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The map label for this gene is frmA [H]

Identifier: 213157313

GI number: 213157313

Start: 2094256

End: 2095365

Strand: Direct

Name: frmA [H]

Synonym: AB57_2002

Alternate gene names: 213157313

Gene position: 2094256-2095365 (Clockwise)

Preceding gene: 213157312

Following gene: 213157319

Centisome position: 51.7

GC content: 43.42

Gene sequence:

>1110_bases
ATGAAATCTCGTGCAGCTGTCGCCTTTGCCCCAGGAAAACCTTTAGAAATTGTTGAAGTTGATGTTGCACCACCCAAGGC
TGGTGAGGTTTTAATAAAAATTACCCATACAGGGGTATGCCATACCGATGCTTTTACATTATCTGGCGATGACCCAGAAG
GTGTTTTCCCAGCGATTTTAGGTCATGAAGGTGCAGGTGTTGTAGTTGAAGTAGGCGAGGGCGTAACAAGTGTTCAACCT
GGCGACCACGTGATTCCACTTTATACAGCTGAATGTAAAGAATGCTTATTCTGTAAATCCGGAAAAACTAACTTGTGTGT
TGCGGTACGTGCGACGCAAGGTAAAGGTGTAATGCCGGATGGCACTACGCGTTTTTCTTATAATGGCCAACCGATTTACC
ACTACATGGGCTGTTCAACCTTTAGTGAATATACTGTAGTTGCAGAGGTCTCTTTAGCTAAAATCAATCCTGAAGCGAAT
CACGAACAAGTTTGTTTACTTGGATGTGGTGTAACGACCGGTATTGGCGCCGTGCATAACACAGCTAAAGTACAAGAAGG
TGATTCGGTTGCCGTATTTGGTTTAGGCGGTATTGGTTTAGCTGTTGTACAAGGTGCACGTCAAGCGAAAGCAGGGCGCA
TTATTGTCGTAGATACCAACCCAGATAAATTTGAACTTGCTAAACAGTTTGGTGCTACCGATTTCTTAAATCCAAAAGAT
TATGACCAACCTATTCAGCAAGTGATTGTAGAAATGACAGGCTGGGGCGTAGATCATTCATTTGAATGTATTGGTAACGT
CAATGTTATGCGCTCGGCTCTAGAATGTGCACATCGTGGGTGGGGACAATCAGTCATTATTGGTGTTGCTGGTGCAGGCC
AAGAAATTTCGACACGCCCATTCCAGTTAGTGACGGGCCGTAAATGGTTAGGTACTGCGTTTGGTGGAGTAAAAGGCCGT
TCACAACTTCCTAAAATGGTCGAAGATGCCATGAAAGGCGATATTCAACTTGAGCCTTTTGTAACACATACCATGCCTCT
ACAAGACATTAATACCGCTTTTGATTTAATGCAAGAAGGTAAGTCAATTCGTACTGTTATTCATTTCTAA

Upstream 100 bases:

>100_bases
AAGCCAATTTTAATTTAAGCAAAATTAAGCTCTTGTATTACGGTTACATAATCTATTTTGCTCGACTATAAGTACCGAAT
GATATAAAGGAAACCCAAAG

Downstream 100 bases:

>100_bases
ATGAAATAGAAAAAGGGCTGTGATTCAGCCCTTTTTTACCACTTATAATTTTATATCTTAGATGGCATTACCACACATGT
CTGTTGTGCCCTGAGGGTAG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MKSRAAVAFAPGKPLEIVEVDVAPPKAGEVLIKITHTGVCHTDAFTLSGDDPEGVFPAILGHEGAGVVVEVGEGVTSVQP
GDHVIPLYTAECKECLFCKSGKTNLCVAVRATQGKGVMPDGTTRFSYNGQPIYHYMGCSTFSEYTVVAEVSLAKINPEAN
HEQVCLLGCGVTTGIGAVHNTAKVQEGDSVAVFGLGGIGLAVVQGARQAKAGRIIVVDTNPDKFELAKQFGATDFLNPKD
YDQPIQQVIVEMTGWGVDHSFECIGNVNVMRSALECAHRGWGQSVIIGVAGAGQEISTRPFQLVTGRKWLGTAFGGVKGR
SQLPKMVEDAMKGDIQLEPFVTHTMPLQDINTAFDLMQEGKSIRTVIHF

Sequences:

>Translated_369_residues
MKSRAAVAFAPGKPLEIVEVDVAPPKAGEVLIKITHTGVCHTDAFTLSGDDPEGVFPAILGHEGAGVVVEVGEGVTSVQP
GDHVIPLYTAECKECLFCKSGKTNLCVAVRATQGKGVMPDGTTRFSYNGQPIYHYMGCSTFSEYTVVAEVSLAKINPEAN
HEQVCLLGCGVTTGIGAVHNTAKVQEGDSVAVFGLGGIGLAVVQGARQAKAGRIIVVDTNPDKFELAKQFGATDFLNPKD
YDQPIQQVIVEMTGWGVDHSFECIGNVNVMRSALECAHRGWGQSVIIGVAGAGQEISTRPFQLVTGRKWLGTAFGGVKGR
SQLPKMVEDAMKGDIQLEPFVTHTMPLQDINTAFDLMQEGKSIRTVIHF
>Mature_369_residues
MKSRAAVAFAPGKPLEIVEVDVAPPKAGEVLIKITHTGVCHTDAFTLSGDDPEGVFPAILGHEGAGVVVEVGEGVTSVQP
GDHVIPLYTAECKECLFCKSGKTNLCVAVRATQGKGVMPDGTTRFSYNGQPIYHYMGCSTFSEYTVVAEVSLAKINPEAN
HEQVCLLGCGVTTGIGAVHNTAKVQEGDSVAVFGLGGIGLAVVQGARQAKAGRIIVVDTNPDKFELAKQFGATDFLNPKD
YDQPIQQVIVEMTGWGVDHSFECIGNVNVMRSALECAHRGWGQSVIIGVAGAGQEISTRPFQLVTGRKWLGTAFGGVKGR
SQLPKMVEDAMKGDIQLEPFVTHTMPLQDINTAFDLMQEGKSIRTVIHF

