Click here to switch to the map view.

The map label for this gene is hmrR [H]

Identifier: 213157477

GI number: 213157477

Start: 2247275

End: 2247691

Strand: Direct

Name: hmrR [H]

Synonym: AB57_2166

Alternate gene names: 213157477

Gene position: 2247275-2247691 (Clockwise)

Preceding gene: 213157475

Following gene: 213157478

Centisome position: 55.48

GC content: 34.77

Gene sequence:

>417_bases
ATGAATATTAGCGAGTTATCAAAACTAAGTGGTTTAAGTACCCCTACAATTCGTTATTATGAGCAAATCAAACTCTTGCC
TAAAGCAAAAAGAAAATCGAATGGCTACCGTGAATATACTGATAATGATTTGAAACAACTTTCTTTAATTCAGCAAGCCC
AGCAAGTTGGCTTTTCTTTAGCAGAAATTAAAGCATTTTTACCGTCAAAGGTAACTACTTGGAACCATGACGCACTCATC
CAAACACTTGAATCTAAAATTCAGGAAATAGAGCTTTTAGAACACAAGCTAAAAGTCAGTAAGCAAAACTTACGTACTAT
GATTGAGGCAATTAATAACAAACCCGATGAAATTACCTGTGAAGAAAATGCCGAACGCCTTATGAACCTCTATTACGATA
AATCAAAAACGCCGTAA

Upstream 100 bases:

>100_bases
AAAGCTGTTACTGAAAGTGTGCGCTTAGTAAAGTTATGAACCTTGCTTTTACATTACTATAAGTCTAAAGTTAACTTTAA
TGTCAATAGAGTATGTGGCT

Downstream 100 bases:

>100_bases
ACCTATAGAATTCTATTGACCTTAAAGTACACTTTAAACATACGATGGATCACAGGTGATAAATGAGGAACCTGTGATGT
TTAAAGTGTGGAATTTTCAA

Product: transcriptional regulator, MerR family

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 138; Mature: 138

Protein sequence:

>138_residues
MNISELSKLSGLSTPTIRYYEQIKLLPKAKRKSNGYREYTDNDLKQLSLIQQAQQVGFSLAEIKAFLPSKVTTWNHDALI
QTLESKIQEIELLEHKLKVSKQNLRTMIEAINNKPDEITCEENAERLMNLYYDKSKTP

Sequences:

>Translated_138_residues
MNISELSKLSGLSTPTIRYYEQIKLLPKAKRKSNGYREYTDNDLKQLSLIQQAQQVGFSLAEIKAFLPSKVTTWNHDALI
QTLESKIQEIELLEHKLKVSKQNLRTMIEAINNKPDEITCEENAERLMNLYYDKSKTP
>Mature_138_residues
MNISELSKLSGLSTPTIRYYEQIKLLPKAKRKSNGYREYTDNDLKQLSLIQQAQQVGFSLAEIKAFLPSKVTTWNHDALI
QTLESKIQEIELLEHKLKVSKQNLRTMIEAINNKPDEITCEENAERLMNLYYDKSKTP

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=93, Percent_Identity=41.9354838709677, Blast_Score=70, Evalue=5e-14,
Organism=Escherichia coli, GI1789687, Length=106, Percent_Identity=31.1320754716981, Blast_Score=67, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15988; Mature: 15988

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISELSKLSGLSTPTIRYYEQIKLLPKAKRKSNGYREYTDNDLKQLSLIQQAQQVGFSL
CCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHH
AEIKAFLPSKVTTWNHDALIQTLESKIQEIELLEHKLKVSKQNLRTMIEAINNKPDEITC
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EENAERLMNLYYDKSKTP
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNISELSKLSGLSTPTIRYYEQIKLLPKAKRKSNGYREYTDNDLKQLSLIQQAQQVGFSL
CCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHH
AEIKAFLPSKVTTWNHDALIQTLESKIQEIELLEHKLKVSKQNLRTMIEAINNKPDEITC
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EENAERLMNLYYDKSKTP
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]