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The map label for this gene is strD [H]

Identifier: 213157110

GI number: 213157110

Start: 1882158

End: 1882847

Strand: Direct

Name: strD [H]

Synonym: AB57_1793

Alternate gene names: 213157110

Gene position: 1882158-1882847 (Clockwise)

Preceding gene: 213157109

Following gene: 213157111

Centisome position: 46.47

GC content: 42.46

Gene sequence:

>690_bases
ATGAAAGCAATGATTTTAGCTGCTGGCTTGGGCAATCGTATGCGTCCACTCACGCTATATACACCAAAGCCTCTGCTTGA
GGTAGGTGGTAAGCCACTTATTGTGTGGCATATTGAAAAACTTAAGAAAATCGGTGTGACCGAAATAGTCATCAATTCTG
CGTGGTTAGCCGACAAACTCATCAGTAGCTTGGGAGATGGTTCTCAATTTGGTGTGGATATCCGTTGGACACGAGAAGAA
GAAGGGCTGGAAACCGCTGGTGGAATTATTAATGCTTTGCCACTGCTTGGAACCGATCCTTTCATTCTGGTGAATGGAGA
TGTATGGACTACAATGGATTTTGAAGCTCTACGCCATATTAAGTTAAACGATGATTTGGCACATCTTGTATTAGTTGATA
ACCCTAAACAGCATCCTGAAGGCGACTTTACATTATTAAATGGACGCGCTTTTACATTTGATCAAGATGTGAAGGGCGAG
AACCTCACTTTTAGTGGTGTATCTGTTATCCATCCTAAGCTTTTTGATGGATTGGAAGCTGGTAAGCGTCCTTTAGCCCC
ATTGTTGAAGCAAGCCATGCACAATCAAAAAATATCTGGTGAAAAGCTTAAAGGTGCATGGGTAGATGTGGGAACGCCTG
AGCGTTTAATGGAGCTAGATTTGCAAATTCGTGAAGGCTTCTACGATTAA

Upstream 100 bases:

>100_bases
GCCGTGGCTATCATGAGCTTGATGACTTCATGGCGTTTATTCACAGTTCAGTAATGCCTAAATTTATTGAAAAATATGGC
CCTTATGAGGTTGCAGCATA

Downstream 100 bases:

>100_bases
CTGCGTAATCGCTAATCGTTAACTAGTGTTCCACGATGCATAAATGGGTATACTTTGTTTTAAATTTTACTTAGATGTTA
TCTGTTTATGCATCCGTTTT

Product: nucleotidyl transferase family protein

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MKAMILAAGLGNRMRPLTLYTPKPLLEVGGKPLIVWHIEKLKKIGVTEIVINSAWLADKLISSLGDGSQFGVDIRWTREE
EGLETAGGIINALPLLGTDPFILVNGDVWTTMDFEALRHIKLNDDLAHLVLVDNPKQHPEGDFTLLNGRAFTFDQDVKGE
NLTFSGVSVIHPKLFDGLEAGKRPLAPLLKQAMHNQKISGEKLKGAWVDVGTPERLMELDLQIREGFYD

Sequences:

>Translated_229_residues
MKAMILAAGLGNRMRPLTLYTPKPLLEVGGKPLIVWHIEKLKKIGVTEIVINSAWLADKLISSLGDGSQFGVDIRWTREE
EGLETAGGIINALPLLGTDPFILVNGDVWTTMDFEALRHIKLNDDLAHLVLVDNPKQHPEGDFTLLNGRAFTFDQDVKGE
NLTFSGVSVIHPKLFDGLEAGKRPLAPLLKQAMHNQKISGEKLKGAWVDVGTPERLMELDLQIREGFYD
>Mature_229_residues
MKAMILAAGLGNRMRPLTLYTPKPLLEVGGKPLIVWHIEKLKKIGVTEIVINSAWLADKLISSLGDGSQFGVDIRWTREE
EGLETAGGIINALPLLGTDPFILVNGDVWTTMDFEALRHIKLNDDLAHLVLVDNPKQHPEGDFTLLNGRAFTFDQDVKGE
NLTFSGVSVIHPKLFDGLEAGKRPLAPLLKQAMHNQKISGEKLKGAWVDVGTPERLMELDLQIREGFYD

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=223, Percent_Identity=28.2511210762332, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI11761619, Length=223, Percent_Identity=28.2511210762332, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI133931050, Length=232, Percent_Identity=29.7413793103448, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=233, Percent_Identity=30.0429184549356, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355443, Length=224, Percent_Identity=26.3392857142857, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24644084, Length=224, Percent_Identity=26.3392857142857, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 25356; Mature: 25356

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMILAAGLGNRMRPLTLYTPKPLLEVGGKPLIVWHIEKLKKIGVTEIVINSAWLADKL
CCEEEEEECCCCCCCEEEEECCCHHHHCCCCEEEEEEEHHHHHCCCEEEEECCHHHHHHH
ISSLGDGSQFGVDIRWTREEEGLETAGGIINALPLLGTDPFILVNGDVWTTMDFEALRHI
HHHCCCCCCCCEEEEECCCCCCCHHHCHHHHHHHHCCCCCEEEECCCEEEEECHHHHHEE
KLNDDLAHLVLVDNPKQHPEGDFTLLNGRAFTFDQDVKGENLTFSGVSVIHPKLFDGLEA
ECCCCEEEEEEECCCCCCCCCCEEEECCEEEEECCCCCCCCEEECCHHEECHHHHHHHHC
GKRPLAPLLKQAMHNQKISGEKLKGAWVDVGTPERLMELDLQIREGFYD
CCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKAMILAAGLGNRMRPLTLYTPKPLLEVGGKPLIVWHIEKLKKIGVTEIVINSAWLADKL
CCEEEEEECCCCCCCEEEEECCCHHHHCCCCEEEEEEEHHHHHCCCEEEEECCHHHHHHH
ISSLGDGSQFGVDIRWTREEEGLETAGGIINALPLLGTDPFILVNGDVWTTMDFEALRHI
HHHCCCCCCCCEEEEECCCCCCCHHHCHHHHHHHHCCCCCEEEECCCEEEEECHHHHHEE
KLNDDLAHLVLVDNPKQHPEGDFTLLNGRAFTFDQDVKGENLTFSGVSVIHPKLFDGLEA
ECCCCEEEEEEECCCCCCCCCCEEEECCEEEEECCCCCCCCEEECCHHEECHHHHHHHHC
GKRPLAPLLKQAMHNQKISGEKLKGAWVDVGTPERLMELDLQIREGFYD
CCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]