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=62.3306233062331, Blast_Score=464, Evalue=1e-131,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=49.8652291105121, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=49.3297587131367, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=49.3261455525606, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=48.5175202156334, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=46.6124661246612, Blast_Score=351, Evalue=5e-97,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=46.6124661246612, Blast_Score=351, Evalue=6e-97,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=45.7765667574932, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=45.983379501385, Blast_Score=341, Evalue=8e-94,
Organism=Homo sapiens, GI156627571, Length=369, Percent_Identity=25.2032520325203, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=86.449864498645, Blast_Score=642, Evalue=0.0,
Organism=Escherichia coli, GI1787863, Length=350, Percent_Identity=28.2857142857143, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082125, Length=380, Percent_Identity=26.8421052631579, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI87081918, Length=348, Percent_Identity=31.3218390804598, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1788073, Length=366, Percent_Identity=27.0491803278689, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1786825, Length=363, Percent_Identity=26.4462809917355, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1790045, Length=358, Percent_Identity=26.2569832402235, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI226510992, Length=365, Percent_Identity=25.7534246575342, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786518, Length=371, Percent_Identity=26.4150943396226, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788407, Length=228, Percent_Identity=27.1929824561404, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=57.9088471849866, Blast_Score=457, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=57.6, Blast_Score=452, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=57.1428571428571, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17562584, Length=373, Percent_Identity=27.0777479892761, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=218, Percent_Identity=32.5688073394495, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=172, Percent_Identity=34.3023255813954, Blast_Score=85, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=60.377358490566, Blast_Score=466, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6319621, Length=368, Percent_Identity=29.0760869565217, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6323729, Length=373, Percent_Identity=27.3458445040214, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=351, Percent_Identity=28.7749287749288, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=310, Percent_Identity=30, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=364, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319955, Length=364, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=374, Percent_Identity=27.807486631016, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=63.0434782608696, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI17137530, Length=254, Percent_Identity=29.5275590551181, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17737897, Length=251, Percent_Identity=29.0836653386454, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39241; Mature: 39241

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRAAVAFAPGKPLEIVEVDVAPPKAGEVLIKITHTGVCHTDAFTLSGDDPEGVFPAIL
CCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEEECCEEECCEEEECCCCCCCCCHHHH
GHEGAGVVVEVGEGVTSVQPGDHVIPLYTAECKECLFCKSGKTNLCVAVRATQGKGVMPD
CCCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHHHEEECCCCCCEEEEEEECCCCCCCCC
GTTRFSYNGQPIYHYMGCSTFSEYTVVAEVSLAKINPEANHEQVCLLGCGVTTGIGAVHN
CCEEEEECCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCEEEEEECCHHHCCCHHCC
TAKVQEGDSVAVFGLGGIGLAVVQGARQAKAGRIIVVDTNPDKFELAKQFGATDFLNPKD
CCEECCCCCEEEEEECCHHHHHHHCCHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCC
YDQPIQQVIVEMTGWGVDHSFECIGNVNVMRSALECAHRGWGQSVIIGVAGAGQEISTRP
HHHHHHHHHHHHHCCCCCCCHHEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRKWLGTAFGGVKGRSQLPKMVEDAMKGDIQLEPFVTHTMPLQDINTAFDLMQEG
EEEEECCHHHHHHHCCCCCHHHHHHHHHHHHCCCEEECCEEEECCCHHHHHHHHHHHHCC
KSIRTVIHF
CCEEEEECC
>Mature Secondary Structure
MKSRAAVAFAPGKPLEIVEVDVAPPKAGEVLIKITHTGVCHTDAFTLSGDDPEGVFPAIL
CCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEEECCEEECCEEEECCCCCCCCCHHHH
GHEGAGVVVEVGEGVTSVQPGDHVIPLYTAECKECLFCKSGKTNLCVAVRATQGKGVMPD
CCCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHHHEEECCCCCCEEEEEEECCCCCCCCC
GTTRFSYNGQPIYHYMGCSTFSEYTVVAEVSLAKINPEANHEQVCLLGCGVTTGIGAVHN
CCEEEEECCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCEEEEEECCHHHCCCHHCC
TAKVQEGDSVAVFGLGGIGLAVVQGARQAKAGRIIVVDTNPDKFELAKQFGATDFLNPKD
CCEECCCCCEEEEEECCHHHHHHHCCHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCC
YDQPIQQVIVEMTGWGVDHSFECIGNVNVMRSALECAHRGWGQSVIIGVAGAGQEISTRP
HHHHHHHHHHHHHCCCCCCCHHEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRKWLGTAFGGVKGRSQLPKMVEDAMKGDIQLEPFVTHTMPLQDINTAFDLMQEG
EEEEECCHHHHHHHCCCCCHHHHHHHHHHHHCCCEEECCEEEECCCHHHHHHHHHHHHCC
KSIRTVIHF
CCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]