSQQGLQKGTMQLSDGETQSALYEKLKQTQDYKGQASGGSAANTTVAFSALGGSAFY
GCRVGHDELGGIYLQGLNDAGIQTTPKSISEGVTGTCMVLISPDSERTMHTYLGITAELSQDQIDFEPLKTAKWLYIEGY
LSTSETARKAVKQAREIAKAHGVKIALSLSDPAMVQYAREGLEELMDDGVDLLFCNEQEALMYTHTTTVEDALTQLRFKN
HTVVITQSAKGALVANPTHHFHVAGRHVEAVDTNGAGDAFAGAFLYALNHHEDLTAAAQLAILISSEVVSQFGPRLAIND
YAKLLENFQKECA

Specific function: Unknown

COG id: COG0524

COG function: function code G; Sugar kinases, ribokinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family [H]

Homologues:

Organism=Homo sapiens, GI32484973, Length=334, Percent_Identity=26.6467065868263, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI32484975, Length=334, Percent_Identity=26.6467065868263, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI11545855, Length=247, Percent_Identity=28.7449392712551, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786684, Length=223, Percent_Identity=27.3542600896861, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87081971, Length=337, Percent_Identity=26.4094955489614, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790193, Length=244, Percent_Identity=30.7377049180328, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17541820, Length=333, Percent_Identity=27.9279279279279, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17532905, Length=284, Percent_Identity=28.5211267605634, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322565, Length=333, Percent_Identity=25.2252252252252, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28571668, Length=333, Percent_Identity=26.7267267267267, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011611
- InterPro:   IPR002173 [H]

Pfam domain/function: PF00294 PfkB [H]

EC number: 2.7.1.73 [C]

Molecular weight: Translated: 36049; Mature: 35918

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00583 PFKB_KINASES_1 ; PS00584 PFKB_KINASES_2 ; PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVDLFAIGNALIDQEFKVSDDFLSQQGLQKGTMQLSDGETQSALYEKLKQTQDYKGQA
CCEEEEEECCHHHHCCCCCCCHHHHHHHCHHHCCEEECCCCHHHHHHHHHHHHCCCCCCC
SGGSAANTTVAFSALGGSAFYGCRVGHDELGGIYLQGLNDAGIQTTPKSISEGVTGTCMV
CCCCCCCCEEEEEECCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCHHHHCCCCEEEEE
LISPDSERTMHTYLGITAELSQDQIDFEPLKTAKWLYIEGYLSTSETARKAVKQAREIAK
EECCCCCCEEHHHCCEEEECCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHH
AHGVKIALSLSDPAMVQYAREGLEELMDDGVDLLFCNEQEALMYTHTTTVEDALTQLRFK
HCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCHHHHHHHHHHC
NHTVVITQSAKGALVANPTHHFHVAGRHVEAVDTNGAGDAFAGAFLYALNHHEDLTAAAQ
CCEEEEEECCCCCEEECCCCEEEEECCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHH
LAILISSEVVSQFGPRLAINDYAKLLENFQKECA
HHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATVDLFAIGNALIDQEFKVSDDFLSQQGLQKGTMQLSDGETQSALYEKLKQTQDYKGQA
CEEEEEECCHHHHCCCCCCCHHHHHHHCHHHCCEEECCCCHHHHHHHHHHHHCCCCCCC
SGGSAANTTVAFSALGGSAFYGCRVGHDELGGIYLQGLNDAGIQTTPKSISEGVTGTCMV
CCCCCCCCEEEEEECCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCHHHHCCCCEEEEE
LISPDSERTMHTYLGITAELSQDQIDFEPLKTAKWLYIEGYLSTSETARKAVKQAREIAK
EECCCCCCEEHHHCCEEEECCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHH
AHGVKIALSLSDPAMVQYAREGLEELMDDGVDLLFCNEQEALMYTHTTTVEDALTQLRFK
HCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCHHHHHHHHHHC
NHTVVITQSAKGALVANPTHHFHVAGRHVEAVDTNGAGDAFAGAFLYALNHHEDLTAAAQ
CCEEEEEECCCCCEEECCCCEEEEECCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHH
LAILISSEVVSQFGPRLAINDYAKLLENFQKECA
HHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; Inosine [C]

Specific reaction: ATP + Inosine --> ADP + H+ + IMP [C]

General reaction: Phospho group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]