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The map label for this gene is cidA1 [H]

Identifier: 213156972

GI number: 213156972

Start: 1736672

End: 1737103

Strand: Direct

Name: cidA1 [H]

Synonym: AB57_1647

Alternate gene names: 213156972

Gene position: 1736672-1737103 (Clockwise)

Preceding gene: 213156968

Following gene: 213156973

Centisome position: 42.88

GC content: 38.89

Gene sequence:

>432_bases
ATGAGTACTGAATCTGCTTCTGGAACACCCTCACAACCATCACTGTTCGTGTTAGTTAAACAAATTCTCATTTTGGCTGG
ATTTTGGTGGATTGGATATCTCTTACACCAAAAACTCGGTGTACCTGTCTCGGCAGGTATTTTAGGTATGTTTTTATTGC
TTTTATGCCTGTTCTTTAAAATTATCAAAATGGATCAGGTAGCAATGGGAGCAACTGTGGTTTTAGGTGAGCTATTACTG
TTTTTTGTGCCTGTAGTCGTTGCCGTTGTCCAGTATAAAACCCTGTTTATGACCGAAGGATGGCAAATCGTCTTAAGCAT
TGGGGTTGGGACCATTTTAGTCATGTTAAGCACTTCACTGACTATTCATTATTACAATCGTTTGAAGGCTTACTTACAGG
CTAGAAAACGTCTTCAACATAAGCATATCTAA

Upstream 100 bases:

>100_bases
AGATTATTCCATTTTGGAATAATATTAACATGAATAATTCATATTTAGCAGGTTTAACCAAGCTAGCATAATAGTGTAGT
TAACCATTTAATTTCGAAAA

Downstream 100 bases:

>100_bases
AGAGCATAATGACATGAATATCTGGTCAATTCTTTGTCTCATCTGGACTTTGGCCGCCTATGTTGTGGCAAAGCGAATCT
ATCAAAAACATCCAAAACTT

Product: LrgA family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MSTESASGTPSQPSLFVLVKQILILAGFWWIGYLLHQKLGVPVSAGILGMFLLLLCLFFKIIKMDQVAMGATVVLGELLL
FFVPVVVAVVQYKTLFMTEGWQIVLSIGVGTILVMLSTSLTIHYYNRLKAYLQARKRLQHKHI

Sequences:

>Translated_143_residues
MSTESASGTPSQPSLFVLVKQILILAGFWWIGYLLHQKLGVPVSAGILGMFLLLLCLFFKIIKMDQVAMGATVVLGELLL
FFVPVVVAVVQYKTLFMTEGWQIVLSIGVGTILVMLSTSLTIHYYNRLKAYLQARKRLQHKHI
>Mature_142_residues
STESASGTPSQPSLFVLVKQILILAGFWWIGYLLHQKLGVPVSAGILGMFLLLLCLFFKIIKMDQVAMGATVVLGELLLF
FVPVVVAVVQYKTLFMTEGWQIVLSIGVGTILVMLSTSLTIHYYNRLKAYLQARKRLQHKHI

Specific function: Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. W

COG id: COG1380

COG function: function code R; Putative effector of murein hydrolase LrgA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidA/LrgA family. CidA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005538 [H]

Pfam domain/function: PF03788 LrgA [H]

EC number: NA

Molecular weight: Translated: 15982; Mature: 15851

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTESASGTPSQPSLFVLVKQILILAGFWWIGYLLHQKLGVPVSAGILGMFLLLLCLFFK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IIKMDQVAMGATVVLGELLLFFVPVVVAVVQYKTLFMTEGWQIVLSIGVGTILVMLSTSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
TIHYYNRLKAYLQARKRLQHKHI
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STESASGTPSQPSLFVLVKQILILAGFWWIGYLLHQKLGVPVSAGILGMFLLLLCLFFK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IIKMDQVAMGATVVLGELLLFFVPVVVAVVQYKTLFMTEGWQIVLSIGVGTILVMLSTSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
TIHYYNRLKAYLQARKRLQHKHI
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]